Nitric Oxide Interaction with the Eye
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The Biology of Nitric Oxide, Part 7
Cell Death and Differentiation (2001) 8, 106 ± 108 ã 2001 Nature Publishing Group All rights reserved 1350-9047/01 $15.00 www.nature.com/cdd Book Review The Biology of Nitric Oxide, Part 7 B BruÈne University of Erlangen-NuÈrnberg, Medical Department IV, Experimental Division, Loschgestrasse 8, 91054 Erlangen, Germany The Biology of Nitric Oxide Part 7. Edited by S Moncada, LE Gustafsson, NP Wiklund, EA Higgs, Portland Press, London, UK: 2000, Pp. 234, £110, ISBN: 1 85578 142 5 This book is in the tradition of previously related titles (The covered by this book are quite extensive and an up-to-date Biology of Nitric Oxide, Parts 1 ± 6) that cover cutting edge summary of the current status of the field is provided. This scientific contribution related to the chemistry, biology, and is excellent for insiders, looking for detailed information, medicine of nitric oxide. Ten years after the initiating new cross-links, or just being interested in the current conference on a series of NO conventions, which was held research focus of individual groups. In this respect, most of in London in September 1989, this book now summarizes the chapters are well organized, providing background about 35 oral communications and approximately 300 poster information, technical comments, results, and a brief presentations of the 6th International Meeting on the Biology discussion. In most papers, figures or tables illustrate of Nitric Oxide, which was organized in September 1999 in major findings and references provide information for more Stockholm, Sweden. With the editors, especially Professor advanced reading on a particular topic. At the same time, Dr. -
RFT List.Xlsx
RFT/Posters Last updated: May 7, 2019 RFT/Posters Session 2 Abstract Title Outcomes of Voretigene Neparvovec-rzyl for Leber Congenital Aaron Nagiel Amaurosis in Eleven Patients: The CHLA Experience AAV2/4-RS1 gene therapy in the retinoschisin knockout mouse Brittni Scruggs model of X-linked retinoschisis Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) in X-linked Alexandria Vitale retinoschisis RFT/Posters Session 3 Rajvardhan Azad Modified Staging System for FEVR Optical Coherence Tomography Measurements of Retinal and Nikisha Kothari Choroidal Thickness In Preterm Infants The Clinical course and progression of incontinentia pigmenti Charles Calvo retinopathy in treated and untreated patients RFT/Posters Session 7 Omar Moinuddin Patient Outcomes in Coats'-like Retinitis Pigmentosa Andrew Tsai Coats like response in Retinitis Pigmentosa Surgical Management of Advanced Coats' Disease - From Lauren Wright Beginning to End Effect of anti-VEGF therapy on persistent vascular leakage and Irina de la Huerta neovascularization in familial exudative vitreoretinopathy Rapid fire presentation A ROP Expert Confidence in Determining Plus Disease in Borderline Agnieshka Baumritter Images Mike Gaynon Prethreshold ROP - VEGF Inhibition Without VEGF Inhibitors Pre-treatment vs. Post-Treatment Optical Coherence Tomographic Robert Gunzenhauser Angiography in children with strabismic and anisometropic amblyopia. Progression from Pre-Plus Disease to Plus Disease in the G-ROP Alomi Parikh Study Practice patterns changes in the treatment of retinopathy -
Nitric Oxide in Health and Disease of the Nervous System H-Y Yun1,2, VL Dawson1,3,4 and TM Dawson1,3
Molecular Psychiatry (1997) 2, 300–310 1997 Stockton Press All rights reserved 1359–4184/97 $12.00 PROGRESS Nitric oxide in health and disease of the nervous system H-Y Yun1,2, VL Dawson1,3,4 and TM Dawson1,3 Departments of 1Neurology; 3Neuroscience; 4Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA Nitric oxide (NO) is a widespread and multifunctional biological messenger molecule. It mediates vasodilation of blood vessels, host defence against infectious agents and tumors, and neurotransmission of the central and peripheral nervous systems. In the nervous system, NO is generated by three nitric oxide synthase (NOS) isoforms (neuronal, endothelial and immunologic NOS). Endothelial NOS and neuronal NOS are constitutively expressed and acti- vated by elevated intracellular calcium, whereas immunologic NOS is inducible with new RNA and protein synthesis upon immune stimulation. Neuronal NOS can be transcriptionally induced under conditions such as neuronal development and injury. NO may play a role not only in physiologic neuronal functions such as neurotransmitter release, neural development, regeneration, synaptic plasticity and regulation of gene expression but also in a variety of neurological disorders in which excessive production of NO leads to neural injury. Keywords: nitric oxide synthase; endothelium-derived relaxing factor; neurotransmission; neurotoxic- ity; neurological diseases Nitric oxide is probably the smallest and most versatile NO synthases isoforms and regulation of NO bioactive molecule identified. Convergence of multi- generation disciplinary efforts in the field of immunology, cardio- vascular pharmacology, chemistry, toxicology and neu- NO is formed by the enzymatic conversion of the guan- robiology led to the revolutionary novel concept of NO idino nitrogen of l-arginine by NO synthase (NOS). -
HHS Public Access Author Manuscript
HHS Public Access Author manuscript Author Manuscript Author ManuscriptOphthalmology Author Manuscript. Author Author Manuscript manuscript; available in PMC 2016 December 01. Published in final edited form as: Ophthalmology. 2015 December ; 122(12): 2373–2379. doi:10.1016/j.ophtha.2015.06.013. Ability of bottle cap color to facilitate accurate glaucoma patient- physician communication regarding medication identity Pujan Dave, BA1, Guadalupe Villarreal Jr., MD1, David S. Friedman, MD, PhD1, Malik Y. Kahook, MD2, and Pradeep Y. Ramulu, MD, PhD1 1Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland 2Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado Abstract Objective—To determine the accuracy of patient-physician communication regarding topical ophthalmic medication use based on bottle cap color, particularly amongst individuals who may have acquired color vision deficiency from glaucoma. Design—Cross-sectional, clinical study. Participants—Patients ≥ 18 years old with primary open-angle, primary angle-closure, pseudoexfoliation, or pigment dispersion glaucoma, bilateral visual acuity of 20/400 or better, and no concurrent conditions that may affect color vision. Methods—One hundred patients provided color descriptions of 11 distinct medication bottle caps. Patient-produced color descriptors were then presented to three physicians. Each physician matched each color descriptor to the medication they thought the descriptor was describing. Main Outcome Measures—Frequency of patient-physician agreement, occurring when all three physicians accurately matched the patient-produced color descriptor to the correct medication. Multivariate regression models evaluated whether patient-physician agreement decreased with degree of better-eye visual field (VF) damage, color descriptor heterogeneity, and/or color vision deficiency, as determined by Hardy-Rand-Rittler (HRR) score and the Lanthony D15 testing index (D15 CCI). -
Acquired Colour Vision Defects in Glaucoma—Their Detection and Clinical Significance
1396 Br J Ophthalmol 1999;83:1396–1402 Br J Ophthalmol: first published as 10.1136/bjo.83.12.1396 on 1 December 1999. Downloaded from PERSPECTIVE Acquired colour vision defects in glaucoma—their detection and clinical significance Mireia Pacheco-Cutillas, Arash Sahraie, David F Edgar Colour vision defects associated with ocular disease have The aims of this paper are: been reported since the 17th century. Köllner1 in 1912 + to provide a review of the modern literature on acquired wrote an acute description of the progressive nature of col- colour vision in POAG our vision loss secondary to ocular disease, dividing defects + to diVerentiate the characteristics of congenital and into “blue-yellow” and “progressive red-green blindness”.2 acquired defects, in order to understand the type of This classification has become known as Köllner’s rule, colour vision defect associated with glaucomatous although it is often imprecisely stated as “patients with damage retinal disease develop blue-yellow discrimination loss, + to compare classic clinical and modern methodologies whereas optic nerve disease causes red-green discrimina- (including modern computerised techniques) for tion loss”. Exceptions to Köllner’s rule34 include some assessing visual function mediated through chromatic optic nerve diseases, notably glaucoma, which are prima- mechanisms rily associated with blue-yellow defects, and also some reti- + to assess the eVects of acquired colour vision defects on nal disorders such as central cone degeneration which may quality of life in patients with POAG. result in red-green defects. Indeed, in some cases, there might be a non-specific chromatic loss. Comparing congenital and acquired colour vision Colour vision defects in glaucoma have been described defects since 18835 and although many early investigations Congenital colour vision deficiencies result from inherited indicated that red-green defects accompanied glaucoma- cone photopigment abnormalities. -
Ocular Hypertension-A Long-Term Follow-Up of Treated and Untreated Patients
Br J Ophthalmol: first published as 10.1136/bjo.61.11.668 on 1 November 1977. Downloaded from British Jouirnal of Ophthalmology, 1977, 61, 668-674 Ocular hypertension-a long-term follow-up of treated and untreated patients ROBERT DAVID, DESIREE G. LIVINGSTON, AND MAURICE H. LUNTZ From the Department of Ophthalmology, University of the Witwatersrand and Johannesburg Teaching Hospitals, Johannesbuirg, South Africa SUMMARY Sixty-one patients with ocular hypertension (1 17 eyes) were followed up for I to 11 years (average 40 7 months). Ten patients (12 eyes) developed visual field defects and optic disc lesions of glaucomatous type ( 10 2 %). Their average age was lower than the average of the sample, and the defect appeared between 1 and 5 years (average 41 3 months). The risk of developing glaucoma was related to the level of the intraocular pressure. Of the 75 eyes with pressures between 21 and 25 mmHg only 2 developed glaucoma, of the 25 cases with pressures of 26 to 30 only 3, but 7 of the 17 eyes with pressures of 31 mmHg or more did so. Prophylactic cryosurgery was carried out where indicated by the presence of lattice retinal degeneration or holes before starting miotic therapy. Fifty eyes were given antiglaucoma therapy and compared with 67 eyes not treated. Treatment did not prevent the development of glaucoma and did not seem to influence the course of the ocular hypertension. The response to treatment was also valueless in predicting future glaucoma. Two untreated patients with high pressures developed central vein occlusion. As no harmful effect of treatment could be detected in the 50 treated eyes, elderly patients (more than 70 years) with copyright. -
Antiproliferative Effects of Carbon Monoxide on Pancreatic Cancer
Digestive and Liver Disease 46 (2014) 369–375 Contents lists available at ScienceDirect Digestive and Liver Disease jou rnal homepage: www.elsevier.com/locate/dld Oncology Antiproliferative effects of carbon monoxide on pancreatic cancer a,b,∗ c,1 a a Libor Vítek , Helena Gbelcová , Lucie Muchová , Katerinaˇ Vánovᡠ, a,2 a a a Jaroslav Zelenka , Renata Koníckovᡠ, Jakub Sukˇ , Marie Zadinova , c d,e d d,e c,∗∗ Zdenekˇ Knejzlík , Shakil Ahmad , Takeshi Fujisawa , Asif Ahmed , Tomásˇ Ruml a Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University in Prague, Prague 2, Czech Republic b 4th Department of Internal Medicine, 1st Faculty of Medicine, Charles University in Prague, Prague 2, Czech Republic c Department of Biochemistry and Microbiology, Institute of Chemical Technology, Prague 6, Czech Republic d Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK e School of Life & Health Sciences, Aston University, Birmingham, UK a r t i c l e i n f o a b s t r a c t Article history: Background: Carbon monoxide, the gaseous product of heme oxygenase, is a signalling molecule with Received 14 June 2013 a broad spectrum of biological activities. The aim of this study was to investigate the effects of carbon Accepted 4 December 2013 monoxide on proliferation of human pancreatic cancer. Available online 14 January 2014 Methods: In vitro studies were performed on human pancreatic cancer cells (CAPAN-2, BxPc3, and PaTu- 8902) treated with a carbon monoxide-releasing molecule or its inactive counterpart, or exposed to Keywords: carbon monoxide gas (500 ppm/24 h). -
The Eyes Have It! Update on Common Conditions Affecting the Eye
Pharmacy Tech Topics™ VOLUME 22 NO. 2 | APRIL 2017 The Eyes Have It! Update on Common Conditions Affecting the Eye AUTHORS: Steven R. Abel, BS Pharm, PharmD, FASHP Kirk Evoy, PharmD, BCACP, BC-ADM, TTS PEER REVIEWERS: Sami Labib, RPh Rita Edwards, CPhT EDITOR: Patricia M. Wegner, BS Pharm, PharmD, FASHP DESIGN EDITOR: Leann Nelson Pharmacy Tech Topics™ (USPS No. 014-766) is published quarterly for $50 per year by the Illinois Council of Health-System Pharmacists, 4055 N. Perryville Road, Loves Park, IL 61111-8653. Phone 815-227-9292. Periodicals Postage Paid at Rockford, IL and additional mailing offices. POSTMASTER: Send address changes to: Pharmacy Tech Topics™, c/o ICHP, 4055 N. Perryville Road, Loves Park, IL 61111-8653 COPYRIGHT ©2017 by the Illinois Council of Health-System Pharmacists unless otherwise noted. All rights reserved. Pharmacy Tech Topics™ is a trademark of the Illinois Council of Health-System Pharmacists. This module is accredited for 2.5 contact hours of continuing pharmacy education and is recognized by the Pharmacy Technician Certification Board (PTCB). Cover image property of ©2017 Adobe Stock. LEARNING OBJECTIVES Upon completion of this module, the subscriber will be able to: 1. Identify the parts of the eye and the function of each part. 2. Summarize various eye disorders including ocular hypertension, glaucoma, infections, dry eyes, conjunctivitis, age-related macular degeneration, macular edema following retinal vein occlusion, and diabetic macular edema. 3. Discuss brand/generic substitutions, possible side effects, and proper administration of ophthalmic medications. 4. Describe the roles of various ophthalmic agents including those used to treat the following conditions: ocular hypertension, glaucoma, infections, dry eyes, conjunctivitis, age-related macular degeneration, macular edema following retinal vein occlusion, and diabetic macular edema. -
Since January 2020 Elsevier Has Created a COVID-19 Resource Centre with Free Information in English and Mandarin on the Novel Coronavirus COVID- 19
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID- 19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. Journal Pre-proof Could nitric oxide help to prevent or treat COVID-19? Jan Martel, Yun-Fei Ko, John D. Young, David M. Ojcius PII: S1286-4579(20)30080-0 DOI: https://doi.org/10.1016/j.micinf.2020.05.002 Reference: MICINF 4713 To appear in: Microbes and Infection Received Date: 1 May 2020 Accepted Date: 4 May 2020 Please cite this article as: J. Martel, Y.-F. Ko, J.D. Young, D.M. Ojcius, Could nitric oxide help to prevent or treat COVID-19?, Microbes and Infection, https://doi.org/10.1016/j.micinf.2020.05.002. This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. -
(SUNDROP): Five Years of Screening with Telemedicine
■ CLINICAL SCIENCE ■ Stanford University Network for Diagnosis of Retinopathy of Prematurity (SUNDROP): Five Years of Screening With Telemedicine Natalia Fijalkowski, BA; Luo Luo Zheng, BS; Michael T. Henderson, BA; Sean K. Wang, BS; Matthew B. Wallenstein, MD; Theodore Leng, MD, MS; Darius M. Moshfeghi, MD INTRODUCTION BACKGROUND AND OBJECTIVE: To report the 5-year results of the Stanford University Network for Diag- Retinopathy of prematurity (ROP) is a vision- nosis of Retinopathy of Prematurity (SUNDROP) tele- threatening disease of disordered retinal vasculature medicine initiative. development in premature and low birth weight in- fants.1,2 The underdeveloped retina overcompensates PATIENTS AND METHODS: Infants requiring retinopathy for ischemia at birth by promoting angiogenesis that of prematurity (ROP) screening at six neonatal inten- can damage nearby structures through retinal edema, sive care units from December 1, 2005, to November traction, or detachment.3,4 At United States schools, 30, 2010, were evaluated with remote retinal photogra- ROP accounts for 14% of pediatric blindness.5 The phy by an ROP specialist. Every infant received outpa- World Health Organization (WHO) found ROP to be tient binocular indirect ophthalmoscope examinations the leading cause of avoidable visual impairment in until termination criteria were achieved or until treat- high-income countries and the second leading cause ment. Outcomes were treatment-warranted ROP (TW- in middle-income countries,6 accounting for 15% to ROP, ETROP type 1) and adverse anatomical events. 35% of pediatric blindness in some nations.7-9 Randomized trials and observational studies RESULTS: Five hundred eleven infants (1,022 eyes) were demonstrate that cryotherapy,10,11 laser photocoagu- screened. -
Relevance of Intraocular Pressure Measurement in Ulcerative Microbial Keratitis
Acta Scientific Ophthalmology (ISSN: 2582-3191) Volume 4 Issue 4 April 2021 Research Article Relevance of Intraocular Pressure Measurement in Ulcerative Microbial Keratitis Shikha Jain, Ashok Pathak*, Rahul Verma and Punam Kapoor Received: February 17, 2021 Department of Ophthalmology, ABVIMS & Dr. RML Hospital, New Delhi, India Published: March 06, 2021 *Corresponding Author: Ashok Pathak, Department of Ophthalmology, ABVIMS & © All rights are reserved by Shikha Jain., et Dr. RML Hospital, New Delhi, India. al. Abstract Purpose: Intraocular pressure measurement in a case of ulcerative microbial keratitis is often neglected as treatment of ulcer takes precedence. However, prolonged rise in IOP can cause optic nerve damage and failure of visual recovery even after complete resolu- tion of keratitis. This prospective longitudinal comparative study was done to evaluate the importance of IOP measurement in cases of ulcerative keratitis. Methods: 122 cases of ulcerative microbial keratitis were divided into three groups based on their etiology- bacterial (Group A), fungal (Group B) and indeterminate (Group C). Comparative evaluation of IOP between all the three groups was done and results recorded. Results: - sponded to treatment. In fungal keratitis, higher IOP was noted later in the follow up visits. The IOP was also related to the size of On presentation, IOP was significantly high in bacterial and indeterminate group (Group A and C) but subsequently re ulcerConclusion: and depth of infiltrate with size more than 5 mm and midstromal level of infiltrate showing a significantly high IOP. - sion. IOP measurement and management although difficult in cases of keratitis if neglected can cause permanent loss of vi Keywords: Ulcerative Microbial Keratitis; Intraocular Pressure; Non Contact Tonometry Introduction often missed as management of ulcer takes precedence. -
Ophthalmic Medications
CHAPTER 33 Ophthalmic Medications Celtina K. Reinert, PharmD LEARNING OBJECTIVES KEY TERMS AND DEFINITIONS After completing this chapter, you should be able to Aqueous humor — the thick, watery fl uid located between the 1. Review the anatomy and physiology of the eye cornea and the lens. 2. Describe glaucoma and the most commonly used treatment approaches Cataract — an eye condition in 3. Describe the causes and symptoms of conjunctivitis and treatment options which a clouding of the lens occurs. Conjunctiva — the tissue around 4. Identify common causes of blindness the eye. 5. Identify medications used in the eye including their dosage forms, therapeutic Conjunctivitis — infl ammation effects, most common side effects, and mechanisms of action of the conjunctiva. Cornea — clear covering over the front of the eye. he eye is the organ for sight. Many things can affect the eye including diabetes, Cycloplegia — paralysis of the muscle that holds the lens in place. T trauma, vision problems, and allergies. Some of these can be improved with Causes a loss of accommodation or treatments including surgery and medications used in the eye. This chapter will ability to focus the lens. discuss these and how ophthalmic medications are used. Diplopia — double vision. Glaucoma — eye condition that can result from increased pressure in the eye and can cause nerve damage. Intraocular pressure (IOP) — measurement of pressure in the eye, usually < 21 mm Hg. Increases in IOP can lead to glaucoma or blindness. Iris — the colored part of the eye. Macula — focal point on the retina that allows for clear, sharp vision especially when focusing on tasks straight ahead.