PATENTS

Recent patent applications in DNA sequencing

Patent # Subject Assignee Inventor(s) Priority Publication application date date WO 200490505 An apparatus for examining the identity of chemical Intl. Frontier Science Poponin V 4/4/2003 10/21/2004 groups in a sample attached to a surface; enables Org. (San Francisco, direct DNA sequencing of samples such as CA, USA) chromosomal or full genomic DNA and identification of successive bases in a single DNA strand. US 20040200979 A method for detecting fluorescence from, e.g., DNA Applera (Norwalk, CT, Reel RT 1/23/2002 10/14/2004 in a channel, by providing an excitation beam of light USA) producing a fluorescent trail, positioning the excitation beam of light to increase spatial resolution and collecting a portion on a detector; used in automated DNA sequencing, capillary electrophoresis or immunoassays. WO 200458942 A blend of two or more DNA polymerases, comprising Stratagene (La Jolla, CA, Borns M 11/5/2003 7/15/2004 http://www.nature.com/naturebiotechnology at least one chimeric DNA polymerase and at least one USA) nonchimeric DNA polymerase; useful in PCR, DNA sequencing and mutagenesis protocols. The polymerases allow for PCR reactions with shorter extension times that will facilitate PCR amplification of genomic DNA templates and improve the efficacy of long PCR. KR 2004055521 A system and method for predicting the function of Electronics and Telecom. Choi JS, Huh MY, 12/21/2002 6/26/2004 a protein, comprising using a DNA sequencer, an Research Inst. (Daejeon, Jung H, Kim, GH; amino sequencer and bioinformatics; system obtains Korea) Kim HB, Kim HG a larger number of domain search data and reduces the time required for analysis of a domain. US 20040117130 A method for improving the accuracy of DNA sequencing Paracel (Pasadena, CA, Arehart AB, Curtin 9/8/2000 6/17/2004 and error probability estimation through the application of a USA) MD, Denisov GA mathematical model to the analysis of electropherograms.

2005 Nature Publishing Group Group 2005 Nature Publishing US 20040110208 A method for DNA sequencing for the biology and Chan S; Su X Chan S, Su X 9/26/2003 6/10/2004 field, involving removing nucleotides from one end of nucleic © acid molecule(s); moving the nucleotides through a channel packed with nanoparticles; identifying nucleotide(s) by Raman spectroscopy; and characterizing the nucleic acid. WO 200429578 New fluorescently labeled dye terminators useful as Amersham Biosciences Chen C, Kumar S, 9/25/2002 4/8/2004 energy transfer dyes, as labels in DNA sequencing (Piscataway, NJ, USA) Rao S reactions and as substrate for DNA polymerase. WO 200429298 An automated method for sequence evaluation used to Applera (Norwalk, CT, Glanowski SA, 9/26/2002 4/8/2004 compare sequence information relating to at least one USA); Glanowski SA; Stockwell TB sample against sequence information relating to at least one Stockwell TB reference; comprises evaluating the quality and coverage of the sample sequence information in comparison to the reference sequence information to identify reportable ranges and sequence variants for the sample sequence information. US 20030232346 A DNA sequencing method comprising separating template Intel (Santa Clara, CA, Su I, Su X 6/17/2002 12/18/2003 nucleic acid into four samples each having a different USA); Su X type of labeled nucleotide, synthesizing labeled nucleic acid strands complementary in sequence to the template, measuring distances between labeled nucleotides, constructing a distance map for labeled nucleic acid strands in each sample and assembling distance maps into a nucleic acid sequence of complementary strands. US 20030224384 A method for assembling subsequences of a DNA sequence, Otu HH; Sayood K Otu HH, Sayood K 11/13/2001 12/4/2003 involving assigning numerical characterization comprising a set of numbers to each subsequence, clustering the sets and aligning the sets to form a consensus sequence for each cluster.

Source: Derwent Information, Alexandria, VA. The status of each application is slightly different from country to country. For further details, contact Derwent Information, 1725 Duke Street, Suite 250, Alexandria, VA 22314. Tel: 1 (800) DERWENT (info.derwent.com).

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