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Of September 2, 2021. This Information Is Current As 2019; 203:1679-2024; ; J Immunol 4 We 203 (7) J Immunol 2019; 203:1679-2024; ; http://www.jimmunol.org/content/203/7 This information is current as of October 3, 2021. Downloaded from Why The JI? Submit online. • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists http://www.jimmunol.org/ • Fast Publication! 4 weeks from acceptance to publication *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: by guest on October 3, 2021 http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. VOL. 203 | NO. 7 | October 1, 2019 | Pages 1679–2026 IN MEMORIAM 1679 Henry Metzger, M.D. (1932–2018), The American Association of Immunologists President, 1991–1992 Dan Kastner and John O’Shea IN THIS ISSUE 1681 Linking miR-155 to Monocyte Defects in Rheumatoid Arthritis See article p. 1766 IL-10 Treatment for Heparin-Induced Thrombocytopenia See article p. 1786 Tissue-Specific Roles for Autophagy Genes See article p. 1820 LSD1 Aids Marginal Zone B Cell Development See article p. 1867 Evolution of Ag Receptors, MHC Class I, and CD1 See article p. 1882 Downloaded from NK Cell Production of IFN-g: Timing Matters See article p. 1981 PILLARS OF IMMUNOLOGY 1 1683 The Colon as a Major Site of Immunoregulation by CD4 T Cell Subsets in the Steady State Alan Sher and Brian L. Kelsall http://www.jimmunol.org/ CUTTING EDGE 1687 Cutting Edge: Ig H Chains Are Sufficient to Determine Most B Cell Clonal Relationships Julian Q. Zhou and Steven H. Kleinstein ALLERGY AND OTHER HYPERSENSITIVITIES 1693 Interplay between Affinity and Valency in Effector Cell Degranulation: A Model System with Polcalcin by guest on October 3, 2021 Allergens and Human Patient–Derived IgE Antibodies Gintare Bucaite, Tara Kang-Pettinger, Jorge Moreira, Hannah J. Gould, Louisa K. James, Brian J. Sutton, and James M. McDonnell 1701 A Mast Cell–Specific Receptor Is Critical for Granuloma Induced by Intrathecal Morphine Infusion Tao Zhang, Rui Liu, Delu Che, Priyanka Pundir, Nan Wang, Shengli Han, Jiao Cao, Yanni Lv, Haiyan Dong, Fang Fang, Jue Wang, Pengyu Ma, Tingting Zhao, Ting Lei, Xinzhong Dong, and Langchong He On the cover: Cumulative abundance plot of shared CNS-infiltrating TCRb clonotypes of two mice during acute experimental autoimmune encephalomyelitis (EAE). In the corresponding study, the identified CNS clonotypes were used to track EAE-associated T cell responses in animals that were protected from EAE during pregnancy. Engler, J. B., N. F. Heckmann, J. Ja¨ger, S. M. Gold, and M. A. Friese. 2019. Pregnancy enables expansion of disease-specific regulatory T cells in an animal model of multiple sclerosis. J. Immunol. 203: 1743–1752. The Journal of Immunology (ISSN 0022-1767) is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852, Phone: 301-634-7197, Fax: 301-246-8401. Subscription terms: New subscriptions and renewals begin January 1 and expire one year later (see http://www.jimmunol.org/subscription for prices and details). A special rate is available to members of The American Association of Immunologists, Inc. (see http://www.aai.org/ membership). The American Association of Immunologists, Inc., is not responsible for undeliverable issues. Replacement issues can be obtained, if available, at the regular price of single issues (see http://www.jimmunol.org/Subscription/Claims). Reprints of individual articles are available only from authors. Periodicals postage paid at Rockville, MD 20852, and at additional mailing offices. Country of origin U.S.A. Printed on acid-free recyclable paper. Postmaster: Send address changes 60 days in advance to The Journal of Immunology, Subscription Department, 1451 Rockville Pike, Suite 650, Rockville, MD 20852. Copyright Ó 2019 by The American Association of Immunologists, Inc. ANTIGEN RECOGNITION AND RESPONSES 1715 Targeting Antigens to CD180 but Not CD40 Programs Immature and Mature B Cell Subsets to Become Efficient APCs Kelsey Roe, Geraldine L. Shu, Kevin E. Draves, Daniela Giordano, Marion Pepper, and Edward A. Clark 1730 Deubiquitinating Enzyme UCH-L1 Promotes Dendritic Cell Antigen Cross-Presentation by Favoring Recycling of MHC Class I Molecules Anna T. Reinicke, Friederike Raczkowski, Malte Mu¨hlig, Pina Schmucker, Timo Lischke, Julia Reichelt, Enja Schneider, Stephanie Zielinski, Marlies Sachs, Elisabeth Jurack, Eva Tolosa, Christian Kurts, Hans-Willi Mittru¨cker, and Catherine Meyer-Schwesinger AUTOIMMUNITY 1743 Pregnancy Enables Expansion of Disease-Specific Regulatory T Cells in an Animal Model of Multiple Sclerosis Jan Broder Engler, Nina F. Heckmann, Jan Ja¨ger, Stefan M. Gold, and Manuel A. Friese 1753 Reduced Annexin A1 Expression Associates with Disease Severity and Inflammation in Multiple Sclerosis Patients Alessandra Colamatteo, Elisa Maggioli, Rodrigo Azevedo Loiola, Madeeha Hamid Sheikh, Gaetano Calı`, Dario Bruzzese, Giorgia Teresa Maniscalco, Diego Centonze, Fabio Buttari, Roberta Lanzillo, Francesco Perna, Bruno Zuccarelli, Downloaded from Maria Mottola, Silvana Cassano, Mario Galgani, Egle Solito, and Veronica De Rosa 1766 Monocyte/Macrophage Abnormalities Specific to Rheumatoid Arthritis Are Linked to miR-155 and Are Differentially Modulated by Different TNF Inhibitors Audrey Paoletti, Julien Rohmer, Bineta Ly, Juliette Pascaud, Elodie Riviere, Raphaele Seror, Benoit Le Goff, http://www.jimmunol.org/ Gaetane Nocturne, and Xavier Mariette 1776 Immunoproteasome Inhibition Selectively Kills Human CD14+ Monocytes and as a Result Dampens IL-23 Secretion Michael Basler, Meike Claus, Moritz Klawitter, Heike Goebel, and Marcus Groettrup 1786 Regulatory T Cells Control PF4/Heparin Antibody Production in Mice Yongwei Zheng, Wen Zhu, Dipica Haribhai, Calvin B. Williams, Richard H. Aster, Renren Wen, and Demin Wang by guest on October 3, 2021 CLINICAL AND HUMAN IMMUNOLOGY 1793 Fetal T Cell Activation in the Amniotic Cavity during Preterm Labor: A Potential Mechanism for a Subset of Idiopathic Preterm Birth Nardhy Gomez-Lopez, Roberto Romero, Yi Xu, Derek Miller, Marcia Arenas-Hernandez, Valeria Garcia-Flores, Bogdan Panaitescu, Jose Galaz, Chaur-Dong Hsu, Robert Para, and Stanley M. Berry IMMUNE REGULATION 1808 Glycolipid Stimulation of Invariant NKT Cells Expands a Unique Tissue-Resident Population of Precursors to Mature NK Cells Endowed with Oncolytic and Antimetastatic Properties Joshua Choi, Patrick T. Rudak, Sylvie Lesage, and S. M. Mansour Haeryfar 1820 Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1 Bernard Khor, Kara L. Conway, Abdifatah S. Omar, Moshe Biton, Adam L. Haber, Noga Rogel, Leigh A. Baxt, Jakob Begun, Petric Kuballa, John D. Gagnon, Kara G. Lassen, Aviv Regev, and Ramnik J. Xavier 1830 AhR Activation Leads to Massive Mobilization of Myeloid-Derived Suppressor Cells with Immunosuppressive Activity through Regulation of CXCR2 and MicroRNA miR-150-5p and miR-543-3p That Target Anti-Inflammatory Genes Wurood Hantoosh Neamah, Narendra P. Singh, Hasan Alghetaa, Osama A. Abdulla, Saurabh Chatterjee, Philip B. Busbee, Mitzi Nagarkatti, and Prakash Nagarkatti 1845 CgCLec-HTM–Mediated Signaling Pathway Regulates Lipopolysaccharide-Induced CgIL-17 and CgTNF Production in Oyster Jiejie Sun, Lingling Wang, Mengmeng Huang, Yinan Li, Weilin Wang, and Linsheng Song 1857 Circulating Picomolar Levels of CCL2 Downregulate Ongoing Chronic Experimental Autoimmune Encephalomyelitis by Induction of Regulatory Mechanisms Nathali Kaushansky, Eszter Bakos, Shirly Becker-Herman, Idit Shachar, and Avraham Ben-Nun IMMUNE SYSTEM DEVELOPMENT 1867 LSD1 Cooperates with Noncanonical NF-kB Signaling to Regulate Marginal Zone B Cell Development Robert R. Haines, Christopher D. Scharer, Jenna L. Lobby, and Jeremy M. Boss IMMUNOGENETICS 1882 Inferring the “Primordial Immune Complex”: Origins of MHC Class I and Antigen Receptors Revealed by Comparative Genomics Yuko Ohta, Masanori Kasahara, Timothy D. O’Connor, and Martin F. Flajnik INFECTIOUS DISEASE AND HOST RESPONSE 1897 T Cell– and Monocyte-Specific RNA-Sequencing Analysis in Septic and Nonseptic Critically Ill Patients and in Patients with Cancer Michael L. Washburn, Zhang Wang, Andrew H. Walton, S. Peter Goedegebuure, David J. Figueroa, Stephanie Van Horn, Julie Grossman, Katja Remlinger, Heather Madsen, James Brown, Roopa Srinivasan, Amaya I. Wolf, Scott B. Berger, Downloaded from Victoria N. Yi, William G. Hawkins, Ryan C. Fields, and Richard S. Hotchkiss 1909 Combination of Modified NS1 and NS3 as a Novel Vaccine Strategy against Dengue Virus Infection Yu-San Kao, Chia-Yi Yu, Hong-Jyun Huang, Sen-Mao Tien, Wan-Yu Wang, Martyr Yang, Robert Anderson, Trai-Ming Yeh, Yee-Shin Lin, and Shu-Wen Wan http://www.jimmunol.org/ 1918 Uncovering Structural and Molecular Dynamics of ESAT-6:b2M Interaction: Asp53 of Human b2-Microglobulin Is Critical for the ESAT-6:b2M Complexation Vishwanath Jha, Nagender Rao Rameshwaram, Sridhara Janardhan, Rajeev Raman, G. Narahari Sastry, Vartika Sharma, Jasti Subba Rao, Dhiraj Kumar, and Sangita Mukhopadhyay INNATE IMMUNITY AND INFLAMMATION 1930 IRF7 Is Involved
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