DOCSLIB.ORG

Epizone Abstract Book 11Th AM

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

11th EPIZONE Annual Meeting Welcome in Parisby ANSES Index 4 THANK YOU 5 WELCOME TO THE 11th EPIZONE ANNUAL MEETING 6 COMMITTEES 7 PROGRAMME 11 KEYNOTE SPEAKERS 23 ORAL PRESENTATIONS 25 Session 1 - Arthropod-borne diseases (arboviruses) 33 Session 2 - Current challenges inside Europe 41 Session 3 - Arthropod-borne diseases (arboviruses) 51 Session 4 - Current challenges inside Europe 59 Session 5 - Animal influenza viruses 67 Session 6 - African swine fever 75 Session 7 - Current challenges inside Europe 83 Session 8 - Threats at the European borders 91 POSTERS 93 Topic 1 - Arthropod-borne diseases (arboviruses) 111 Topic 2 - Threats at the European borders 133 Topic 3 - Current challenges inside Europe 151 Topic 4 - African swine fever 173 Topic 5 - Animal influenza viruses 185 Overview of posters 191 NOTES THANK YOU We are very grateful to the sponsor of the 11th EPIZONE Annual Meeting • ANSES Also a big thank you to everybody else involved in the 11th EPIZONE Annual Meeting • Administration Bureau EPIZONE at Wageningen University • All members of the committees • Keynote speakers • Chair persons • Oral presenters • Poster presenters • Participants 4 - EPIZONE - 11th Annual Meeting, 19-21 September 2017 - ANSES, Paris, France WELCOME 11th EPIZONE Annual Meeting: Crossing barriers The French agency for food, environmental and occupational health & safety (ANSES) warmly welcomes all the participants of the 11th EPIZONE meeting here in Paris. The theme of this year’s event is “Crossing barriers”, not only with regard to species barriers or to the barriers between different scientific disciplines, but also the crossing of geographical barriers. ANSES is committed to crossing barriers – those between public and private stakeholders, those which may exist between various scientific disciplines, and the barriers created by borders, since ANSES has numerous collaborations with institutes around the world. ANSES undertakes monitoring, expert assessment, research and reference activities in a broad range of topics that encompass human health, animal health and well-being, and plant health. “Investigate, evaluate and protect” - this summarises the missions of ANSES, based on collaborative and impartial expert assessment of the health risks and benefits of chemical, biological and physical agents, often through the prism of the human and social sciences. ANSES works with approximately 800 external experts selected primarily based on their scientific expertise and on a review of potential conflicts of interest. The Agency also relies on a network of 11 reference and research laboratories located throughout France that are recognisedth in Europe and internationally a wide range of fields and disciplines and are located 11in geographical EPIZONE proximity Annual to their respective Meeting sectors. It also assesses the effectiveness and risks of veterinary medicinal products, plant protection products, fertilisers, growing media and their adjuvants, as well as biocides, with a view to delivering marketing authorisations. ANSESCrossing also provides assessments Barriers of chemicals within the framework of the European REACH and CLP regulations.Paris, France Like human health, animal health can be threatened by numerous pathogens (bacteria, viruses, parasites), some of which can also affect humans (zoonoses). ANSES contributes to the prevention and control of the major and emerging animal diseases affecting both farm animals and wildlife, and in doing so participates in the protection of public health. Via the French agency for veterinary medicinal products (ANMV), ANSES is also the competent French authority for the assessment and management of veterinary medicinal products. Global climate change, as well as new forms of globalisation in trade, have led over the last few years to the emergence in Europe of exotic animal diseases with a high economic impact. The emergence of these infectious animal diseases remains a topical issue which has often mobilised the ANSES teams, for example : new variants of the bluetongue virus, tick-borne diseases, African swine fever, etc. However, other more established diseases also remain a concern for France and for Europe and warrant our sustained Welcome efforts. Another challenge is to develop methods of screening, analytical diagnosis and control, in accordance with the European and international standards in force, while integrating new technologies for analysing genomes and proteins. The detailed analysis of host/ pathogen interactions, as well as the development of new epidemiological methods, will enable ANSES to continue to combat emerging and re-emerging animal diseases, in line with the «One Health» concept promoted by the World Health Organisation. I sincerely hope that this 11th annual meeting of EPIZONE will be an opportunity to cross barriers and to provide the “epizootic community” with effective ways of working together to plan new initiatives, to interact and to enjoy our time here together in Paris. Dr Roger GENET EPIZONE - 11th Annual Meeting, 19-21 September 2017 - ANSES, Paris, France - 5 Committees The 11th EPIZONE Annual Meeting is organised by ANSES, French agency for food, environmental and occupational health & safety SCIENTIFIC COMMITTEE Marie-Frédérique LE POTIER, ANSES, Ploufragan-Plouzané Laboratory, France Stéphan ZIENTARA, Maisons-Alfort Laboratory for Animal Health, France Martin BEER, Federal Research Institute for Animal Health, Germany Donald KING, the Pirbright institute, United Kingdom Emiliana BROCCHI, Experimental Zooprophylactic Institute of Lombardy and Emilia Romagna, Italy Annette BOTTNER, Technical University of Denmark Thierry van den BERG, Veterinary and Agrochemical Research Centre, Belgium Jose Manuel VISCAINO, Universidad Complutense Madrid, Spain Wim van der POEL, Wageningen University & Research, Netherlands Alejandro BRUN, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Spain Smietanka KRZYSZTOF, PIWET, National Veterinary Research Institute, Poland Christian GRIOT, Institut für Virologie und Immunologie, Swiss Confederation Dolores GAVIER-WIDEN, National Veterinary Institute, Sweden Labib BAKKALI, Maisons-Alfort Laboratory for Animal Health, France Benoît DURAND, Maisons-Alfort Laboratory for Animal Health, France Emmanuel BRÉARD, Maisons-Alfort Laboratory for Animal Health, France Béatrice GRASLAND, ANSES, Ploufragan-Plouzané Laboratory, France Gaëlle SIMON, ANSES, Ploufragan-Plouzané Laboratory, France Stephen VALAS, ANSES, Niort Laboratory, France Thierry MORIN, ANSES, Ploufragan-Plouzané Laboratory, France LOCAL ORGANISATION COMMITTEE- ANSES, FRANCE Marie-Frédérique LE POTIER, Ploufragan-Plouzané Laboratory Stephan ZIENTARA, Maisons-Alfort Laboratory for Animal Health Fabrice COUTUREAU, Department of Communication and Institutional Relations Nathalie THIERIET, Department of Communication and Institutional Relations Labib BAKKALI, Maisons-Alfort Laboratory for Animal Health Sylvie LECOLLINET, Maisons-Alfort Laboratory for Animal Health Damien VITOUR, Maisons-Alfort Laboratory for Animal Health Benoît DURAND, Maisons-Alfort Laboratory for Animal Health Maud MARSOT, Maisons-Alfort Laboratory for Animal Health Charlotte DUNOYER, Risk Asssessment Department Corinne SAILLEAU, Maisons-Alfort Laboratory for Animal Health Emanuel BRÉARD, Maisons-Alfort Laboratory for Animal Health 6 - EPIZONE - 11th Annual Meeting, 19-21 September 2017 - ANSES, Paris, France 11th EPIZONE Annual Meeting Crossing Barriers Paris, France Programme EPIZONE - 11th Annual Meeting, 19-21 September 2017 - ANSES, Paris, France - 7 Tuesday 19 th September 2017 YOUNG EPIZONE MEETING Room 1 08:00 Registration and welcome desks 09:00 WELCOME ADRESSES Wim van der POEL, Coordinator Epizone Stéphan ZIENTARA & Marie-Frédérique LE POTIER, Scientific Committee, ANSES, France 09:2010:00 ICE-BREAKING GAME Laura ZANI, Friedrich-Loeffler-Institut, Germany 11:00 Coffee break 11:30 WORKSHOP ON ‘‘COMMUNICATION SKILLS’’ Baudouin JURDANT, Professor emeritus of science information and communication, Université Paris-Diderot, Lisbonne, Portugal 12:30 Lunch break at The Loft, into the Cité des sciences INVITED SPEAKERS ‘COMMUNICATION’ 14:00 Clémentine SCHILTE, communication officer, center for translational science, Institut Pasteur, Paris 14:40 Brigitte RAULT, communication on animal experiments, office of animal experimentation, INSERM, Paris 15:20 Sophie FÉLIX, scientific journalism, communication and publishing, Université Paris-Saclay, Paris 16:00 Pauline MAISONNASSE, scientific popularization,IDMIT, Paris 11th EPIZONE ANNUAL MEETING 15:00 Registration and welcome desks 19:00 Welcome cocktail 8 - EPIZONE - 11th Annual Meeting, 19-21 September 2017 - ANSES, Paris, France Programme Wednesday 20th September 2017 08:00 Registration and welcome desks 09:00 WELCOME ADRESSES - Amphitheatre Dr Roger GENET, Director General, ANSES, France Wim van der POEL, Coordinator Epizone Stéphan ZIENTARA & Marie-Frédérique LE POTIER, Scientific Committee, ANSES, France 09:20 PLENARY SESSIONS - Amphitheatre Keynote: The emergence, persistence and evolution of bluetongue viruses in Europe since 1998 - Peter MERTENS Keynote: Rift Valley fever: Unanswered questions and unmet needs - Jeroen KORTEKAAS 10:20 Coffee break & poster session SESSION 1: ARTHROPOD-BORNE DISEASES (ARBOVIRUSES) SESSION 2: CURRENT CHALLENGES INSIDE EUROPE Chairs : Stéphan Zientara & Jose Manuel Viscainot - Amphitheatre Chairs : Benoît Durand & Wim van der Poel - Room 1 11:00 C1 - Natalia Golender - Novel topotypes of bluetongue
Recommended publications
  • WSC 10-11 Conf 7 Layout Master

    WSC 10-11 Conf 7 Layout Master

    The Armed Forces Institute of Pathology Department of Veterinary Pathology Conference Coordinator Matthew Wegner, DVM WEDNESDAY SLIDE CONFERENCE 2010-2011 Conference 7 29 September 2010 Conference Moderator: Thomas Lipscomb, DVM, Diplomate ACVP CASE I: 598-10 (AFIP 3165072). sometimes contain many PAS-positive granules which are thought to be phagocytic debris and possibly Signalment: 14-month-old , female, intact, Boxer dog phagocytized organisms that perhaps Boxers and (Canis familiaris). French bulldogs are not able to process due to a genetic lysosomal defect.1 In recent years, the condition has History: Intestine and colon biopsies were submitted been successfully treated with enrofloxacin2 and a new from a patient with chronic diarrhea. report indicates that this treatment correlates with eradication of intramucosal Escherichia coli, and the Gross Pathology: Not reported. few cases that don’t respond have an enrofloxacin- resistant strain of E. coli.3 Histopathologic Description: Colon: The small intestine is normal but the colonic submucosa is greatly The histiocytic influx is reportedly centered in the expanded by swollen, foamy/granular histiocytes that submucosa and into the deep mucosa and may expand occasionally contain a large clear vacuole. A few of through the muscular wall to the serosa and adjacent these histiocytes are in the deep mucosal lamina lymph nodes.1 Mucosal biopsies only may miss the propria as well, between the muscularis mucosa and lesions. Mucosal ulceration progresses with chronicity the crypts. Many scattered small lymphocytes with from superficial erosions to patchy ulcers that stop at plasma cells and neutrophils are also in the submucosa, the submucosa to only patchy intact islands of mucosa.
  • Investigating the Role of Host TTR-Rbps During SFV4 and MHV-68 Infection

    Investigating the Role of Host TTR-Rbps During SFV4 and MHV-68 Infection

    Investigating the role of host TTR-RBPs during SFV4 and MHV-68 infection Thesis submitted in accordance with the requirements of the University of Liverpool for the degree of Doctor in Philosophy by Jamie Casswell October 2019 Contents Figure Contents Page……………………………………………………………………………………7 Table Contents Page…………………………………………………………………………………….9 Acknowledgements……………………………………………………………………………………10 Abbreviations…………………………………………………………………………………………….11 Abstract……………………………………………………………………………………………………..17 1. Chapter 1 Introduction……………………………………………………………………………19 1.1 DNA and RNA viruses ............................................................................. 20 1.2 Taxonomy of eukaryotic viruses ............................................................. 21 1.3 Arboviruses ............................................................................................ 22 1.4 Togaviridae ............................................................................................ 22 1.4.1 Alphaviruses ............................................................................................................................. 23 1.4.1.1 Semliki Forest Virus ........................................................................................................... 25 1.4.1.2 Alphavirus virion structure and structural proteins ......................................................... 26 1.4.1.3 Alphavirus non-structural proteins ................................................................................... 29 1.4.1.4 Alphavirus genome organisation
  • Veterinary Parasitology 180 (2011) 203–208

    Veterinary Parasitology 180 (2011) 203–208

    Veterinary Parasitology 180 (2011) 203–208 View metadata, citation and similar papers at core.ac.uk brought to you by CORE Contents lists available at ScienceDirect provided by Elsevier - Publisher Connector Veterinary Parasitology jo urnal homepage: www.elsevier.com/locate/vetpar Detection and molecular characterization of a canine piroplasm from Brazil a b a c João F. Soares , Aline Girotto , Paulo E. Brandão , Aleksandro S. Da Silva , c c a,∗ Raqueli T. Franc¸ a , Sonia T.A. Lopes , Marcelo B. Labruna a Department of Preventive Veterinary Medicine and Animal Health, Faculty of Veterinary Medicine, University of São Paulo, Av. Prof. Orlando Marques de Paiva 87, Cidade Universitária, 05508-270 São Paulo, SP, Brazil b Department of Preventive Veterinary Medicine, Faculty of Veterinary Medicine, Londrina State University-UEL, Londrina-PR, Brazil c Department of Small Animals, Federal University of Santa Maria -UFSM, Santa Maria, Rio Grande do Sul, Brazil a r t i c l e i n f o a b s t r a c t Article history: In the beginning of the 20th century, a new canine disease was reported in Brazil under the Received 20 August 2010 name “nambiuvú”, whose etiological agent was called Rangelia vitalii, a distinct piroplasm Received in revised form 15 March 2011 that was shown to parasitize not only erythrocytes, but also leucocytes and endothelial Accepted 16 March 2011 cells. In this new century, more publications on R. vitalii were reported from Brazil, includ- ing an extensive study on its ultrastructural analysis, in addition to clinical, pathological, Keywords: and epidemiological data on nambiuvú.
  • Construção E Aplicação De Hmms De Perfil Para a Detecção E Classificação De Vírus

    Construção E Aplicação De Hmms De Perfil Para a Detecção E Classificação De Vírus

    UNIVERSIDADE DE SÃO PAULO PROGRAMA INTERUNIDADES DE PÓS-GRADUAÇÃO EM BIOINFORMÁTICA Construção e Aplicação de HMMs de Perfil para a Detecção e Classificação de Vírus Miriã Nunes Guimarães SÃO PAULO 2019 Construção e Aplicação de HMMs de Perfil para a Detecção e Classificação de Vírus Miriã Nunes Guimarães Dissertação apresentada à Universidade de São Paulo, como parte das exigências do Programa de Pós-Graduação Interunidades em Bioinformática, para obtenção do título de Mestre em Ciências. Área de Concentração: Bioinformática Orientador: Prof. Dr. Arthur Gruber SÃO PAULO 2019 “Na vida, não existe nada a temer, mas a entender.” Marie Curie Agradecimentos Ao Professor Arthur Gruber pela oportunidade desde o início como estagiária no laboratório, pela orientação neste período de aprendizado no mestrado e por fornecer um ambiente de trabalho favorável. À aluna de doutorado Liliane Santana Oliveira que aguentou todas as minhas amolações diárias no laboratório pelo Hangouts, por dúvidas que eram erros meus em comandos de execução, pela paciência, pela amizade, pela companhia nos bandejões da faculdade com cardápio glutenfree que nem sempre eram tão bons assim. À aluna de mestrado Irina Yuri Kawashima que estava comigo no laboratório diariamente, pelas várias discussões sobre o mundo dos vírus e de conhecimentos da bioinformática, pelas ferramentas para facilitar o andamento do projeto, por todas guloseimas glutenfree que seria impossível eu não agradecer pois tenho ciência que não vou encontrar outra amiga masterchef assim. À Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) pelo financiamento durante estes 24 meses de mestrado. Aos meus pais pelo carinho e preocupação comigo durante estes 24 anos, pelo incentivo aos estudos e pelo apoio para eu me manter a uma distância de quase 400km de pura saudade.
  • Study of Chikungunya Virus Entry and Host Response to Infection Marie Cresson

    Study of Chikungunya Virus Entry and Host Response to Infection Marie Cresson

    Study of chikungunya virus entry and host response to infection Marie Cresson To cite this version: Marie Cresson. Study of chikungunya virus entry and host response to infection. Virology. Uni- versité de Lyon; Institut Pasteur of Shanghai. Chinese Academy of Sciences, 2019. English. NNT : 2019LYSE1050. tel-03270900 HAL Id: tel-03270900 https://tel.archives-ouvertes.fr/tel-03270900 Submitted on 25 Jun 2021 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. N°d’ordre NNT : 2019LYSE1050 THESE de DOCTORAT DE L’UNIVERSITE DE LYON opérée au sein de l’Université Claude Bernard Lyon 1 Ecole Doctorale N° 341 – E2M2 Evolution, Ecosystèmes, Microbiologie, Modélisation Spécialité de doctorat : Biologie Discipline : Virologie Soutenue publiquement le 15/04/2019, par : Marie Cresson Study of chikungunya virus entry and host response to infection Devant le jury composé de : Choumet Valérie - Chargée de recherche - Institut Pasteur Paris Rapporteure Meng Guangxun - Professeur - Institut Pasteur Shanghai Rapporteur Lozach Pierre-Yves - Chargé de recherche - CHU d'Heidelberg Rapporteur Kretz Carole - Professeure - Université Claude Bernard Lyon 1 Examinatrice Roques Pierre - Directeur de recherche - CEA Fontenay-aux-Roses Examinateur Maisse-Paradisi Carine - Chargée de recherche - INRA Directrice de thèse Lavillette Dimitri - Professeur - Institut Pasteur Shanghai Co-directeur de thèse 2 UNIVERSITE CLAUDE BERNARD - LYON 1 Président de l’Université M.
  • Universidade Federal Do Rio Grande Do Sul Faculdade De Veterinária Especialização Em Análises Clínicas Veterinárias

    Universidade Federal Do Rio Grande Do Sul Faculdade De Veterinária Especialização Em Análises Clínicas Veterinárias

    UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL FACULDADE DE VETERINÁRIA ESPECIALIZAÇÃO EM ANÁLISES CLÍNICAS VETERINÁRIAS INFECÇÕES CAUSADAS POR HEMATOZOÁRIOS EM CÃES E GATOS DE OCORRÊNCIA NO BRASIL: SEMELHANÇAS E PARTICULARIDADES. Elusa Santos de Andrade PORTO ALEGRE 2007 UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL FACULDADE DE VETERINÁRIA ESPECIALIZAÇÃO EM ANÁLISES CLÍNICAS VETERINÁRIAS INFECÇÕES CAUSADAS POR HEMATOZOÁRIOS EM CÃES E GATOS DE OCORRÊNCIA NO BRASIL: SEMELHANÇAS E PARTICULARIDADES. Autor: Elusa Santos de Andrade Monografia apresentada à Faculdade de Veterinária como requisito para obtenção do grau de ESPECIALISTA EM ANÁLISES CLÍNICAS VETERINÁRIAS Orientadora: Silvia Gonzalez Monteiro PORTO ALEGRE 2007 RESUMO A presente monografia foi elaborada a partir de uma revisão bibliográfica sobre as infecções causadas por hematozoários em cães e gatos de ocorrência no Brasil. Através desta, buscou-se aprofundar e discutir diversos aspectos comuns e particulares dessas infecções e seus agentes, abordando morfologia, histórico, prevenção e salientando aspectos semelhantes e particularidades, tais como: epidemiologia, vetores, ciclo, patogenia, métodos de diagnóstico, tratamento e controle. São revisados os parasitos dos gêneros Babesia, Cytauxzoon, Rangelia, Hepatozoon e Trypanosoma enfatizando as espécies Babesia canis vogeli, Cytauxzoon felis, Rangelia vitalli, Hepatozoon canis, Trypanosoma cruzi e Trypanosoma evansi. Concluiu-se que para um correto diagnóstico, tratamento e prevenção das infecções por hematozoários em cães e gatos são necessários alguns requisitos, os quais sejam: conhecimento atualizado do clínico, anamnese e exame clínico minuciosos, preparo adequado e conhecimento atualizado do analista clínico veterinário, controle dos vetores, conscientização das autoridades e da população. Palavras-chave: Babesia, Cytauxzoon, Rangelia, Hepatozoon, Trypanosoma cruzi, evansi, parasito, vetor. ABSTRACT The present monograph was elaborated from a bibliographical revision about the dogs and cats’s infections caused for blood protozoals, in Brazil.
  • Changes in the Enzymes ALT, CK and AST During the Acute

    Changes in the Enzymes ALT, CK and AST During the Acute

    Full Article Rev. Bras. Parasitol. Vet., Jaboticabal, v. 21, n. 3, p. 243-248, jul.-set. 2012 ISSN 0103-846X (impresso) / ISSN 1984-2961 (eletrônico) Rangelia vitalii: changes in the enzymes ALT, CK and AST during the acute phase of experimental infection in dogs Rangelia vitalii: mudanças nas enzimas ALT, CK e AST na fase aguda da infecção experimental em cães Márcio Machado Costa1*; Raqueli Teresinha França1; Aleksandro Schafer Da Silva2; Carlos Breno Paim1, Francine Paim1; Carlos Henrique do Amaral3; Guilherme Lopes Dornelles1; João Paulo Monteiro Carvalho Mori da Cunha1; João Fabio Soares4; Marcelo Bahia Labruna4; Cinthia Melazzo Andrade Mazzanti1; Silvia Gonzalez Monteiro2; Sonia Terezinha dos Anjos Lopes1 1Department of Small Animals, Federal University of Santa Maria – UFSM, Santa Maria, RS, Brazil 2Department of Microbiology and Parasitology, Federal University of Santa Maria – UFSM, Santa Maria, RS, Brazil 3Department of Veterinary Medicine, Federal University of Paraná – UFPR, Curitiba, PR, Brazil 4Department of Preventive Veterinary Medicine and Animal Health, University of São Paulo – USP, Brazil Received October 27, 2011 Accepted June 8, 2012 Abstract Rangelia vitalii is a protozoon that causes diseases in dogs, and anemia is the most common laboratory finding. However, few studies on the biochemical changes in dogs infected with this protozoon exist. Thus, this study aimed to investigate the biochemical changes in dogs experimentally infected with R. vitalii, during the acute phase of the infection. For this study, 12 female dogs (aged 6-12 months and weighing between 4 and 7 kg) were used, divided in two groups. Group A was composed of healthy dogs (n = 5); and group B consisted of infected animals (n = 7).
  • Western Equine Encephalitis Virus Is a Recombinant Virus (RNA Recombination/Alphavirus/Evolution of RNA Viruses) CHANG S

    Western Equine Encephalitis Virus Is a Recombinant Virus (RNA Recombination/Alphavirus/Evolution of RNA Viruses) CHANG S

    Proc. Natl. Acad. Sci. USA Vol. 85, pp. 5997-6001, August 1988 Evolution Western equine encephalitis virus is a recombinant virus (RNA recombination/Alphavirus/evolution of RNA viruses) CHANG S. HAHN, SHLOMO LUSTIG*, ELLEN G. STRAUSS, AND JAMES H. STRAUSSt Division of Biology, 156-29, California Institute of Technology, Pasadena, CA 91125 Communicated by James Bonner, April 14, 1988 ABSTRACT The alphaviruses are a group of 26 mosquito- virus; O'Nyong-nyong virus; and Ross River virus. Sindbis borne viruses that cause a variety of human diseases. Many of and Semliki Forest viruses have been intensively studied as the New World alphaviruses cause encephalitis, whereas the models for alphavirus replication (7). Sindbis virus is widely Old World viruses more typically cause fever, rash, and distributed, being found in Europe, India, southeast Asia, arthralgia. The genome is a single-stranded nonsegmented Australia, and Africa. Close relatives of this virus, such as RNA molecule of + polarity; it is about 11,700 nucleotides in Ockelbo virus in Europe (8) and Babanki virus in Africa, length. Several alphavirus genomes have been sequenced in cause disease in humans characterized by fever, rash, and whole or in part, and these sequences demonstrate that alpha- arthritis. Chikungunya and O'Nyong-nyong viruses have viruses have descended from a common ancestor by divergent caused large epidemics in Africa of a dengue-like disease also evolution. We have now obtained the sequence of the 3'- characterized by fever, rash, and arthralgia. Ross River virus terminal 4288 nucleotides of the RNA of the New World is the causative agent of epidemic polyarthritis in Australia Alphavirus western equine encephalitis virus (WEEV).
  • Hepatozoon Canis (James, 1905) (Adeleida: Hepatozoidae)

    Hepatozoon Canis (James, 1905) (Adeleida: Hepatozoidae)

    Hepatozoon canis (James, 1905) (Adeleida: Hepatozoidae) EM CÃES DO BRASIL, COM UMA REVISÃO DO GÊNERO EM MEMBROS DA ORDEM CARNÍVORA TESE Apresentada ao Decanato de Pesquisa e Pós-Graduação da Universidade Federal Rural do Rio de Janeiro para obtenção do grau de Mestre em Ciências CLAUDETE DE ARAÚJO MASSARD NOVEMBRO 1 9 7 9 AGRADECIMENTOS Sensibilizada pelo apoio recebido durante o desenvol- vimento deste estudo, agradeço: ao Prof. Dr. WILHELM OTTO DANIEL MARTIN NEITZ, Titu- lar da Área de Parasitologia da Universidade Federal Rural do Rio de Janeiro, pela orientação e contribuição na minha forma- ção científica; ao Prof. e esposo CARLOS LUIZ MASSARD e ao Prof. HU- GO EDISON BARBOZA DE REZENDE, pela orientação, estímulo e aju- da no desenvolvimento e estruturação da tese; a todos os professores, colegas de Pós-Graduação e companheiros de trabalho da Área de Parasitologia da U.F.R.R.J. pelo ambiente de amizade, cooperação e sugestões sempre pro- porcionadas; aos Profs. BERNARDO JORGE CARRILLO E ANA MARGARIDA LANGENEGGER DE REZENDE, pela ajuda nos estudos anátomo e his- topatológicos; ii aos Srs. WALDYR JACINTHO DA SILVA, WALTER FLAUSINO e ARCHANJO GONÇALVES DA SILVA, pelo auxílio nos trabalhos de la- boratório; ao Prof. OSWALDO DUARTE GONÇALVES pela revisão literá- ria è normativa da penúltima versão do trabalho; a SUELÍ DE ANDRADE BORRET pelos serviços datilográfi- cos; ao Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) e a Universidade Federal Rural do Rio de Ja- neiro, pelo auxílio e facilidades proporcionadas ao desenvolvi- mento deste trabalho. BIOGRAFIA CLAUDETE DE ARAÚJO MASSARD, filha de Luiz Pessoa de Araújo e Iracema Cavalcanti de Araújo, nasceu a 31 de outubro de 1951 no Rio de Janeiro, Estado do Rio de Janeiro.
  • Rangelia Vitalii Infection in a Dog from São Paulo City, Brazil: Case Report

    Rangelia Vitalii Infection in a Dog from São Paulo City, Brazil: Case Report

    CASE REPORT ISSN Online 1678-4456 Rangelia vitalii infection in a dog from São Paulo city, Brazil: case report Infecção por Rangelia vitalli em cão da zona norte de São Paulo/SP: relato de caso Bruna Regina Figura da Silva1,2; Marcelo Bahia Labruna3; Arlei Marcili1; Caio Rodrigues dos Santos4; Bárbara Buff Blumer Bastos2; Jessica Tainá Bordin2; Jonas Moraes-Filho1 1 Universidade Santo Amaro, Curso de Mestrado em Medicina e Bem-Estar Animal, São Paulo – SP, Brazil 2 Hospital Veterinário São Sebastião, São Paulo – SP, Brazil 3 Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Medicina Veterinária Preventiva e Saúde Animal, São Paulo – SP, Brazil 4 Laboratório Vet-Biotec Biotecnologia e Diagnóstico, Cotia – SP, Brazil ABSTRACT Canine rangeliosis is an extravascular hemolytic disease caused by the protozoan Rangelia vitalii, which is transmitted by ticks of the species Amblyomma aureolatum. The most common clinical signs are apathy, hyperthermia and spontaneous bleeding. Anemia and thrombocytopenia are the most common hematological findings. This work reports a clinical case of canine Rangeliosis treated at a private veterinary hospital, in São Paulo city in 2017. A dog was treated at a veterinary hospital in the north of São Paulo, with progressive weight loss, apathy and tail injury. Anemia and thrombocytopenia were observed on the hemogram. Rangelia vitalii DNA was detected in animal blood by real-time PCR (qPCR). In addition to the supportive treatment, doxycycline and subcutaneous imidocarb applications were used. The sample collected after treatment with the antibiotic continued to present protozoal DNA. The disease should be considered as a differential diagnosis and there is a great need for further studies about the therapy used.
  • Medical Aspects of Biological Warfare

    Medical Aspects of Biological Warfare

    Alphavirus Encephalitides Chapter 20 ALPHAVIRUS ENCEPHALITIDES SHELLEY P. HONNOLD, DVM, PhD*; ERIC C. MOSSEL, PhD†; LESLEY C. DUPUY, PhD‡; ELAINE M. MORAZZANI, PhD§; SHANNON S. MARTIN, PhD¥; MARY KATE HART, PhD¶; GEORGE V. LUDWIG, PhD**; MICHAEL D. PARKER, PhD††; JONATHAN F. SMITH, PhD‡‡; DOUGLAS S. REED, PhD§§; and PAMELA J. GLASS, PhD¥¥ INTRODUCTION HISTORY AND SIGNIFICANCE ANTIGENICITY AND EPIDEMIOLOGY Antigenic and Genetic Relationships Epidemiology and Ecology STRUCTURE AND REPLICATION OF ALPHAVIRUSES Virion Structure PATHOGENESIS CLINICAL DISEASE AND DIAGNOSIS Venezuelan Equine Encephalitis Eastern Equine Encephalitis Western Equine Encephalitis Differential Diagnosis of Alphavirus Encephalitis Medical Management and Prevention IMMUNOPROPHYLAXIS Relevant Immune Effector Mechanisms Passive Immunization Active Immunization THERAPEUTICS SUMMARY 479 244-949 DLA DS.indb 479 6/4/18 11:58 AM Medical Aspects of Biological Warfare *Lieutenant Colonel, Veterinary Corps, US Army; Director, Research Support and Chief, Pathology Division, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Maryland 21702; formerly, Biodefense Research Pathologist, Pathology Division, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Maryland †Major, Medical Service Corps, US Army Reserve; Microbiologist, Division of Virology, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Maryland 21702; formerly, Science and Technology Advisor, Detachment
  • Eastern Equine Encephalitis Case Definition

    Eastern Equine Encephalitis Case Definition

    CASE DEFINITION FOR EASTERN EQUINE ENCEPHALITIS 1. General disease/pathogen information: Eastern equine encephalomyelitis (EEE) is a mosquito-borne viral disease that primarily affects horses. EEE, also known as sleeping sickness, is characterized by central nervous system dysfunction and a moderate to high case fatality rate. The causal virus is maintained in nature in an alternating infection cycle between mosquitoes and birds. Humans and horses serve as dead-end hosts. Although horses and humans are most often affected by the virus, birds may exhibit clinical signs, and infection and disease occasionally occurs in other livestock, deer, dogs, and a variety of mammalian, reptile, and amphibian species. 1.1. Etiologic agent: EEE is caused by the Eastern equine encephalomyelitis virus (EEEV), an Alphavirus of the family Togaviridae. It is closely related to the Western and Venezuelan equine encephalomyelitis viruses and Highlands J virus, all of which cause similar neurological dysfunction disorders in horses. There are two distinct antigenic variants of EEEV. The North American variant is more pathogenic than the South and Central American variant. 1.2. Distribution/frequency of agent or pathogen in U.S.: EEEV is distributed throughout the Western Hemisphere. It has also been reported in the Caribbean Islands, Mexico, Central America, and South America. In North America, it is found in eastern Canada and all States in the United States east of the Mississippi River as well as Arkansas, Iowa, Minnesota, South Dakota, Oklahoma, Louisiana, and Texas. EEEV is endemic in the Gulf of Mexico region of the United States. 1.3. Clinical signs: Horses infected with EEEV will initially develop fever, lethargy, and anorexia.