DENT-1440: General and Oral Pathology 1
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Applications of Cytokeratin Expression in the Diagnosis of Oral Diseases
Jemds.com Review Article Applications of Cytokeratin Expression in the Diagnosis of Oral Diseases Archana Sonone1, Alka Hande2, Madhuri Gawande3,Swati Patil4 1, 2, 3, 4 Department of Oral Pathology and Microbiology, Sharad Pawar Dental College, Datta Meghe Institute of Medical Sciences (Deemed to Be University) Sawangi (Meghe), Wardha, Maharashtra, India. ABSTRACT All mammalian cells have a complex intracytoplasmic cytoskeleton made up of three Corresponding Author: main structural units and related proteins, tubulin containing microtubules, actin Dr. Archana Sonone. Department of Oral Pathology and containing microfilaments, and Intermediate Filaments (IF). There are six types of Microbiology, Sharad Pawar Dental IFs; cytokeratin fibres consisting of type I and type II IFs. Cytokeratins (CK), College, Datta Meghe Institute of Medical . comprising of collections of IFs that are explicitly communicated by epithelial tissues Sciences (Deemed to Be University) There are 20 unique polypeptides of CK expressed by epithelium that have been Sawangi (Meghe), Wardha, Maharashtra, indexed based on their molecular weight (range 40-70 kDa). India. CK and associated filaments give a framework to epithelial cells and tissues to E-mail: [email protected] maintain their structural integrity. Thus, ensure mechanical resilience, sustain stress, establish cell polarity, and to protect against variations in hydrostatic pressure. DOI: 10.14260/jemds/2021/50 Genetic encoding of cytokeratins shows homogeneous “nucleotide sequence”. 54 How to Cite This Article: genes are responsible for encoding of cytokeratin in humans which are congregated Sonone A, Hande A, Gawande M, et al. on chromosome no. 2. Genetic mutation of cytokeratins is important for Applications of cytokeratin expression in pathophysiology of various mucocutaneous disorders, which is mostly autosomal the diagnosis of oral diseases. -
Management of Anterior Spacing with Peg Lateral by Interdisciplinary Approach : a Case Report
Case Report Management of Anterior Spacing with Peg Lateral by Interdisciplinary Approach : A Case Report Dr Sanjay Prasad Gupta Assistant Professor & Consultant Orthodontist, Department of Orthodontics, Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu Correspondence: Dr Sanjay Prasad Gupta; Email: [email protected] ABSTRACT Anterior spacing is a common esthetic problem of patient during dental consultation. The most common etiology include tooth size and arch length discrepancy. Maxillary lateral incisors vary in form more than any other tooth in the mouth except the third molars. Microdontia is a condition where the teeth are smaller than the normal size. Microdontia of maxillary lateral incisor is called as “peg lateral”, that exhibit converging mesial and distal surfaces of crown forming a cone like shape. A carefully documented diagnosis and treatment plan are essential if the clinician is to apply the most effective approach to address the patient’s needs. A patient sometimes requires a multidisciplinary approach to correct the esthetics and to improve the occlusion. This case report describes the management of an adult female patient with a proclined upper anterior teeth, upper anterior spacing, deep bite and peg shaped upper right lateral incisor tooth through orthodontic and restorative treatment approach. Key words: Anterior spacing, Peg lateral, Esthetic, Interdisciplinary approach INTRODUCTION Peg shaped lateral incisors occur in approximately 2% to 5% of the general population, and women show a Maxillary lateral incisors vary in form more than any slightly higher frequency than men. Usually they are found other tooth in the mouth except the third molars. If the equally on the right and left, uni or bilaterally, however variation is too great, it is considered a developmental some studies have shown their bilateral occurrence anomaly.1 Developmental alterations which are most slightly higher than the unilateral occurrence. -
Glossary for Narrative Writing
Periodontal Assessment and Treatment Planning Gingival description Color: o pink o erythematous o cyanotic o racial pigmentation o metallic pigmentation o uniformity Contour: o recession o clefts o enlarged papillae o cratered papillae o blunted papillae o highly rolled o bulbous o knife-edged o scalloped o stippled Consistency: o firm o edematous o hyperplastic o fibrotic Band of gingiva: o amount o quality o location o treatability Bleeding tendency: o sulcus base, lining o gingival margins Suppuration Sinus tract formation Pocket depths Pseudopockets Frena Pain Other pathology Dental Description Defective restorations: o overhangs o open contacts o poor contours Fractured cusps 1 ww.links2success.biz [email protected] 914-303-6464 Caries Deposits: o Type . plaque . calculus . stain . matera alba o Location . supragingival . subgingival o Severity . mild . moderate . severe Wear facets Percussion sensitivity Tooth vitality Attrition, erosion, abrasion Occlusal plane level Occlusion findings Furcations Mobility Fremitus Radiographic findings Film dates Crown:root ratio Amount of bone loss o horizontal; vertical o localized; generalized Root length and shape Overhangs Bulbous crowns Fenestrations Dehiscences Tooth resorption Retained root tips Impacted teeth Root proximities Tilted teeth Radiolucencies/opacities Etiologic factors Local: o plaque o calculus o overhangs 2 ww.links2success.biz [email protected] 914-303-6464 o orthodontic apparatus o open margins o open contacts o improper -
Oral Health in Prevalent Types of Ehlers–Danlos Syndromes
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Ghent University Academic Bibliography J Oral Pathol Med (2005) 34: 298–307 ª Blackwell Munksgaard 2005 Æ All rights reserved www.blackwellmunksgaard.com/jopm Oral health in prevalent types of Ehlers–Danlos syndromes Peter J. De Coster1, Luc C. Martens1, Anne De Paepe2 1Department of Paediatric Dentistry, Centre for Special Care, Paecamed Research, Ghent University, Ghent; 2Centre for Medical Genetics, Ghent University Hospital, Ghent, Belgium BACKGROUND: The Ehlers–Danlos syndromes (EDS) Introduction comprise a heterogenous group of heritable disorders of connective tissue, characterized by joint hypermobility, The Ehlers–Danlos syndromes (EDS) comprise a het- skin hyperextensibility and tissue fragility. Most EDS erogenous group of heritable disorders of connective types are caused by mutations in genes encoding different tissue, largely characterized by joint hypermobility, skin types of collagen or enzymes, essential for normal pro- hyperextensibility and tissue fragility (1) (Fig. 1). The cessing of collagen. clinical features, modes of inheritance and molecular METHODS: Oral health was assessed in 31 subjects with bases differ according to the type. EDS are caused by a EDS (16 with hypermobility EDS, nine with classical EDS genetic defect causing an error in the synthesis or and six with vascular EDS), including signs and symptoms processing of collagen types I, III or V. The distribution of temporomandibular disorders (TMD), alterations of and function of these collagen types are displayed in dental hard tissues, oral mucosa and periodontium, and Table 1. At present, two classifications of EDS are was compared with matched controls. -
Regional Odontodysplasia: Report of an Unusual Case Involving Mandibular Arch
Regional odontodysplasia: Report of an unusual case involving mandibular arch N. S. Venkatesh Babu, R. Jha Smriti, D. Bang Pratima Abstract Regional odontodysplasia (RO) is a rare developmental anomaly involving both mesodermal and ectodermal components in primary or permanent dentition. It affects the maxilla and the mandible or both; however, maxilla is more commonly involved. This article reports the case of 33-month-old boy who came with the chief complaint of delayed eruption of mandibular teeth. Findings of clinical and radiographic examination were consistent with those of RO. Maxillary dentition was unaffected. Clinical and radiographic features and treatment options are discussed. Keywords: Mandibular arch, primary teeth, regional odontodysplasia Introduction cases of mandibular involvement have been reported so far.[5,8,9] Regional odontodysplasia (RO) is a rare developmental dental anomaly that involves ectoderm and mesoderm The teeth with RO often display a brownish or yellowish derived tissues.[1] It can affect either primary or permanent discoloration and most frequent clinical symptoms dentition.[2] This condition was first described by Hitchin accompanied by this anomaly are failure of eruption and in 1934. The prevalence of this condition is still not clear gingival enlargement. Radiologically, the affected teeth since the studies reported till date have mainly been based illustrate hypoplastic crowns and lack of contrast between on case reports. enamel and dentin is usually apparent. Enamel and the dentin are very thin, -
Case Report Talon Cusp Type I: Restorative Management
Hindawi Publishing Corporation Case Reports in Dentistry Volume 2015, Article ID 425979, 5 pages http://dx.doi.org/10.1155/2015/425979 Case Report Talon Cusp Type I: Restorative Management Rafael Alberto dos Santos Maia,1 Wanessa Christine de Souza-Zaroni,2 Raul Sampaio Mei,3 and Fernando Lamers2 1 Oral and Maxillofacial Surgery, HGU, University of Cuiaba,´ 78016-000 Cuiaba,´ MT, Brazil 2School of Dentistry, Cruzeiro do Sul University (UNICSUL), 08060-070 Sao˜ Paulo, SP, Brazil 3School of Dentistry, University Center of Grande Dourados (UNIGRAN), 79824-900 Dourados, MS, Brazil Correspondence should be addressed to Wanessa Christine de Souza-Zaroni; [email protected] Received 9 February 2015; Accepted 15 April 2015 Academic Editor: Carla Evans Copyright © 2015 Rafael Alberto dos Santos Maia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The teeth are formed during intrauterine life (i.e., gestation) during the odontogenesis stage. During this period, the teeth move until they enter the oral cavity. This course covers various stages of dental development, namely, initiation, proliferation, histodif- ferentiation, morphodifferentiation, and apposition. The talon cusp is an anomaly that occurs during morphodifferentiation, and this anomaly may have numerous adverse clinical effects on oral health. The objective of this study was to report a case of “Talon Cusp Type I” and to discuss diagnostic methods, treatment options for this anomaly, and the importance of knowledge of this morphological change among dental professionals so that it is not confused with other morphological changes; such knowledge is required to avoid unnecessary surgical procedures, to perform treatments that prevent caries and malocclusions as well as enhancing aesthetics, and to improve the oral health and quality of life of the patient. -
Establishment of a Dental Effects of Hypophosphatasia Registry Thesis
Establishment of a Dental Effects of Hypophosphatasia Registry Thesis Presented in Partial Fulfillment of the Requirements for the Degree Master of Science in the Graduate School of The Ohio State University By Jennifer Laura Winslow, DMD Graduate Program in Dentistry The Ohio State University 2018 Thesis Committee Ann Griffen, DDS, MS, Advisor Sasigarn Bowden, MD Brian Foster, PhD Copyrighted by Jennifer Laura Winslow, D.M.D. 2018 Abstract Purpose: Hypophosphatasia (HPP) is a metabolic disease that affects development of mineralized tissues including the dentition. Early loss of primary teeth is a nearly universal finding, and although problems in the permanent dentition have been reported, findings have not been described in detail. In addition, enzyme replacement therapy is now available, but very little is known about its effects on the dentition. HPP is rare and few dental providers see many cases, so a registry is needed to collect an adequate sample to represent the range of manifestations and the dental effects of enzyme replacement therapy. Devising a way to recruit patients nationally while still meeting the IRB requirements for human subjects research presented multiple challenges. Methods: A way to recruit patients nationally while still meeting the local IRB requirements for human subjects research was devised in collaboration with our Office of Human Research. The solution included pathways for obtaining consent and transferring protected information, and required that the clinician providing the clinical data refer the patient to the study and interact with study personnel only after the patient has given permission. Data forms and a custom database application were developed. Results: The registry is established and has been successfully piloted with 2 participants, and we are now initiating wider recruitment. -
Spectrum of Dentin Dysplasia in a Family
CASE REPORT Spectrumof dentin dysplasia in a family: case report and literature review W. Kim Seow, BDS, MDSc, DDSc, PhD Stephen Shusterman, DMD Abstract The dentin dysplasias (DD),which maybe classified as type I (DD1)or type 2 (DD2),form a group of rare, inherited abnormalitiesthat are clinically distinct fromdentinogenesis imperfecta. Studies of affected families mayhelp to distinguish different types of DDand provide further insight into their etiology and clinical management.This report describes a family that showed characteristic dental features of DD1, including clinically normalcrowns in both primaryand permanentdentitions, and mobileteeth that maybe associated with prematureexfoliation. Radiographicfeatures included calcification of the pulp with crescent-shaped, radiolucent pulp remnants, short, tapering, taurodontic roots, and manyperiapical pathoses that maybe q¢sts or granulomas.A spectrumof dentin dysplasia wasnoted within the family. Strategies to prevent pulp and periapical infections and early exfoliation of the teeth include meticulousoral hygieneand effective caries-preventivemeasures. ( P ed iatr Dent16:437-42,1994) Introduction and literature review Histologically, in DD1, most of the coronal and Dentin dysplasias (DD) form a group of rare dentin mantle dentin of the root is usually reported to be abnormalities that are clinically distinct from normal, and the dentin defect is confined mainly to the dentinogenesis imperfecta. 1-3 Since its recognition in root2, s, 10 The dysplastic dentin has been reported to 19203 as "rootless teeth" and as "dentin dysplasia" by consist of numerous denticles, containing whorls of Rushton in 1933,4 the clinical features of DDhave been osteodentin that block the normal course of the den- tinal tubules,s, 10,11 well described. -
Talon Cusp: a Case Report and Literature Review 1R Kalpana, 2M Thubashini
OMPJ R Kalpana, M Thubashini 10.5005/jp-journals-10037-1045 CASE REPORT Talon Cusp: A Case Report and Literature Review 1R Kalpana, 2M Thubashini ABSTRACT The prevalence of talon cusp varies with race, age, Talon cusp is a well‑delineated accessory cusp thought to and the criteria used to define this abnormality. A review arise as a result of evagination on the surface of a tooth before of the literature suggests that 75% of the cases are in the calcification has occurred. It is seen projecting from the cin permanent dentition and 25% in the primary dentition. gulum or cementoenamel junction of maxillary or mandibular anterior tooth. It is named due to its resemblance to eagle’s This anomaly has a greater predilection in the maxilla talon, which is the shape of eagle’s claw when hooked on to its (with more than 90% of the cases reported) than in the prey. The incidence is 0.04 to 8%. This article reports a case mandible (only 10% of the cases).7 In the permanent denti- of talon cusp on maxillary permanent lateral incisor. When it occurs on the facial aspect, the effects are mainly esthetic and tion, 55% of the cases involved maxillary lateral incisors, 4,8 functional and so early detection and treatment is essential in 33% involved central incisors and 4% involved canines. its management to avoid complications. The purpose of this article is to report a case of palatal Keywords: Talon cusp, Evagination, Maxillary lateral incisor. talon cusp on the permanent maxillary lateral incisor How to cite this article: Kalpana R, Thubashini M. -
Dental Anomalies: Foundational Articles and Consensus Recommendations, 2021
Dental Anomalies: Foundational Articles and Consensus Recommendations, 2021 Adekoya-Sofowora CA. Natal and neonatal teeth: a review. Niger Postgrad Med J 2008;15:38-41 Al-Ani AH, Antoun JS, Thomson WM, Merriman TR, Farella M. Hypodontia: An Update on Its Etiology, Classification, and Clinical Management. Biomed Res Int. 2017:9378325. doi.org/10.1155/2017/9378325. Anthonappa RP, King NM, Rabie AB. Aetiology of supernumerary teeth: A literature review. Eur Arch Paediatr Dent. 2013;14:279-88. Dashash, M. Yeung CA, Jamous I, Blinkhorn A. Interventions for the restorative care of amelogenesis imperfecta in children and adolescents. Cochrane Database Syst Rev 2013;6:CD007157. Gallacher A, Ali R, Bhakta S. Dens invaginatus: diagnosis and management strategies. Br Dent J 2016;221:383-7. Gill DS, Barker CS. The multidisciplinary management of hypodontia: a team approach. Br Dent J 2015;218:143-9. Khalaf K, Miskelly J, Voge E, Macfarlane TV. Prevalence of hypodontia and associated factors: a systematic review and meta-analysis. J Orthod. 2014; 41:299-316. Lammi L. Arte S, Somer M, Javinen H, et al. Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. Am. J. Hum. Genet. 2004, 74:1043–1050. Marvin ML, Mazzoni S, Herron CM, Edwards S, et al. AXIN2-associated autosomal dominant ectodermal dysplasia and neoplastic syndrome. Am J Med Genet A. 2011,155 898–902. Seow WK. Developmental defects of enamel and dentine: Challenges for basic science research and clinical management. Aust Dent J 2014;59:143-54. Shields ED, Bixler D, El-Kafrawy AM. A proposed classification for heritable human dentine defects with a description of a new entity. -
Hyperdontia: 3 Cases Reported Dentistry Section
Case Report Hyperdontia: 3 Cases Reported Dentistry Section SUJATA M. BYAHATTI ABSTRACT In some cases, there appears to be a hereditary tendency for A supernumerary tooth may closely resemble the teeth of the the development of supernumerary teeth. A supernumerary group to which it belongs, i.e molars, premolars, or anterior tooth is an additional entity to the normal series and is seen in all teeth, or it may bear little resemblance in size or shape to the quadrants of the jaw. teeth with which it is associated. It has been suggested that The incidence of these teeth is not uncommon. Different variants supernumerary teeth develop from a third tooth bud which of supernumerary teeth are discussed and reviewed in detail in arises from the dental lamina near the permanent tooth bud, the following article. or possibly from the splitting of the permanent tooth bud itself. Key Words: Supernumerary teeth, Mesiodens, Upper distomolar INTRODUCTION The extraction of these teeth is a general rule for avoiding A supernumerary tooth (or hyperodontia) is defined as an increase complications [15]. Nevertheless, some authors such as Koch in the number of teeth in a given individual, i.e., more than 20 et al [20] do not recommend the extractions of impacted teeth in deciduous or temporary teeth and over 32 teeth in the case of the children under 10 years of age, since in this particular age group, permanent dentition [1], [2]. such procedures often require general anaesthesia. Kruger [21] considers that the extraction of supernumerary teeth should be Supernumerary teeth are a rare alteration in the development of postponed until the apexes of the adjacent teeth have sealed. -
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Eur opean Rev iew for Med ical and Pharmacol ogical Sci ences 2014; 18: 440-444 Radiographic evaluation of the prevalence of enamel pearls in a sample adult dental population H. ÇOLAK, M.M. HAMIDI, R. UZGUR 1, E. ERCAN, M. TURKAL 1 Department of Restorative Dentistry, Kirikkale University School of Dentistry, Kirikkale, Turkey 1Department of Prosthodontics, Kirikkale University School of Dentistry, Kirikkale, Turkey Abstract. – AIM: Enamel pearls are a tooth One theory of the enamel pearl etiology is that anomaly that can act as contributing factors in the enamel pearls develop as a result of a localized development of periodontal disease. Studies that developmental activity of a remnant of Hertwig’s have addressed the prevalence of enamel pearls in epithelial root sheath which has remained adher - populations were scarce. The purpose of this study 5 was to evaluate the prevalence of enamel pearls in ent to the root surface during root development . the permanent dentition of Turkish dental patients It is believed that cells differentiate into function - by means of panoramic radiographs. ing ameloblasts and produce enamel deposits on PATIENTS AND METHODS: Panoramic radi - the root. The conditions needed for local differ - ographs of 6912 patients were examined for the entiation and functioning of ameloblasts in this presence of enamel pearls. All data (age, sex and ectopic position are not fully understood 6,7 . systemic disease or syndrome) were obtained from the patient files and analyzed for enamel The most common site for enamel pearls is at pearls. Descriptive characteristics of sexes, the cementoenamel junction of multirooted jaws, and dental localization were recorded.