Malformations of the Human Cerebral Cortex Patterns and Causes
Marie-Claire de Wit de Wit (all).ps Front - 1 T1 - Black CyanMagenta Yellow
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Malformations of the Human Cerebral Cortex
Patterns and Causes
Aanlegstoornissen van de hersenschors: patronen en oorzaken
PROEFSCHRIFT The studies in this thesis were financially supported by The Erasmus MC Revolving Fund
ter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam op gezag van de rector magnificus
Prof.dr. H.G. Schmidt
en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op vrijdag 10 september 2010 om 11:30 uur
door
Marie-Claire Yvette de Wit Financial support for publication: Erasmus University Rotterdam, UCB Pharma B.V., Cyberonics Europe N.V., Sanofi-Aventis Netherlands B.V. geboren te Amsterdam
ISBN 978-90-5335-305-9
Cover: neurons in the hippocampal cortex of the brainbow mouse, courtesy of Tamily A.
Weissman, Ph.D, Harvard University, USA.
Printed by Ridderprint B.V., Ridderkerk.
© Marie-Claire de Wit, 2010.
No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means without permission of the author, or, when appropriate, of the publishers of the publications.
de Wit_DEF.indd 2 02-08-10 16:32 de Wit (all).ps Front - 2 T1 - Black CyanMagenta Yellow
Malformations of the Human Cerebral Cortex
Patterns and Causes
Aanlegstoornissen van de hersenschors: patronen en oorzaken
PROEFSCHRIFT The studies in this thesis were financially supported by The Erasmus MC Revolving Fund
ter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam op gezag van de rector magnificus
Prof.dr. H.G. Schmidt
en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op vrijdag 10 september 2010 om 11:30 uur
door
Marie-Claire Yvette de Wit Financial support for publication: Erasmus University Rotterdam, UCB Pharma B.V., Cyberonics Europe N.V., Sanofi-Aventis Netherlands B.V. geboren te Amsterdam
ISBN 978-90-5335-305-9
Cover: neurons in the hippocampal cortex of the brainbow mouse, courtesy of Tamily A.
Weissman, Ph.D, Harvard University, USA.
Printed by Ridderprint B.V., Ridderkerk.
© Marie-Claire de Wit, 2010.
No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means without permission of the author, or, when appropriate, of the publishers of the publications.
de Wit_DEF.indd 3 02-08-10 16:32 de Wit (all).ps Back - 2 T1 - Black CyanMagenta Yellow
PROMOTIECOMMISSIE
Promotoren: Prof.dr. W.F.M. Arts Prof.dr. F.G. Grosveld
Overige leden: Dr. D.J.J. Halley Malformations of the Human Cerebral Cortex Prof.dr. P.A.E. Sillevis Smitt Prof.dr. D. Lindhout Patterns and Causes Co-promotoren: Dr. I.F.M. de Coo Dr. G.M.S. Mancini
de Wit_DEF.indd 4 02-08-10 16:32 de Wit (all).ps Front - 3 T1 - Black CyanMagenta Yellow
PROMOTIECOMMISSIE
Promotoren: Prof.dr. W.F.M. Arts Prof.dr. F.G. Grosveld
Overige leden: Dr. D.J.J. Halley Malformations of the Human Cerebral Cortex Prof.dr. P.A.E. Sillevis Smitt Prof.dr. D. Lindhout Patterns and Causes Co-promotoren: Dr. I.F.M. de Coo Dr. G.M.S. Mancini
de Wit_DEF.indd 5 02-08-10 16:32 de Wit (all).ps Back - 3 T1 - Black CyanMagenta Yellow
Malformations of the Human Cerebral Cortex: Patterns and Causes Chapter 7 General Discussion 157
TABLE OF CONTENTS Summary 167
Chapter 1 Introduction 9 Samenvatting 171
List of abbreviations 174 Chapter 2 Classification 45
Chapter 2.1 Cortical brain malformations: results of clinical, neuroradiological and 47 Appendix 175 genetic classification. Arch Neurol. 2008 Mar;65(3):358-66. Dankwoord 182
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