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Genetic Testing for Hypertriglyceridemia--Experience

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Genetic Testing for Hypertriglyceridemia--Experience Journal of Clinical Lipidology (2020) -, -–- 1 52 2 53 3 Abstracts 54 4 55 5 56 6 Scientific Poster Abstracts Selected for the National Lipid 57 7 58 8 Association 2020 Scientific Sessions, December 13-16, 59 9 60 10 2020, Chicago, IL 61 11 62 12 2020 Program Planners: Christie M. Ballantyne, MD, Kevin Meyers, MD, Bernard Rosner, PhD, Joshua Samuels, 63 13 FACP, FACC, FNLA; Anne C. Goldberg, MD, FNLA; MD, MS, Joseph Flynn, MD and the, SHIP AHOY Investigator 64 14 John Casey Elkins, DNP, Med, NP-C, CLS, FNLA; Peter 65 15 H. Jones, MD, FNLA; Carol Kirkpatrick, PhD, RDN, Lead Author’s Financial Disclosure: Grant funding 66 16 MPH, CLS, FNLA; Pamela B. Morris, MD, FNLA; Alan from American Heart Association. 67 17 Thomas Remaley, MD, PhD; Joseph J. Saseen, PharmD, 68 18 CLS, FNLA; Daneil E. Soffer, MD, FNLA Study Funding: American Heart Association SFRN in 69 19 2020 Abstracts Committee: David Davidson, MD; Marlys HTN. 70 20 L. Koschinsky PhD, FAHA, FNLA; Ann Liebeskind, MD, Background/Synopsis: Excess adiposity and dyslipi- 71 21 FNLA (Chair); Scott H. Merryman, MD; Noreen T. Nazir demia are associated with higher arterial stiffness in adults. 72 22 MD, FACC; David Neff, MD; Amy L. H. Peterson, MD; Limited data show similar relationships in youth. 73 23 Kaye-Eileen Willard, MD 74 24 The National Lipid Association (NLA) is pleased to Objective/Purpose: We evaluated the effect of abnor- 75 25 announce that 87 abstracts were accepted for presentation malities in fasting lipid profile and pulse wave velocity 76 26 in the poster format for the NLA 2020 Scientific Sessions. (PWV) in a cohort of youth recruited to study the effect of 77 27 Each abstract was reviewed by the NLA Scientific Sessions blood pressure on cardiovascular (CV) target organ damage. 78 28 Abstracts Committee prior to acceptance. Methods: Youth (N5324) with mean age 15.6 years 79 29 Posters may be viewed from Sunday, December 13 at 6 p.m., (11.1-18.9), 51% male, 65% white, 23% with hypertension, 80 30 through 2 p.m. on Wednesday, December 15. The NLA mean BMI 28 and mean HDL-C 45 (15-88 mg/dl) had 81 31 Young Investigator Awards Ceremony will take place on anthropometrics, BP, labs and PWV measured. Participants 82 32 Tuesday, December 15 from 11:50 a.m. -12:20 p.m. Posters were classified as normal vs. high BMI (.595th%) and 83 33 were judged on quality of science, originality, interest to the normal vs. low HDL-C (,540 mg/dl). Means by HDL 84 34 field of lipidology, and overall impression with cash awards category were evaluated by t-test. PWV stratified by BMI 85 35 of $1,500 for first place, $1000 to second place, and $500 to and HDL-C category was evaluated by ANCOVA. A 86 36 third place. The first place Young Investigator winner also general linear model was constructed to see if HDL 87 37 was selected to give an oral presentation during the sessions. category remained a significant determinant of PWV. 88 38 89 Three additional abstracts are selected to give an oral Results: Participants with low HDL-C were more likely 39 presentation during the abstract session. 90 40 to be male, white and Hispanic. They had higher BMI, SBP, 91 Note: Young Investigator abstract titles are marked with an 41 LDL-C, TG, glucose, insulin, CRP and PWV (all p,0.05). 92 asterisk.* Encore abstracts are marked with a dagger 42 Significant determinants of PWV included age, mean 93 symbol.† The Foundation of the NLA Hunninghake FH 43 ^ 94 Abstract award winner is marked with a caret. 44 95 45 *This award is supported by a donation from Amgen Inc. 96 46 Visceral Obesity, Metabolic Syndrome and 97 47 Atherosclerosis 98 48 99 49 104 100 50 High Body Mass Index and Low HDL 101 51 Interaction Affects Pulse Wave Velocity in 102 Youth: the SHIP AHOY Study Elaine Urbina, MD, MS, (Cincinnati, OH) Amy Shah, MD, MS, Michael Ferguson, MD, Marc Lande, MD, Figure PWV by BMI and HDL-C Categories. ABS 5.6.0 DTD JACL1584_proof 9 July 2020 5:50 pm 2 Journal of Clinical Lipidology, Vol -,No-, - 2020 103 159 104 160 105 Characteristics of the Study Population Stratified by HDL Category (means, standard deviations or percentage) 161 106 HDL .5 40 N5203 HDL , 40 N5121 T test or X2 162 107 163 108 Variable Mean SD Mean SD P value 164 109 Age (years) 15.6 1.7 15.5 1.7 NS 165 110 Sex (% male) 55.0 71.7 0.003 166 111 Race (%Caucasian) 60.5 71.7 0.04 167 112 (% African American) 26.5 22.5 168 113 (% Asian) 7.0 0.8 169 114 (% Other) 6.0 5.0 170 Ethnicity (% Hispanic) 12.5 22.5 0.03 115 171 Height (cm) 169.0 9.5 171.2 10.6 NS 116 Weight (cm) 75.6 23.0 91.4 25.7 0.0001 172 117 Waist circumference (cm) 83.7 16.7 98.1 19.3 0.0001 173 118 Waist/Height ratio 0.5 0.1 0.6 0.1 0.0001 174 119 BMI (kg/m2) 26.4 7.5 30.9 6.8 0.0001 175 120 BMI percentile 75.3 27.1 91.5 14.8 0.0001 176 121 SBP (mmHg) 120.0 13.7 126.2 10.0 0.0001 177 122 SBP percentile 68.6 31.1 82.5 19.7 0.0001 178 123 DBP (mmHg) 71.2 11.2 71.7 9.7 NS 179 124 DBP percentile 63.3 30.2 65.5 27.1 0.0001 180 125 Hypertensive (percent) 39.4 52.1 0.0002 181 Heart Rate (beats/min) 70.1 13.0 72.8 12.4 NS 126 182 Total Cholesterol (mg/dl) 152.9 29.9 151.8 36.4 NS 127 LDL-C (mg/dl) 86.2 26.6 93.1 29.5 0.04 183 128 HDL-C (mg/dl) 52.1 8.7 33.6 4.9 0.0001 184 129 Triglycerides (mg/dl) 79.6 36.4 126.8 71.7 0.0001 185 130 Glucose (mg/dl) 88.3 7.6 91.6 10.7 0.003 186 131 Insulin (microIU/ml) 16.0 11.2 27.7 21.2 0.0001 187 132 HOMA_IR 3.5 2.6 6.4 5.3 0.0001 188 133 C-reactive protein (mg/dl) 1.5 2.7 2.7 3.0 0.0006 189 134 Creatinine (mg/dl) 0.7 0.2 0.7 0.2 NS 190 135 Uric acid (mg/dl) 5.4 1.5 6.2 1.6 0.0001 191 136 Pulse Wave Velocity (m/sec) HIGHER IS STIFFER 5.0 0.8 5.3 0.9 0.0007 192 137 193 138 194 arterial pressure, BMI z-score and BMI z-score by HDL Lead Author’s Financial Disclosure: Nothing to 139 195 category interaction (r2 5 0.19, all parameter estimate disclose. 140 p,0.02). PWV increased (stiffer) across categories from 196 141 Study Funding: Developed through an independent 197 low BMI/high HDL to low BMI/low HDL to high BMI/ educational grant from Kowa. 142 high HDL to high BMI/low HDL (model p , 0.0001). 198 143 Background/Synopsis: Online education has been 199 144 Conclusions: We conclude that the combination of high shown to be an effective method for improving 200 145 BMI and low HDL-C has a deleterious effect on arterial clinician knowledge and competence. Additionally, lipid 201 146 stiffness. Measures to control adiposity and increase management in patients with insulin resistance can be 202 147 physical activity are likely necessary in youth to prevent challenging. 203 148 early vascular aging. Objective/Purpose: We sought to determine if online 204 149 continuing medical education (CME) could improve the 205 150 Diabetes, Insulin Resistance and Dyslipidemia knowledge, competence, and confidence of cardiologists, 206 151 primary care physicians (PCPs) and nurses/nurse practi- 207 152 106 tioners (NPs) related to statin use in patients with insulin 208 resistance. 153 Success of Online CME at Improving 209 154 Knowledge, Competence, and Confidence Methods: The CME activity was a 15-minute video 210 155 Related to Statin Therapy in Patient’s with discussion between 2 experts in the field of lipid manage- 211 156 Insulin Resistance ment. A repeated pairs pre-/post-assessment study design 212 157 was used and chi-square test (P ,.05 is considered signif- 213 158 Amy Larkin, PharmD, (Nicholasville, KY) icant) assessed educational effect for each activity. 214 Julie Schrand, Joy Marko, MS, APN-C, CCMEP Cramer’s V was used to calculate the effect size (0.06- ABS 5.6.0 DTD JACL1584_proof 9 July 2020 5:50 pm Hypertriglyceridemia 3 215 0.15 is a noticeable effect, 0.16-0.26 considerable, and Background/Synopsis: Lipid guidelines are ever- 271 216 .0.26 extensive). The activity launched June 11, 2019 and evolving, creating confusion for clinicians. 272 217 273 data were collected through July 26, 2019. Objective/Purpose: We sought to determine if online 218 274 Results: In total, 282 cardiologists, 515 PCPs, and 995 continuing medical education (CME) could improve the 219 275 nurses/NPs were included in the study. Overall, there were knowledge, competence, and confidence of cardiologists, 220 276 knowledge, competence and confidence improvements seen primary care physicians (PCPs) and nurses/nurse practi- 221 277 among all groups (P,.01) from pre- to post-assessment: tioners (NPs) related to guideline-based management of 222 278 lipid disorders.
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