RDS-Summit

Inaugural Reward Deficiency Syndrome Summit

Reward Deficiency Syndrome (RDS) in the 21st Century: , Neurogenetic, Neuroimaging Tools for Therapy and Recovery

Sponsors

November 16-18, 2015 San Francisco, USA Program at Glance

November 16, 2015 @ SIERRA B

08:30-09:00 Registrations

09:00-09:30 Introduction to the Reward Deficiency Syndrome Summit

09:30-12:20 Keynote Session I

12:20-17:00 Scientific Session I

17:00-18:00 Special Evening Movie I

November 17, 2015 @ SIERRA B

09:00-10:40 Keynote Session II

11:00-15:40 Scientific Session II

16:00-17:00 Special Evening Movie II

November 18, 2015 @ SIERRA B

09:30-11:30 Scientific Session III DAY 1 Monday, November 16, 2015 Keynote Session I @ SIERRA B

Keynote Session I : 09:30-12:20

09:30-09:55 09:55-10:20

Kenneth Blum David E. Smith University of Florida, USA University of California at San Francisco, USA Presentation on: “Dopamine Resistance” in Brain Presentation on: Process Addictions and Addiction Reward Circuitry as a Function of Genetic Addiction Transfer Risk Score (Garspdx) Polymorphisms in RDS: Synaptamine Complex Variant (Kb220z) Induced “Dopamine Sensitivity” as a Pro-recovery Agent David E. Smith is recognized as a national leader in the treatment of addictive disease, the psychopharmacology of drugs, new research Kenneth Blum is widely designated as Father strategies in the management of drug abuse of Psychiatric because of the DRD2 problems, and appropriate prescribing practices gene and its correlation with various psychiatric for physicians. He teaches that addiction is a disorders including the “Reward Deficiency primary medical illness which is best treated in Syndrome (RDS)” which term he has coined. He a multidisciplinary fashion, utilizing the group is also known as the “Father of Neuro-Nutrient process and the 12-Step programs of Alcoholics Therapy” for his discovery of successful nutrient Anonymous, Narcotics Anonymous and Cocaine therapy for RDS. He holds numerous domestic and Anonymous. He lectures on the management foreign patents and is co-founder and Chairman & of psychoactive drug dependence, including Chief Scientific Officer (CSO) of LifeGen Inc. He cocaine, alcohol and prescription drugs. He also is a former Full Professor in the Department of speaks on the subjects of impaired and recovering , University of Texas Health Science clinicians, substance abuse in the workplace, Center, San Antonio, Texas; Volunteer Professor in dual diagnosis disorders, and substance abuse the Department of & McKnight Brain and the criminal justice system, among many Institute, University of Florida College of Medicine, other topics. He provides medical review of DOT Gainesville, Florida and Adjunct Full Professor of and private industry drug testing and prescription Psychiatry at the University of Vermont College drug plans, and legal consultation. Dr. Smith of Medicine, Burlington, Vermont. He currently founded the Haight Ashbury Free Clinics in 1967, serves as advisor for Dominion inaugurating the principle of “Health Care is a Diagnostics LLC, North Kingstown, Rhode Island, Right, not a Privilege”. He has served on federal, Malibu Beach Recovery Center, Malibu Beach state and local bodies addressing substance use, California, and is the Scientific Director of PATH abuse and treatment, and has received numerous Foundation, New York. He is an honorary Faculty awards, including the 2013 Peter E. Haas Award of IIOAB, India. He has been recently appointed from the University of California Berkeley. He CSO of G&G Holistic Addiction Treatment Centers lectures extensively and is the author/co-author in North Miami Beach Florida. To his credit he has of over 360 professional articles and books, over 400 publications in peer reviewed journals, 14 including Unchain Your Brain: 10 Steps to Breaking books and has received many awards including the Addictions that Steal Your Life, with Dr. Daniel a Lifetime Achievement Award from the National Amen. Institute of Holistic Addiction Studies.

RDS Summit | Nov 16-18, 2015 | San Francisco, USA 3 DAY 1 Monday, November 16, 2015 Keynote Session I @ SIERRA B

10:20-10:45 11:05-11:30

David Baron Panayotis K. Thanos Keck School of Medicine at USC, USA University of Buffalo, USA

Presentation on: Reward Deficiency Syndrome in Presentation on: Dopamine D2, Obesity and Sports Psychiatry Reward Deficiency Syndrome

David Baron is currently Professor and Vice Chair, Panayotis K. Thanos is interested in translational and Chief of Psychiatry at University Hospital at the research utilizing various rodent models of Keck School of Medicine, University of Southern psychopathology to better understand the California. Dr. Baron is also the Director of the mechanisms involved in substance use disorders Global Center for Exercise, Psychiatry and Sport (SUD) and addiction including the role of at USC and Chairman of the Section on Exercise, dopamine signaling, genes, environment, as well Psychiatry and Sport for the World Psychiatric brain circuit mapping and connectivity changes in Association/World Health Organization. He is food, drug and alcohol abuse. Dr. Thanos is the also a current member of the Executive Board of Director of the Behavioral Directors for the International Society of Sports and Neuroimaging Lab and has authored more Psychiatrists and the 2010 Consumer Council than 85 peer reviewed articles on reward and of America “Top Doc” for Sport Psychiatry. Dr. addiction. Baron is the former Deputy Clinical Director of the National Institute of Mental Health and Chair of the Department Psychiatry at the NIH graduate school 1989-1997 and Temple University (1998- 2010). He developed, and holds the copyright on the only validated screener specifical for athletes (BDSA), which is currently in use in over 7 countries. He has over 30 years of clinical experience in sports medicine and sports psychiatry and has worked with athletes of all ages and levels of competition including NCAA, Olympic, and professional. He has published over 130 peer reviewed publications and presented over 300 scientific presentations in the US and over 30 invited international talks, many in the area of Doping in Sports and Depression, Drug Use and in athletes. His current clinical and research interests are in the neuropsychiatric sequel of recurrent sub-clinical concussion and TBI in athletes, specifically focused on developing more sensitive, user-friendly screening instruments and methods, and increasing public awareness of this growing problem. Coffee Break: 10:45-11:05

RDS Summit | Nov 16-18, 2015 | San Francisco, USA 4 DAY 1 Monday, November 16, 2015 Keynote Session I @ SIERRA B

11:30-11:55 11:55-12:20

Peter Banys John J. Giordano University of California at San Francisco, USA National Institute For Holistic Addiction Studies, USA Presentation on: The Evolving Landscape of Presentation on: Comprehensive Holistic Approaches International Drug Policy Reforms and Cannabis in Addiction Medicine Legalization in California

In his 35-year career at VA/UCSF, Dr. Banys John J. Giordano is the former president and has developed two addiction fellowships, has founder of the prestigious G & G Holistic Addiction engaged in direct clinical care, research, and Treatment Center, a 62 bed in-patient/out-patient teaching of UCSF psychiatry residents and JACHO accredited addiction treatment facility. He substance abuse physician fellows. Most recently is a therapist, a Certified Addiction Professional he spent 2½ years living and working in Hanoi to (CAP), a Master Addictions Counselor (MAC), assist in scaling up methadone programs and to and a Certified Criminal Justice Specialist (CCJS). develop community screenings for depression. He He also earned a Masters Certification in Neuro is a section co-editor (Special Problems) for the linguistics Programming (NLP), and is a Certified 2014 edition of the ASAM Textbook of Addiction Eye Movement Desensitization and Reprocessing Medicine. He is a member of Lt. Governor Gavin (EMDR) Specialist and a professional expert Newsom’s Blue Ribbon Commission (BRC) on witness for the state and federal government. marijuana law reform, and has written a series of He is also a Karate Grand Master 10th degree marijuana reform-related briefings available on black belt. He is also certified in Traditional Indian the BRC and CSAM websites. Medicine as well as Mindfulness and Powerful Mind-Body Awareness Therapy Skills. Most recently, he was awarded an Honorary Doctorate of Humane Letters from Mount Sinai University. His Influential book, Proven Holistic Treatment for Addiction & Chronic Relapse, is being utilized by several state hospitals and numerous treatment centers across the country.

RDS Summit | Nov 16-18, 2015 | San Francisco, USA 5 DAY 1 Monday, November 16, 2015 Scientific Session I @ SIERRA B: 12:20-17:00

Substance Abuse David E. Smith, University of California at San Francisco, USA Session Chairs: Dieter J. Meyerhoff, University of California at San Francisco, USA

Presentation on: Polysubstance Use and Brain Function. Why Bother? Dieter J. Meyerhoff, University of California at San Francisco, USA 12:20-12:40

Presentation on: Interactions Between Methamphetamine and Stress: A Dangerous Combination Bryan K. Yamamoto, Indiana University School of Medicine, USA 12:40-13:00

Presentation on: Mental Health and Substance Use Correlates in a Population Sample of Canadian Adults with and Without a History of Traumatic Brain Injuries Gabriela Ilie, St. Michael’s Hospital, Canada 13:00-13:20

Lunch Break: 13:20-14:20 @ Tiburon-Sausalito

Presentation on: Role of A5 Subunit Containing Nicotinic Receptors in Key Circuits Involved In Nicotinic Addiction and Beyond Rouba Kozak, Pfizer Inc., USA 14:20-14:40

Presentation on: Quality of Life of Users of Psychoactive Substances, Relatives and Non-Users Tais de Campos Moreira, Federal University of Health Sciences of Porto Alegre /UFCSPA, Brazil 14:40-15:00

Presentation on: The Concerning State of Opioid Addiction Trials and Guidelines: To Whom Does this Evidence Apply Zainab Samaan, McMaster University, Canada 15:00-15:20

Presentation on: Medication Abuse in Europe: Which Pharmacoepidemiological Ressources? Maryse Lapeyre Mestre, University of Toulouse, France 15:20-15:40

Presentation on: “This is your Brain on Drugs”: Adolescent Substance Use Prevention Through Neuroscience Education Sion K. Harris, Boston Children’s Hospital, USA 15:40-16:00 Coffee Break: 16:00-16:20

Presentation on: Family Members Affected by a Relative’s Substance Misuse Looking for Social Support: Who Are They? Maria de Fatima Padin, Federal University of Sao Paul, Brazil 16:20-16:40

Presentation on: ADAR2-Dependent GluA2 Editing Regulates Cocaine Seeking Ghazaleh Sadri Vakili, Mass General Institute for Neurodegenerative Disease, USA 16:40-17:00 Special Evening Movie An American Epidemic 17:00-18:00 Michael R. DeLeon, Steered Straight, Inc., USA Reception: 18:00-19:00

RDS Summit | Nov 16-18, 2015 | San Francisco, USA 6 DAY 2 Tuesday, November 17, 2015 Keynote Session II @ SIERRA B

Keynote Session II : 09:00-11:00

09:00-09:25 09:25-09:50

Rajendra D. Badgaiyan Timothy D. Brewerton University of Minnesota, USA The Hearth Center for Eating Disorders, USA Presentation on: Dopamine Neurotransmission In Presentation on: Are Eating Disorders Reward Reward Deficiency Syndrome Deficiency Syndromes?

Rajendra D. Badgaiyan is the Director and Principal Timothy D. Brewerton, MD, DFAPA, FAED, Investigator of Molecular and Functional Brain DFAACAP is Clinical Professor of Psychiatry & Imaging Laboratory and Director of the University Behavioral Sciences at the MUSC (Charleston), Laboratory for Advanced Radiochemistry. He and Executive Medical Director of the Hearth graduated from Gandhi Medical College, Bhopal Center for Eating Disorders (Columbia, SC). He is in India and completed his psychiatry residency triple board certified in general, child/adolescent training at Harvard Medical School. He had and forensic psychiatry; Distinguished Fellow of postdoctoral training in cognitive neuroscience the APA and the AACAP; Founding Fellow of the at University of Oregon, University of Pittsburgh Academy of Eating Disorders; former president and Harvard University. He also had training in of the Eating Disorders Research Society; author molecular imaging at Massachusetts General of over 140 articles/book chapters; Editor of Hospital, Boston, and clinical research training at the Clinical Handbook of Eating Disorders: An MIT. He is board certified in General Psychiatry Integrated Approach (2004), Co-editor of Eating and in Addiction Medicine. He is a member of Disorders, Addictions, and Substance Use a numerous National and International Scientific Disorders: Research, Clinical and Treatment Societies. He is the Editor-in-Chief of 7 international Perspectives (2014). scientific journals and a member of the editorial board of over 40 other scientific publications. He has organized a number of International conferences and symposia.

RDS Summit | Nov 16-18, 2015 | San Francisco, USA 7 DAY 2 Tuesday, November 17, 2015 Keynote Session II @ SIERRA B

09:50-10:15 10:15-10:40

Marcelo Febo Giulio Maria Pasinetti University of Florida, USA Mount Sinai School of Medicine, USA Presentation on: Resting State Functional Presentation on: Novel Prophylactic and Therapeutic Connectivity in Rat Brain During Extended Daily Interventions for Stress-Induced Depression Access to Cocaine and Abstinence

Marcelo Febo completed his PhD at the University Giulio Maria Pasinetti is a Professor of Psychiatry, of Puerto Rico Medical School and postdoctoral Professor of Neuroscience and Professor studies at the University of Massachusetts of and Adult Development, in the Medical Center. His work focuses on measuring Department of Psychiatry at Mount Sinai School in vivo functional and structural changes in the rat of Medicine, New York. He graduated from Milan brain following chronic drug exposure. Over the University School of Medicine in 1982, and he past decade he has pursued this goal through the received his PhD from the University of Milan use of high field functional magnetic resonance in 1988. He joined the Mount Sinai School of imaging in awake rats and mice. He has been Medicine’s faculty in 1996 and has consistently funded early in his career by the National Institute maintained an outstanding record of excellence on Drug Abuse to examine the relationship and exceptional productivity. between cocaine sensitization and alterations in He was also recently awarded with an NIH funded maternal brain activity. He is presently Program research grant supporting a ‘’Center of Excellence Director of Translational Research Imaging at the for Research in Complementary and Alternative University of Florida Brain Institute and is also a Medicine in Alzheimer’s disease,’’ of which he is faculty member of the Department of Psychiatry. the Principal Investigator and Director. The NIH funded Center is the first in the country exploring the potential beneficial role of natural grape -derived polyphenolic compounds implicated in mechanisms associated with the prevention of Alzheimer’s disease (AD) . He also serves as the Director of the Basic and Biomedical Research and Training Program, GRECC James J. Peters Veterans Affairs Medical Center at the Bronx VA.

Coffee Break: 10:40-11:00

RDS Summit | Nov 16-18, 2015 | San Francisco, USA 8 DAY 2 Tuesday, November 17, 2015 Scientific Session II @ SIERRA B: 11:00-15:40

Addiction Treatment Norman S. Miller, Bear River Health at Walloon Lake, USA Session Chairs: Deborah Matteliano, University at Buffalo, USA

Presentation on: Opioid Medications: Efficacy and Risks Norman S. Miller, Bear River Health at Walloon Lake, USA 11:00-11:20

Presentation on: Promoting Epigenetic Networks using Biopsycho-Spiritual Approaches for Treating Prescription Opioid Addiction Deborah Matteliano, State University of New York, USA 11:20-11:40

Presentation on: An Assessment of Outcomes Measure Implementation in the Addiction Treatment Space Alexander K. Moler, Alexandra L. Carlin, The Coalition Against Drug Abuse, USA 11:40-12:00

Presentation on: Modeling Recovery Brett C. Ginsburg, The University of Texas Health Science Center at San Antonio, USA 12:00-12:20

Presentation on: Getting In and Out Whole: Connecting with Patients Emotional Pain in the Psychiatric Setting Judith Van Sant, Our Lady of Lourdes School of Nursing, USA 12:20-12:40

Presentation on: Integrating Substance Use and Eating Disorder Treatment: Adapting Evidence Based Treatments Therese K. Killeen, University of South Carolina, USA 12:40-13:00

Lunch Break: 13:00-14:00 @ Tiburon-Sausalito

Presentation on: Motivational Interviewing - Patient - Centered Communication in Brief Health Care Encounters Tatjana Petrova, Chicago State University, USA 14:00-14:20

Presentation on: Mechanisms of Pain and Opioid Pharmacology Thersilla Oberbarnscheidt, Central Michigan University, USA 14:20-14:40 Alcoholism

Presentation on: Similarities and Differences in Neurocognitive and Neuroimaging Findings among Internet Gaming Disorder and Alcohol Use Disorder Jung Seok Choi, Seoul National University College of Medicine, South Korea 14:40-15:00

Presentation on: Greater Mesolimbic Loss-Sensitivity in Young Adult Social Drinkers at Risk for Alcohol Dependence Jane E. Joseph, Medical University of South Carolina, USA 15:00-15:20

Presentation on: Dopaminergic Pathways in Alcohol Dependence: First Data on Indian Population Meera Vaswani, All India Institute of Medical Sciences, India 15:20-15:40

RDS Summit | Nov 16-18, 2015 | San Francisco, USA 9 Coffee Break: 15:40-16:00

Special Evening Movie American Addict 2 16:00-17:00 Gregory A. Smith,MD, Pain MD Productions, USA http://drgregorysmith.com/

DAY 3 Wednesday November 18, 2015 Scientific Session III @ SIERRA B: 09:30-11:30

Neurobiology of RDS

Edward J. Modestino, Massachusetts College of Pharmacy and Health Sciences, USA Session Chairs: David Nussbaum, University of Toronto, Canada

Presentation on: Expression of Reward Reficiency Syndrome Depends on More than Dopamine David Nussbaum, University of Toronto, Canada 09:30-09:50

Presentation on: Fetal Alcohol Spectrum Disorder-Can Prenatal Nutrition Strategy Make a Difference for Brain Development? Miyoung Suh, University of Manitoba, Canada 09:50-10:10

Presentation on: Reward Deficiency Syndrome: Attentional/Arousal Subtypes, Limitations of Current Diagnostic Nosology, and Future Research Edward J. Modestino, Massachusetts College of Pharmacy and Health Sciences, USA 10:10-10:30 Presentation on: The Oxidative Stress Induced Nitric Oxide Dependent Mitochondrial DNA Overproliferation and Deletion in the Context of the Cancer and : Recent Challenge

10:30-10:50 Gjumrakch Aliev, GALLY International Biomedical Research Consulting LLC., USA

Presentation on: A Glutamatergic Reward Input from the Dorsal Raphe to the Ventral Tegmental Dopamine Neurons Marisela Morales, National Institute on Drug Abuse, USA 10:50-11:10

Presentation on: Role of Mesolimbic Dopamine in Food and Drug Reward Valentina Bassareo, University of Cagliari, Italy 11:10-11:30

Lunch Break: 12:00-13:00 @ Tiburon-Sausalito

Departures

RDS Summit | Nov 16-18, 2015 | San Francisco, USA 10 Notes We wish to meet you again at RDS Summit- 2016

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