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NYU Physician Hitting the Bull’S-Eye in Prostate Cancer Steven B

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NYU Physician Hitting the Bull’S-Eye in Prostate Cancer Steven B NYUTHE MAGAZINE OF NEW YORK UNIVERSITPHY SCHOOL OF MEDICINEYSICIAWINTER 2012–2013N volume 64 • No. MISSING 2 A CRUCIAL TARGET BIOPSIES FOR PROSTATE CANCER OFTEN OVERLOOK DANGEROUS LESIONS PLUS The Truth About Low Testosterone The Male Biological Clock Neuroscience and the Love Song of Finches Help Us Make Dreams Come True EVERY ASPIRING PHYSICIAN DREAMS OF THE DAY SOMEONE WILL MAKE A GIFT ONLINE CALL HIM OR HER “DOCTOR” FOR THE FIRST TIME. But getting there Please visit www.nyu.edu/alumni. takes a lot more than hard work and dedication—it takes resources. By contributing to the NYU School of Medicine Alumni Campaign, you help To discuss special ensure that our next generation of physicians will have access to the best giving opportunities, teaching and research, along with a competitive fi nancial assistance package. call Anthony J. Grieco, MD, Associate Dean for Alumni Relations, When you make a gift, you help us guarantee that all of our students will at 212.263.5390. have the means to complete our rigorous education. One day, you may even have the privilege of addressing them yourself as “Doctor.” Thank you for your generosity. THE MAGAZINE OF NEW YORK UNIVERSITY SCHOOL OF MEDICINE WINTER 2012–2013 VOLUME 64 NO. NYUPHYSICIAN 2 New York University Martin Lipton, Esq. Chairman, “ We’ve made progress. But Board of Trustees if anyone thinks that we’ve John Sexton President optimized screening by using a nonspecific marker and Robert Berne Executive Vice President randomly placing 12 needles for Health • and taking 12 specimens, NYU Langone Medical Center then he's naive.” Kenneth G. Langone Chairman, Board of Trustees Robert I. Grossman, MD Dean and Chief Executive Officer COVER STORIES • NYU PHYSICIAN Hitting the Bull’s-Eye in Prostate Cancer Steven B. Abramson, MD 10 New imaging techniques Anthony J. Grieco, MD Editors, Science pioneered at NYU Langone and Medicine DEPARTMENTS distinguish deadly lesions. Marjorie Shaffer 02 From the Dean The Truth About Low T Editor Men’s Health As testosterone replacement 14 therapy grows more popular, Nicole Dyer Contributing Editor 03 The Balm After the Storm debate rages over its safety and Hurricane Sandy inflicts unprecedented efficacy. How can patients and Sherry Zucker damage on the Medical Center. physicians sort out the science Print Production from the hype? Coordinator 06 News From Medicine Segal Savad Design • Regional Differences Found in Imaging The Risks of Fathering Art Direction • Paying the Toll in Pancreatic Cancer a Child Later in Life • New Hope for Diagnosing Mesothelioma 20 A growing body of research Nancy E. Sherman • The Synapse You Can’t Live Without indicates that certain brain Copy Editor disorders in children are related • 28 Faculty Conversation to their father’s age. ON THE COVER: Q&A with Richard Novick, MD ILLUSTRatION BY The Melody of Finches STUART BRIERS 30 Faculty News A neuroscientist learns how • Dean’s Honors Day 24 zebra finches perfect their love Master Clinician Philip K. Moskowitz, MD song and, in the process, makes Master Scientist Danny Reinberg, PhD some surprising discoveries Master Educator and Mentor about how neurons hook up. Linda R. Tewksbury, MD Valentine Mott Founders Awardee Larry A. Silverstein ERS I • Dr. Llinás Honored • Dr. Tsien Receives Neuroscience Award • Dr. Littman Elected to Institute of Medicine TUART BR TUART S 32 Obituary ON BY I Dr. Robert Porges ILLUSTRAT NYU PHYSICIAN WINTER 2012–2013 1 MESSAGE FROM THE DEAN Men’s & CEO Health by the Numbers Men’s Health 241,740 Although men are living longer and enjoying Estimated number of prostate cancer healthier lives, there is much room for cases diagnosed among U.S. men in improvement. This issue of NYU Physician 2012, second only to skin cancer* highlights some of the health challenges men encounter as they age. Prostate cancer is the second leading cause of cancer death, 2.5 million but today in the United States doctors are Estimated number of U.S. men diagnosed with prostate cancer still unable to distinguish reliably between who are still alive** aggressive and nonaggressive tumors. You will read about how our urologists and radiologists are working to solve this 1 in13 urgent problem, proving once again that Lifetime odds of a man's collaborative teamwork can yield meaningful developing lung cancer* results in the clinic. Our story on hypogonadism, or low testosterone, explores whether testosterone replacement therapy works and who should receive it, an important and relatively recent issue in men’s health. 79% Another story describes the emerging evidence for a male biological Percent of all fatal suicides clock, a phrase almost unheard of a mere decade ago. committed by males** You will also find a remarkable story about a neuroscientist who is learning about the neuronal basis of behavior through the love song of finches, a thoughtful Q&A with Dr. Richard Novick, one of our 307,225 Number of U.S. men killed by heart pioneering microbiologists, and the latest research from our laboratories. disease in 2009, accounting for I cannot end this letter without mentioning Hurricane Sandy. The roughly 1 in every 4 male deaths*** accompanying story provides many details about the heroism of our healthcare providers during the night the hurricane slammed into our Medical Center. The following weeks brought many losses and many 30 million lessons, but it also highlighted what I will always remain thankful Number of U.S. men with for, the dedication of the entire NYU Langone community and our erectile dysfunction**** determination to prevail. Eugene Braunwald (’52), the Distinguished Hersey Professor of Medicine at Harvard and one of our most illustrious alumni, wrote a 25% Percent of men ages 35 to 44 who letter to the class of 2016 that bears repeating here. “I admire enormously have high blood pressure***** the courage of the entire NYU Medical School family to deal with this extraordinary event. I know from personal experience that from adversity comes strength and that my beloved alma mater will be even better and stronger after the recovery from this devastating event.” I 20 to 30 or more Number of times per hour that men wholeheartedly concur. • can momentarily stop breathing, during a bout of sleep apnea**** *American Cancer Society **Centers for Disease Control and Prevention ***National Vital Statistics Reports ****National Institutes of Health DEAN & CEO ROBERT I. GROSSMAN, MD *****American Heart Association NYU PHYSICIAN PHOTOGRAPH BY 2 WINTER 2012–2013 JOHN ABBOTT The Balm After the Storm NYU Langone confronts the worst crisis in its history. ON Monday, OCTOBER 29, 2012—one operations, the year after Hurricane Irene forced NYU Incident Command Langone Medical Center to evacuate its Team (ICT)— patients and close its doors—Hurricane administrators Sandy did one better, plunging the Medical charged with Center into the worst crisis of its history. hospital-wide crisis Extensive damage to the main campus management— forced the closure of Tisch Hospital, the began meeting and Rusk Institute of Rehabilitation Medicine, conferring frequently. and our three research buildings—the The ICT and Skirball Institute of Biomolecular Medicine, executive leadership the Joan and Joel Smilow Research Center, faced an impossibly and the Medical Sciences Building—for complex calculation. more than two months. The storm also Would more than shuttered Bellevue Hospital Center and the 575 inpatients, Manhattan VA Medical Center, both home particularly those to many of NYU Langone’s researchers who were most frail, and clinicians and our primary teaching Ambulances lined up outside be less at risk if they were sheltered in place affiliates. All told, the unprecedented the Medical Center to receive during the storm? “There are significant risks evacuated patients. disaster disrupted operations at the heart to transferring patients,” Dr. Birnbaum of our three core missions: education, notes. “It’s the least desirable option.” research, and patient care. filled its basement. For some researchers, On the previous Friday, NYU Langone On the night of the disaster, 322 patients this represented the loss of years of work. In began to discharge all medically stable were safely transferred to 14 other the aftermath of the hurricane, every effort patients, reducing its census to 325. At hospitals within 13 hours—a physical and was made to salvage as much as possible in the same time, Real Estate Development + logistical challenge of epic proportions. research laboratories. “I have been inspired Facilities also began implementing a wide Some 1,000 medical and professional by the entire NYU Langone community,” range of measures to secure the physical personnel—including nurses, physicians, said Dafna Bar-Sagi, PhD, senior vice plant and mitigate the storm’s impact. fellows, residents, medical students, president and vice dean for science, “not As an additional precaution, the Medical and therapists—along with firefighters the least of which are our postdocs and Center announced on Sunday, October 28, and countless volunteers from our grad students. Armed with positive the cancellation of all scheduled surgeries administrative and support staff rose to the attitudes, determination, and apparently and procedures—with the exception of challenge, evacuating every single patient. quite strong biceps, they carried more than emergent procedures—through Tuesday, Another population was also at risk. 3,500 pounds of dry ice up hundreds of October 30, and the closure of all off- Tens of thousands of genetically altered stairs and then repeated this and many campus ambulatory care centers and mice used to study myriad diseases other tasks. Their efforts saved countless on-campus physician offices. To ensure were housed in the basements of two specimens and samples, bolstering the that the patient census be kept at a of the research facilities. The power future success of our research programs.” minimum throughout the storm, Tisch DONAGHY I outage damaged sensitive, sophisticated Days before the storm’s arrival, the Medical Hospital’s Emergency Department was OR L equipment, compromised ongoing Center began implementing a wide range of also closed.
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