MDPI Annual Report 2020 Contents
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The Biology of Nitric Oxide, Part 7
Cell Death and Differentiation (2001) 8, 106 ± 108 ã 2001 Nature Publishing Group All rights reserved 1350-9047/01 $15.00 www.nature.com/cdd Book Review The Biology of Nitric Oxide, Part 7 B BruÈne University of Erlangen-NuÈrnberg, Medical Department IV, Experimental Division, Loschgestrasse 8, 91054 Erlangen, Germany The Biology of Nitric Oxide Part 7. Edited by S Moncada, LE Gustafsson, NP Wiklund, EA Higgs, Portland Press, London, UK: 2000, Pp. 234, £110, ISBN: 1 85578 142 5 This book is in the tradition of previously related titles (The covered by this book are quite extensive and an up-to-date Biology of Nitric Oxide, Parts 1 ± 6) that cover cutting edge summary of the current status of the field is provided. This scientific contribution related to the chemistry, biology, and is excellent for insiders, looking for detailed information, medicine of nitric oxide. Ten years after the initiating new cross-links, or just being interested in the current conference on a series of NO conventions, which was held research focus of individual groups. In this respect, most of in London in September 1989, this book now summarizes the chapters are well organized, providing background about 35 oral communications and approximately 300 poster information, technical comments, results, and a brief presentations of the 6th International Meeting on the Biology discussion. In most papers, figures or tables illustrate of Nitric Oxide, which was organized in September 1999 in major findings and references provide information for more Stockholm, Sweden. With the editors, especially Professor advanced reading on a particular topic. At the same time, Dr. -
Nitric Oxide in Health and Disease of the Nervous System H-Y Yun1,2, VL Dawson1,3,4 and TM Dawson1,3
Molecular Psychiatry (1997) 2, 300–310 1997 Stockton Press All rights reserved 1359–4184/97 $12.00 PROGRESS Nitric oxide in health and disease of the nervous system H-Y Yun1,2, VL Dawson1,3,4 and TM Dawson1,3 Departments of 1Neurology; 3Neuroscience; 4Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA Nitric oxide (NO) is a widespread and multifunctional biological messenger molecule. It mediates vasodilation of blood vessels, host defence against infectious agents and tumors, and neurotransmission of the central and peripheral nervous systems. In the nervous system, NO is generated by three nitric oxide synthase (NOS) isoforms (neuronal, endothelial and immunologic NOS). Endothelial NOS and neuronal NOS are constitutively expressed and acti- vated by elevated intracellular calcium, whereas immunologic NOS is inducible with new RNA and protein synthesis upon immune stimulation. Neuronal NOS can be transcriptionally induced under conditions such as neuronal development and injury. NO may play a role not only in physiologic neuronal functions such as neurotransmitter release, neural development, regeneration, synaptic plasticity and regulation of gene expression but also in a variety of neurological disorders in which excessive production of NO leads to neural injury. Keywords: nitric oxide synthase; endothelium-derived relaxing factor; neurotransmission; neurotoxic- ity; neurological diseases Nitric oxide is probably the smallest and most versatile NO synthases isoforms and regulation of NO bioactive molecule identified. Convergence of multi- generation disciplinary efforts in the field of immunology, cardio- vascular pharmacology, chemistry, toxicology and neu- NO is formed by the enzymatic conversion of the guan- robiology led to the revolutionary novel concept of NO idino nitrogen of l-arginine by NO synthase (NOS). -
How Frequently Are Articles in Predatory Open Access Journals Cited
publications Article How Frequently Are Articles in Predatory Open Access Journals Cited Bo-Christer Björk 1,*, Sari Kanto-Karvonen 2 and J. Tuomas Harviainen 2 1 Hanken School of Economics, P.O. Box 479, FI-00101 Helsinki, Finland 2 Department of Information Studies and Interactive Media, Tampere University, FI-33014 Tampere, Finland; Sari.Kanto@ilmarinen.fi (S.K.-K.); tuomas.harviainen@tuni.fi (J.T.H.) * Correspondence: bo-christer.bjork@hanken.fi Received: 19 February 2020; Accepted: 24 March 2020; Published: 26 March 2020 Abstract: Predatory journals are Open Access journals of highly questionable scientific quality. Such journals pretend to use peer review for quality assurance, and spam academics with requests for submissions, in order to collect author payments. In recent years predatory journals have received a lot of negative media. While much has been said about the harm that such journals cause to academic publishing in general, an overlooked aspect is how much articles in such journals are actually read and in particular cited, that is if they have any significant impact on the research in their fields. Other studies have already demonstrated that only some of the articles in predatory journals contain faulty and directly harmful results, while a lot of the articles present mediocre and poorly reported studies. We studied citation statistics over a five-year period in Google Scholar for 250 random articles published in such journals in 2014 and found an average of 2.6 citations per article, and that 56% of the articles had no citations at all. For comparison, a random sample of articles published in the approximately 25,000 peer reviewed journals included in the Scopus index had an average of 18, 1 citations in the same period with only 9% receiving no citations. -
Antiproliferative Effects of Carbon Monoxide on Pancreatic Cancer
Digestive and Liver Disease 46 (2014) 369–375 Contents lists available at ScienceDirect Digestive and Liver Disease jou rnal homepage: www.elsevier.com/locate/dld Oncology Antiproliferative effects of carbon monoxide on pancreatic cancer a,b,∗ c,1 a a Libor Vítek , Helena Gbelcová , Lucie Muchová , Katerinaˇ Vánovᡠ, a,2 a a a Jaroslav Zelenka , Renata Koníckovᡠ, Jakub Sukˇ , Marie Zadinova , c d,e d d,e c,∗∗ Zdenekˇ Knejzlík , Shakil Ahmad , Takeshi Fujisawa , Asif Ahmed , Tomásˇ Ruml a Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University in Prague, Prague 2, Czech Republic b 4th Department of Internal Medicine, 1st Faculty of Medicine, Charles University in Prague, Prague 2, Czech Republic c Department of Biochemistry and Microbiology, Institute of Chemical Technology, Prague 6, Czech Republic d Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK e School of Life & Health Sciences, Aston University, Birmingham, UK a r t i c l e i n f o a b s t r a c t Article history: Background: Carbon monoxide, the gaseous product of heme oxygenase, is a signalling molecule with Received 14 June 2013 a broad spectrum of biological activities. The aim of this study was to investigate the effects of carbon Accepted 4 December 2013 monoxide on proliferation of human pancreatic cancer. Available online 14 January 2014 Methods: In vitro studies were performed on human pancreatic cancer cells (CAPAN-2, BxPc3, and PaTu- 8902) treated with a carbon monoxide-releasing molecule or its inactive counterpart, or exposed to Keywords: carbon monoxide gas (500 ppm/24 h). -
Since January 2020 Elsevier Has Created a COVID-19 Resource Centre with Free Information in English and Mandarin on the Novel Coronavirus COVID- 19
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. Journal Pre-proof Could nitric oxide help to prevent or treat COVID-19? Jan Martel, Yun-Fei Ko, John D. Young, David M. Ojcius PII: S1286-4579(20)30080-0 DOI: https://doi.org/10.1016/j.micinf.2020.05.002 Reference: MICINF 4713 To appear in: Microbes and Infection Received Date: 1 May 2020 Accepted Date: 4 May 2020 Please cite this article as: J. Martel, Y.-F. Ko, J.D. Young, D.M. Ojcius, Could nitric oxide help to prevent or treat COVID-19?, Microbes and Infection, https://doi.org/10.1016/j.micinf.2020.05.002. This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. -
Specialissue
IMPACT FACTOR 2.524 an Open Access Journal by MDPI Artificial Intelligence and Complexity in Art, Music, Games and Design Guest Editors: Message from the Guest Editors Dr. Juan Romero This Special Issue will focus on both the use of complexity Computation Department, ideas and artificial intelligence methods to analyse and Universidade da Coruña, Coruña, A, Spain evaluate aesthetic properties and to drive systems that generate aesthetically engaging artefacts, including but [email protected] not limited to: music, sound, images, animations, designs, Dr. Colin Johnson architectural plans, choreographies, poetry, text, jokes, etc. School of Computer Science, University of Nottingham, Computational aesthetics Nottingham NG8 1BB, UK Formalising ideas of aesthetics using ideas from colin.johnson@ entropy and information theory nottingham.ac.uk Computational Creativity Artificial Intelligence in art, design, architecture, music and games Deadline for manuscript Information Theory in art, design, architecture, submissions: music and games closed (30 September 2020) Complex systems in art, music and design Evolutionary art Evolutionary music Artificial life in arts Swarm art Pattern recognition and aesthetics Cellular automata in architecture Computational intelligence in arts mdpi.com/si/31991 SpeciaIslsue IMPACT FACTOR 2.524 an Open Access Journal by MDPI Editor-in-Chief Message from the Editor-in-Chief Prof. Dr. Kevin H. Knuth The concept of entropy is traditionally a quantity in physics Department of Physics, University that has to do with temperature. However, it is now clear at Albany, 1400 Washington that entropy is deeply related to information theory and Avenue, Albany, NY 12222, USA the process of inference. As such, entropic techniques have found broad application in the sciences. -
Mental Health Literacy and Dementia
Article Mental Health Literacy and Dementia Hannah Carr 1 and Adrian Furnham 2,* 1 Research Department of Clinical, Educational and Health Psychology, University College London, London WC1E 6BT, UK; [email protected] 2 Norwegian Business School (BI), 0484 Oslo, Norway * Correspondence: [email protected]; Tel.: +44-207-607-6265 Abstract: This study aimed to investigate mental health literacy (MHL) with respect to dementia. Three forms of dementia were investigated. In all, 167 participants completed an online questionnaire which consisted of five vignettes that described the three dementia conditions, as well as depression and typical ageing. The vignette characters had no age specified, or they were described as 50-years- old or 70-years-old. Participants had to firstly decide if there was a disorder present and identify it by name, then answer questions relating to treatment and help-seeking. Results showed that participants could identify Alzheimer’s Disease significantly more so than they could vascular or frontotemporal dementia. All three dementias were significantly more recognised when the vignette was described as a 70-year-old. Frontotemporal dementia was significantly misdiagnosed as depression. Participant education and mental health experience did not influence the identification of dementia. Compared to some other well-known mental illnesses like schizophrenia, lay people are relatively good at recognising Alzheimer’s disease, but much less so at other forms of dementia. Implications and limitations of the study are discussed. Keywords: mental health literacy; lay theories; Alzheimer’s disease; frontotemporal dementia; vascular dementia Citation: Carr, H.; Furnham, A. Mental Health Literacy and Dementia. Psychiatry Int. -
Chanwuyi Lifestyle Medicine Program Alleviates Immunological Deviation and Improves Behaviors in Autism
Article Chanwuyi Lifestyle Medicine Program Alleviates Immunological Deviation and Improves Behaviors in Autism Agnes S. Chan 1,2,*, Yvonne M. Y. Han 3, Sophia L. Sze 1,2, Chun-kwok Wong 4 , Ida M. T. Chu 4 and Mei-chun Cheung 5 1 Neuropsychology Laboratory, Department of Psychology, The Chinese University of Hong Kong, Hong Kong, China; [email protected] 2 Research Center for Neuropsychological Well-Being, The Chinese University of Hong Kong, Hong Kong, China 3 Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China; [email protected] 4 Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; [email protected] (C.-k.W.); [email protected] (I.M.T.C.) 5 Department of Social Work, The Chinese University of Hong Kong, Hong Kong, China; [email protected] * Correspondence: [email protected]; Tel.: +852-394-366-54 Abstract: Given the association between deviated inflammatory chemokines, the pathogenesis of autism spectrum disorders (ASD), and our previous findings of the Chanwuyi Lifestyle Medicine Program regarding improved cognitive and behavioral problems in ASD, the present study aims to explore if this intervention can alter pro-inflammatory chemokines concentration. Thirty-two boys with ASD were assigned to the experimental group receiving the Chanwuyi Lifestyle Medicine Program for 7 months or the control group without a change in their lifestyle. The experimental group, Citation: Chan, A.S.; Han, Y.M.Y.; Sze, S.L.; Wong, C.-k.; Chu, I.M.T.; but not the control group, demonstrated significantly reduced CCL2 and CXCL8, a trend of reduction Cheung, M.-c. -
Journal of Molecular Biology
JOURNAL OF MOLECULAR BIOLOGY AUTHOR INFORMATION PACK TABLE OF CONTENTS XXX . • Description p.1 • Audience p.2 • Impact Factor p.2 • Abstracting and Indexing p.2 • Editorial Board p.2 • Guide for Authors p.6 ISSN: 0022-2836 DESCRIPTION . Journal of Molecular Biology (JMB) provides high quality, comprehensive and broad coverage in all areas of molecular biology. The journal publishes original scientific research papers that provide mechanistic and functional insights and report a significant advance to the field. The journal encourages the submission of multidisciplinary studies that use complementary experimental and computational approaches to address challenging biological questions. Research areas include but are not limited to: Biomolecular interactions, signaling networks, systems biology Cell cycle, cell growth, cell differentiation Cell death, autophagy Cell signaling and regulation Chemical biology Computational biology, in combination with experimental studies DNA replication, repair, and recombination Development, regenerative biology, mechanistic and functional studies of stem cells Epigenetics, chromatin structure and function Gene expression Receptors, channels, and transporters Membrane processes Cell surface proteins and cell adhesion Methodological advances, both experimental and theoretical, including databases Microbiology, virology, and interactions with the host or environment Microbiota mechanistic and functional studies Nuclear organization Post-translational modifications, proteomics Processing and function of biologically -
The Role of Nitric Oxide in Immune Response Against Trypanosoma Cruzi Infection
The Open Nitric Oxide Journal, 2010, 2, 1-6 1 Open Access The Role of Nitric Oxide in Immune Response Against Trypanosoma Cruzi Infection Wander Rogério Pavanelli*,1 and Jean Jerley Nogueira Silva*,2 1Department of Pathology Science, CCB, State University of Londrina-UEL, Londrina, PR, Brazil; 2Department of Physic and Informatics, Institute of Physic of São Carlos, University of São Paulo, Brazil Abstract: Nitric oxide (NO) is a free radical synthesized from L-arginine by three different NO-synthases (NOS). NO exhibits multiple and complex biological functions and many of its effects can be mostly attributed to its strong oxidant capacity, which provides it a high affinity to metals, mainly metal with low spin configuration. Molecular targets of NO are diverse and include both low molecular weight species (e.g. thiols) and macromolecules that can be either activated or inhibited as a consequence of reacting with NO. Thus, NO is an important mediator of immune homeostasis and host defence, and changes in its generation or actions can contribute to pathologic states. The knowledge of novel effects of NO has been not only an important addition to our understanding of immunology but also a foundation for the development of new approaches for the management and treatment of various diseases, including Chagas’ disease. Herein, the multiple mechanisms by which NO can directly or indirectly affect the generation of an immune response against T. cruzi infection are discussed. Keywords: Nitric oxide, immune response, T. cruzi. INTRODUCTION metal centres of proteins with exquisite spatial and temporal resolution. Such structural modifications may modulate Nitrogen monoxide, also called nitric oxide (NO) is a radical with a small molecular weight (30 kDa) that performs protein function as cGMP-independent cellular-control multiple biologic activities. -
Business As Usual with Article Processing Charges in the Transition Towards OA Publishing: a Case Study Based on Elsevier
publications Article Business as Usual with Article Processing Charges in the Transition towards OA Publishing: A Case Study Based on Elsevier Sergio Copiello Department of Architecture, IUAV University of Venice, Dorsoduro 2206, 30123 Venice, Italy; [email protected]; Tel.: +39-041-257-1387 Received: 21 June 2019; Accepted: 26 November 2019; Published: 6 January 2020 Abstract: This paper addresses the topic of the article processing charges (APCs) that are paid when publishing articles using the open access (OA) option. Building on the Elsevier OA price list, company balance sheet figures, and ScienceDirect data, tentative answers to three questions are outlined using a Monte Carlo approach to deal with the uncertainty inherent in the inputs. The first question refers to the level of APCs from the market perspective, under the hypothesis that all the articles published in Elsevier journals exploit the OA model so that the subscription to ScienceDirect becomes worthless. The second question is how much Elsevier should charge for publishing all the articles under the OA model, assuming the profit margin reduces and adheres to the market benchmark. The third issue is how many articles would have to be accepted, in an OA-only publishing landscape, so that the publisher benefits from the same revenue and profit margin as in the recent past. The results point to high APCs, nearly twice the current level, being required to preserve the publisher’s profit margin. Otherwise, by relaxing that constraint, a downward shift of APCs can be expected so they would tend to get close to current values. Accordingly, the article acceptance rate could be likely to grow from 26–27% to about 35–55%. -
Alzheimer's Disease and Frontotemporal Dementia
diagnostics Article Alzheimer’s Disease and Frontotemporal Dementia: A Robust Classification Method of EEG Signals and a Comparison of Validation Methods Andreas Miltiadous 1 , Katerina D. Tzimourta 2 , Nikolaos Giannakeas 1 , Markos G. Tsipouras 2, Theodora Afrantou 3 , Panagiotis Ioannidis 3 and Alexandros T. Tzallas 1,* 1 Department of Informatics and Telecommunications, School of Informatics and Telecommunications, University of Ioannina, Kostakioi, 47 100 Arta, Greece; [email protected] (A.M.); [email protected] (N.G.) 2 Department of Electrical and Computer Engineering, Faculty of Engineering, University of Western Macedonia, 50 100 Kozani, Greece; [email protected] (K.D.T.); [email protected] (M.G.T.) 3 2nd Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, GR54636 Thessaloniki, Greece; [email protected] (T.A.); [email protected] (P.I.) * Correspondence: [email protected] Abstract: Dementia is the clinical syndrome characterized by progressive loss of cognitive and emotional abilities to a degree severe enough to interfere with daily functioning. Alzheimer’s disease (AD) is the most common neurogenerative disorder, making up 50–70% of total dementia cases. Another dementia type is frontotemporal dementia (FTD), which is associated with circumscribed degeneration of the prefrontal and anterior temporal cortex and mainly affects personality and social skills. With the rapid advancement in electroencephalogram (EEG) sensors, the EEG has Citation: Miltiadous, A.; Tzimourta, become a suitable, accurate, and highly sensitive biomarker for the identification of neuronal and K.D.; Giannakeas, N.; Tsipouras, cognitive dynamics in most cases of dementia, such as AD and FTD, through EEG signal analysis and M.G.; Afrantou, T.; Ioannidis, P.; Tzallas, A.T.