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Astrazeneca PLC (Incorporated with Limited Liability In BASE PROSPECTUS AstraZeneca PLC (incorporated with limited liability in England) U.S.$5,000,000,000 Euro Medium Term Note Programme AstraZeneca PLC (the "Issuer") has established a Euro Medium Term Note Programme (the "Programme") described in this Base Prospectus. Pursuant to the Programme, the Issuer may from time to time issue notes ("Notes") up to the maximum aggregate principal amount of U.S.$5,000,000,000. Notes will be issued in series (each a "Series") in bearer form. Each Series may comprise one or more tranches (each a "Tranche") issued on different issue dates. Each Tranche of Notes will be issued on the terms set out herein under "Terms and Conditions of the Notes" (the "Conditions") as completed by a document setting out the final terms of such Tranche (the "Final Terms") or as amended, supplemented and/or replaced in a separate prospectus specific to such Tranche (the "Drawdown Prospectus") as described under "Final Terms and Drawdown Prospectuses" below. In the case of a Tranche of Notes which is the subject of a Drawdown Prospectus, each reference in this Base Prospectus to information being specified or identified in the relevant Final Terms shall be read and construed as a reference to such information being specified or identified in the relevant Drawdown Prospectus unless the context requires otherwise. This Base Prospectus must be read and construed together with all documents incorporated by reference herein, any amendments or supplements hereto and, in relation to any Tranche of Notes which is the subject of Final Terms, must be read and construed together with the relevant Final Terms. The Notes are constituted by, have the benefit of and are in all respects subject to a trust deed dated 10 September 2007 and amended and restated on 5 May 2016 (the "Trust Deed") between the Issuer and Deutsche Trustee Company Limited (the "Trustee", which expression shall include all persons appointed for the time being as trustee or trustees under the Trust Deed) as trustee for the holders of the Notes (the "Noteholders"). The Notes also have the benefit of an amended and restated agency agreement dated 24 June 2015 (the "Agency Agreement") between the Issuer, Deutsche Bank AG, London Branch as principal paying agent (the "Principal Paying Agent") and Deutsche Bank AG, Hong Kong Branch as CMU lodging and paying agent (the "CMU Lodging and Paying Agent"). This Base Prospectus has been approved by the United Kingdom Financial Conduct Authority (the "FCA"), which is the United Kingdom competent authority for the purposes of Directive 2003/71/EC, as amended, including by Directive 2010/73/EU, and as implemented by any relevant implementing measures in the United Kingdom (the "Prospectus Directive"), as a base prospectus issued in compliance with the Prospectus Directive for the purpose of giving information with regard to the issue of Notes issued under the Programme described in this Base Prospectus during the period of twelve months after the date hereof. Applications have been made for the Notes to be admitted to listing on the Official List of the FCA and to trading on the Regulated Market of the London Stock Exchange plc (the "London Stock Exchange") during the period of twelve months after the date hereof. The Regulated Market of the London Stock Exchange is a regulated market for the purposes of Directive 2004/39/EC on markets in financial instruments (the "MiFID Directive"). The Notes are to be admitted to trading on a market which is a regulated market for the purposes of the MiFID Directive (each a "Regulated Market") and offered to the public in any Member State of the European Economic Area and may only be issued under the Programme in minimum denominations of at least EUR 100,000 (or its equivalent in another currency). Investing in Notes issued under the Programme involves certain risks. The principal risk factors that may affect the ability of the Issuer to fulfil its obligations under the Notes are discussed under "Risk Factors" below. Arranger CITIGROUP Dealers BARCLAYS BOFA MERRILL LYNCH CITIGROUP DEUTSCHE BANK GOLDMAN SACHS INTERNATIONAL HSBC J.P. MORGAN CAZENOVE MORGAN STANLEY The date of this Base Prospectus is 10 August 2017 CONTENTS Page IMPORTANT NOTICES ............................................................................................................................. 1 DESCRIPTION OF THE PROGRAMME ................................................................................................... 4 RISK FACTORS .......................................................................................................................................... 8 DOCUMENTS INCORPORATED BY REFERENCE ............................................................................. 26 FINAL TERMS AND DRAWDOWN PROSPECTUSES ........................................................................ 27 FORMS OF NOTES .................................................................................................................................. 28 TERMS AND CONDITIONS OF THE NOTES ....................................................................................... 31 FORM OF FINAL TERMS ........................................................................................................................ 58 SUMMARY OF PROVISIONS RELATING TO THE NOTES WHILE IN GLOBAL FORM ............... 65 USE OF PROCEEDS ................................................................................................................................. 68 DESCRIPTION OF THE ISSUER ............................................................................................................. 69 TAXATION ............................................................................................................................................... 97 SUBSCRIPTION AND SALE ................................................................................................................... 99 GENERAL INFORMATION .................................................................................................................. 103 IMPORTANT NOTICES The Issuer accepts responsibility for the information contained in this Base Prospectus and declares that, having taken all reasonable care to ensure that such is the case, the information contained in this Base Prospectus is, to the best of its knowledge, in accordance with the facts and contains no omission likely to affect its import. No person has been authorised to give any information or to make any representation not contained in or not consistent with this Base Prospectus or any other document entered into in relation to the Programme or any information supplied by the Issuer or such other information as is in the public domain and, if given or made, such information or representation should not be relied upon as having been authorised by the Issuer, the Trustee or any Dealer. Neither the Dealers nor any of their respective affiliates nor the Agents or the Trustee have authorised the whole or any part of this Base Prospectus and none of them makes any representation or warranty or accepts any responsibility as to the accuracy or completeness of the information contained in this Base Prospectus. Neither the delivery of this Base Prospectus or any Final Terms nor the offering, sale or delivery of any Note shall, in any circumstances, create any implication that the information contained in this Base Prospectus is true subsequent to the date hereof or the date upon which this Base Prospectus has been most recently amended or supplemented or that there has been no adverse change, or any event reasonably likely to involve any adverse change, in the prospects or financial or trading position of the Issuer since the date thereof or, the date upon which this Base Prospectus has been most recently amended or supplemented or that any other information supplied in connection with the Programme is correct at any time subsequent to the date on which it is supplied or, if different, the date indicated in the document containing the same. The distribution of this Base Prospectus and any Final Terms and the offering, sale and delivery of the Notes in certain jurisdictions may be restricted by law. Persons into whose possession this Base Prospectus or any Final Terms comes are required by the Issuer and the Dealers to inform themselves about and to observe any such restrictions. For a description of certain restrictions on offers, sales and deliveries of Notes and on the distribution of this Base Prospectus or any Final Terms and other offering material relating to the Notes, see "Subscription and Sale". In particular, Notes have not been and will not be registered under the United States Securities Act of 1933 (as amended) (the "Securities Act") and are subject to U.S. tax law requirements. Subject to certain exceptions, Notes may not be offered, sold or delivered within the United States or to U.S. persons. Neither this Base Prospectus nor any Final Terms constitutes an offer or an invitation to subscribe for or purchase any Notes and should not be considered as a recommendation by the Issuer, the Dealers or any of them that any recipient of this Base Prospectus or any Final Terms should subscribe for or purchase any Notes. Each recipient of this Base Prospectus or any Final Terms shall be taken to have made its own investigation and appraisal of the condition (financial or otherwise) of the Issuer. The maximum aggregate principal amount of Notes outstanding at any one time under the Programme will
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