A) the Body to Produce Reproductive Cells B) Cells to Communicate with Each Other C) Cells to Synthesize Proteins D) the Body To
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Neural Nets Different Individuals: Its Own Germ Rondoni), Buffy Tuft-Eared Marmoset Cells As Well As Those of Its Sibling
Current Biology Magazine an individual animal may contain bare-ear marmoset (Mico leucippe), Primer reproduction-competent germ cells black-crowned dwarf marmoset (Mico in its gonads from two genetically humilis), Rondon’s marmoset (Mico Neural nets different individuals: its own germ rondoni), buffy tuft-eared marmoset cells as well as those of its sibling. (Callithrix aurita) and black-headed Hence, their offspring may not marmoset (Callithrix nigriceps) are at Andreas Hejnol and Fabian Rentzsch be the genetic descendant of the vulnerable status in the International physiological parents. Union for Conservation of Nature “The nerve-net of the lower animals (IUCN) red list of threatened species contains the germ out of which has Does chimerism affect parental (http://www.iucnredlist.org/search). grown the central nervous systems of care? Chimerism has been noted to The buffy-headed marmoset (Callithrix the higher forms.” affect parental care especially male fl aviceps) is listed as an endangered — G.H. Parker: The Elementary parental care. It has been observed species by IUCN. Habitat destruction Nervous System, 1919 that fathers provide signifi cantly due to human encroachment as higher care to chimeric infants than well as the pet trade are among the Although modern evolutionary biology non-chimeric infants. major threats for extinction of these has abandoned the use of ‘lower’ or marmoset species. ‘higher’ for animals, the quote of G.H. Baby marmosets benefi t from male Parker captures quite well the current parental and alloparental care, Where I can fi nd out more? understanding of the nerve net as the what do genetics say? Very recently, Aeckerle, N., Drummer, C., Debowski, K., evolutionarily oldest organization of Viebahn, C., and Behr, R. -
Neural Control of Movement: Motor Neuron Subtypes, Proprioception and Recurrent Inhibition
List of Papers This thesis is based on the following papers, which are referred to in the text by their Roman numerals. I Enjin A, Rabe N, Nakanishi ST, Vallstedt A, Gezelius H, Mem- ic F, Lind M, Hjalt T, Tourtellotte WG, Bruder C, Eichele G, Whelan PJ, Kullander K (2010) Identification of novel spinal cholinergic genetic subtypes disclose Chodl and Pitx2 as mark- ers for fast motor neurons and partition cells. J Comp Neurol 518:2284-2304. II Wootz H, Enjin A, Wallen-Mackenzie Å, Lindholm D, Kul- lander K (2010) Reduced VGLUT2 expression increases motor neuron viability in Sod1G93A mice. Neurobiol Dis 37:58-66 III Enjin A, Leao KE, Mikulovic S, Le Merre P, Tourtellotte WG, Kullander K. 5-ht1d marks gamma motor neurons and regulates development of sensorimotor connections Manuscript IV Enjin A, Leao KE, Eriksson A, Larhammar M, Gezelius H, Lamotte d’Incamps B, Nagaraja C, Kullander K. Development of spinal motor circuits in the absence of VIAAT-mediated Renshaw cell signaling Manuscript Reprints were made with permission from the respective publishers. Cover illustration Carousel by Sasha Svensson Contents Introduction.....................................................................................................9 Background...................................................................................................11 Neural control of movement.....................................................................11 The motor neuron.....................................................................................12 Organization -
Let's Form a Reflex Arc Model
Journal of Inquiry Based Activities (JIBA) /Araştırma Temelli Etkinlik Dergisi (ATED) Vol 9, No 2, 84-95, 2019 LET’S FORM A REFLEX ARC MODEL: A STEM ACTIVITY1 Ayşegül Kağnıcı2, Özlem Sadi3 ABSTRACT The purpose of this study is to introduce an activity which has been designed in accordance with Science, Technology, Engineering, Mathematics (STEM) education within the scope of 5E learning model and to present the implementation steps of it. The activity plan is on the topics of Nerves, Hormones and Homeostasis in Human Physiology Unit in 11th grade biology curriculum. The activity was implemented with the participation of 49 students at a public high school. For the implementation of the activity, the students were divided into groups of five and they tried to complete the activity in four class hours. The participant students stated that they both learned and enjoyed learning while they were creating their model. Moreover, the teachers who implemented the activity stated that the equipment used in the activity is easy to access, which creates an advantage for the activity to be done in class. Keywords: biology education, reflex arc, STEM, nervous system. REFLEKS YAYI MODELİ OLUŞTURALIM: BİR STEM ETKİNLİĞİ ÖZ Bu çalışmanın amacı STEM eğitimine uygun olarak tasarlanan bir etkinliğin 5E öğrenme modeli kapsamında tanıtılması ve uygulama basamaklarının sunulmasıdır. Etkinlik planı, 11. Sınıf Biyoloji Dersi Öğretim Programında bulunan İnsan Fizyolojisi ünitesindeki Sinirler, Hormonlar ve Homeostazi konusu ile ilgilidir. Etkinliğin özellikle, omuriliğin görevleri ile refleks yayının çalışma mekanizmalarının öğrenilmesi noktasında faydalı olacağı düşünülmüştür. Etkinlik, bir devlet lisesinde öğrenim gören 49 öğrencinin katılımıyla gerçekleştirilmiştir. Etkinliğin uygulanmasında öğrenciler beşer kişilik gruplar oluşturmuş ve dört ders saati boyunca etkinliği tamamlamaya çalışmışlardır. -
The Reflex Arc: How a Stimulus Elicits a Response
The Reflex Arc How a Stimulus Elicits a Response A Knee-Jerk Response • What happened? • When the hammer hit the knee the foot jerked up. • Why? Reacting to Changes • You need to keep the conditions inside your body constant. Doing this is called homeostasis. Small changes inside your body can cause its cells to be damaged or destroyed. Yet, there are big changes going on outside your body. • You need to detect a change in the environment (a stimulus) and react to the change (a response) in a way that maintains homeostasis. When you do this without thinking, it is called a reflex. Reacting to Changes • It can get very hot or very cold outside, but the temperature inside your body stays the same. How? • When it gets cold outside (stimulus) you shiver (response) and keep the temperature inside your body from dropping. • When it gets hot outside (stimulus) you perspire (response) and keep the temperature inside your body from rising. Posture • In order to maintain your posture (even bad posture - stop slouching) your muscles are constantly monitoring their shape. A change in shape of a muscle (the stimulus) causes the muscle to readjust its shape (the response) and maintain your posture. • The knee-jerk reflex is base on the hammer changing the shape of a muscle. Revisiting the Knee-Jerk Response • What is the stimulus? The hammer hits the tendon. • What is the response? The muscle contracts, causing the foot to jerk upward. Other Reflexes Stimulus Response The aroma of your favorite Salivation food A nasty odor Nausea A bright light shining in your Pupils get smaller eye An insect flying towards your Blinking eye How is a Stimulus Detected? • Some cells are specialized to react to a specific stimulus. -
The Polyp and the Medusa Life on the Move
The Polyp and the Medusa Life on the Move Millions of years ago, unlikely pioneers sparked a revolution. Cnidarians set animal life in motion. So much of what we take for granted today began with Cnidarians. FROM SHAPE OF LIFE The Polyp and the Medusa Life on the Move Take a moment to follow these instructions: Raise your right hand in front of your eyes. Make a fist. Make the peace sign with your first and second fingers. Make a fist again. Open your hand. Read the next paragraph. What you just did was exhibit a trait we associate with all animals, a trait called, quite simply, movement. And not only did you just move your hand, but you moved it after passing the idea of movement through your brain and nerve cells to command the muscles in your hand to obey. To do this, your body needs muscles to move and nerves to transmit and coordinate movement, whether voluntary or involuntary. The bit of business involved in making fists and peace signs is pretty complex behavior, but it pales by comparison with the suites of thought and movement associated with throwing a curve ball, walking, swimming, dancing, breathing, landing an airplane, running down prey, or fleeing a predator. But whether by thought or instinct, you and all animals except sponges have the ability to move and to carry out complex sequences of movement called behavior. In fact, movement is such a basic part of being an animal that we tend to define animalness as having the ability to move and behave. -
ALS and Other Motor Neuron Diseases Can Represent Diagnostic Challenges
Review Article Address correspondence to Dr Ezgi Tiryaki, Hennepin ALS and Other Motor County Medical Center, Department of Neurology, 701 Park Avenue P5-200, Neuron Diseases Minneapolis, MN 55415, [email protected]. Ezgi Tiryaki, MD; Holli A. Horak, MD, FAAN Relationship Disclosure: Dr Tiryaki’s institution receives support from The ALS Association. Dr Horak’s ABSTRACT institution receives a grant from the Centers for Disease Purpose of Review: This review describes the most common motor neuron disease, Control and Prevention. ALS. It discusses the diagnosis and evaluation of ALS and the current understanding of its Unlabeled Use of pathophysiology, including new genetic underpinnings of the disease. This article also Products/Investigational covers other motor neuron diseases, reviews how to distinguish them from ALS, and Use Disclosure: Drs Tiryaki and Horak discuss discusses their pathophysiology. the unlabeled use of various Recent Findings: In this article, the spectrum of cognitive involvement in ALS, new concepts drugs for the symptomatic about protein synthesis pathology in the etiology of ALS, and new genetic associations will be management of ALS. * 2014, American Academy covered. This concept has changed over the past 3 to 4 years with the discovery of new of Neurology. genes and genetic processes that may trigger the disease. As of 2014, two-thirds of familial ALS and 10% of sporadic ALS can be explained by genetics. TAR DNA binding protein 43 kDa (TDP-43), for instance, has been shown to cause frontotemporal dementia as well as some cases of familial ALS, and is associated with frontotemporal dysfunction in ALS. Summary: The anterior horn cells control all voluntary movement: motor activity, res- piratory, speech, and swallowing functions are dependent upon signals from the anterior horn cells. -
Innovations Present in the Primate Interneuron Repertoire
Article Innovations present in the primate interneuron repertoire https://doi.org/10.1038/s41586-020-2781-z Fenna M. Krienen1,2 ✉, Melissa Goldman1,2, Qiangge Zhang2,3, Ricardo C. H. del Rosario2, Marta Florio1,2, Robert Machold4, Arpiar Saunders1,2, Kirsten Levandowski2,3, Heather Zaniewski2,3, Received: 19 July 2019 Benjamin Schuman4, Carolyn Wu3, Alyssa Lutservitz1,2, Christopher D. Mullally1,2, Nora Reed1,2, Accepted: 1 July 2020 Elizabeth Bien1,2, Laura Bortolin1,2, Marian Fernandez-Otero2,5, Jessica D. Lin2, Alec Wysoker2, James Nemesh2, David Kulp2, Monika Burns5, Victor Tkachev6,7,8, Richard Smith9,10, Published online: xx xx xxxx Christopher A. Walsh9,10, Jordane Dimidschstein2, Bernardo Rudy4,11, Leslie S. Kean6,7,8, Check for updates Sabina Berretta5,12,13, Gord Fishell2,14, Guoping Feng2,3 & Steven A. McCarroll1,2 ✉ Primates and rodents, which descended from a common ancestor around 90 million years ago1, exhibit profound diferences in behaviour and cognitive capacity; the cellular basis for these diferences is unknown. Here we use single-nucleus RNA sequencing to profle RNA expression in 188,776 individual interneurons across homologous brain regions from three primates (human, macaque and marmoset), a rodent (mouse) and a weasel (ferret). Homologous interneuron types—which were readily identifed by their RNA-expression patterns—varied in abundance and RNA expression among ferrets, mice and primates, but varied less among primates. Only a modest fraction of the genes identifed as ‘markers’ of specifc interneuron subtypes in any one species had this property in another species. In the primate neocortex, dozens of genes showed spatial expression gradients among interneurons of the same type, which suggests that regional variation in cortical contexts shapes the RNA expression patterns of adult neocortical interneurons. -
Increased Brain Size and Glial Cell Number in CD81-Null Mice
THE JOURNAL OF COMPARATIVE NEUROLOGY 453:22–32 (2002) Increased Brain Size and Glial Cell Number in CD81-Null Mice ELDON E. GEISERT, JR.,1* ROBERT W. WILLIAMS,1 GRACE R. GEISERT,1 LIYING FAN,1 ANDREW M. ASBURY,1 HOLDEN T. MAECKER,2 JUN DENG,2 AND SHOSHANA LEVY2 1Department of Anatomy and Neurobiology, and Neuroscience Institute, University of Tennessee, Health Science Center, Memphis, Tennessee 38163 2Department of Medicine, Division of Oncology, Stanford University Medical Center, Stanford, California 94305 ABSTRACT A key issue in the development of the central nervous system (CNS) is understanding the molecular mechanisms regulating cell number. The present study examines the role of CD81 (previously known as TAPA, the target of the antiproliferative antibody) in the control of brain size and glial cell number. CD81 is a member of the tetraspanin family of proteins. This group of small membrane proteins is associated with the regulation of cell migration and mitotic activity. Glial cells express CD81, and antibodies directed against this protein suppress the mitotic activity of cultured cells. In this study, we examine the effects of the CD81 Ϫ/Ϫ mutation on the CNS of mature mice. These mice have extremely large brains, as much as 30% larger than the brains of wild-type (ϩ/ϩ) littermates. The increase in brain weight is accompanied by an increase in the number astrocytes and microglia, whereas the number of neurons and oligodendrocytes in the CD81 Ϫ/Ϫ animals appears to be normal. When the CD81 Ϫ/Ϫ mutation is placed on different genetic backgrounds, there is a remark- able range in the penetrance of the null allele phenotype, demonstrating that the mutation can be affected by modifier loci. -
Spinal Cord Organization
Lecture 4 Spinal Cord Organization The spinal cord . Afferent tract • connects with spinal nerves, through afferent BRAIN neuron & efferent axons in spinal roots; reflex receptor interneuron • communicates with the brain, by means of cell ascending and descending pathways that body form tracts in spinal white matter; and white matter muscle • gives rise to spinal reflexes, pre-determined gray matter Efferent neuron by interneuronal circuits. Spinal Cord Section Gross anatomy of the spinal cord: The spinal cord is a cylinder of CNS. The spinal cord exhibits subtle cervical and lumbar (lumbosacral) enlargements produced by extra neurons in segments that innervate limbs. The region of spinal cord caudal to the lumbar enlargement is conus medullaris. Caudal to this, a terminal filament of (nonfunctional) glial tissue extends into the tail. terminal filament lumbar enlargement conus medullaris cervical enlargement A spinal cord segment = a portion of spinal cord that spinal ganglion gives rise to a pair (right & left) of spinal nerves. Each spinal dorsal nerve is attached to the spinal cord by means of dorsal and spinal ventral roots composed of rootlets. Spinal segments, spinal root (rootlets) nerve roots, and spinal nerves are all identified numerically by th region, e.g., 6 cervical (C6) spinal segment. ventral Sacral and caudal spinal roots (surrounding the conus root medullaris and terminal filament and streaming caudally to (rootlets) reach corresponding intervertebral foramina) collectively constitute the cauda equina. Both the spinal cord (CNS) and spinal roots (PNS) are enveloped by meninges within the vertebral canal. Spinal nerves (which are formed in intervertebral foramina) are covered by connective tissue (epineurium, perineurium, & endoneurium) rather than meninges. -
Convergent Evolution of the Ladder-Like Ventral Nerve Cord in Annelida Conrad Helm1*, Patrick Beckers2, Thomas Bartolomaeus2, Stephan H
Helm et al. Frontiers in Zoology (2018) 15:36 https://doi.org/10.1186/s12983-018-0280-y RESEARCH Open Access Convergent evolution of the ladder-like ventral nerve cord in Annelida Conrad Helm1*, Patrick Beckers2, Thomas Bartolomaeus2, Stephan H. Drukewitz3, Ioannis Kourtesis1, Anne Weigert4, Günter Purschke5, Katrine Worsaae6, Torsten H. Struck7 and Christoph Bleidorn1,8* Abstract Background: A median, segmented, annelid nerve cord has repeatedly been compared to the arthropod and vertebrate nerve cords and became the most used textbook representation of the annelid nervous system. Recent phylogenomic analyses, however, challenge the hypothesis that a subepidermal rope-ladder-like ventral nerve cord (VNC) composed of a paired serial chain of ganglia and somata-free connectives represents either a plesiomorphic or a typical condition in annelids. Results: Using a comparative approach by combining phylogenomic analyses with morphological methods (immunohistochemistry and CLSM, histology and TEM), we compiled a comprehensive dataset to reconstruct the evolution of the annelid VNC. Our phylogenomic analyses generally support previous topologies. However, the so far hard-to-place Apistobranchidae and Psammodrilidae are now incorporated among the basally branching annelids with high support. Based on this topology we reconstruct an intraepidermal VNC as the ancestral state in Annelida. Thus, a subepidermal ladder-like nerve cord clearly represents a derived condition. Conclusions: Based on the presented data, a ladder-like appearance of the ventral nerve cord evolved repeatedly, and independently of the transition from an intraepidermal to a subepidermal cord during annelid evolution. Our investigations thereby propose an alternative set of neuroanatomical characteristics for the last common ancestor of Annelida or perhaps even Spiralia. -
Animal Phylum Poster Porifera
Phylum PORIFERA CNIDARIA PLATYHELMINTHES ANNELIDA MOLLUSCA ECHINODERMATA ARTHROPODA CHORDATA Hexactinellida -- glass (siliceous) Anthozoa -- corals and sea Turbellaria -- free-living or symbiotic Polychaetes -- segmented Gastopods -- snails and slugs Asteroidea -- starfish Trilobitomorpha -- tribolites (extinct) Urochordata -- tunicates Groups sponges anemones flatworms (Dugusia) bristleworms Bivalves -- clams, scallops, mussels Echinoidea -- sea urchins, sand Chelicerata Cephalochordata -- lancelets (organisms studied in detail in Demospongia -- spongin or Hydrazoa -- hydras, some corals Trematoda -- flukes (parasitic) Oligochaetes -- earthworms (Lumbricus) Cephalopods -- squid, octopus, dollars Arachnida -- spiders, scorpions Mixini -- hagfish siliceous sponges Xiphosura -- horseshoe crabs Bio1AL are underlined) Cubozoa -- box jellyfish, sea wasps Cestoda -- tapeworms (parasitic) Hirudinea -- leeches nautilus Holothuroidea -- sea cucumbers Petromyzontida -- lamprey Mandibulata Calcarea -- calcareous sponges Scyphozoa -- jellyfish, sea nettles Monogenea -- parasitic flatworms Polyplacophora -- chitons Ophiuroidea -- brittle stars Chondrichtyes -- sharks, skates Crustacea -- crustaceans (shrimp, crayfish Scleropongiae -- coralline or Crinoidea -- sea lily, feather stars Actinipterygia -- ray-finned fish tropical reef sponges Hexapoda -- insects (cockroach, fruit fly) Sarcopterygia -- lobed-finned fish Myriapoda Amphibia (frog, newt) Chilopoda -- centipedes Diplopoda -- millipedes Reptilia (snake, turtle) Aves (chicken, hummingbird) Mammalia -
Robert Quine
Robert Quine http://www.furious.com/perfect/quine/brianeno.html Robert Quine Quine relaxing in his New York loft by Brian Eno Robert Quine was one of my first friends in New York. We met in about 1979, not long after he'd left the Voidoids and not long after I'd had one of my regular losses of faith in much of the work I'd been doing until that point. Our friendship clicked and resolved itself around the following: a love of wandering round New York and eating in obscure oriental restaurants; a feeling for music that was 'at the edge of music'; a conviction that Nabokov was the greatest writer of the twentieth century, and a shared sense of humour. For, despite Robert's daunting appearance, he was actually very funny and as sweet and good-hearted a person as you could imagine. And paranoid too, I should mention: he lived in a flat on St Mark's Place which had more defences on the door than The Bank of England. But then he did have a huge collection of beautiful electric guitars - a collection which, along with his records and books, left an increasingly narrow path between the Fort Knox door and what he laughingly described as 'the kitchen' - an unused single-plate electric cooker sitting on a table. I don't think I ever visited Quine without him digging out some obscure doo-wop song or old jazz record and getting me to listen to a genius piece of guitar playing by some long-forgotten craftsman.