______DEPARTMENT OF BIOCHEMISTRY
Job Description Postdoctoral Research Associate in Investigating gene silencing in X Job title chromosome inactivation Division Medical Sciences
Department Biochemistry
Location New Biochemistry Building, South Parks Road, Oxford
Grade and salary Grade 7: £32,817 -£40,322 per annum
Hours Full time (37.5 hours per week)
Contract type Fixed Term Contract for up to 2 years in the first instance
Reporting to Prof Neil Brockdorff, Principal Investigator
Vacancy reference 151950
You are required to submit a CV and a supporting statement with your application. The supporting statement must outline how you meet each of the selection criteria for the role (see below for details). Your Additional information application will not be processed if you do not include both documents. Applicants who fail to provide a point by point response detailing how they meet the essential criteria listed below will not be shortlisted.
Research topic Molecular mechanism of X chromosome inactivation
Principal Investigator / Prof Neil Brockdorff supervisor
Project team Prof Neil Brockdorff www.ox.ac.uk/ Project web site https://sites.google.com/site/brockdorfflab/ The funds supporting this research project are provided by Wellcome Funding partner Trust Recent publications See lab website
The role
Reporting to the Principal Investigator, Prof Neil Brockdorff the post holder is a member of a research group with responsibility for carrying out research on gene silencing and chromatin modification in X chromosome inactivation. The post holder may provide guidance to less experienced members of the research group, including postdocs, research assistants, technicians, and PhD and project students.
Responsibilities Manage own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines
Adapt existing and develop new scientific techniques and experimental protocols
Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate
Contribute ideas for new research projects
Develop ideas for generating research income, and present detailed research proposals to senior researchers
Collaborate in the preparation of scientific reports and journal articles and occasionally present papers and posters
Use specialist scientific equipment in a laboratory environment
Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques
Represent the research group at external meetings/seminars, either with other members of the group or alone
Carry out collaborative projects with colleagues in partner institutions, and research groups
Selection criteria Essential selection criteria 1. Hold a PhD/DPhil, or be near completion of a PhD/DPhil in a field relevant to the project 2. The applicant must have experience with CRISPR/Cas9 mediated genome modification in mouse ES cells. 3. The applicant must have experience using degron systems to perturb protein function in mouse ES cells. 4. The applicant must have proven experience in applying genome wide chromatin and gene expression methods (chip-seq, RNA-seq and ATAC-seq), and data analysis of the outputs of these methods using computational genomics methods. 5. The applicant must have an excellent research track record to include paper(s) in high ranking research journal(s).
151950 Research Associate Gr 7 JD – Brockdorff 2
Pre-employment screening Standard checks If you are offered the post, the offer will b