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Clinical Evaluation of Pipecuronium Bromide and Its Comparison With
Scholars Journal of Applied Medical Sciences (SJAMS) ISSN 2320-6691 (Online) Sch. J. App. Med. Sci., 2013; 1(6):943-950 ISSN 2347-954X (Print) ©Scholars Academic and Scientific Publisher (An International Publisher for Academic and Scientific Resources) www.saspublisher.com Research Article Clinical Evaluation of Pipecuronium Bromide and its Comparison with Pancuronium Bromide Kaushal RP Associate Professor, Department of cardiac anesthesia, Gandhi Medical College, Bhopal, India. *Corresponding author Kaushal RP Email: Abstract: The study was carried out to compare the intubating conditions, cardiovascular responses, neuro-muscular blocking properties and reversal characteristics of pipecuronium bromide and pancuronium bromide. This is a prospective hospital based study. 100 patients belonging to ASA grade I or II physical status aged 18 to 70 years were divided into two groups of 50 patients each. Group 1 received pipecuronium bromide in the dose of .08 mg / kg and group 2 patients received pancuronium bromide in dose of 0.1 mg/kg. Each patient was pre medicated uniformly. Time for onset of apnoea for pipecuronium and pancuronium were 91.64+ 3.59 sec. and 118.84 + 12.53 sec. respectively. The mean time for intubation was 126.60 +12.55 sec. and 144.60 + 22.87 sec. with pipecuronium and pancuronium respectively. Mean duration of block for pipecuronium was 78.64 + 8.97 min. the block for pancuronium lasted from +36-40 min with a mean duration of block 41.60+ 5.57 min. The mean duration of maintenance dose in pipecuronium cases was 45.08 + 7.19 min., while it was 27.06 + 5.01 min in pancuronium cases. -
Pancuronium Bromide (Pavulon | Evaluation of Its Clinical Pharmacology*
PANCURONIUM BROMIDE (PAVULON | EVALUATION OF ITS CLINICAL PHARMACOLOGY* ALLEN B. DOBKIN, M.D., WILLIAM EVEBS,M.D., SION GHANOONI, M.D., ASHLEYA. LEVY, VH.D., AND EDWARDT. THOMAS,M.B. PANCURONIUMBROMIDE IS AN amino steroid muscle relaxant (Figure 1) which was synthesized in 1964 by Hewett and Savage and has been studied and evaluated clinically in Europe during the past four years2-5 It is an odourless, white, crystal- line powder with a bitter astringent taste, melts at 215~ with decomposition, and is soluble in 50 parts of chloroform and one part water at 20~ The co]ourless solution is stable while sealed, but breaks down in a few hours after exposure to air. In Europe it is available in 2-ml ampoules containing 4 mg pancuronium bro- mide, 18 nag sodium chloride B.P. and water for injection B.P. to 2 mls. The prepara- tion which was used in this study contains preservatives (acetic acid and sodium acetate) to buffer the solution to pH 4.0. OOC.CH 3N~~ 2BP- CH3CO0 H H20 -- Pancur'ontum Bromide - Pavuton (R) FIGURE 1. Structural formula for paneuronium bromide - Pavulon| Pharmacological studies have shown that it has no hormonal action but is a potent non-depolarizing skeletal muscle relaxant like'tubocurarine and gallamine. It has a more rapid onset of action than tubocurarine with a similar duration of action. It has a somewhat longer action than gallamine. It has no significant effect on the blood pressure or the tracheobronchial tree due to the very. slight ganglion- blocking action and the claim is that no histamine is released, a It does not affect *From the Department of Anesthesiology, State University Itospital, State University of New York, Upstate Medical Center, Syracuse, New York, 13210, U.S.A. -
Executive Clemency: the Lethal Absence of Hope
American University Criminal Law Brief Volume 3 Issue 1 Article 1 2007 Executive Clemency: The Lethal Absence Of Hope Jonathan Harris Lothlórien Redmond Follow this and additional works at: https://digitalcommons.wcl.american.edu/clb Part of the Criminal Law Commons Recommended Citation Harris, Jonathan, and Lothlórien Redmond. "Executive Clemency: The Lethal Absence Of Hope." Criminal Law Brief 3, no. 1 (2007): 2-15. This Article is brought to you for free and open access by the Washington College of Law Journals & Law Reviews at Digital Commons @ American University Washington College of Law. It has been accepted for inclusion in American University Criminal Law Brief by an authorized editor of Digital Commons @ American University Washington College of Law. For more information, please contact [email protected]. EXECUTIVE CLEMENCY: THE LETHAL ABSENCE OF HOPE1 Jonathan Harris* and Lothlórien Redmond** Executive clemency is an act by a governmental chief Section 2 of the Constitution.9 In 1833, Chief Justice John executive that relieves in whole, or in part, the consequences Marshall described the basis and scope of the Presidential par- resulting from a criminal conviction.2 Although not limited to don power in the following sweeping terms: death penalty cases, the concept of clemency is most common- ly associated with the decision by a sitting state governor A pardon is an act of grace, proceeding from the power whether to commute a sentence of death to a lesser sentence, intrusted with the execution of the laws, which usually to life imprisonment.3 It is in that context that this arti- exempts the individual, on whom it is bestowed, from cle examines the meaning and process of clemency. -
Malta Medicines List April 08
Defined Daily Doses Pharmacological Dispensing Active Ingredients Trade Name Dosage strength Dosage form ATC Code Comments (WHO) Classification Class Glucobay 50 50mg Alpha Glucosidase Inhibitor - Blood Acarbose Tablet 300mg A10BF01 PoM Glucose Lowering Glucobay 100 100mg Medicine Rantudil® Forte 60mg Capsule hard Anti-inflammatory and Acemetacine 0.12g anti rheumatic, non M01AB11 PoM steroidal Rantudil® Retard 90mg Slow release capsule Carbonic Anhydrase Inhibitor - Acetazolamide Diamox 250mg Tablet 750mg S01EC01 PoM Antiglaucoma Preparation Parasympatho- Powder and solvent for solution for mimetic - Acetylcholine Chloride Miovisin® 10mg/ml Refer to PIL S01EB09 PoM eye irrigation Antiglaucoma Preparation Acetylcysteine 200mg/ml Concentrate for solution for Acetylcysteine 200mg/ml Refer to PIL Antidote PoM Injection injection V03AB23 Zovirax™ Suspension 200mg/5ml Oral suspension Aciclovir Medovir 200 200mg Tablet Virucid 200 Zovirax® 200mg Dispersible film-coated tablets 4g Antiviral J05AB01 PoM Zovirax® 800mg Aciclovir Medovir 800 800mg Tablet Aciclovir Virucid 800 Virucid 400 400mg Tablet Aciclovir Merck 250mg Powder for solution for inj Immunovir® Zovirax® Cream PoM PoM Numark Cold Sore Cream 5% w/w (5g/100g)Cream Refer to PIL Antiviral D06BB03 Vitasorb Cold Sore OTC Cream Medovir PoM Neotigason® 10mg Acitretin Capsule 35mg Retinoid - Antipsoriatic D05BB02 PoM Neotigason® 25mg Acrivastine Benadryl® Allergy Relief 8mg Capsule 24mg Antihistamine R06AX18 OTC Carbomix 81.3%w/w Granules for oral suspension Antidiarrhoeal and Activated Charcoal -
Clinical Pharmacokinetics of Muscle Relaxants
i ,I .. / ,""- Clinical Pharmacokinetics 2: 330-343 (1977) © ADIS Press 1977 Clinical Pharmacokinetics of Muscle Relaxants L.B. Wingard and DR. Cook Departments of Pharmacology and Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania SUl1lmary Muscle relaxants are commonly used as an adjunct to general anaesthesia and to facilitate ventilator care in the intensive care unit. The muscle relaxants are unique in that the degree of neurol1luscular blockade can be directly measured. Thus, for some of the muscle relaxants it is possible to correlate the degree of neuromuscular blockade with the plasma concentration of drug. This quantilalive pllGrmacokinelic approach has been applied primarily to d tubocurarine and to a lesser extent to suxamethonium (succinylcholine), gallamine and pan curoniul1l. The pharl1lacokinetic information for the other relaxants is mostly descriptive and incomplete. The variation in drug concentration over time is in.fluenced by the distribution, metabolism and excretion of drug. Metabolism by plasma cholinesterase plays a maJor role in the termina tion (~f action of suxamethonium. Although pancuronium is partly metabolised its major metabolites have moderate pharmacological activity. The other relaxants are excreted through the kidney. For gallamine and dimethyl-tubocurarine, renal excretion appears to be the only means qf eliinination. However, biliary excretion probably provides an alternative route of elimination for d-tubocurarine and pancuronium. In patients with impaired renal function the duration qf neuromusClilar blockade may be markedly prolonged following standard doses of gallamine or dimethyl-tubocurarine, may be slightly prolonged following standard doses of pancumnium, and is near normal following standard doses qf d-tubocurarine. Following large or repeated doses q(pancuronium or d-tubocurarine, the duration q{ neuromuscular blockade may be markedly prolonged. -
Inhibitory Actions of Vecuronium Bromide on Acetylcholine and Glutamate Responses at the Frog and Crayfish Neuromuscular Junction
Inhibitory Actions of Vecuronium Bromide on Acetylcholine and Glutamate Responses at the Frog and Crayfish Neuromuscular Junction Haruhiko SHINOZAKI and Michiko ISHIDA The Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113, Japan Accepted November 7, 1983 Abstract-Effects of vecuronium bromide, an analog of pancuronium, on the cholinergic and glutamatergic neuromuscular junction were investigated. Vecuronium depressed the postsynaptic response of the frog end-plate at lower concentrations than 10-6 g/ml without affecting the presynaptic events. Vecuronium decreased the amplitude of the double ACh potential, but the second potential was more markedly reduced than the first. In analogy with d-tubocurarine, this suggests that vecuronium may act in part as an open channel blocker at the frog end-plate. Vecuro nium depressed both the glutamate response and the excitatory junctional potential at the crayfish neuromuscular junction, although high concentrations were required. The drug increased the decay rate of extracellularly recorded excitatory functional potentials at the crayfish neuromuscular junction. The reduction of the crayfish synaptic response caused by vecuronium can be explained by the open channel blocking action at this functional site. The problem that cholinergic antagonists possess a property of channel blocking at the other transmitter system was discussed. Vecuronium is an analog of pancuronium, The neuromuscular blocking action of pan but is not the bis-quarternary ammonium, one curonium has been well documented (2). quarternary moiety of pancuronium being The comparison of pharmacological activities replaced by a tertiary amine (Fig. 11. Although of vecuronium to pancuronium was already it is known that replacement of one quar done in some earlier studies (3-6), and ternary moiety of the bis-quarternary am the effectiveness of both drugs is almost monium structure by a primary amine group the same, however, electrophysiological results in a considerable loss of potency (1), studies are lacking. -
Summary of Product Characteristics
Health Products Regulatory Authority Summary of Product Characteristics 1 NAME OF THE MEDICINAL PRODUCT Pancuronium Bromide 2 mg/ml Solution for Injection 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each 1 ml contains 2 mg of pancuronium bromide. Each 2 ml ampoule contains 4 mg of pancuronium bromide. Excipients with known effect: For the full list of excipients, see section 6.1. 3 PHARMACEUTICAL FORM Solution for injection. A clear, colourless solution with a pH of 3.8 – 4.2. 4 CLINICAL PARTICULARS 4.1 Therapeutic Indications Pancuronium bromide is a neuromuscular blocking agent with a long duration of action. It is used as an adjuvant in surgical anaesthesia to obtain relaxation of the skeletal muscles in a wide range of surgical procedures. It is also used as relaxant in orthopaedic manipulations. Used in intensive care therapy for a variety of pathologies e.g. intractable status asthmaticus and tetanus. 4.2 Posology and method of administration Posology The use of a peripheral nerve stimulator is recommended for monitoring the neuromuscular block and recovery. The following may be used as a guideline: ADULT: Initial dose: 50-80 micrograms/kg (intubation within 150 to 120 seconds) Or 80-100 micrograms/kg (intubation accomplished within 120-90 seconds). Incremental doses: 10-20 micrograms/kg PAEDIATRIC: Initial dose: 60-100 micrograms/kg Incremental doses: 10-20 micrograms/kg NEONATES: Initial dose: 30-40 micrograms/kg Incremental doses: As neonates are sensitive this dose should be adjusted according to the initial response but generally incremental doses lie in the range 10 to 20 micrograms/kg. Ifsuxamethonium is used for intubation, the administration of pancuronium bromide should be delayed until the patient has clinically recovered from the neuromuscular block induced by suxamethonium. -
Prescribing Information Pancuronium Bromide
PRESCRIBING INFORMATION PANCURONIUM BROMIDE INJECTION ABBOTT Standard 1 mg/mL Vials and 2 mg/mL Ampoules Nondepolarizing Neuromuscular Blocking Agent Hospira Healthcare Corporation Control#: 162429 1111 Dr.-Frederik-Philips Blvd., Suite 600 Saint-Laurent (Quebec) H4M 2X6 DATE OF REVISION: May 21, 2013 PRESCRIBING INFORMATION NAME OF DRUG PANCURONIUM BROMIDE INJECTION ABBOTT Standard 1 mg/mL Vials and 2 mg/mL Ampoules THERAPEUTIC CLASSIFICATION Nondepolarizing Neuromuscular Blocking Agent ACTION AND CLINICAL PHARMACOLOGY PANCURONIUM BROMIDE INJECTION is a nondepolarizing neuromuscular blocking agent possessing all of the characteristic pharmacological actions of this class of drugs (curariform). It acts by competing for cholinergic receptors at the motor end-plate. The antagonism to acetylcholine is inhibited and neuromuscular block is reversed by anticholinesterase agents such as pyridostigmine, neostigmine, and edrophonium. Pancuronium is approximately 1/3 less potent than vecuronium and approximately 5 times as potent as d-tubocurarine: the duration of neuromuscular blockade produced by pancuronium is longer than that of vecuronium at initially equipotent doses. The onset and duration of action of pancuronium are dose-dependent. The ED (dose required 95 to produce 95% suppression of muscle twitch response) is approximately 0.05 mg/kg under balanced anesthesia and 0.03 mg/kg under halothane anesthesia. These doses produce effective skeletal muscle relaxation (as judged by time from maximum effect to 25% recovery of control twitch height) for approximately 22 minutes: the duration from injection to 90% recovery of control twitch height is approximately 65 minutes. The intubating dose of 0.1 mg/kg (balanced anesthesia) will effectively abolish twitch response within approximately 4 minutes: time from injection to 25% recovery from this dose is approximately 100 minutes. -
Crips, Ganglife, Redemption, & Tookie
Page 1 of 5 AFRIKAN RESISTANCE, AFRIKAN LIBERATION 30 NOVEMBER 2005 FROM: MR. DAVEY D CNN ****************** CRIPS, GANGLIFE, REDEMPTION, & TOOKIE – CAN WE HAVE PEACE IN THE HOOD? by Davey D on Breakdown FM This is an insightful interview with former gang member/ Peace Warrior Aqueela Sherrill You can peep this interview here: http://odeo.com/audio/460407/view Former LA gang member AQEELA SHERRILLS was instrumental in the historic 1992 gang truce between the Crips and Bloods in the aftermath of the Rodney King Uprisings. In this interview he gives us a serious breakdown and understanding of what LA gang members are going through, how they see the situation surrounding Tookie and the on going efforts to bring about peace in the hood. Sherrill who is cited in Jeff Chang’s Hip Hop history book ‘Can’t Stop Won’t Stop’explains that he is runs a pro gang agency and expounds upon the fact that gangs have come to be surrogate parents for many over the years. He notes that many gang members are victims to larger enemies and societal ills like poverty and abuse at home. Aqeela talks about the abuse he suffered at the hands of an older brother who molested him. He explains that violation was something he picked up in prison and it resulted in Aqeela lashing out and becoming a hardened gang member himself. He talks in depth about the concept of reverence and healing and that a lot of work is needed to heal the deep wounds that have been inflicted by this country by those who live in the inner city. -
So Long As They Die Lethal Injections in the United States
April 2006 Volume 18, No. 1(G) So Long as They Die Lethal Injections in the United States Summary......................................................................................................................................... 1 Recommendations......................................................................................................................... 7 To State and Federal Corrections Agencies.......................................................................... 7 To State Legislators and the U.S. Congress.......................................................................... 8 I. Development of Lethal Injection Protocols ......................................................................... 9 Oklahoma.................................................................................................................................13 Texas.........................................................................................................................................15 Tennessee.................................................................................................................................17 Lethal Injection Machines .....................................................................................................18 Public Access to Lethal Injection Protocols.......................................................................20 II. Lethal Injection Drugs ..........................................................................................................21 Potassium Chloride.................................................................................................................22 -
Download Leaflet View the Patient Leaflet in PDF Format
Package leaflet: Information for the user Pancuronium Bromide 2 mg/ml Solution for Injection pancuronium bromide Read all of this leaflet carefully before you start using this medicine because it contains important information for you. • Keep this leaflet. You may need to read it again. • If you have any further questions, ask your doctor, pharmacist or nurse. • If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible effects not listed in this leaflet. See section 4. What is in this leaflet 1. What Pancuronium Bromide Solution for Injection is and what it is used for 2. What you need to know before you use Pancuronium Bromide Solution for Injection 3. How to use Pancuronium Bromide Solution for Injection 4. Possible side effects 5. How to store Pancuronium Bromide Solution for Injection 6. Contents of the pack and other information 1. What Pancuronium Bromide Solution for Injection is and what it is used for Pancuronium bromide is one of a group of medicines called ‘non-depolarising’ muscle relaxants. Pancuronium bromide solution for injection is used to relax muscles during surgery, including caesarean section and in intensive care. You must talk to a doctor if you do not feel better or if you feel worse. 2. What you need to know before you use Pancuronium Bromide solution for injection Do not use Pancuronium Bromide Solution for Injection if you are allergic to pancuronium bromide or any of the ingredients of this medicine (listed in section 6. Warning and precautions Talk to your doctor or -
Amnesty International, Human Rights & U.S. Policy
AMNESTY INTERNATIONAL, HUMAN RIGHTS & U.S. POLICY Maria Baldwin A Dissertation Submitted to the Graduate College of Bowling Green State University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY December 2006 Committee: Gary R. Hess, Advisor Franklin W. Goza Graduate Faculty Representative Robert Buffington Douglas Forsyth ii ABSTRACT Gary R. Hess, Advisor This dissertation assesses Amnesty International’s ability to influence U.S. foreign policy through an examination of its human rights campaigns in three different nations—Guatemala, the United States and the People’s Republic of China. While these nations are quite different from one another, according to Amnesty International they share an important characteristic; each nation has violated their citizens’ human rights. Sometimes the human rights violations, which provoked Amnesty International’s involvement occurred on a large scale; such as the “disappearances” connected with Guatemala’s long civil war or the imprisonment of political dissidents in the PRC. Other times the human rights violations that spurred Amnesty International’s involvement occurred on a smaller-scale but still undermined the Universal Declaration of Human Rights; such as the United States use of capital punishment. During the Guatemalan and Chinese campaigns Amnesty International attempted to influence the United States relations with these countries by pressuring U.S. policymakers to construct foreign policies that reflected a grave concern for institutionalized human rights abuse and demanded its end. Similarly during its campaign against the United States use of the death penalty Amnesty International attempted to make it a foreign policy liability for the United States. How effective Amnesty International has been in achieving these goals is the subject of this dissertation.