Medical Aspects of Biological Warfare
Alphavirus Encephalitides Chapter 20 ALPHAVIRUS ENCEPHALITIDES SHELLEY P. HONNOLD, DVM, PhD*; ERIC C. MOSSEL, PhD†; LESLEY C. DUPUY, PhD‡; ELAINE M. MORAZZANI, PhD§; SHANNON S. MARTIN, PhD¥; MARY KATE HART, PhD¶; GEORGE V. LUDWIG, PhD**; MICHAEL D. PARKER, PhD††; JONATHAN F. SMITH, PhD‡‡; DOUGLAS S. REED, PhD§§; and PAMELA J. GLASS, PhD¥¥ INTRODUCTION HISTORY AND SIGNIFICANCE ANTIGENICITY AND EPIDEMIOLOGY Antigenic and Genetic Relationships Epidemiology and Ecology STRUCTURE AND REPLICATION OF ALPHAVIRUSES Virion Structure PATHOGENESIS CLINICAL DISEASE AND DIAGNOSIS Venezuelan Equine Encephalitis Eastern Equine Encephalitis Western Equine Encephalitis Differential Diagnosis of Alphavirus Encephalitis Medical Management and Prevention IMMUNOPROPHYLAXIS Relevant Immune Effector Mechanisms Passive Immunization Active Immunization THERAPEUTICS SUMMARY 479 244-949 DLA DS.indb 479 6/4/18 11:58 AM Medical Aspects of Biological Warfare *Lieutenant Colonel, Veterinary Corps, US Army; Director, Research Support and Chief, Pathology Division, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Maryland 21702; formerly, Biodefense Research Pathologist, Pathology Division, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Maryland †Major, Medical Service Corps, US Army Reserve; Microbiologist, Division of Virology, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Maryland 21702; formerly, Science and Technology Advisor, Detachment
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