Malformations of the Human Cerebral Cortex Patterns and Causes

Marie-Claire de Wit de Wit (all).ps Front - 1 T1 - Black CyanMagenta Yellow

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Malformations of the Human Cerebral Cortex

Patterns and Causes

Aanlegstoornissen van de hersenschors: patronen en oorzaken

PROEFSCHRIFT The studies in this thesis were financially supported by The Erasmus MC Revolving Fund

ter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam op gezag van de rector magnificus

Prof.dr. H.G. Schmidt

en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op vrijdag 10 september 2010 om 11:30 uur

door

Marie-Claire Yvette de Wit Financial support for publication: Erasmus University Rotterdam, UCB Pharma B.V., Cyberonics Europe N.V., Sanofi-Aventis Netherlands B.V. geboren te Amsterdam

ISBN 978-90-5335-305-9

Cover: neurons in the hippocampal cortex of the brainbow mouse, courtesy of Tamily A.

Weissman, Ph.D, Harvard University, USA.

Printed by Ridderprint B.V., Ridderkerk.

© Marie-Claire de Wit, 2010.

No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means without permission of the author, or, when appropriate, of the publishers of the publications.

de Wit_DEF.indd 2 02-08-10 16:32 de Wit (all).ps Front - 2 T1 - Black CyanMagenta Yellow

Malformations of the Human Cerebral Cortex

Patterns and Causes

Aanlegstoornissen van de hersenschors: patronen en oorzaken

PROEFSCHRIFT The studies in this thesis were financially supported by The Erasmus MC Revolving Fund

ter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam op gezag van de rector magnificus

Prof.dr. H.G. Schmidt

en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op vrijdag 10 september 2010 om 11:30 uur

door

Marie-Claire Yvette de Wit Financial support for publication: Erasmus University Rotterdam, UCB Pharma B.V., Cyberonics Europe N.V., Sanofi-Aventis Netherlands B.V. geboren te Amsterdam

ISBN 978-90-5335-305-9

Cover: neurons in the hippocampal cortex of the brainbow mouse, courtesy of Tamily A.

Weissman, Ph.D, Harvard University, USA.

Printed by Ridderprint B.V., Ridderkerk.

© Marie-Claire de Wit, 2010.

No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means without permission of the author, or, when appropriate, of the publishers of the publications.

de Wit_DEF.indd 3 02-08-10 16:32 de Wit (all).ps Back - 2 T1 - Black CyanMagenta Yellow

PROMOTIECOMMISSIE

Promotoren: Prof.dr. W.F.M. Arts Prof.dr. F.G. Grosveld

Overige leden: Dr. D.J.J. Halley Malformations of the Human Cerebral Cortex Prof.dr. P.A.E. Sillevis Smitt Prof.dr. D. Lindhout Patterns and Causes Co-promotoren: Dr. I.F.M. de Coo Dr. G.M.S. Mancini

de Wit_DEF.indd 4 02-08-10 16:32 de Wit (all).ps Front - 3 T1 - Black CyanMagenta Yellow

PROMOTIECOMMISSIE

Promotoren: Prof.dr. W.F.M. Arts Prof.dr. F.G. Grosveld

Overige leden: Dr. D.J.J. Halley Malformations of the Human Cerebral Cortex Prof.dr. P.A.E. Sillevis Smitt Prof.dr. D. Lindhout Patterns and Causes Co-promotoren: Dr. I.F.M. de Coo Dr. G.M.S. Mancini

de Wit_DEF.indd 5 02-08-10 16:32 de Wit (all).ps Back - 3 T1 - Black CyanMagenta Yellow

Malformations of the Human Cerebral Cortex: Patterns and Causes Chapter 7 General Discussion 157

TABLE OF CONTENTS Summary 167

Chapter 1 Introduction 9 Samenvatting 171

List of abbreviations 174 Chapter 2 Classification 45

Chapter 2.1 Cortical brain malformations: results of clinical, neuroradiological and 47 Appendix 175 genetic classification. Arch Neurol. 2008 Mar;65(3):358-66. Dankwoord 182

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