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Hoc Marmor Poni Jussit Collegium Optime Merito Noble Physician of the Age Nothing in His Memory Will Perish. Royal College Ofphy 292 Lishman 56 J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.58.3.292 on 1 March 1995. Downloaded from Vogt C, Vogt 0. Alterations anatomiques de la schizo- nine dinucleotide phosphate-diaphorase neurons in phrenie et d'autres psychoses dites fonctionelles. temporal lobe of schizophrenics implies anomalous First International Congress of Neuropathology 1952;1: cortical development. Arch Gen Psychiatry 515-32. 178-87. 1993;50: 57 Plum F. Prospects for research on schizophrenia. 3. 65 Zipursky RB, Lim KO, Sullivan EV, Brown BW, Neuropsychology. Neuropathological findings. Neuro- Pfefferbaum A. Widespread cerebral grey matter volume sciences Research Program Bulletin 1972;10:384-8. deficits in schizophrenia. Arch Gen Psychiatry 58 Bogerts B, Meertz E, Schonfeldt-Bausch R. Basal ganglia 195-205. 1992;49: and limbic system pathology in schizophrenia. A mor- 66 Harvey I, Ron MA, du Boulay G, Wicks D, Lewis SW, phometric study of brain volume and shrinkage. Arch Murray RM. Reduction of cortical volume in schizo- Gen Psychiatry 1985;42:784-91. phrenia on magnetic resonance imaging. Psychol Med 59 Brown R, Colter N, Corsellis JA, et al. Postmortem 1993;23:591-604. evidence of structural brain changes in schizophrenia. 67 Harvey I, Persuad R, Ron MA, Barker G, Murray RM. Differences in brain weight, temporal horn area, and Volumetric MRI measurements in bipolars compared parahippocampal gyrus compared with affective disor- with schizophrenics and healthy controls. Psychol Med der. Arch Gen Psychiatry 1986;43:36-42. 1994;24:689-99. 60 Crow TJ, Ball J, Bloom SR, et al. Schizophrenia as an 68 Pakkenberg B. Post-mortem study of chronic schizo- anomaly of development of cerebral asymmetry. Arch phrenic brains. BrJ'Psychiatry 1987;151:744-52. Gen Psychiatry 1989;46:1 145-50. 69 Weinberger DR. Implications of normal brain develop- 61 Kovelman JA, Scheibel AB. A neurohistological correlate ment for the pathogenesis of schizophrenia. Arch Gen of schizophrenia. Biol Psychiatry 1984;19:1601-21. Psychiatry 1987;44:660-9. 62 Conrad AJ, Scheibel AB. Schizophrenia and the hip- 70 Murray RM, Lewis SW, Owen MJ, Foerster A. The neu- pocampus: the embryological hypothesis extended. rodevelopmental origins of dementia praecox. In: Schizophr Bull 1987;13:577-87. Bebbington P, McGuffin P, eds. Schizophrenia: the major 63 Akbarian S, Bunney WE, Potkin SG, et al. Altered distrib- issues. Oxford: Heinemann, 1988; Ch 8. ution of nicotinamide-adenine dinucleotide phosphate- 71 Heyman I, Murray RM. Schizophrenia and neurodevelop- diaphorase cells in frontal lobe of schizophrenics implies ment. Journal of the Royal College ofPhysicians of London disturbances of cortical development. Arch Gen 1992;26: 143-6. Psychiatry 1993:50:169-77. 72 Murray RM. Neurodevelopmental schizophrenia: the 64 Akbarian S, Viniuela A, Kim JJ, Potkin SG, Bunney WE, rediscovery of dementia praecox. Br Y Psychiatry Jones EG. Distorted distribution of nicotinamide-ade- 1995(in press). Thomas Sydenham "The British Epistolaris describing smallpox, venereal dis- Hippocrates" ease, hysteria, and podagra (gout), and the celebrated Tractatus de Podagra et Hydrope, Details of Sydenham's life are few. The London 1683. These works were published Sydenhams, an ancient family were in the in Britain, Geneva, and in Amsterdam. time of King John, seated at Sydenham near There is an anecdote about him, curso- Bridgewater. Thomas was son of Mary rily dismissed by Munk as "utterly value- Geffery of Catherstone and William less": when asked why he did not write Sydenham. Little is known of his childhood. about diseases of the head, he answered In 1642 he was entered at Magdalen Hall, that he did not undertake to write upon dis- Oxford, and left shortly after for military eases that he was unable to cure. Times service as a Parliamentarian. He probably don't change. Referring to his failure to returned to Magdalen Hall in 1646, advised become a Fellow of the Royal College, by Dr Thomas Coxe (PRCP, 1682) to read Lettsom wrote in 1804: "The great medicine, taking the degree of MB in April Sydenham, for all his labours, only gained 1648. He was made a Fellow of All Souls, the sad and unjust recompense of calumny http://jnnp.bmj.com/ but went to Wadham as a commoner. He and ignorance . ". However, Munk' moved to Westminster, before 1661 when relates that ". he did not proceed doctor his earliest account of epidemics of London (MD) till after a lapse of twenty eight years were written. On 25 June 1663 he was ... he was content with the minor degree, admitted Licentiate of the College of and, as such, was, by the statutes ... inad- Physicians. missible as a Candidate, and a fortiori, as a In 1666 was published the first edition of Fellow . examination of the Annals Methodus Curandi Febres, observa- prope hunc locum sepultus est propriis enables me positively to assert that he never on September 25, 2021 by guest. Protected copyright. tionibus superstructa, in the Philosophical sought admission to the fellowship." THOMAS SYDENHAM Transactions, which became Transactions of Sydenham had a powerful influence on medicus in omne aevum nobilis the Royal Society, in four sections: continued contemporary medicine. Diligent and scien- natus erat AD 1624 fevers, the symptoms of continued fevers, tific in his methods, observation and prag- vixit annos 65 intermittent fever, smallpox. The dedication matism were his hallmarks. He saw himself deletis veteris monumenti vestigiis, includes a tribute to Robert Boyle. A sec- as the servant of God and nature. ne rei memoria interiret, ond edition in 1668 included a chapter on In 1689 still in practice, he was ill with hoc marmor poni jussit collegium the plague, which was epidemic in London renal stone, haematuria, and gout. He died regale medicorum londinense AD 1810 in 1645 and 1646. It contains Latin elegiacs at home in Pall Mall on 29 December 1689 optime merito revering Dr John Locke, the "founder of and was buried in the church of St James's, nearby is the burial place of analytical philosophy of the mind".' The Westminster. THOMAS SYDENHAM third edition (1676) bore the new title J M S PEARCE 304 Beverley Road, noble physician of the age Observationes Medicae, and was dedicated to Born AD 1624 Dr and included Anlaby, Mapletoft copious new Hull HUIO 7BG, UK He lived to 65 years material. Sydenham took the degree of age erases remnants and monuments, Doctor of Medicine, not at Oxford, but at nothing in his memory will perish. Cambridge (May 17 1676), possibly This marble is placed by command of the because his son was two years earlier admit- Royal College of Physicians of London AD ted a pensioner at Pembroke College. 1 Brown J. Locke and Sydenham and other papers. 1810 in greatest merit For three months in 1677 he was laid low Edinburgh: David Douglas, 1882:33-135. by haematuria and gout, an affliction he 2 Munk W. The Roll of the Royal College of Physicians of London. 2nd ed, vol 1, 1518 to Epitaph to Thomas Sydenham first suffered in 1649. Then followed a 1700. London: published by the on the tablet erected series of College, Epistola Responsaria and Dissertatio Pall Mall East, 1878:309-14. by the College in 1810.
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