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Neuroscience and Neurological Disorders Joint Event on alliedacademies International Conference on NEUROSCIENCE AND NEUROLOGICAL DISORDERS International Conference on & PSYCHIATRY AND PSYCHOLOGICAL DISORDERS June 28-29, 2018 | Dublin, Ireland DAY 1 Keynote Forum Neuroscience Congress 2018 & Psychiatry 2018 Page 13 alliedacademies Joint Event on International Conference on NEUROSCIENCE AND NEUROLOGICAL DISORDERS & International Conference on PSYCHIATRY AND PSYCHOLOGICAL DISORDERS June 28-29, 2018 | Dublin, Ireland Giulio Maria Pasinetti, J Neurol Neurorehabil Res 2018, Volume 3 PRINCIPLES OF INFLAMMASOME PRIMING AND INHIBITION: IMPLICATIONS FOR PSYCHIATRIC DISORDERS he production of inflammatory proteins by the innate immune system is a Ttightly orchestrated procedure that allows the body to efficiently respond Giulio Maria Pasinetti to exogenous and endogenous threats. In the talk the author will first discuss Icahn School of Medicine accumulating evidence suggesting that disturbances in the inflammatory USA response system not only provoke autoimmune disorders, but also can have deleterious effects on neuronal function and mental health. As inflammation in the brain is primarily mediated by microglia, the immune inflammatory cells of Biography the brain, there has been an expanding focus on the mechanisms through which Giulio Maria Pasinetti is The Saunders Family these cells initiate and propagate neuroinflammation. Based on this evidence Chair and Professor of Neurology, received an MD the author will debate novel concepts about how microglia can enter persistently from the Milan University School of Medicine and active states upon their initial recognition of an environmental stressor and a PhD from the University of Milan. He is currently are thereafter prone to elicit amplified and persistent inflammatory responses the Program Director of the NIH funded Mount following subsequent exposures to stressors. In view of the recent evidence Sinai Centre for Molecular Integrative Neuroresil- suggesting that primed microglia may be respond to environmental insults ience and the Chief of the Brain Institute Centre of Excellence for Novel Approaches to Neurodi- through mechanisms involving the NLRP3 inflammasome; in the presentation agnostics and Neurotherapeutics. He is also a the author will then discuss new concepts supporting the activation of NLRP3 Professor of Psychiatry, of Neuroscience, and inflammasome mechanisms responsible for the generation of inflammatory of Geriatrics and Adult Development. He is the interleukins into functional forms that elicit several consequential effects in the recipient of several academic awards including local neuronal environment. This evidence supports the principle that within the prestigious Zenith and Temple awards from primed neuroimmune systems a lowered threshold for NLRP3 activation can the Alzheimer’s Association. Most recently, also cause persistent neuroinflammation or the amplified production of inflammatory he was awarded with The Faculty Council Award’’ for academic excellence at Mount Sinai School cytokines. Collectively, the take home message of my presentation will provide of Medicine and “The Charles Dana Alliance for novel evidence suggesting that targeting the NLRP3 inflammasome complex Brain Research Award” from Dana Foundation, may represent an innovative approach to limit neuroinflammatory states in recognizing productivity and worldwide leader- psychiatric disorders. ship in his field of expertise, which further empha- sizes his standing as an academic role model. [email protected] Note: Journal of Neurology and Neurorehabilitation Research | Volume 3 Page 14 alliedacademies Joint Event on International Conference on NEUROSCIENCE AND NEUROLOGICAL DISORDERS & International Conference on PSYCHIATRY AND PSYCHOLOGICAL DISORDERS June 28-29, 2018 | Dublin, Ireland Diane Roberts Stoler, J Neurol Neurorehabil Res 2018, Volume 3 CUTTING-EDGE TECHNOLOGY FOR EVALUATION AND TREATMENT OF BOTH THE CAUSE AND SYMPTOMS OF NEUROLOGICAL DISORDERS standard electroencephalogram (EEG) records electrical activity or Abrainwaves representing underlying cortical brain activity, while a Diane Roberts Stoler Quantitative EEG (qEEG) process allows you to create a brain map through Dr. Diane Brain Health, USA precise measurement and quantitative comparison identifying patterns of dysfunction. In the past, qEEG would produce visual pictures of the various hertz of the brain and amplitude. Brain mapping is a set of neuroscience techniques predicated on the mapping of (biological) quantities or properties Biography onto spatial representations of the brain resulting in maps. Unlike other QEEG Diane Roberts Stoler is a Neuropsychologist, software qEEG-Pro provides in-depth sLoreta information, as well as protocol Board Certified Health Psychologist, Board Cer- recommendations for treating causes and symptoms of neurological disorders, tified Sports Psychologist, and Performing Arts along with 2 and 3 dimensional photos with locations of specific Brodmann Psychologist with over 35 years of clinical expe- areas and neural networks. The author will present step-by-step on how rience. She is a sought-after international brain qEEG Pro works showing clinicians how to evaluate through evidence-based injury Consultant, forensic expert, speaker and technology causes of various symptoms of neurological disorders, along with brain injury survivor. She is the author of three books, the latest is coping with Concussion and discussing specific treatment modalities to help patients regain their life again, Mild Traumatic Brain Injury. She is a verified ther- as Diane has done with her own. apist by Good Therapy and a syndicated blogger for Psychology Today. As a neuro feedback Prac- titioner,she specializes in Brain Rehabilitation and Brain Fitness. She uses the latest cutting-edge technology to help brain injury and brain trauma survivors regain control of their lives and become thrives. [email protected] Note: Journal of Neurology and Neurorehabilitation Research | Volume 3 Page 15 alliedacademies Joint Event on International Conference on NEUROSCIENCE AND NEUROLOGICAL DISORDERS & International Conference on PSYCHIATRY AND PSYCHOLOGICAL DISORDERS June 28-29, 2018 | Dublin, Ireland Amarnath Mallik, J Neurol Neurorehabil Res 2018, Volume 3 DEPRESSION IN WOMEN epression is common among women and likely due to certain biological, Dhormonal and social factors that are unique to women. Women are at higher Amarnath Mallik risk than men of developing depression particularly during the reproductive Woodlands Hospital, India years. The burden of depression is 50% higher for females than males. Mood changes in women may be due to life events (divorce, death) or may be due to hormones (pregnancy, menstrual cycle). MDD is the fourth common cause of disability in female in all age groups. Life time prevalence is 10%-25% and Biography more common among married women. Late life depression is also common Amarnath Mallik is a Consultant Psychiatrist in the elderly women. Dysthymia (Persistent Depressive Disorder) is common and he completed his practice from institutes in women. Bipolar disorder occurs with similar frequency in men and women like Kothari Medical Centre, Kolkata, Woodlands but Bipolar II significantly more common in female. Research suggests that Hospital, Kolkata and Belle Vue Nursing home in women, hormones play a role in the development and severity of bipolar Mumbai, India. He is a Specialist in the field of disorder. Mixed mania and rapid cycling is more common in bipolar women. Psychiatry and his expertise lies in the field of Post-partum period is associated with high risk of onset and relapse of BD. Neuropsychiatry. Premenstrual dysphoria is a heritable disorder. Genes related to estrogen and [email protected] serotonins are believed to be of primary importance in PMDD. In studies it has been seen that centrally active progesterone metabolite allopregnanolone has potential role in the pathogenesis of PMDD. Mood and anxiety disorders are prevalent during pregnancy. Prenatal depression and Prenatal Bipolar Disorders are common, and risk of recurrence of mania or depression needs proper management. During the post-partum period about 85% of women experience some mood disturbance and 10% to 15% of women experience clinically significant symptoms. Post-partum depressions are of three categories: Post- partum Blues, Non-psychotic major depression and Puerperal Psychosis. Post-menopausal depression is also common and due to declining levels of estrogen and progesterone. In PMD, vasomotor symptoms may be related to the dysregulation of thermoregulatory center, associated with fluctuations in estrogen levels and increased noradrenergic tone in hypothalamus. Management of Depression in women is very important. Psychotherapy, Cognitive Behavior Therapy plays a useful role. Different antidepressant drugs are used considering safety, efficacy and tolerability. Mood stabilizers are used Note: for Bipolar Disorders, ECT is also used. Prevention of suicide needs special attention. Journal of Neurology and Neurorehabilitation Research | Volume 3 Page 16 Joint Event on alliedacademies International Conference on NEUROSCIENCE AND NEUROLOGICAL DISORDERS International Conference on & PSYCHIATRY AND PSYCHOLOGICAL DISORDERS June 28-29, 2018 | Dublin, Ireland DAY 2 Keynote Forum Neuroscience Congress 2018 & Psychiatry 2018 Page 27 alliedacademies Joint Event on International Conference on NEUROSCIENCE AND NEUROLOGICAL DISORDERS & International Conference
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