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Fosfomycin for Lower Urinary Tract Infections: Comparative Clinical and Cost-Effectiveness

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Fosfomycin for Lower Urinary Tract Infections: Comparative Clinical and Cost-Effectiveness CADTH RAPID RESPONSE REPORT: SUMMARY OF ABSTRACTS Fosfomycin for Lower Urinary Tract Infections: Comparative Clinical and Cost-Effectiveness Service Line: Rapid Response Service Version: 1.0 Publication Date: April 12, 2018 Report Length: 8 Pages Authors: Kelsey Seal, Caitlyn Ford Cite As: Fosfomycin for Lower Urinary Tract Infections: Comparative Clinical and Cost-Effectiveness. Ottawa: CADTH; 2018 Apr. (CADTH rapid response report: summary of abstracts). Acknowledgments: Disclaimer: The inf ormation in this document is intended to help Canadian health care decision-makers, health care prof essionals, health sy stems leaders, and policy -makers make well-inf ormed decisions and thereby improv e the quality of health care serv ices. While patients and others may access this document, the document is made av ailable f or inf ormational purposes only and no representations or warranties are made with respect to its f itness f or any particular purpose. The inf ormation in this document should not be used as a substitute f or prof essional medical adv ice or as a substitute f or the application of clinical judgment in respect of the care of a particular patient or other prof essional judgment in any decision-making process. The Canadian Agency f or Drugs and Technologies in Health (CADTH) does not endorse any inf ormation, drugs, therapies, treatments, products, processes, or serv ic es. While care has been taken to ensure that the inf ormation prepared by CADTH in this document is accurate, complete, and up-to-date as at the applicable date the material was f irst published by CADTH, CADTH does not make any guarantees to that ef f ect. CADTH does not guarantee and is not responsible f or the quality , currency , propriety , accuracy, or reasonableness of any statements, information, or conclusions contained in any third-party materials used in preparing this document. The v iews and opinions of third parties published in this document do not necessarily state or ref lect those of CADTH. CADTH is not responsible f or any errors, omissions, injury , loss, or damage arising f rom or relating to the use (or misuse) of any inf ormation, statements, or conclusions contained in or implied by the contents of this document or any of the source materials. This document may contain links to third-party websites. CADTH does not hav e control ov er the content of such sites. Use of third-party sites is gov erned by the third-party website owners’ own terms and conditions set out f or such sites. CADTH does not make any guarantee with respect to any inf ormation contained on such third-party sites and CADTH is not responsible f or any injury , loss, or damage suf f ered as a result of using such third-party sites. CADTH has no responsibility f or the collection, use, and disclosure of personal inf ormation by third-party sites. Subject to the af orementioned limitations, the v iews expressed herein are those of CADTH and do not necessarily represent the v iews of Canada’s f ederal, prov incial, or territorial gov ernments or any third party supplier of inf ormation. This document is prepared and intended f or use in the context of the Canadian health care sy stem. The use of this document outside of Canada is done so at the user’s own risk. This disclaimer and any questions or matters of any nature arising f rom or relating to the content or use (or misuse) of this document will be gov erned by and interpreted in accordance with the laws of the Prov ince of Ontario and the laws of Canada applicable therein, and all proceedings shall be subject to the exclusiv e jurisdiction of the courts of the Prov ince of Ontario, Canada. The copy right and other intellectual property rights in this document are owned by CADTH and its licensors. These rights are protected by the Canadian Copyright Act and other national and international laws and agreements. Users are permitted to make copies of this document f or non-commercial purposes only , prov ided it is not modif ied when reproduced and appropriate credit is giv en to CADTH and its licensors. About CADTH: CADTH is an independent, not-f or-prof it organization responsible f or prov iding Canada’s health care decision-makers with objectiv e ev idence to help make inf ormed decisions about the optimal use of drugs, medical dev ices, diagnostics, and procedures in our health care sy stem. Funding: CADTH receiv es f unding f rom Canada’s f ederal, prov incial, and territorial gov ernments, with the exception of Quebec. SUMMARY OF ABSTRACTS Fosf omycin f or Lower Urinary Tract Inf ections 2 Research Questions 1. What is the comparative clinical effectiveness of fosfomycin compared with other antibiotics for the treatment of lower urinary tract infections? 2. What is the comparative cost effectiveness of fosfomycin compared with other antibiotics for the treatment of lower urinary tract infections? Key Findings Two non-randomized studies and one economic evaluation were identified regarding the use of Fosfomycin for the treatment of lower urinary tract infections . Methods A limited literature search was conducted on key resources including PubMed, The Cochrane Library, University of York Centre for Reviews and Dissemination (CRD) databases, Canadian and major international health technology agencies, as well as a focused Internet search. No filters were applied to lim it the retrieval by study type. Where possible, retrieval was limited to the human population. The search was also limited to English language documents published between January 1, 2013 and March 29, 2018. Internet links were provided, where available. Selection Criteria One reviewer screened citations and selected studies based on the inclusion criteria presented in Table 1. Table 1: Selection Criteria Population Patients with lower urinary tract infections (UTIs) (acute uncomplicated cystitis) Intervention Fosfomycin (also termed phosphomycin, phosphonomycin, Monurol and Monuril) Comparator Other antibiotics used for lower UTIs (e.g., nitrofurantoin, trimethoprim/sulfamethozazole, fluoroquinolones [ciprofloxacin, norfloxaxin], beta-lactams [amoxicillin-clavulanate]) Outcomes Q1: Clinical effectiveness (e.g., change in infection status, safety, adverse events) Q2: Cost-effectiveness Study Designs Health technology assessments, systematic reviews, meta-analyses, randomized controlled trials, non- randomized studies, economic evaluations SUMMARY OF ABSTRACTS Fosf omycin f or Lower Urinary Tract Inf ections 3 Results Rapid Response reports are organized so that the higher quality evidence is presented first. Therefore, health technology assessment reports, systematic reviews, and meta-analyses are presented first. These are followed by randomized controlled trials, non-randomized studies, and economic evaluations. Two non-randomized studies and one economic evaluation were identified on the use of Fosfomycin for the treatment of lower urinary tract infections . No relevant health technology assessments, systematic reviews, meta-analyses, or randomized controlled trials were identified. Additional references of potential interest are provided in the appendix. Overall Summary of Findings Two non-randomized studies1-2 were identified regarding the clinical effectivenes s of Fosfomycin for the treatment of lower urinary tract infections (UTI). One study1 compared Fosfomycin with etrapenem in 178 patients who had extended-spectrum beta-lactamase UTIs. The study authors concluded that Fofomycin was non-inferior to ertapenem for treating these patients and should be considered as step-down therapy to treat these infections. The second study2 examined Fosfomycin plus amikicin with ceftazidime on 129 children with vesicoureteral reflux and recurring relapsing UTIs. The study authors concluded that both Fosfomycin plus amikacin or ceftazidime were effective medications and preventive strategies in these children.2 One economic evaluation3 examined the cost-effectiveness of Fosfomycin for the treatment of uncomplicated UTIs in Ontario. In the base case analysis, the cost-per-patient for treating uncomplicated UTIs with Fosfomycin was $105.12 as compared with other antibiotics ($96.19 for sulfonamides, $98.85 for fluoroquinolones, and $99.09 for nitrofurantoins ). The study authors concluded that, in addition to being a safe and effective to treat UTIs, Fosfomycin is similar in cost to other reimbursed antibiotics. References Summarized Health Technology Assessments No literature was identified. Systematic Reviews and Meta-analyses No literature was identified. Randomized Controlled Trials No literature was identified. SUMMARY OF ABSTRACTS Fosf omycin f or Lower Urinary Tract Inf ections 4 Non-Randomized Studies 1. Veve MP, Wagner JL, Kenney RM, Grunwald JL, Davis SL. Comparison of Fosfomycin to ertapenem for outpatient or step-down therapy of extended-spectrum beta-lactamase urinary tract infections. Int J Antimicrob Agents. 2016 Jul;48(1):56-60. PubMed: PM27234673 2. Wu TH, Huang FL, Fu LS, Chou CM, Chien YL, Huang CM, et al. Treatment of recurrent complicated urinary tract infections in children with vesicoureteral reflux. J Microbiol Immunol Infect. 2016 Oct;49(5):717-22. PubMed: PM25442872 Economic Evaluations 3. Perrault L, Dahan S, Iliza AC, LeLorier J, Zhanel GG. Cost-effectiveness analysis of fosfomycin for treatment of uncomplicated urinary tract infections in Ontario. Can J Infect Dis Med Microbiol [Internet]. 2017 [cited 2018 Apr 12] ;2017:6362804. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337864 PubMed: PM28316632 SUMMARY OF ABSTRACTS Fosf omycin f or Lower Urinary Tract Inf ections 5 Appendix — Further Information Systematic Reviews and Meta-Analyses Multiple Indications 4. Grabein B, Graninger W, Rodriguez BJ, Dinh A, Liesenfeld DB. Intravenous Fosfomycin-back to the future. Systematic review and meta-analysis of the clinical literature. Clin Microbiol Infect. 2017 Jun;23(6):363-72. PubMed: PM27956267 Prophylaxis Studies 5. Noreikaite J, Jones P, Fitzpatrick J, Amitharaj R, Pietropaolo A, Vasdev N, et al. Fosfomycin vs. quinolone-based antibiotic prophylaxis for transrectal ultrasound-guided biopsy of the prostate: a systematic review and meta-analysis. Prostate Cancer Prostatic Dis.
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