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Job Description Postdoctoral Research Associate in Investigating silencing in X Job title chromosome inactivation Division Medical Sciences

Department Biochemistry

Location New Biochemistry Building, South Parks Road, Oxford

Grade and salary Grade 7: £32,817 -£40,322 per annum

Hours Full time (37.5 hours per week)

Contract type Fixed Term Contract for up to 2 years in the first instance

Reporting to Prof Neil Brockdorff, Principal Investigator

Vacancy reference 151950

You are required to submit a CV and a supporting statement with your application. The supporting statement must outline how you meet each of the selection criteria for the role (see below for details). Your Additional information application will not be processed if you do not include both documents. Applicants who fail to provide a point by point response detailing how they meet the essential criteria listed below will not be shortlisted.

Research topic Molecular mechanism of inactivation

Principal Investigator / Prof Neil Brockdorff supervisor

Project team Prof Neil Brockdorff www.ox.ac.uk/ Project web site https://sites.google.com/site/brockdorfflab/ The funds supporting this research project are provided by Wellcome Funding partner Trust Recent publications See lab website

The role

Reporting to the Principal Investigator, Prof Neil Brockdorff the post holder is a member of a research group with responsibility for carrying out research on and chromatin modification in X chromosome inactivation. The post holder may provide guidance to less experienced members of the research group, including postdocs, research assistants, technicians, and PhD and project students.

Responsibilities  Manage own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines

 Adapt existing and develop new scientific techniques and experimental protocols

 Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate

 Contribute ideas for new research projects

 Develop ideas for generating research income, and present detailed research proposals to senior researchers

 Collaborate in the preparation of scientific reports and journal articles and occasionally present papers and posters

 Use specialist scientific equipment in a laboratory environment

 Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques

 Represent the research group at external meetings/seminars, either with other members of the group or alone

 Carry out collaborative projects with colleagues in partner institutions, and research groups

Selection criteria Essential selection criteria 1. Hold a PhD/DPhil, or be near completion of a PhD/DPhil in a field relevant to the project 2. The applicant must have experience with CRISPR/Cas9 mediated modification in mouse ES cells. 3. The applicant must have experience using degron systems to perturb protein function in mouse ES cells. 4. The applicant must have proven experience in applying genome wide chromatin and methods (chip-seq, RNA-seq and ATAC-seq), and data analysis of the outputs of these methods using computational genomics methods. 5. The applicant must have an excellent research track record to include paper(s) in high ranking research journal(s).

151950 Research Associate Gr 7 JD – Brockdorff 2

Pre-employment screening Standard checks If you are offered the post, the offer will b