DOCSLIB.ORG

Download Download

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Download Download TRADITIONAL KNOWLEDGE IJATM.2020;2(2):20-25. International Journal of Ayurveda and Traditional Medicine Physico-chemical Evaluation of an Ethnomedicinal Formulation Karmaranga (Averrhoa ​ ​ ​ Carambola linn.) Fruit Oil. ​ 1 1 2 P Shetty Shifa, ​ Faisal Mohammed, P​ rabhu Suchitra 1 ​ ​ ​ D​ ept. of PG Studies in Dravyaguna Vijnana, Sri Dharmasthala Manjunatheshwara College of Ayurveda and 2 Hospital, Kuthpady, Udupi. S​ ri Dharmasthala Manjunatheshwara Centre for Research in Ayurveda and Allied ​ Sciences, Udupi. ABSTRACT Introduction: Processing of crude drugs helps the transformation of the pharmacological action of a drug bestowing it with better efficacy and greater bioavailability. Lesser explored traditional practices have many such single drug therapies that can ​ be brought into the limelight. One such folklore practice is Taila Paka of Karmaranga (Averrhoa carambola Linn.) Phala ​ ​ ​ ​ which is used traditionally in treating joint disorders. Standardization of drugs is of paramount importance in order to deliver a promising treatment with respect to safety and efficacy, with this background the oil prepared using Karmaranga fruits is ​ taken for its analytical study. Methods: The present study exclusively deals with the physico-chemical analysis of Karmaranga Taila by standard oil ​ ​ ​ ​ parameters including High-performance thin-layer chromatography (HPTLC). ​ ​ Results: The sample was liquid at room temperature with a reddish-brown color and agreeable odor. As the fruits are rich in ​ vitamin C, HPTLC was done along with ascorbic acid running parallel to the test sample. There were 3 and 7 bands respectively observed in short UV and long UV. Simultaneously ascorbic acid showed a blue fluorescent band at Rf 0.48, after derivatization with vanillin sulphuric acid spraying reagent, there were two bands evident in A.carambola oil at Rf 0.48 ​ and 0.57 (all purple). Conclusions: This study can serve as a standard reference for the preliminary identification of Karmaranga Taila. ​ ​ ​ _________________________________________________________________________________ ​ Keywords: HPTLC; Karmaranga Taila; Physico-chemical analysis; Traditional formulation. ​ ​___________​ ______________________​ _____________________________​ __________________ ​ INTRODUCTION Tremendous amount of traditional knowledge hidden Averrhoa carambola Linn., belonging to the family Oxalidaceae,2 commonly called star fruit in Indian within tribals on herbal medicine is unknown to the outer ​ world. Karmaranga is a plant drug mentioned under markets. Edible fruits of this plant are commonly used as 3 ​ ​ 1 a home remedy for cough and cold. Phalavarga of Bhavaprakasha Nighantu. F​ ruits have ​ ​ ​ ​ Madhura Amla Rasa, Snigdha Ruksha Guru Guna, and Correspondence:​ ​Dr. Shifa Shetty P. Post-Graduate Amla Vipaka, Sheeta Virya according to Bhavaprakasha ​ ​ Scholar, Department of Dravyaguna, Sri Dharmasthala and Ushna Virya according to Rajanighantu. It is ​ ​ ​ ​ Manjunatheshwara College of Ayurveda and Hospital, attributed with Grahi, Hridya, Bala Pushtikara Karma. ​ Kuthpady, 574118 Udupi, Karnataka, India. Email: With all the above qualities it is one of the best sannihitharai09@gmail.com. Phone: +91-8073898748. Vata-Kaphahara Dravya. Botanically it is identified as ​ IJATM I VOL 2 I ISSUE 2 I JUNE 2020 ​ ​ ​ ​ ​ ​ Free Full Text Articles are Available at https://ijatm.org/ 20 ​ ​ Shifa Shetty P. et.al. Physico-chemical Evaluation of an Ethnomedicinal Formulation Karmaranga (Averrhoa Carambola linn.) Fruit Oil. ​ ​ ​ Siddhi Laxana were obtained, the heat source was turned A lesser-known folklore use of this fruit is in the form of ​ oil in various joint pains.4 Standardization is the process off, and later the oil was packed in airtight containers. ​ of implementing and developing technical standards This oil was further analyzed as per standard protocol at based on the consensus of different parties that include SDM center for Research in Ayurveda and Allied firms, users, interest groups, standard organization and Sciences, Udupi. governments.5 With a growing demand for ​ Analytical Study: evidence-based medicine, any formulation classical or Following physico-chemical parameters were tested to folklore has to undergo standardization techniques as per standardize Karmaranga Taila as per the ASU testing API before administration. Fruits of Karmaranga have ​ ​ ​ ​ protocols prescribed by API and laboratory procedures for been studied extensively for its nutritional benefits but, testing Siddha and Ayurvedic medicines by CCRAS.7 currently, no medicinal formulation is in practice. This ​ paper exclusively deals with the physico-chemical Refractive index, Specific gravity, determination of acid analysis of an Anuktayoga- Karmaranga Taila prepared value, determination of saponification value, ​ ​ ​ using a drug that is classically described by various determination of rancidity, determination of iodine value, Nighantukaras with reference to its standard oil determination of the unsaponifiable matter, peroxide ​ parameters in order to form a basis for further clinical value, and viscosity along with chromatographic analysis trials. The expected outcome of the study was to do were carried out. preliminary physico-chemical analysis of Karmaranga ​ Sample preparation for High-performance thin-layer Taila. chromatography (HPTLC) : A sample obtained in the procedure for the determination METHOD of the unsaponifiable matter is dissolved in 10 ml of As the preparation methods varied from one ethno group chloroform this was followed for the sample of to another, to maintain the uniformity general method of A.carambola, and chloroform soluble portion was used ​ preparation of Taila was followed as per Sharangadhara for HPTLC. 6 ​ ​ Samhitha. (​ Figure 1) ​ ​ 3.75 kgs of Karmaranga Phala Kalka was added to 15 HPTLC: ​ liters of Tila Taila, to this 60 liters of Phalarasa was 3, 6, 9µl of the above sample was applied on a precoated ​ ​ ​ added and heated over Mandagni. The color and odor of silica gel F on aluminum plates to a bandwidth of 8 mm ​ ​ ​254 Taila gradually started changing by the end of the first using Linomat 5 TLC applicator. The plate was developed day. Taila Paka was done for 3 days as the Dravadravya in Toluene – Ethyl acetate (9:1) and the developed plates ​ ​ ​ used was Swarasa. On the third day, oil was were visualized under UV 254 and 366 nm, and after ​ ​ continuously tested by subjecting the Kalka to fire until derivatization in vanillin-sulphuric acid spray reagent and ​ the hissing sound disappeared and also was rolled scanned under UV 254 and 366 nm. Rf, the colour of the ​ ​ between the fingers to form a wick. Once the Sneha spots, and the densitometric scan were recorded ​ 1a 1b 1c 1d Figure 1a. Fruits of A.carambola . Figure 1b. .Kalka .Figure 1c. Swarasa. Figure 1d. Subject to Taila Paka. ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ IJATM I VOL 2 I ISSUE 2 I JUNE 2020 21 Free Full T​ex​ t Articles a​ re​ Available at h​ tt​ ps://ijatm.org/ ​ Shifa Shetty P. et.al. Physico-chemical Evaluation of an Ethnomedicinal Formulation Karmaranga (Averrhoa Carambola linn.) Fruit Oil. ​ ​ < Table 1. Standardization parameter of A. carambola ​ ​ RESULT fruit oil. Results of standardization with respect to parameters like Parameter Results n = 3 %w/w refractive index, saponification value, iodine number, etc Averrhoa carambola were tabulated (Table 1). Results of HPTLC (Table 2) Linn. fruit oil showed that in the short UV of the test sample there were Refractive index 1.47032 3 bands identified at Rf of 0.25, 0.37, 0.48 (all green). In Specific gravity 0.9204 long UV, there were 7 bands identified at 0.27, 0.44, 0.48, Acid value 1.10±0.00 0.57, 0.67, 0.79, 0.91(all fluorescent blue). Saponification value 218.52±0.01 Simultaneously ascorbic acid showed a blue fluorescent Iodine value 188.94±2.46 band at Rf 0.48, after derivatization with vanillin sulphuric acid spraying reagent, there were two bands Unsaponifiable matter (%) 3.78 evident in A.carambola oil at R 0.48 and 0.57 (all purple) Peroxide value 0.19±0.01 ​ ​f (Figure 2-5). Viscosity 64.38 Rancidity Oil is not oxidized Table 2. Standardization parameter of A. carambola fruit oil. ​ ​ ​ Short UV Ascorbic acid Long UV Ascorbic acid After Ascorbic acid derivatization 0.25 (Green) - - - - - - - 0.27 (F. blue) - - - 0.37 (Green) - - - - - - - 0.44 (F. blue) - - - 0.48 (Green) - - - 0.48 (Purple) - - 0.50 (F. blue) - - - 0.57 (F. blue) - 0.57 (Purple) - - - 0.67 (F. blue) - - - - - 0.79 (F. blue) - - - - - 0.91 (F. blue) - - - 2a 2b 2c Figure 2. HPTLC Photodocumentation of a sample of Chloroform fraction of fruit oil of A.carambola Linn. ​ ​ ​ Figure 2a. Short UV . Figure 2b.Long UV . Figure 2c. After derivatization. ​ ​ ​ ​ ​ ​ ​ ​ Track 1: Fruit oil of A.carambola - 3µl Track 2: Fruit oil of A.carambola - 6µl, Track 3: Fruit oil of A.carambola - 9µl, Track 4:Ascorbic ​ ​ ​ ​ ​ ​ acid- 6µl, Solvent system- Toluene: Ethyl acetate (9.0: 1.0) 22 IJATM I VOL 2 I ISSUE 2 I JUNE 2020 ​ ​ ​ ​ ​ ​ Free Full Text Articles are Available at https://ijatm.org/ ​ Shifa Shetty P. et.al. Physico-chemical Evaluation of an Ethnomedicinal Formulation Karmaranga (Averrhoa Carambola linn.) Fruit Oil. ​ ​ ​ 3a 3b 3d 3c Figure 3. Densitometric scan of the sample of fruit of A.carambola Linn. at 254nm . Figure 3a and 3c sample of A. carambola. Figure ​ ​ ​ ​ ​ ​ ​ ​ 3a and 3c Ascorbic acid. ​ 4b 4a 4d 4c Figure 4. Densitometric scan of the sample of fruit of A.carambola Linn. at 366nm . Figure 4a and 4c sample of A. carambola. Figure ​
Load more

Recommended publications
  • Jayumedsci-2-2-209.Pdf
    Journal of Ayurveda Medical Sciences Refereed, Indexed, Peer reviewed, Open access, Quarterly Journal for Rapid Publication of Ayurveda and Other Traditional Medicine Research ISSN: 2456-4990 www.jayumedsci.com J Ayu Med Sci | 2017 | Vol 2 | Issue 2 (Apr – June) ©Journal of Ayurveda Medical Sciences – HRGS’ Ayurveda Journal Faisal et al. J Ayu Med Sci 2017; 2(2): 209-13 HRGS’ Ayurveda Journal Journal of Ayurveda Medical Sciences Peer Reviewed Journal of Ayurveda and other Traditional Medicines ISSN: 2456-4990|www.jayumedsci.com|jayumedsci@gmail.com Short Communication Clinical efficacy of Vrukshamla Beeja Taila (Kokum Butter) in the Management of Padadari (Cracked Heels) Faisal Mohammed1, Sreekant Vishnu Joshi2*, Shridhara Bairy Tantrady3 1Department of Dravyaguna Vignanam, SDM College of Ayurveda and Hospital, Kuthpady, Udupi, 574118. 2School of Ayurvedic Science and Research, Rai Technology University, Bangalore Rural District, Bangalore 561204. 3Department of Dravyaguna Vignanam, SDM College of Ayurveda and Hospital, Kuthpady, Udupi, 574118, India. *Correspondence: Mobile: +91-8792509773; Email: doctorsreekantjoshi@gmail.com ABSTRACT Introduction: Padadari (Cracked heels) is one of the commonly existing podiatric diseases in our society, which is basically caused by the habit of excessive walking that is often associated with excessive dryness leading to the cracking or splitting. Kokum butter oil extracted from the seeds of Vrukshamla (Garcinia indica Choisy.) is used by folklore Vaidyas in Western Ghats of India to treat Padadari, but no study has been documented till date regarding its efficacy in the management of the Padadari. The drug is available easily and used extensively in folk practice. Methods: The Vrukshamla beeja taila (VBT) was prepared by traditional seed-kernel boiling method and then given to 23 patients of Padadari, which were selected from out-patient and in-patient departments of SDM Hospital of Ayurveda, Udupi.
    [Show full text]
  • District Census Handbook, Udupi, Part XII-A & B, Series-30
    CENSUS OF INDIA 2001 SERIES - 30 KARNATAKA PART XII - A & B : VILLAGE AND TOWN DIRECTORY & PRIMARY CENSUS ABSTRACT DISTRICT CENSUS HANDBOOK UDUPI DIRECTORATE OF CENSUS OPERATIONS, KARNATAKA,BANGALORE MOT -DMrid Stt~'$ 'Silhrurrull ii:s lkorcm1lJ.orll Ime4llf ~ ;a :sJImlllll w!IniirdIn IImIllre iitt ttlhe 'S!DdIiiestt: ({l)if aIIIl1tlbYe ii'SibmInll'S :amrdl giiwe tt:IDWYII!l «\)jf ttlhe~. lTlt iis uiir.dl ttlbmtt: ~ iitt :l!l 1tJruIle Soo1tltil Sea tOIDD.:oxum:. ~ ttIhm: :l!lllle ~ ;mmH lbmti\rrdl iiJm 11498 «lDll rnre «\)jf ~ iislli2ll1lulls \\\VlInDdIn line ~ sallitiiih :are mUlw gIDll)wwu lhmne.. fie ~ ii'S ~ fM "!Ell P'cadrlOO c&e Saonltat M;anU'_ llit ii'S ifino>m ttlInii'S ttlhalt Ulbrese iitt-s ifamooJrs lI:ro!rs:allit IrtOY.ck$., \\WIIniirdIn Ihmw: ~d iitmnlID D:s_.dl$ ~ 1IlIneiiJr ~ mtme_. TIney;:me jjrumt ;a br tOIDlhm!l!lll1l!'£ cammIl .'SlP'lliitt iilm1nol ~ mIDlMliic.. lP~ ~ JlDlRIDjeatitmm; @ mIDdk lriisiilmg \OOlIl1: @fttlhe ~ ttl1niis ii'S ltlhre (QDD]]Y ~ m1Jim:dtii;a ~ ~ mdks m(j)w «(l)j[ AIr_fum Sea IrIOXllllllrdi <allMxmtt: M;m])p.e.. "'Ulme ~ 1IlIJP> m ~ jp)~ if(jj)~. lflIl):(lQ: iisTharrmll ii'S ~ ;a :sqJ_turmre mmiiIke iilm area DWI lIllM mnrOlfIf: ttlhrm_ 15(0) y.anndk; iiIm wMirdhtlIn.. lIlt Jhm; (()1l):Q00JIlIlt ~ D I s T INDIA KARNATAKA DISTRICT UDUPI Km 5 o 5 [0 [5 Km Ul C.D. Block boundary of Udupi is co-terminus o -with laluk boundary , TOTAL AREA OF DISTRICT (IN SQ.KM) __ _______ __ 38.880.00 ..... -. TOTAL POPULATION OF DISTRICT ____________ __ __ 1.112.243 I TOTAL NUMBER OF TOWNS IN" DISTRICT •••• __ ._ .06 :"- TOTAL NU MBER OF VILLAGES [N DISTRICT _____ .
    [Show full text]
  • Trade Marks Journal No: 1947 , 11/05/2020 Class 5
    Trade Marks Journal No: 1947 , 11/05/2020 Class 5 2654104 03/01/2014 SAHUL INDIA LTD MANGALAM-B, 2ND FLOOR, 26, HEMANTA BASU SARANI, KOLKATA - 700 001 MANUFACTURER & MERCHANT AN INDIAN COMPANY Used Since :01/01/1999 To be associated with: 861487 KOLKATA PHARMACEUTICAL PREPARATIONS, AYURVEDIC TEA & HERBAL TEA, AYURVEDIC & HERBAL DRINK, AYURVEDIC & HERBAL MEDICINES, AYURVEDIC PREPARATIONS, VETERINARY AND SANITARY PREPARATIONS, DIETETIC SUBSTANCES ADAPTED FOR MEDICAL USE, FOOD OF BABIES, MATERIALS FOR STOPPING TEETH, DENTAL WAX, DISINFECTANTS, PREPARATION FOR DESTROYING VERMIN, MEDICINAL OILS and COD LIVER OIL INCLUDED IN CLASS- 5. THIS IS SUBJECT TO ASSOCIATION WITH REGISTERED/PENDING REGISTRATION NO.861487.. 321 Trade Marks Journal No: 1947 , 11/05/2020 Class 5 REX'S BALM 2687194 26/02/2014 REX (U&A) REMEDIES PRIVATE LIMITED A-5/11, G.T KARNAL ROAD, INDUSTRIAL AREA, DELHI-110 033 MANUFACTURERS, MERCHANTS AND TRADERS Address for service in India/Attorney address: BMJ LAW PARTNER DLF CAPITAL GREENS, PHASE 1, TOWER C, 233, LEVEL 23, SHIVAJI MARG, MOTI NAGAR, NEW DELHI-110015 Used Since :02/02/1995 To be associated with: 1627591, 1627594, 1947647, 2124412, 2124413, 2124414, 2124418 DELHI UNANI AND AYURVEDIC MEDICINES AND MEDICINAL PREPARATIONS 322 Trade Marks Journal No: 1947 , 11/05/2020 Class 5 2813487 22/09/2014 ORGANIC INDIA PVT.LTD. PLOT NO 266 KAMTA CHINHAT FAIZABAD ROAD LUCKNOW 227105 U.P. MERCHANTS & MANUFACTURERS Address for service in India/Attorney address: LALL & SETHI D - 17, SOUTH EXTENSION PART - II, NEW DELHI - 110 049. Used Since :01/06/2014 To be associated with: 2519579 DELHI “pharmaceutical substances, dietetic substances adapted for medical use, ayurvedic herbal supplements”.
    [Show full text]
  • Report of the Joint Committee Constituted in the O.A. No. 254 Of
    REPORT OF THE JOINT COMMITTEE CONSTITUTED BY HON’BLE NGT ( SZ) IN THE OA NO. 254 OF 2020 IN THE MATTER OF SMT SUGANDHI SHEKAR VERSUS UNION OF INDIA RELATING TO ESTABLISHMENT OF FISH MEAL (MILL) AND OIL COMPANY IN COASTAL AREA/RIVER BANKS ALONG THE BANKS OF UDHYAVARA RIVER, UDUPI DISTRICT, KARNATAKA. 1.0. PREAMBLE In the OA No 254 of 2020, filed by Smt Sugandhi Shekar Versus Union of India, the Hon’ble National Green Tribunal (SZ), issued an Order dated 14.12.2020 with the following directions: “ 7. Considering the circumstances, in order to ascertain the real state of affairs and also the alleged violation, we feel it appropriate to appoint a Joint Committee comprising of (1) a Senior Officer from Ministry of Environment, Forests and Climate Change (MoEF&CC), Regional Office, Bangalore (2) a Senior Officer from Central Pollution Control Board (CPCB), Regional Office, Bangalore, (3) a Representative Officer of the Karnataka State Coastal Zone Management Authority (KSCZMA) and (4) a Senior Officer from Karnataka State Pollution Control Board (KSPCB) to inspect the area in question and submit a factual as well as action taken report, if there is any violation found. 8. The committee is directed to ascertain as to whether there was any violation of environmental laws in establishing such units in that area, including Coastal Regulation Zone (CRZ) violation, whether necessary permission have been obtained by them for the purpose of starting the units or continuing the units in that area, whether there is any pollution caused on account of functioning of those units and if there is any violation and environmental damage caused on account of their activities including pollution caused to air as well as water then, the committee is directed to assess the environmental compensation apart from taking action for violation in running the units under the respective statues.
    [Show full text]
  • Antifungal and Antioxidant Activities of Organic and Aqueous Extracts of Annona Squamosa Linn. Leaves
    journal of food and drug analysis 23 (2015) 795e802 Available online at www.sciencedirect.com ScienceDirect journal homepage: www.jfda-online.com Original Article Antifungal and antioxidant activities of organic and aqueous extracts of Annona squamosa Linn. leaves * Narasimharaju Kalidindi a, , Nagarasanakote Venkataswamy Thimmaiah b, Nagepally Venkataramareddy Jagadeesh c, Ramaiah Nandeep a, Sathyanarayana Swetha a, Bharat Kalidindi d a Department of Pharmacology, Visveswarapura Institute of Pharmaceutical Sciences, Bangalore, Karnataka, India b Department of Pharmacology, KLE College of Pharmacy, Belgaum, Karnataka, India c Department of Pharmacology, SET's College of Pharmacy, Dharwad, Karnataka, India d SDM College of Ayurveda Kuthpady, Udupi, Karnataka, India article info abstract Article history: An increasing demand for natural additives has shifted the attention from synthetic to Received 2 October 2014 natural antioxidants and antifungal agents. This study was carried out to evaluate the Received in revised form antifungal and antioxidant activities of methanol, chloroform, and aqueous extracts of 16 February 2015 Annona squamosa Linn. leaves. The antifungal activities of all extracts of A. squamosa leaves Accepted 5 May 2015 against five different strains of fungi (Alternaria alternata, Candida albicans, Fusarium solani, Available online 26 July 2015 Microsporum canis, and Aspergillus niger) were evaluated by the agar well diffusion method and the minimum inhibitory concentration of each extract was assessed by antifungal suscep- Keywords: tibility using the broth microdilution method. The antioxidant potential of each extract was acetogenins determined by free radicals (1,1-diphenyl-2-picrylhydrazyl, nitric oxide, and hydrogen Annona peroxide) scavenging activity and reducing power property of A. squamosa leaves. Both antifungal organic and aqueous extracts were found to express dose-dependent inhibition against all antioxidant tested fungi strains in both agar well diffusion and broth dilution methods.
    [Show full text]
  • Exploration and Elucidation of Various Medicinal Plants Used in The
    Journal of Pharmacognosy and Phytochemistry 2019; 8(1): 1887-1890 E-ISSN: 2278-4136 P-ISSN: 2349-8234 JPP 2019; 8(1): 1887-1890 Exploration and elucidation of various medicinal Received: 26-11-2018 Accepted: 29-12-2018 plants used in the management of dermatological disorders by folklore practitioners of Udupi Faisal Mohammed Assistant Professor, Department of District, Karnataka, India Dravyaguna, Sri Dharmasthala Manjunatheshwara Ayurveda College and Hospital, Kuthpady, Udupi, Karnataka, India Faisal Mohammed and Shetty P Shifa Shetty P Shifa PG Scholar Department of Abstract Dravyaguna, Sri Dharmasthala Introduction: Ayurveda emphasizes to utilize the flora which is available in and around us for medicinal Manjunatheshwara Ayurveda purpose. It also believes everything is medicinal in nature thus suggests to collect the information about College and Hospital, these local medicinal flora from the Vanavaasi (Primitive tribes), Ajapa (Goatherds), Avipa (Shepherds) Kuthpady, Udupi, Karnataka, and Gopa (Cowherds). Traditionally the science of healing is taught from one generation to another, India which is now kept as a secret. Hence an attempt is made in this direction to collect the information from traditional healers who use locally available plants of their place for skin ailments located in coastal region of Karnataka called Udupi. Methodology: The information regarding the plant species, their local name, part used, mode of usage along with dosage of the medicinal plants used by them. The data was collected by randomly selecting 24 informers who were from 16 different villages and data is collected using a Self-prepared questionnaire based interviews. Results and Conclusion: The ethno-medico-botanical survey is documented and it reveals that 27 different plant species belonging to 16 families which were used by the folklore practitioners to successfully prevent and treat various ailments of skin as well as hair.
    [Show full text]
  • Neuroprotective Functions of Alpinia Galanga in Forebrain Ischemia Induced Neuronal Damage and Oxidative Insults in Rat Hippocampus
    Original Article Neuroprotective Functions of Alpinia galanga in Forebrain Ischemia Induced Neuronal Damage and Oxidative Insults in Rat Hippocampus Ravi Mundugaru*1,2 Senthilkumar Sivanesan1, Padmaja Udaykumar3, Vidyadhara D J4, Suchitra Narayan Prabhu5, Basavaiah Ravishankar6 1Department of Research and Development, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamilnadu, INDIA. 2Department of Pharmacology, Kodagu Institute of Medical Sciences, Madikeri, Karnataka 571 201, INDIA. 3Department of Pharmacology, Father Muller Medical College, Mangalore, Karnataka, INDIA. 4Department of Neurophysiology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur road, Bangalore- 560029, Karnataka, INDIA 5Department of Pharmacognosy and Phytochemistry, SDM Centre for Research in Ayurveda and Allied Sciences, Udupi, Karnataka, INDIA. 6Department of Pharmacology and Toxicology Laboratory, SDM Centre for research in Ayurveda and Allied Sciences, Kuthpady, Udupi, Karnataka, INDIA. ABSTRACT Introduction: The rhizomes of Alpinia galanga (L.) Willd (Zingiberaceae) commonly known as greater galangal, a ginger substitute for food and was traditionally used as nervine tonic and stimulant. The present study was designed to screen the neuroprotective role of hydroalcoholic extract of rhizome of Alpinia galanga (HAAG) in transient forebrain ischemia induced neuronal damage and oxidative injury in the rat brain. Materials and Method: The transient forebrain ischemia was induced by bilateral common carotid artery occlusion in anesthetized rats for 60 min, followed by reperfusion injury. The transient forebrain ischemia induced neuronal damage and oxidative stress was assessed by estimating the percentage survival neurons in the Cornu ammonis CA1 and CA3 regions of hippocampus, MDA levels and antioxidant enzymes activities in the brain homogenate. Open field, actophotometer and grip strength tests were used for behavioral assessment.
    [Show full text]
  • Pharmacognostical and Preliminary Phytochemical Characterization of Tender Leaves of Combretum Latifolium Blume - a Folklore Medicinal Plant
    INTERNATIONAL AYURVEDIC MEDICAL JOURNAL Research Article ISSN: 2320 5091 Impact Factor: 5.344 PHARMACOGNOSTICAL AND PRELIMINARY PHYTOCHEMICAL CHARACTERIZATION OF TENDER LEAVES OF COMBRETUM LATIFOLIUM BLUME - A FOLKLORE MEDICINAL PLANT Ravikrishna.S1*, Suchitra. N. Prabhu2 1Associate Professor, Department of Agadatantra, Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Kuthpady, Udupi, Karnataka, India 2Research officer, Department of Pharmacognosy and Phytochemistry, Sri Dharmasthala Manjunatheshwara Centre for Research in Ayurveda and Allied Sciences, Kuthpady, Udupi, Karnataka, India Corresponding Author: drrkaithal@gmail.com https://doi.org/10.46607/iamj0708082020 (Published online: August 2020) Open Access © International Ayurvedic Medical Journal, India 2020 Article Received:17/07/2020 - Peer Reviewed:04/08/2020 - Accepted for Publication:04/08/2020 ABSTRACT Objective: The study is undertaken with the intention to document the pharmacognostic characters in order to ascertain identity, quality and authenticity of the crude drug. Further the Phytochemical class predominantly to which the plant belongs will be of great importance contributing to its biological activity and therapeutic use. The tender leaves of Combretum latifolium(C. latifolium)Blume. are used to render the immune system strong. Com- bretum species are extensively used in traditional medicinal system from inflammation to diuretic. The present study is a step to unleash its phytochemical characterization which may be responsible for its biological activity. Pharmacognostic characters will serve the drugs identity and authentication. Materials and methods: Sample of crude plant material were collected around Udupi area and its identity was thus confirmed by botanist. Macro- microscopic study of the preserved specimen in the fixative was conducted in the department of Pharmacognosy and preliminary phytochemical test and HPTLC fingerprint of the leaf extract was carried out as per testing proto- cols.
    [Show full text]
  • World Journal of Pharmaceutical Research Niyathi Et Al
    World Journal of Pharmaceutical Research Niyathi et al. World Journal of Pharmaceutical SJIF ImpactResearch Factor 8.084 Volume 8, Issue 13, 550-561. Review Article ISSN 2277– 7105 PHARMACOGNOSTIC, PHYTOCHEMICAL AND HPTLC PROFILE OF THEV DHANTU [PETIOLE OF COLOCASIA ESCULENTA (LINN.) SCHOTT.] Dr. Niyathi*, 1Dr. Chaithra Hebbar, 2Dr. Suma V. Mallya, 3Dr. Mohammed Faisal and 4Suchitra Narayan Prabhu *PG Scholar, Department of Dravyaguna Vigyana, Sri Dharmasthala Manjunatheshwara College of Ayurveda & Hospital, Kuthpady, Udupi- 574118, Karnataka, India. 1Professor and Head, Department of Agadatantra, Research Head, Folklore Medicine Research Centre, Sri Dharmasthala Manjunatheshwara College of Ayurveda & Hospital, Kuthpady, Udupi- 574118, Karnataka, India. 2Associate Professor, Department of Dravyaguna Vigyana, Sri Dharmasthala Manjunatheshwara College of Ayurveda & Hospital, Kuthpady, Udupi- 574118, Karnataka, India. 3Associate Professor, Department of Dravyaguna Vigyana, Sri Dharmasthala Manjunatheshwara College of Ayurveda & Hospital, Kuthpady, Udupi- 574118, Karnataka, India. 4Research Officer, Department of Pharmaceutical Chemistry and Pharmacognosy, S. D. M. Centre for Research in Ayurveda and Allied Sciences, Kuthpady, Udupi- 574118, Karnataka, India. ABSTRACT Article Received on 02 Oct. 2019, Introduction: Ayurveda always emphasizes on utility of local flora in Revised on 22 Oct. 2019, treatment. It also advices to know about the plant completely with Accepted on 12 Nov. 2019, DOI: 10.20959/wjpr201913-16266 respect to its identity,
    [Show full text]
  • In-Vitro Evaluation of Scoparia Dulcis Linn. for Anti – Urolithiatic Activity
    The Journal of Phytopharmacology 2018; 7(3): 285-287 Online at: www.phytopharmajournal.com Research Article In-vitro evaluation of Scoparia dulcis Linn. for anti – ISSN 2320-480X urolithiatic activity JPHYTO 2018; 7(3): 285-287 May- June Hima Sasidharan, Suma Venkatesh Mallya*, Prabhu Suchitra, Koppala Narayana Sunil Kumar Received: 27-02-2018 Accepted: 26-04-2018 ABSTRACT © 2018, All rights reserved Introduction: Urolithiasis is a complex process that occurs from series of several physicochemical event Hima Sasidharan PG Scholar, Shree Dharmasthala including super-saturation, nucleation, growth, aggregation and retention within the kidneys. Data from in- Manjunatheshwara College of vitro, in- vivo and clinical trials reveal that phytotherapeutic agents could be useful as either alternative or an Ayurveda, Kuthpady, Udupi, 574118, adjunct therapy in the management of Urolithiasis. Scoparia dulcis (L.) have been reported to possess Karnataka, India antiurolithiatic property by various folk lore practitioners. Methods: The in- vitro antiurolithiatic study of the Suma Venkatesh Mallya whole plant of S. dulcis (L). through titrimetric and turbidity method to check their potential in dissolving Associate Professor, Shree calcium oxalate crystals using Cystone as the standard compound Result: The aqueous extract showed Dharmasthala Manjunatheshwara relatively higher dissolution of 66.96% of stones than the alcoholic extract. The turbidity showed by the College of Ayurveda, Kuthpady, Udupi, alcohol extract and the aqueous extract of test drug
    [Show full text]
  • New Institution Registration List.Xlsx
    Details of establishment registered with CPCSEA NAME OF THE ANIMAL REGISTRATION DATE OF RENEWAL Sl No. ESTABLISHMENT WITH STATE HOUSE NUMBER REGISTRATION STATUS ADDRESS FACILITY Eurofins Advinus Limited, Plot No.21&22, Phase II, 2/PO/RcBi/SL/99/ 27.02.2018 to 1 Peenya Industrial Area, Karnataka Small / Large 09.03.1999 CPCSEA 26.02.2023 P.B.No. 5813, Bangalore - 560 058, Karnataka Aurigene Discovery Technology Ltd. 3/PO/RcBi-S/RcBi- Discovery Research 14.03.2017 to 2 Telangana Small / Large 11.03.1999 L/99/CPCSEA Bollaram Road, Miyapur 13.03.2022 Hyderabad - 500 049, Telangana INTOX, Institute for Toxicological Studies 6/PO/RcBi/S/99/C 375, Uravade, Pirangut- 31.07.2017 to 3 Maharashtra Small 09.03.1999 PCSEA Uravade Road Tal.Mulshi, 30.07.2022 District-Pune-412 108, Maharashtra National Centre for Cell Sciences (An Autonomous Institution of the 7/GO/ReBi/S/99/C Department of 10.03.2017 to 4 Maharashtra Small 09.03.1999 PCSEA Biotechnology, Government 09.03.2022 of India NCCS Complex, Ganesh Khind, Pune - 411 007, Maharashtra Institute of Nuclear Medicine & Allied Sciences (INMAS) Govt of India, Ministry of Defence, Defence 8/GO/RBi/S/99/CP Research & Development 13.04.2017 to 5 Delhi Small 09.03.1999 CSEA Organisation, Institute of 12.04.2022 Nuclear Medicine & Allied Sciences, Brig. S.K. Mazumdar Road, Delhi – 110 054 Institute of Genomics & Integrative Biology Centre for Biochemical 9/GO/RBiBt/S/99/ Technology 11.04.2017 to 6 Delhi Small 09.03.1999 CPCSEA Council for Scientific & 10.04.2022 Industrial Research Delhi University Campus, Mall Road, Delhi-110 007 All India Institute of Medical 10/GO/ReBiBt/S/99 Sciences 08.09.2017 to 7 Delhi Small 09.03.1999 /CPCSEA (AIIMS), Ansari Nagar 07.09.2022 New Delhi-110 029 Shreya Life Sciences Pvt.
    [Show full text]
  • Karnataka State District Profile 1991
    CENSUS OF INDIA 1991 Dr. M. VIJAVANUNNI of the Indian Administrative Service Registrar General & Census Commissioner, India Registrar General of India (In charge of the census of India and vital statistics) Office Address: 2A Mansingh Road New Delhi 110011, India Telephone: (91-11 )338 3761 Fax: (91-11}3383145 Email: rgindia@hub.nic.in Internet: http://www.censusindia.net Registrar General of India's publications can be purchased from the following: • The Sales Depot (Phone:338 6583) Office of the Registrar General of India 2-A Mansingh Road New Delhi 110 011, India • Directorates of Census Operations in the capitals of all states and union territories in India • The Controller of Publication Ofd Secretariat Civil Lines Delhi 110054 • Kitab Mahal State ~mporia Complex, Unit No.21 aaba Kharak Singh Marg New Delhi 110001 • Sales outlets of the Controller of Pubtication aU over tndia Census data available on floppy disks can be purchased from the following: • Office of the Registrar General, Jndia Data Processing Division 2nd Floor, 'E' Wing Pushpa Bhawan Madangir Road New Delhi 110062, India Telephone: (91-11)698 1558 Fax: (91-11)6980295 Email: rgdpd@rgi.satyam.net.in © Registrar General of India The contents of this publication may be quoted citing the source dearly PREFACE "To see a world in a grain of sand And a heaven in a wild flower Hold infinity in the palm of your hand And eternity in an hour" Such as described in the above verse would be the graphic outcome of the effort to consolidate the district-level data relating to all the districts of a state or the union territories into a Single tome as is this volume.
    [Show full text]