Journal of Molecular Biology
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Structural Data in Synthetic Biology Approaches for Studying General Design Principles of Cellular Signaling Networks
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Structure Perspective Structural Data in Synthetic Biology Approaches for Studying General Design Principles of Cellular Signaling Networks Christina Kiel1,2,* and Luis Serrano1,2,3 1EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain 2Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain 3ICREA, Pg. Lluı´s Companys 23, 08010 Barcelona, Spain *Correspondence: [email protected] http://dx.doi.org/10.1016/j.str.2012.10.002 In recent years, high-throughput discovery of macromolecular protein structures and complexes has played a major role in advancing a more systems-oriented view of protein interaction and signaling networks. The design of biological systems often employs structural information or structure-based protein design to successfully implement synthetic signaling circuits or for rewiring signaling flows. Here, we summarize the latest advances in using structural information for studying protein interaction and signaling networks, and in synthetic biology approaches. We then provide a perspective of how combining structural biology with engineered cell signaling modules—using additional information from quantitative biochemistry and proteo- mics, gene evolution, and mathematical modeling—can provide insight into signaling modules and the general design principles of cell signaling. Ultimately, this will improve our understanding of cell- and tissue-type-specific signal transduction. Integrating the quantitative effects of disease mutations into these systems may provide a basis for elucidating the molecular mechanisms of diseases. Introduction further complicated by the fact that often proteins recruit binding There is growing three-dimensional (3D) structural information partners using several domain or linear motifs. -
Tissue and Cell
TISSUE AND CELL AUTHOR INFORMATION PACK TABLE OF CONTENTS XXX . • Description p.1 • Impact Factor p.1 • Abstracting and Indexing p.1 • Editorial Board p.1 • Guide for Authors p.3 ISSN: 0040-8166 DESCRIPTION . Tissue and Cell is devoted to original research on the organization of cells, subcellular and extracellular components at all levels, including the grouping and interrelations of cells in tissues and organs. The journal encourages submission of ultrastructural studies that provide novel insights into structure, function and physiology of cells and tissues, in health and disease. Bioengineering and stem cells studies focused on the description of morphological and/or histological data are also welcomed. Studies investigating the effect of compounds and/or substances on structure of cells and tissues are generally outside the scope of this journal. For consideration, studies should contain a clear rationale on the use of (a) given substance(s), have a compelling morphological and structural focus and present novel incremental findings from previous literature. IMPACT FACTOR . 2020: 2.466 © Clarivate Analytics Journal Citation Reports 2021 ABSTRACTING AND INDEXING . Scopus PubMed/Medline Cambridge Scientific Abstracts Current Awareness in Biological Sciences Current Contents - Life Sciences Embase Embase Science Citation Index Web of Science EDITORIAL BOARD . Editor Pietro Lupetti, University of Siena, Siena, Italy AUTHOR INFORMATION PACK 1 Oct 2021 www.elsevier.com/locate/tice 1 Managing Editor Giacomo Spinsanti, University of Siena, -
Synthetic Biology Applying Engineering to Biology
Synthetic Biology Applying Engineering to Biology Report of a NEST High-Level Expert Group EUR 21796 PROJECT REPORT Interested in European research? RTD info is our quarterly magazine keeping you in touch with main developments (results, programmes, events, etc). It is available in English, French and German. A free sample copy or free subscription can be obtained from: European Commission Directorate-General for Research Information and Communication Unit B-1049 Brussels Fax : (32-2) 29-58220 E-mail: [email protected] Internet: http://europa.eu.int/comm/research/rtdinfo/index_en.html EUROPEAN COMMISSION Directorate-General for Research Directorate B — Structuring the European Research Area Unit B1 — Anticipation of Scientific and Technological Needs (NEST activity); Basic Research E-mail: [email protected] Contact: Christian Krassnig European Commission Office SDME 01/37 B-1049 Brussels Tel. (32-2) 29-86445 Fax (32-2) 29-93173 E-mail: [email protected] For further information on the NEST activity please refer to the following website: http://www.cordis.lu/nest/home.html EUROPEAN COMMISSION Synthetic Biology Applying Engineering to Biology Report of a NEST High-Level Expert Group NEST - New and Energing Science and Technology - is a research activity under the European Community’s 6th Framework Programme Directorate-General for Research Structuring the European Research Area 2005 Anticipating Scientific and Technological Needs; Basic Research EUR 21796 Europe Direct is a service to help you find answers to your questions about the European Union Freephone number: 00 800 6 7 8 9 10 11 LEGAL NOTICE: Neither the European Commission nor any person acting on behalf of the Commission is responsible for the use which might be made of the following information. -
The Rewards of Platform Unity: Moving to One Repository at Universidad De La Salle Delivers Benefits
Case Study The rewards of platform unity: moving to one repository at Universidad de La Salle delivers benefits To better support the mission that drives Colombia’s Universidad de La Salle — to generate knowledge that will transform Colombian society by contributing to equity, the defense of life and human development — the university recognized the need to combine three separate digital platforms into a single unifying online presence while simultaneously addressing a long list of technical challenges. After considering several options, it identified Digital Commons as the perfect fit for its needs. This case study charts the university’s decision-making process, the rewards it has subsequently reaped and eight tips for other institutions embarking on a digital repository journey. Introduction Founded in 1964, Universidad de La Salle1 is a private Catholic the other its digital educative resources. So, a cross-department institution with around 14,000 students and 700 postgraduates task force set out to find a single solution that would provide enrolled in a wide array of courses and degree programs. It them with key items on their wish list: is rated a “High Quality University” by Colombia’s National Accreditation Council2 (CNA). Back in 2018, the institution’s five • One entry point to the university’s intellectual output journals were stored on Public Knowledge Project’s Open Journal • Support for the full journal-publishing cycle Systems (OJS) platform. Initially, OJS ticked many boxes for the (including peer review) journals team, as Editorial Head Alfredo Morales recalls: “We • Robust customer support were able to consolidate all our titles, standardize publishing criteria and increase visibility inside and outside the university.” • Effective SEO and indexing of journal articles in Google Scholar • Standardization of metadata But the team also encountered issues that impacted their productivity and content discoverability. -
Get Noticed Promoting Your Article for Maximum Impact Get Noticed 2 GET NOTICED
Get Noticed Promoting your article for maximum impact GET NOTICED 2 GET NOTICED More than one million scientific articles are published each year, and that number is rising. So it’s increasingly important for you to find ways to make your article stand out. While there is much that publishers and editors can do to help, as the paper’s author you are often best placed to explain why your findings are so important or novel. This brochure shows you what Elsevier does and what you can do yourself to ensure that your article gets the attention it deserves. GET NOTICED 3 1 PREPARING YOUR ARTICLE SEO Optimizing your article for search engines – Search Engine Optimization (SEO) – helps to ensure it appears higher in the results returned by search engines such as Google and Google Scholar, Elsevier’s Scirus, IEEE Xplore, Pubmed, and SciPlore.org. This helps you attract more readers, gain higher visibility in the academic community and potentially increase citations. Below are a few SEO guidelines: • Use keywords, especially in the title and abstract. • Add captions with keywords to all photographs, images, graphs and tables. • Add titles or subheadings (with keywords) to the different sections of your article. For more detailed information on how to use SEO, see our guideline: elsevier.com/earlycareer/guides GIVE your researcH THE IMpact it deserVes Thanks to advances in technology, there are many ways to move beyond publishing a flat PDF article and achieve greater impact. You can take advantage of the technologies available on ScienceDirect – Elsevier’s full-text article database – to enhance your article’s value for readers. -
Redundancy and Specificity F Mechta-Grigoriou Et Al 2379
Oncogene (2001) 20, 2378 ± 2389 ã 2001 Nature Publishing Group All rights reserved 0950 ± 9232/01 $15.00 www.nature.com/onc The mammalian Jun proteins: redundancy and speci®city Fatima Mechta-Grigoriou1, Damien Gerald1 and Moshe Yaniv*,1 1Unite des virus oncogenes, CNRS URA 1644, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France The AP-1 transcription factor is composed of a mixture transcription factors. These proteins are characterized of homo- and hetero-dimers formed between Jun and Fos by a highly charged, basic DNA binding domain, proteins. The dierent Jun and Fos family members vary immediately adjacent to an amphipathic dimerization signi®cantly in their relative abundance and their domain, referred as the `Leucine zipper' (Kouzarides interactions with additional proteins generating a and Zi, 1988; Landschulz et al., 1988). Dimerization complex network of transcriptional regulators. Thus, is required for speci®c and high anity binding to the the functional activity of AP-1 in any given cell depends palindromic DNA sequence, TGAC/GTCA (Rauscher on the relative amount of speci®c Jun/Fos proteins which et al., 1988; Gentz et al., 1989; Hirai and Yaniv, 1989; are expressed, as well as other potential interacting Ransone et al., 1989; Schuermann et al., 1989; Turner proteins. This diversity of AP-1 components has and Tjian, 1989). The dierent AP-1 dimers exhibit complicated our understanding of AP-1 function and similar DNA binding speci®cities but dier in their resulted in a paucity of information about the precise transactivation eciencies (Chiu et al., 1989; Hirai et role of individual AP-1 members in distinct cellular al., 1990; Kerppola and Curran, 1991b; Suzuki et al., processes. -
Journal of Biotechnology
JOURNAL OF BIOTECHNOLOGY AUTHOR INFORMATION PACK TABLE OF CONTENTS XXX . • Description p.1 • Audience p.1 • Impact Factor p.1 • Abstracting and Indexing p.2 • Editorial Board p.2 • Guide for Authors p.4 ISSN: 0168-1656 DESCRIPTION . Journal of Biotechnology provides a medium for the rapid publication of both full-length articles and short communications on novel and innovative aspects of biotechnology. The Journal will accept papers ranging from genetic or molecular biological positions to those covering biochemical, chemical or bioprocess engineering aspects as well as computer application of new software concepts, provided that in each case the material is directly relevant to biotechnological systems. Papers presenting information of a multidisciplinary nature that would not be suitable for publication in a journal devoted to a single discipline, are particularly welcome. The following areas are covered in the Journal: * Nucleic Acids/Molecular Biology * Physiology/Biochemistry * Biochemical Engineering/Bioprocess Engineering * Industrial Processes/New Products * Medical Biotechnology * Agro- and Food Biotechnology * Genomics and Bioinformatics More information on these areas can be foundhere Benefits to authors We also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services. Please see our Guide for Authors for information on article submission. If you require any further information or help, please visit our Support Center AUDIENCE . Microbiologists, Molecular Biologists, Environmental Scientists, Genetic Engineers. IMPACT FACTOR . 2020: 3.307 © Clarivate Analytics Journal Citation Reports 2021 AUTHOR INFORMATION PACK 28 Sep 2021 www.elsevier.com/locate/jbiotec 1 ABSTRACTING AND INDEXING . -
BIOSIS Previews/Biological Abstracts (1980-2008) Covers Life Sciences and Biological and Biomedical Research
BIOSIS Previews/Biological Abstracts (1980-2008) covers life sciences and biological and biomedical research. This includes traditional areas of biology, such as botany, zoology and microbiology, as well as experimental, clinical and veterinary medicine, biotechnology, environmental studies, and agriculture. Interdisciplinary fields such as biochemistry, biophysics and bioengineering are also included. Access 1. At the Library Home Page (http://www.cityu.edu.hk/lib/), click on the Databases tab. 2. Select BIOSIS Previews / Biological Abstracts from the alphabetical list of databases. OR At the Library Home Page (http://www.cityu.edu.hk/lib/), select E-Resources. 1. Select Databases Title List. 2. From the alphabetical list, select BIOSIS Previews / Biological Abstracts. Search 1. Click on Basic Search. 2. Enter search term(s). 3. Optional. Click on Limits to select options to filter search. 4. Optional. Check box to exclude Related Terms to narrow search results. 5. Click on Search. Advanced Search 1. Click on Advanced Search. 2. Enter search term(s). 3. Select field to search. Default is Keyword. 4. Optional. Click on Limits to select options to filter search. 5. Click on Search. Search Tips Basic Search results are given a star rating based on relevancy with most starred records displayed first. Ranking and display of search results in Advanced Search varies between databases. Select Multi-Field Search option to search by a specific field, e.g. journal abbreviation. Use Find Citation option to retrieve specific journal article citations. Use Search Tools to match search terms with relevant subject headings. Also provides access to thesaurus, permuted index and scope notes for subject headings. -
1 SCOPE the Journal Molecular Biology Covers a Wide Range Of
SCOPE The journal Molecular Biology covers a wide range of problems related to molecular, cell, and computational biology, including genomics, proteomics, bioinformatics, molecular virology and immunology, molecular development biology, and molecular evolution. Molecular Biology publishes reviews, mini-reviews, and experimental and theoretical works. Annually, the journal publishes special issues devoted to the most rapidly developing branches of physicochemical biology. The journal features both Russia and international authors. FOUNDERS Russian Academy of Sciences, Moscow, Russia; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia ABSTRACTING AND INDEXING Molecular Biology is indexed/abstracted in AGRICOLA, Academic OneFile, BIOSIS, Biological Abstracts, CAB Abstracts, CAB International, Chemical Abstracts Service (CAS), Current Abstracts, EBSCO Academic Search, EBSCO Biological and Agricultural Index, EBSCO Biomedical Reference Collection, EBSCO OmniFile Full Text (H.W. Wilson), EBSCO STM Source, EBSCO Science Full Text Select (H.W. Wilson), EBSCO TOC Premier, EMBiology, Expanded Academic, Global Health, Google Scholar, Health Reference Center Academic, Highbeam, Journal Citation Reports/Science Edition, OCLC, SCImago, SCOPUS, Science Citation Index Expanded (SciSearch), Science Select, Summon by ProQuest, and Zoological Record. CONTACTS mailing address: Leninsky pr. 32A, Moscow, 119334 Russia telephone: +7(499)343-78-07; e-mail: [email protected] 1 MOLECULAR BIOLOGY INSTRUCTIONS FOR AUTHORS Any -
Front Matter
ANTICANCER RESEARCH International Journal of Cancer Research and Treatment ISSN: 0250-7005 Volume 40, Number 1, January 2020 Contents Review Current Treatment of Colorectal Liver Metastasis as a Chronic Disease. N.M. DÖRR, M. BARTELS, M.H. MORGUL (Leipzig; Münster, Germany) ......................................................................................................................... 1 Experimental Studies SAHA and EGCG Promote Apoptosis in Triple-negative Breast Cancer Cells, Possibly Through the Modulation of cIAP2. K.L. STEED, H.R. JORDAN, T.O. TOLLEFSBOL (Birmingham, AL, USA) .......................................... 9 Genetic Polymorphisms in IL-10 Promoter Are Associated With Smoking and Prostate Cancer Risk in African Americans. M. ABBAS, T. MASON, A. IBAD, M. KHRAIWESH, V. APPREY, Y. KANAAN, B. WILSON, G. DUNSTON, L. RICKS-SANTI, H. BRIM (Washington, DC; Silver Spring, MD; Hampton, VA, USA) ................. 27 High Expression of c-Met, PKC λ and ALDH1A3 Predicts a Poor Prognosis in Late-stage Breast Cancer. H. MOTOMURA, Y. NOZAKI, C. ONAGA, A. OZAKI, S. TAMORI, T.-A. SHIINA, S. KANAI, C. OHIRA, Y. HARA, Y. HARADA, R. TAKASAWA, T. HANAWA, S.-I. TANUMA, Y. MANO, T. SATO, K. SATO, K. AKIMOTO (Chiba, Japan) ............................................................................................................................................... 35 Targeting Fibroblast Growth Factor Receptor (FGFR) and Phosphoinositide 3-kinase (PI3K) Signaling Pathways in Medulloblastoma Cell Lines. S. HOLZHAUSER, M. LUKOSEVICIUTE, -
Curriculum Vitae
Curriculum Vitae Name and Address: Mohammad Nabiuni (22.04.1967) ID number: 0381613208 No. 43, Mofatteh Ave, Kharazmi University, Department of Cell and Molecular Biology, Faculty of Biological Sciences, Tehran, Iran, Post Cod: 15614, Email Address: [email protected] [email protected] Last Degrees: Post Doc in Neuroscience, University of Central Florida, Orlando, Florida (2007). Ph.D. in Cell and Developmental Biology (Developmental Neuroscience), Manchester, UK, (2006). MSc in Developmental Biology, Tarbiat Moallem University, Tehran, Iran, (1992) BSc in Biology, Urmieh University, Urmieh, Iran, (1989). Current Position: Associate Professor in Cell and Developmental Biology, Department of Cell and Molecular Biology, Kharazmi University, Tehran, Iran. Postgraduate Representative of Cell and Molecular Biology Department in Karaj Campus, Kharazmi University. Technical Experiences: Cell and tissue culture. Proteomoics skills including: Protein identification methods, Mass spectrometry and Electrophoresis (1D &2D), LC/MS methods in proteomics study. Histochemical and Immunocytochemical techniques. Handling and working with laboratory animals (Rodents). Taxidermal skills working with animals for museum and experimental laboratories. Working as co-investigator of project of Iranian Fauna (National project to investigate fauna of Iran) Caspian Sea and Persian Gulf. Teaching Experiences: Four years’ experience in teaching to the PhD, MSc and BSc students in field of Developmental Genetics, Cell and Tissue Culture course, Species and speciation, Evolutionary Biology, Biostatistics and Animal Biodiversity (2007- 2011). Three years experiences as demonstrator at UMIST in Manchester for undergraduate students in field of Histology, Embryology, Cell Biology and Developmental Biology (2002-2005). Eight years’ experience as an instructor of applied biology, experimental embryology, general biology and evolution (Department of Biology, University of Teacher Training, Tehran, Iran, 1992- 2000). -
Abstractsof Biochemistry in Various Abstracting Services
ABSTRACTS OF BIOCHEMISTRY IN VARIOUS ABSTRACTING SERVICES V G Bhat SIET Institute Hyderabad ·.('hepracticability of accepting the &,uthor synopses' So f a r as the abstract is concerned, for publication in abstracting services is discussed there is hardly any difference noticed. In the selecting a few examples from leading abstracting case of the Chemical Abstracts most efficient services. In the field of biochemistry hardly any editing is observed. Of course CA wants difference is found between the author abstracts and the abstracts published in the various abstracting slanted ab st r ac t s , This being biochemistry services. d isc ipl ine , hardly any diffe rence was observed between author abstracts and those of CA. Other services have published author ab st r-act s Research and development in aU areas of with very little change. Russian abstracts in science and technology to-day are tending more Refe r at lvn ii Zh.ur na l are all translated from and more to cut across traditional disciplinary author abstracts. boundaries. As a result almost aU progress reports published in scientific and engineering EXAMPLE ] periodicals contain new information of potential use to practitioners in various disciplines, and Indian Science Abstracts th •.•secondary information services of each of the principal- disciplines are abstracting and MULLAKHANBHAl M.F., BHAT J. V. indexing more and more reports from other (llS, Bangalore-12): Vitamins and nitrogen disciplines. A study has been carried out with requirements of Arthrobacter species. J a view to identify the degree of duplication, to Indian Inst. sei 1966, 48(4), l4~-56.