Edward J. Kennelly, Ph.D. 3206 Fairfield Avenue, 7H Bronx, NY 10463 718-601-0366 [email protected]

EDUCATION

Colby College 1983-1987 B.A. Biology 1987 Waterville, ME

University College Cork 1985-1986 Junior Year Abroad Cork, Ireland

Washington University 1987-1993 Ph.D. Biology 1993 St. Louis, MO Mentor: Professor Walter H. Lewis

POSITIONS

Since 1993, Dr. Kennelly has held positions at the University of Illinois at Chicago, the U.S. Food and Drug Administration, the City University of New York, and the Chinese University of Hong Kong in the following capacities.

University of Illinois at Chicago (1993-1996) Conducted research in natural product sweeteners and cancer chemopreventive agents

Postdoctoral Fellowship in Pharmacognosy 1993-1995 Mentor: Professor A. Douglas Kinghorn

Visiting Assistant Professor 1996

U.S. Food and Drug Administration (1996-1998) Conducted research on plant toxicants.

Senior Staff Fellow 1996-1998 Basic Food and Drug Law Course 1997 Member, Science Council 1998 Pharmacopoeia 1998 Botanical Nomenclature Subcommittee

City University of New York (CUNY) 1998-present: Conduct phytochemical research on medicinal in a laboratory comprised of undergraduate, masters, and doctoral students as well as visiting scientists and postdoctoral fellows, with grants from federal, state, and industrial sources.

Lehman College, CUNY Assistant Professor 1998-2003 Bronx, NY Associate Professor (tenured) 2004-2008

Professor 2009-present

Edward J. Kennelly—curriculum vitae 1

Chinese University of Hong Kong 2014-2015

Institute of Chinese Medicine Fulbright Scholar 2014-2015

Conducted research on traditional Chinese Medicine as practiced in Hong Kong as part of an 8-month sabbatical at the Chinese University sponsored by the Fulbright Scholar Program.

CUNY Doctoral Faculty Positions:

The Graduate Center Graduate Faculty 1998-present City University of New York Ph.D. Program in Biology New York, NY Graduate Faculty 1998-present Ph.D. Program in Biochemistry

Graduate Faculty 2006-present Ph.D. Program in Chemistry

CUNY Administrative Positions:

Chair of Biological Sciences Lehman College 2004-2007 Chaired a Department of 14 faculty, 5 technical lines, and approximately 40 adjunct lines. Website: http://www.lehman.edu/academics/biology

Executive Officer The Graduate Center, CUNY 2008-present Ph.D. Program in Biochemistry Currently direct CUNY-wide Ph.D. program with approximately 120 faculty and 50 doctoral students at eight different CUNY campuses in the five boroughs of New York City. Website: www.gc.cuny.edu/Page-Elements/Academics-Research-Centers-Initiatives/Doctoral-Programs/Biochemistry

Other Positions:

Honorary Research Associate The New York Botanical Garden 1999-present Institute of Economic Botany Conduct collaborative botanical research with scientists and doctoral students at the NYBG.

Food Advisory Board Food and Drug Administration 2009-2012 CFSAN Provide expertise to FDA on botanical dietary supplements on as needed basis.

American Society of Pharmacognosy Editor, ASP Newsletter 2006-present Editor of quarterly newsletter for professional organization of ca. 800 researchers with interest in natural products and human health.

American Society of Pharmacognosy Vice President 2014-2015

American Society of Pharmacognosy President 2015-2016

Edward J. Kennelly—curriculum vitae 2

PUBLICATIONS Over 135 publications in the area of plant secondary metabolites and ethnobotany. Edward J. Kennelly is the corresponding author in those marked with an asterisk (*).

2015 Chan, T.; Wu, S.B.; Kennelly, E.J.* 2015. Metabolic profiling and proper identification of botanicals: A case study of black cohosh. In Botanicals: Methods and Techniques for Quality & Authenticity, edited by Reynertson, K.; Mahmood, K. (CRC Press Taylor & Francis Group). Flores, G.; Wu, S.B.; Negrin, A.; Kennelly, E.J.* 2015. Chemical composition and antioxidant activity of seven cultivars of guava (Psidium guajava) fruits. Food Chem. 170: 327-35. PMID: 25306353 Fujita, A.; Sarkarb, D.; Wu, S.B.; Kennelly, E.J.; Shetty, K.; Genovesea, M.I. 2015. Evaluation of phenolic-linked bioactives of camu-camu (Myrciaria dubia Mc. Vaugh) for antihyperglycemia, antihypertension, antimicrobial properties and cellular rejuvenation. Food Research International doi:10.1016. Jackson, D.N.; Yang, L.; Wu, S.; Kennelly, E.J.; Lipke, P.N. 2015 Garcinia benzophenones promote hyphal apoptosis and potentiate activity of fluconazole in C. albicans biofilms. Antimicrob Agents Chemother. AAC.00820-15. [Epub ahead of print] Kulakowski. D.; Kitalong, C.; Negrin, A.; Tadao, V.R.; Balick, M.J.; Kennelly, E.J.* 2015. Traditional preparation of Phaleria nisidai, a Palauan tea, reduces exposure to toxic daphnane-type diterpene esters while maintaining immunomodulatory activity. J. Ethnopharmacol. 173: 273-279. Li, P.; Huang, W.; Jingxian Zhuo, J.-X.; Guo, Z.Y.; Cao, W.G.; Xu, L.; Ma, L.; Chen, Z.E.; Kennelly, E.J.; Wu, S.B.; Long, C.L. 2015. Seven new Lycopodium alkaloids from the aerial parts of Phlegmariurus squarrosus Tetrahedron 71: 5308-5314. Meyer, R.S.; Whitaker, B.D.; Little, D.P.; Wu, S.B.; Kennelly, E.J.; Long, C.L.; Litt, A. 2015. Parallel reductions in phenolic constituents resulting from the domestication of eggplant. Phytochemistry 115: 194-206. Ramirez, J.E.; Zambrano, R.; Sepulveda, B.; Kennelly, E.J.; Simirgiotis, M.J. 2015. Antocyanins and antioxidant capacities of six Chilean berries by HPLC-HR-ESI-ToF-MS. Food Chem. 176: 106-114.

2014

Ahmed, S.; Stepp, J.R.; Orians, C.; Griffin, T.; Matyas, C.; Robbat, A.; Cash, S.; Xue, D.; Long, C.; Unachukwu, U.; Buckley, S.; Small, D.; Kennelly, E. 2014. Effects of extreme climate events on tea (Camellia sinensis) functional quality validate indigenous farmer knowledge and sensory preferences in tropical China. PLoS One. 9:e109126. PMID: 25286362 Ahmed, S.; Orians, C.M.; Griffin, T.S.; Buckley, S.; Unachukwu, U.; Stratton, A.E.; Stepp, J.R.; Robbat, A. Jr.; Cash, S.; Kennelly, E.J. 2014. Effects of water availability and pest pressures on tea (Camellia sinensis) growth and functional quality. AoB Plants. PMID: 24790117 Brito, A.; Areche, C.; Sepúlveda, B.; Kennelly, E.J.; Simirgiotis, M.J. 2014. Anthocyanin characterization, total phenolic quantification and antioxidant features of some Chilean edible extracts. Molecules 19:10936-10955. PMID: 25072199 Fonseca, F.N.; Papanicolaou, G.; Lin, H.; Lau, C.B.; Kennelly, E.J.; Cassileth, B.R.; Cunningham-Rundles, S. 2014. Echinacea purpurea (L.) Moench modulates human T-cell cytokine response. Int Immunopharmacol. 19: 94-102. PMID: 24434371 Gu, R.H.; Wang, Y.H.; Long, B.; Kennelly, E.J.; Wu, S.H.; Liu, B.; Li, P.; Long, C.H. 2014. Prospecting for bioactive constituents from traditional medicinal plants through ethnobotanical approaches. Biological & Pharmaceutical Bulletin 37: 903-915. Guo, Z.Y.; Li, P.; Huang, W.; Wang, J.J.; Liu, Y.J.; Liu, B.; Wang, Y.L.; Wu, S.B.; Kennelly, E.J.; Long, C.L. 2014. Antioxidant and anti-inflammatory caffeoyl phenylpropanoid and secoiridoid glycosides Edward J. Kennelly—curriculum vitae 3

from Jasminum nervosum stems, a Chinese folk medicine. Phytochemistry. 106: 124-133. PMID: 25107663. Kavalier, A.R.; Ma, C.; Figueroa, M.; Kincaid, D.; Matthews, P.D.; Kennelly, E.J.* 2014. Targeted analysis of polyphenol metabolism during development of hop (Humulus lupulus L.) cones following treatment with prohexadione-calcium. Food Chem. 15: 145: 254-263. PMID: 24128475 Kulakowski, D.M.; Wu, S.B.; Balick, M.J.; Kennelly, E.J.* 2014. Merging bioactivity with liquid chromatography-mass spectrometry-based chemometrics to identify minor immunomodulatory compounds from a Micronesian adaptogen, Phaleria nisidai. J Chromatogr A. 1364: 74-82. PMID: 25218635. Lai, P.K.; Chan, J.Y.; Wu, S.B.; Cheng, L.; Ho, G.K.; Lau, C.P.; Kennelly, E.J.; Leung, P.C.; Fung, K.P.; Lau, C.B. 2014. Anti-inflammatory activities of an active fraction isolated from the root of Astragalus membranaceus in RAW 264.7 macrophages. Phytother Res. 28:395-404. PMID: 23640962. Li, P.; Wang, Y.; Guo, Z.Y.; Wu, S.B.; Kennelly, E.J.; Wang, J.J.; Tan, L.; Long, C.H. Separation of three bioactive isomers from Bidens pilosa by countercurrent chromatography. J. Liquid Chromatogr. Related Tech. 37. Lyles, J.T.; Negrin, A.; Khan, S.I.; He, K.; Kennelly, E.J.* 2014. In vitro antiplasmodial activity of benzophenones and xanthones from edible fruits of Garcinia species. Planta Med. 80: 676-681. PMID: 24963617 Ramirez, J.E.; Zambrano, R.; Sepulveda, B.; Kennelly, E.J.; Simirgiotis, M.J. 2014 Antocyanins and antioxidant capacities of six Chilean berries by HPLC-HR-ESI-ToF-MS. Food Chem. 176: 106-114. Wang, J.; Li, P.; Li, B.; Guo, Z.; Kennelly, E.J.; Long, C. 2014. Bioactivities of compounds from Elephantopus scaber, an ethnomedicinal Plant from Southwest China. Evid Based Complement Alternat Med. 2014: 569594. PMID: 24963325 Wang, J.; Petrova, V.; Wu, S.B.; Zhu, M.; Kennelly, E.J.; Long, C. 2014 Antioxidants from Gerbera piloselloides: an ethnomedicinal plant from southwestern China. Nat Prod Res. 28:2072-2075. PMID: 24895993 Wu, S.B.; Long, C.; Kennelly, E.J. 2014. Structural diversity and bioactivities of natural benzophenones. Nat. Prod. Rep. 31:1158-1174. PMID: 24972079 Wu, S.B.; Yue, G.G.; To, M.H.; Keller, A.C.; Lau, C.B.; Kennelly, E.J.* 2014. Transport in Caco-2 cell monolayers of antidiabetic cucurbitane triterpenoids from Momordica charantia fruits. Planta Med. 80: 907-911. PMID: 25116119

2013 Ahmed, S.; Peters, C.M.; Chunlin, L.; Meyer, R.; Unachukwu, U.; Litt, A.; Kennelly, E.J.; Stepp, J.R. 2013. Biodiversity and phytochemical quality in indigenous and state ‐ supported tea management systems of Yunnan, China. Conservation Letters 6: 28-36. Ahmed,S.; Orians, C.; Griffin, T.; Buckley, S.; Unachukwu, U.; Stratton, A.E.; Stepp, J.R.; Robbat, A.; Cash, S.; Kennelly, E.J. Effects of water availability and pest pressures on tea (Camellia sinensis) growth and functional quality. AoB Plants, plt054 Borquez, J.; Kennelly, E.J.; Simirgiotis, M.J. 2013. Activity guided isolation of isoflavones and hyphenated HPLC-PDA-ESI-ToF-MS metabolome profiling of Azorella madreporica Clos. from northern Chile. Food Res. Int. 52:288-297. Einbond, L.S.; Mighty, J.; Kashiwazaki, R.; Figueroa, M.; Jalees, F.; Acuna, U.M.; Le Gendre, O.; Foster, D.A.; Kennelly, E.J.* 2013. Garcinia benzophenones inhibit the growth of human colon cancer cells and synergize with sulindac sulfide and turmeric. Anticancer Agents Med. Chem. 13: 540-1550. Flores, G.; D Dastmalchi, K.; Wu, S.-B.; Whalen, K.; Dabo, A.J.; Reynertson, K.A.; Foronjy, R.F.; D'Armiento, J.M.; Kennelly, E.J.* 2013. Phenolic-rich extract from the Costa Rican guava (Psidium friedrichsthalianum) pulp with antioxidant and anti-inflammatory activity. Potential for COPD therapy. Food Chem. 141: 889-895. Edward J. Kennelly—curriculum vitae 4

Huang, W.; Wu, S.-B.; Wang, Y.-L.; Guo, Z.-Y.; Kennelly, E.J.; Long, C.-L. 2013 Chemical constituents from Striga asiatica and its chemotaxonomic study. Biochem. Syst. Ecol. 61: 3548-3559. Jiang, B.; Kronenberg, F.; Balick, M.J.; Kennelly, E.J.* 2013. Stability of black cohosh triterpene glycosides and polyphenols: potential clinical relevance. Phytomedicine, 20: 564-569. Kronenberg, F.; Kennelly, E.J. 2013. Phytochemical identity and stability of herbal products: challenges for clinical research. Maturitas. 76: 291-293. Lai, P.K.; Chan, J.Y.; Wu, S.B.; Cheng, L.; Ho, G.K.; Lau, C.P.; Kennelly, E.J.; Leung, P.C.; Fung, K.P.; Lau, C.B. 2013. Anti-inflammatory activities of an active fraction isolated from the root of Astragalus membranaceus in RAW 264.7 Macrophages. Phytother Res. DOI: 10.1002/ptr.5002. Li, P.; Yeling, W.; Zhiyong, G.; Wu, S.B.; Kennelly, E.J.; Jianjun, W.; Li, T.; Long, C.L.2013 Separation of three bioactive isomers from Bidens pilosa by countercurrent chromatography. Journal of Liquid Chromatography & Related Technologies DOI:10.1080/10826076.2013.853308 Ma, C.; Dastmalchi, K.; Flores, G.; Wu, S.B.; Pedraza-Peñalosa, P.; Long, C.; Kennelly, E.J.* 2013. Antioxidant and metabolite profiling of North American and neotropical blueberries using LC-TOF-MS and multivariate analyses. J. Agric. Food Chem. 61: 3548-3559. Ma, L.J.; Wang, Y.H.; Tang, G.H.; Wang, Y.L.; Ma, C.; Dastmalchi, K.; Kennelly, E.J.; Long, C.L. 2013. New monoterpene lactones from Actaea cimicifuga. Planta Med. 79: 308-311. Petrova, V.I.; Kennelly, E.J. 2013 Blueberries: A “super fruit” complement to cereals. Cereal Foods World 58: 13-17. Wu, S.B.; Long, C.; Kennelly, E.J.* 2013. Phytochemistry and health benefits of jaboticaba, an emerging fruit crop from Brazil. Food Res. Int. 54: 148-159. Wu, S.B.; Meyer, R.S.; Whitaker, B.D.; Litt, A.; Kennelly, E.J. 2013. A new liquid chromatography-mass spectrometry-based strategy to integrate chemistry, morphology, and evolution of eggplant (Solanum) species. J. Chromatogr. A 1314: 154-172. Wu, S.B.; Wu, J.; Yin, Z.; Zhang, J.; Long, C.; Kennelly, E.J.*; Zheng, S. 2013. Bioactive and marker compounds from two edible dark-colored Myrciaria fruits and the synthesis of jaboticabin. J. Agric. Food Chem. 61:4035-4043. Simirgiotis, M.J.; Ramirez, J.E.; Schmeda Hirschmann, G.; Kennelly, E.J. 2013. Bioactive coumarins and HPLC-PDA-ESI-ToF-MS metabolic profiling of edible queule fruits (Gomortega keule), an endangered endemic Chilean species. Food Research International 54: 532-543. Simirgiotis, M.J.; Schmeda-Hirschmann, G.; Bórquez, J.; Kennelly, E.J. 2013. The Passiflora tripartita (banana passion) fruit: A source of bioactive flavonoid C-glycosides isolated by HSCCC and characterized by HPLC–DAD–ESI/MS/MS. Molecules. 18:1672-1692.

2012 Acuna, U.M.; Dastmalchi, K.; Basile, M.J.; Kennelly, E.J.* 2012. Quantitative high-performance liquid chromatography photo-diode array (HPLC-PDA) analysis of benzophenones and biflavonoids in eight Garcinia species. J. Food Compos. Anal. 25: 215-220. Bradbury, L.M.T.; Shumskaya, M.; Tzfadia, O.; Wu, S.; Kennelly, E.J.; Wurtzel, E.T. 2012. Lycopene cyclase paralog CruP protects against reactive oxygen species in oxygenic photosynthetic organisms. Proc. Natl. Acad. Sci. U.S.A. 109: 10767-10768. Carter, G.T.; Kennelly, E.J.; O’Neil-Johnson, M., Editors 2012. 2012 International Congress on Natural Products Research: Global change, natural products and human health. Planta Medica 78. (Guest editor for Planta Medica special volume for ICNPR2012 that I helped to organize in New York City). Dastmalchi, K.; Flores, G.; Wu, S.; Ma, C.; Dabo, A.J.; Whalen, K.; Reynertson, K.A.; Foronjy, R.F.; D'Armiento, J.M.; Kennelly, E.J.* 2012. Edible Myrciaria vexator fruits: Bioactive phenolics for potential COPD therapy. Bioorg. Med. Chem. 20: 4549-4555. Flores, G.; Dastmalchi, K.; Dabo, A.J.; Whalen, K.; Pedraza-Penalosa, P.; Foronjy, R.F.; D'Armiento, J.M.; Kennelly, E.J.* 2012. Antioxidants of therapeutic relevance in COPD from the neotropical blueberry Anthopterus wardii. Food Chem. 131: 119-125. Flores, G.; Dastmalchi, K.; Paulino, S.; Whalen, K.; Dabo, A.J.; Reynertson, K.A.; Foronjy, R.F.; Edward J. Kennelly—curriculum vitae 5

D'Armiento, J.M.; Kennelly, E.J.* 2012. Anthocyanins from Eugenia brasiliensis edible fruits as potential therapeutics for COPD treatment. Food Chem. 134: 1256-1262. Huang, Q.; Bi, J.; Sun, Q.; Yang, F.; Wang, Y.; Tang, G.; Zhao, F.; Wang, H.; Xu, J.; Kennelly, E.J.; Long, C.; Yin, G. 2012. Bioactive isoquinoline alkaloids from Corydalis saxicola. Planta Med. 78: 65-70. Henderson, F.; Vandebroek, I.; Balick, M. J.; Kennelly, E.J. 2012. Ethnobotanical research skills for students of underrepresented minorities in STEM disciplines. Ethnobotany Research & Applications 10: 389-402. Nagler, M.; Kronenberg, F.; Kennelly, E.J.; Jiang, B.; Ma, C.H. 2012. The use of indicators for unobservable product qualities: Inferences based on consumer sorting. Int. J. Market. Stud. 4: 19-34. Quinlan, R.F.; Shumskaya, M.; Bradbury, L.M.T.; Beltran, J.; Ma, C.; Kennelly, E.J.; Wurtzel, E.T. 2012. Synergistic interactions between carotene ring hydroxylases drive lutein formation in plant carotenoid biosynthesis. Plant Physiol. 160: 204-214. Wu, S.B.; Dastmalchi, K.; Long, C.; Kennelly, E.J.* 2012. Metabolite profiling of jaboticaba (Myrciaria cauliflora) and other dark-colored fruit juices. J. Agric. Food Chem. 60: 7513-7525. Wu, S.B.; Meyer, R.S.; Whitaker, B.D.; Litt, A.; Kennelly, E.J. 2012. Antioxidant glucosylated caffeoylquinic acid derivatives in the invasive tropical soda apple, Solanum viarum. J. Nat. Prod. 75: 2246-2250. Yue, G.G.L.; Cheng, S.; Yu, H.; Xu, Z.; Lee, J.K.M.; Hon, P.; Lee, M.Y.H.; Kennelly, E.J.; Deng, G.; Yeung, S.K.; Cassileth, B.R.; Fung, K.; Leung, P.; Lau, C.B.S. 2012. The role of turmerones on curcumin transportation and P-glycoprotein activities in intestinal Caco-2 cells. J. Med. Food 15: 242-252. 2011 Dastmalchi, K.; Flores, G.; Petrova, V.; Pedraza-Penalosa, P.; Kennelly, E.J.* 2011. Edible neotropical blueberries: Antioxidant and compositional fingerprint analysis. J. Agric. Food Chem. 59: 3020-3026. Hong, F.; Xiao, W.; Ragupathi, G.; Lau, C.B.S.; Leung, P.C.; Yeung, K.S.; George, C.; Cassileth, B.; Kennelly, E.J.; Livingston, P.O. 2011. The known immunologically active components of Astragalus account for only a small proportion of the immunological adjuvant activity when combined with conjugate vaccines. Planta Med. 77, 817-824. Jiang, B.; Ma, C.; Motley, T.; Kronenberg, F.; Kennelly, E.J.* 2011. Phytochemical fingerprinting to thwart black cohosh adulteration: a 15 Actaea species analysis. Phytochem. Anal. 22, 339-351. Kavalier, A.R.; Litt, A.; Ma, C.; Pitra, N.J.; Coles, M.C.; Kennelly, E.J.*; Matthews, P.D. 2011. Phytochemical and morphological characterization of Hop (Humulus lupulus L.) cones over five developmental stages using high performance liquid chromatography coupled to time-of-flight mass spectrometry, ultrahigh performance liquid chromatography photodiode array detection, and light microscopy techniques. J. Agric. Food Chem. 59, 4783-4793. Kavalier, A.R.; Pitra, N.J.; Koelling, J.M.; Coles, M.C.; Kennelly, E.J.*; Matthews, P.D. 2011. Increase in cone biomass and terpenophenolics in hops (Humulus lupulus L.) by treatment with prohexadione-calcium. J. Agric. Food Chem. 59, 6720-6729. Keller, A.C.; Ma, J.; Kavalier, A.; He, K.; Brillantes, A.B.; Kennelly, E.J.* 2011. Saponins from the traditional medicinal plant Momordica charantia stimulate insulin secretion in vitro. Phytomedicine 19, 32-37. Ma, C.; Dastmalchi, K.; Whitaker, B.D.; Kennelly, E.J. 2011. Two new antioxidant malonated caffeoylquinic acid isomers in fruits of wild eggplant relatives. J. Agric. Food Chem. 59, 9645-9651. Ma, C.; Kavalier, A.R.; Jiang, B.; Kennelly, E.J.* 2011. Metabolic profiling of Actaea species extracts using high performance liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry. J. Chromatogr. A 1218, 1461-1476. Mazzola, E.P.; Parkinson, A.; Kennelly, E.J.; Coxon, B.; Einbond, L.S.; Freedberg, D.I. Utility of coupled-HSQC experiments in the intact structural elucidation of three complex saponins from Blighia sapida. Carbohydr. Res. 2011, 346, 759-768. Edward J. Kennelly—curriculum vitae 6

Nagler, M.; Kronenberg, F.; Kennelly, E.J.; Jiang, B.; 2011. Pricing for a credence good: An exploratory analysis. J. Prod. & Brand Manag. 20: 238-249 Xiao, W.; Motley, T.J.; Unachukwu, U.J.; Lau, C.B.S.; Jiang, B.; Hong, F.; Leung, P.; Wang, Q.; Livingston, P.O.; Cassileth, B.R.; Kennelly, E.J.* 2011. Chemical and genetic assessment of variability in commercial radix Astragali (Astragalus spp.) by ion trap LC-MS and nuclear ribosomal DNA barcoding sequence analyses. J. Agric. Food Chem. 59: 1548-1556.

2010 Acuna, U.M.; Figueroa, M.; Kavalier, A.; Jancovski, N.; Basile, M.J.; Kennelly, E.J.* Benzophenones and biflavonoids from Rheedia edulis. J. Nat. Prod. 2010, 73: 1775-1779. Ahmed, S.; Unachukwu, U.; Stepp, J.R.; Peters, C.M.; Long, C.; Kennelly, E.J. 2010. Pu-erh tea tasting in Yunnan, China: Correlation of drinkers' perceptions to phytochemistry. J. Ethnopharmacol., 132: 176-185. Fusco, D.; Liu, X.; Savage, C.; Taur, Y.; Xiao, W.; Kennelly, E.J.; Yuan, J.; Cassileth, B.; Salvatore, M.; Papanicolaou, G.A. 2010. Echinacea purpurea aerial extract alters course of influenza infection in mice. Vaccine 28: 3956-3962. Huang, Y.; Jiang, B.; Nuntanakorn, P.; Kennelly, E.J.; Shord, S.; Lawal, T.O.; Soni, K.K.; Mahady, G.B. 2010. Fukinolic acid derivatives and triterpene glycosides from black cohosh inhibit CYP isozymes, but are not cytotoxic to Hep-G2 cells in vitro. Curr. Drug Saf. 5: 118-124. Lin, H.; Stanchina, E.; Zhou, X.K.; Hong, F.; Seidman, A.; Fornier, M.; Xiao, W.; Kennelly, E.J.; Wesa, K.; Cassileth, B.R.; Cunningham-Rundles, S. 2010. Maitake beta-glucan promotes recovery of leukocytes and myeloid cell function in peripheral blood from paclitaxel hematotoxicity. Cancer Immunol. Immunother. 59: 885-897. Ma, C.; Whitaker, B.D.; Kennelly, E.J.* 2010. New 5-O-Caffeoylquinic acid derivatives in fruit of the wild eggplant relative Solanum viarum. J. Agric. Food Chem. 58, 11036-11042. Ma, J.; Whittaker, P.; Keller, A.C.; Mazzola, E.P.; Pawar, R.S.; White, K.D.; Callahan, J.H.; Kennelly, E.J.; Krynitsky, A.J.; Rader, J.I. 2010. Cucurbitane-type triterpenoids from Momordica charantia. Planta Med. 76: 1758-1761. Unachukwu, U.J.; Ahmed, S.; Kavalier, A.; Lyles, J.T.; Kennelly, E.J.* 2010. White and green teas (Camellia sinensis var. sinensis): variation in phenolic, methylxanthine, and antioxidant profiles. J. Food Sci. 75: C541-C548. Yang, H.; Figueroa, M.; To, S.; Baggett, S.; Jiang, B.; Basile, M.J.; Weinstein, I.B.; Kennelly, E.J.* 2010. Benzophenones and biflavonoids from Garcinia livingstonei fruits. J. Agric. Food Chem. 58: 4749-4755. Yue, G.G.; Chan, B.C.; Hon, P.; Kennelly, E.J.; Yeung, S.K.; Cassileth, B.R.; Fung, K.; Leung, P.; Lau, C.B. 2010. Immunostimulatory activities of polysaccharide extract isolated from Curcuma longa. Int. J. Biol. Macromol. 47: 342-347.

2009 Acuna, U.M.; Jancovski, N.; Kennelly, E.J. 2009. Polyisoprenylated benzophenones from : potential drugs and lead compounds. Current Topics in Medicinal Chemistry 9: 1560-1580 Keller, A.C.; Vandebroek, I.; Liu, Y.; Balick, M.J.; Kronenberg, F.; Kennelly, E.J.*; Brillantes, A.M. 2009. Costus spicatus tea failed to improve diabetic progression in C57BLKS/J db/db mice, a model of type 2 diabetes mellitus. J. Ethnopharmacol., 121: 248-254. Betz, J.M.; Anderson, L.; Avigan, M.I.; Barnes, J.; Farnsworth, N.R.; Gerdén, B.; herderson, L.; Kennelly, E.J.; Koetter, U.; Lessard, S.; Low Dog, T.; McLaughlin, M.; Naser, B.; Osmers, R.G.W.; Pellicore, L.S.; Senior, J.R.; van Breeman, R.B.; Wuttke, W.; Cardellina, J.H. 2009. Black cohosh: considerations of safety and benefit. Nutrition Today 44: 155-162

2008 Chan, B.Y.; Lau, K.S.; Jiang, B.; Kennelly, E.J.; Kronenberg, F.; Kung, A.W. 2008. Ethanolic extract of Edward J. Kennelly—curriculum vitae 7

Actaea racemosa (black cohosh) potentiates bone nodule formation in MC3T3-E1 preosteoblast cells. Bone, 43:567-573. Jiang, B.; Lyles, J.T.; Reynertson, K.A.; Kronenberg, F.; Kennelly, E.J.* 2008 Stability evaluation of selected polyphenols and triterpene glycosides in black cohosh. J. Agric. Food Chem., 56: 9510-9519. Jiang, B.; Reynertson, K.A.; Keller, A.C.; Einbond, L.S.; Bemis, D.L.; Weinstein, I.B.; Kronenberg, F.; Kennelly, E.J.* 2008. Extraction methods play a critical role in chemical profile and biological activities of black cohosh. Nat. Prod. Comm., 3: 1519-1532. Protiva, P.; Hopkins, M.E.; Baggett, S.; Yang, H.; Lipkin, M.; Holt, P.R.; Kennelly, E.J.; Weinstein, I.B. 2008. Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response. J. Cancer, 123: 687-694. Reynertson, K.A.; Yang, H.; Jiang, B.; Basile, M.J.; Kennelly, E.J.* Quantitative analysis of antiradical phenolic constituents from fourteen edible Myrtaceae fruits. Food Chem., 109: 883-890. 2007 Einbond, L.S.; Shimizu, M.; Nuntanakorn, P.; Seter, C.; Cheng, R.; Jiang, B.; Kronenberg, F.; Kennelly, E.J.; Weinstein, I.B. 2007. Actein and a fraction of black cohosh potentiate antiproliferative effects of chemotherapy agents on human breast cancer cells. Planta Med. 72: 1200-1206. Einbond, L.S.; Su, T.; Wu, H.A.; Friedman, R.; Wang, X.; Jiang, B.; Hagan, T.; Kennelly, E.J.; Kronenberg, F.; Weinstein, I.B. 2007 Gene expression analysis of the mechanisms whereby black cohosh inhibits human breast cancer cell growth. Anticancer Res. 27: 697-712 Ma, J.; Dey, M.; Yang, H.; Poulev, A.; Pouleva, R.; Dorn, R.; Lipsky, P.E.; Kennelly, E.J.; Raskin, I. 2007. Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii. Phytochemistry. 68: 1172-1178. Nuntanakorn, P.; Jiang, B.; Yang, H.; Cervantes-Cervantes, M.; Kronenberg, F.; Kennelly, E.J.* 2007. Analysis of polyphenolic compounds and radical scavenging activity of four Actaea species. Phytochem. Anal. 18: 219-228 Simirgiotis, M.J.; Adachi, S.; To, S.; Yang, H.; Reynertson, K.A.; Basile, M.J.; Gil, R.R.; Weinstein, I.B.; Kennelly, E.J.* 2007. Cytotoxic chalcones and antioxidants from the fruits of Syzygium samarangense (wax jambu). Food Chem., 107: 813-819 2006 Baggett, S.; Mazzola, E.P.; Kennelly, E.J.* 2006. Benzophenones : Isolation, structural elucidation, and biological activities In : Studies in Natural Product Chemistry, Vol 32 , Atta-Ur-Rahman, Editor, (Elsevier, New York), pp 721-771. Jiang, B.; Kronenberg, F.; Balick, M.J.; Kennelly, E.J.* 2006. Analysis of formononetin from black cohosh (Actaea racemosa). Phytomedicine, 13: 477-486. Jiang, B.; Kronenberg, F.; Nuntanakorn, P.; Qiu, M.-H.; Kennelly, E.J.* 2006. Evaluation of the botanical authenticity and phytochemical profile of black cohosh products by high-performance liquid chromatography with selected ion monitoring liquid chromatography-mass spectrometry. J. Agric. Food Chem. 54: 3242-3253. (Received national press coverage, including Science News). Logendra, S.; Ribnicky, D.M.; Yang, H.; Poulev, A.; Ma, J.; Kennelly, E.J.; Raskin, I. 2006. Bioassay-guided isolation of aldose reductase inhibitors from Artemisia dracunculus. Phytochemistry, 67: 1539-1546. Luo, X.-D.; Wu, D.-G.; Cai, X.-H.; Kennelly, E.J. 2006. New antioxidant phenolic glycosides from Walsura yunnanensis. Chem. Biodivers. 3: 224-230 Nuntanakorn, P.; Jiang, B.; Einbond, L.; Yang, H.; Kronenberg, F.; Weinstein, I.B..; Kennelly, E.J.* 2006. Polyphenolic constituents from Actaea racemosa, J. Nat. Prod., 69: 314-318. Reynertson, K.A.; Wallace, A.M.; Adachi, S.; Gil, R.R.; Yang, H.; Basile, M.J.; D’Armiento, J.; Weinstein, I.B.; Kennelly, E.J.* 2006. Bioactive depsides and anthocyanins from jaboticaba (Myrciaria cauliflora). J. Nat. Prod. 69: 1228-1230. Yang, H.; Jiang, B.; Reynertson, K.A.; Basile, M.J.; Kennelly, E.J.* 2006. Comparative analyses of bioactive coumarins from seven parts of Mammea americana by HPLC-PDA with LC-MS. J. Agric. Food Chem. 54: 4114-4120. Edward J. Kennelly—curriculum vitae 8

2005 Baggett, S.; Protiva, P.; Mazzola, E.P.; Yang, H.; Ressler, E.T.; Basile, M.J. Weinstein, I.B.; Kennelly, E.J.* 2005.Bioactive benzophenones from Garcinia xanthochymus fruits. J. Nat. Prod., 68: 379-382. Jiang , B.; Yang, H.; Nuntanakorn, P.; Balick, M.J.; Kronenberg, F.; Kennelly, E.J.* 2005. The value of plant collections in ethnopharmacology: a case study of an 85-year-old black cohosh (Actaea racemosa L.) sample. J. Ethnopharmacol., 96: 521-528. (Received national press coverage,) Reynertson, K.A.; Balick, M.J.; Lee, R.; Raynor, W.; Pelep, Y.; Kennelly, E.J.* 2005. A traditional method of Cinnamomum carolinense preparation eliminates safrole from a therapeutic Pohnpeian tea. J. Ethnopharmacol., 102: 269-274. Yang, H.; Protiva, P.; Gil, R.; Jiang, B.; Baggett, S.; Weinstein, I.B.; Kennelly, E.J.* 2005. Antioxidant and cytotoxic isoprenylated courmarins from Mammea americana. Planta Med., 71: 852-860. 2004 Einbond, L.; Reynertson, K.A.; Luo, X.-D.; Basile, M.J.; Kennelly, E.J.* 2004. Anthocyanin antioxidants from edible fruits. Food Chem., 84: 23-28 Einbond, L.; Shimazu, M.; Xiao, D.-H.; Nuntanakorn, P.; Lim, J.T.E.; Suzui, M.; Seter, TC.; Pertel, T.; Kennelly, E.J.; Kronenberg, F.; Weinstein, I.B. 2004. Growth inhibitory activity of extracts and purified components of black cohosh on human breast cancer cells. Breast Canc. Res. Treat., 83: 221-231. Ma, J.; Yang, H.; Basile, M.J.; Kennelly, E.J.* 2004. Analysis of polyphenolic antioxidants from the fruits of three Pouteria species by selected ion monitoring liquid chromatography-mass spectrometry. J. Agric. Food Chem., 52: 5873-5878. 2003 Lupu, R.; Mehmi I.; Atlas, E.; Tsai, M.-S.; Pisha, E.; Oketch-Rabah, H.A.; Nuntanakorn, P.; Kennelly, E.J.; Kronenberg F. 2003. Black cohosh, a menopausal remedy, does not have estrogenic activity and does not promote breast cancer cell growth. Int. J. Oncol. 23: 1407-1412. Ma, J.; Luo, X.-D.; Protiva, P.; Yang, H.; Ma, C.; Basile, M.J.; Weinstein, I.B.; Kennelly, E.J.* 2003. Bioactive novel polyphenols from the fruit of Manilkara zapota (sapodilla). J. Nat. Prod., 66: 983-986. Ososki, A.L.; Kennelly, E.J.* Phytoestrogens: A review of the present state of research. 2003. Phytother. Res., 17: 845-869. (Listed by John Wiley and Sons as one of the top three most accessed articles in Phytotherapy Research in 2004.) Yang, H.; Protiva, P.; Cui, B.; Ma, C.; Baggett, S.; Hequet, V.; Mori, S.; Weinstein, I.B.; Kennelly, E.J.* 2003. New bioactive polyphenols from Theobroma grandiflorum (“cupuaçu”). J. Nat. Prod., 66: 1501-1504. 2002 Luo, X.-D.; Basile, M.J.; Kennelly, E.J.* 2002. Polyphenolic antioxidants from the fruits of Chrysophyllum cainito (Star Apple). J. Agric. Food Chem., 50: 1379-1382. Kennelly, E.J. Sweet and non-sweet constituents of Stevia rebaudiana. 2002. In Stevia: Medicinal and Aromatic Plants - Industrial Profiles. A.D. Kinghorn, Ed. Taylor & Francis, London, pp. 68-85. Kennelly, E.J.*; Baggett, S.; Nuntanakorn, P.; Ososki, A.L.; Mori, S.A.; Duke, J.; Coleton, M.; Kronenberg, F. 2002. Analysis of thirteen populations of black cohosh for formononetin. Phytomedicine 9: 461-467. Muño-Acuña, U.; Atha, D.; Ma, J.; Nee, M.; Kennelly, E.J.* 2002. Antioxidant capacities of ten edible North American fruits. Phytother. Res., 16: 63-65. Opler, A.; Mizell, R.; Robert, A.; Cervantes-Cervantes, M.; Kincaid, D.; Kennelly, E.J. 2002. Use of brine shrimp assay to study herbal teas in the classroom. Am. Bio. Teach. 64: 516-524.

2000 Irikura, B.; Kennelly, E.J.* 2000. Blue cohosh. The Physician’s Guide to Alternative Medicine. Vol. II. American Health Consultants, Atlanta, pp. 193-195.

Edward J. Kennelly—curriculum vitae 9

1999 Irikura, B.; Kennelly, E.J.* 1999. Blue cohosh: A word of caution. Altern. Ther. Women’s Health, 1: 81-83. Kennelly, E.J.*; Mazzola, E.P.; Flynn, T.J.; McCloud, T.G.; Danford, D.E.; Betz, J.M. 1999. Detecting potential teratogenic alkaloids from blue cohosh rhizomes using an in vitro rat embryo culture. J. Nat. Prod., 62: 1385-1389. 1998 Chang, L.-C.;Bhat, K.P.L.; Pisha, E.; Kennelly, E.J.; Fong, H.H.S.; Pezzuto, J.M.; Kinghorn, A.D. 1998. Activity-guided isolation of steroidal alkaloid antiestrogen-binding site inhibitors from Pachysandra procumbens. J. Nat. Prod., 61: 1257 -1262. Kinghorn, A.D.; Cui, B.; Kennelly, E.J.; Luyengi, L.; Chang, L.C. 1998. Novel plant constituents of biological interest. In Proceedings of the International Symposium on Natural Medicines. H. Ageta, N. Aimi, Y. Ebizuka, T. Fujita, and G. Honda, Eds. Elsevier Science B.V., New York, pp. 125-135. Kinghorn, A.D.; Ito, A.; Kennelly, E.J.; Kim, N.-C.; Westenburg, H.E. 1998. Studies on some edible and medicinal plants of Mesoamerica. Proc. West. Pharmacol. Soc., 41: 253-258. Kinghorn, A.D.; Kaneda, N.; Baek, N.-I.; Kennelly, E.J.; Soejarto, D.D. 1998. Noncariogenic intense natural sweeteners. Med. Res. Rev., 18: 347-360.

1997 Chung, M.-S.; Kim, N.-C.; Long, L.; Shamon, L.; Ahmad, W.-Y.; Sagrero-Nieves, L.; Kardono, L.B.S.; Kennelly, E.J.; Pezzuto, J.M.; Soejarto, D.D.; Kinghorn, A.D. 1997. Dereplication of saccharide and polyol constituents of candidate sweet-tasting plants: Isolation of the sesquiterpene glycoside mukurozioside IIb as a sweet principle of Sapindus rarak. Phytochem. Anal., 8: 49-54. Shao, Y.; Poobrasert, O.; Kennelly, E.J.; Chin, C.-K.; Ho, C.-T.; Huang, M.-T.; Garrison, S.A.; Cordell, G.A. 1997. Steroidal saponins from Asparagus officinalis and their antitumor activity. Planta Med., 63: 258-260. Kennelly, E.J.* 1997. Status of testing for botanical products in the U.S. market. Food Test. Anal., 3: 8-9. Kennelly, E.J.; Gerhäuser, C.; Graham, J.G.; Beecher, C.W.W.; Pezzuto, J.M.; Kinghorn, A.D. 1997. Induction of quinone reductase by withanolides isolated from Physalis philadelphica (tomatillos). J. Agric. Food Chem., 45: 3771-3777. Kinghorn, A.D.; Kennelly, E.J. 1997. Medical applications of plant toxicants. In CRC Handbook of Plant and Fungal Toxicants. J.P.F. D’Mello, Ed. CRC Press, Boca Raton, FL, pp. 255-268. Shin, K.H.; Woo, W.S.; Lim, S.S.; Shrim, C.S.; Chung, H.S.; Kennelly, E.J.; Kinghorn, A.D. 1997. Elgonica-dimers A and B, Two potent alcohol metabolism inhibitory constituents of Aloe arborescens. J. Nat. Prod., 60: 1180 -1182. 1996 Kennelly, E.J.; Cai, L.; Kim, N.-C.; Kinghorn, A.D. 1996. Abrusoside E, A further sweet-tasting cycloartane glycoside from the of Abrus precatorius. Phytochemistry, 41: 1381-1383. Kennelly, E.J.; Suttisri, R.; Kinghorn, A.D. 1996. Novel sweet-tasting saponins of the cycloartane, oleanane, secodammarane, and steroidal types. In Saponins: Chemistry and Biological Activity. G.R. Waller and K. Yamaski, Eds. Plenum Publishing Corp., New York, pp. 13-24. 1995 Kennelly, E.J.; Cai, L.; Long, L.; Shamon, L.; Zaw, K.; Zhou, B.-N.; Pezzuto, J.M.; Kinghorn, A.D. 1995. Novel highly sweet secodammarane glycosides from Pterocarya paliurus. J. Agric. Food Chem., 43: 2602-2607. Kinghorn, A.D.; Kennelly, E.J. 1995. Discovery of highly sweet compounds from natural sources. J. Chem. Educ., 72: 676-680. Kinghorn, A.D.; Kennelly, E.J.; Luyengi, L. 1995. New pharmaceuticals and non-nutritive sweeteners from plants. In Phytochemicals and Health. D.L. Gustine and H.E. Flores, Eds. American Society of Plant Physiologists: Rockville, MD, 236-246.

1994 Edward J. Kennelly—curriculum vitae 10

Baek, N.-I.; Kennelly, E.J.; Kardono, L.B.S.; Tsauri, S.; Padmawinata, K.; Soejarto, D.D.; Kinghorn, A.D. 1994. Flavonoids and a proanthocyanidin from the rhizomes of Selliguea feei. Phytochemistry, 36: 513-518. Nishizawa, M.; Yamada, H.; Yamaguchi, Y.; Hatakeyama, S.; Lee, I.-S.; Kennelly, E.J.; Kim, J.; Kinghorn, A.D. 1994. Structure revision of polypodoside A: Major sweet principle of Polypodium glycyrrhiza. Chem. Lett., 1555-1558, 1979. 1993 Lewis, W. H.; Kennelly, E.J.; Bass, G.N.; Wedner, H.J.; Elvin-Lewis, M.P.; Fast, F.D. 1991. Ritualistic use of the holly Ilex guayusa by Amazonian Jívaro Indians. J. Ethnopharmacol., 33: 25-30. Kennelly, E.J.; Lewis, W.H.; Winter, R.E.K.; Johnson, S.; Elvin-Lewis, M.P.; Gossling, J. 1993. Triterpenoid saponins from Gouania lupuloides. J. Nat. Prod., 56: 402-410. 1991 Kohl, D.H.; Kennelly, E.J.; Zhu, Y.; Schubert, K.R.; Shearer, G. 1991. Proline accumulation, nitrogenase (C2H2 reducing) activity, and activities of enzymes related to proline metabolism in water stressed nodules. J. Exp. Bot., 42: 831-837.

Patents: D’Armiento, J.; Kennelly, E.J.; Reynertson, K.A.; Wallace, A.M. 2006. Bioactive depside and anthocyanin compounds, compositions, and methods of use. U.S. Provisional Application for Patent, filed July 31, 2006. Kavalier, A.R.; Matthews, P.D.; Rademacher, W.; Kennelly, E.J. 2011. Treatment of hop plants with acylcyclohexanedione bioregulators. PCT Int. Appl. 2010-EP60765; 2009-230120P, 14.

INTERNATIONAL TALKS Since joining the faculty at CUNY in 1998, Dr. Kennelly has given talks at conferences and universities around the world. Some examples are provided below.

Kennelly, E.J. Yunnan Agricultural University (Yunnan, China, August, 1998) "Bioactive natural products and biotechnology." Kennelly, E.J. Silpakorn University (Bangkok, Thailand, August, 1998) "Botanical dietary supplements." Kennelly, E.J. Institute of Chemistry, University of Talca (Talca, Chile, January, 2008), “Edible Clusiaceae fruits for cancer chemoprevention.” Kennelly, E.J. Chinese University of Hong Kong (New Territories, Hong Kong, May, 2010) “Plant polyphenols for human health.” (Dr. Kennelly has presented multiple talks at Chinese University of Hong Kong) Kennelly, E.J. Minzu University (Beijing, China, January 2012) “Plants polyphenols for chronic obstructive pulmonary disease.” (Dr. Kennelly has presented multiple talks at Minzu University as part of a joint grant). Kennelly, E.J. 13th International Congress of Ethnobiology (Montpellier, France, May, 2012), “Metabolomics to enhance ethnopharmacological studies in China.” Kennelly, E.J. School of Pharmacy, Fudan University (Shanghai, China, January, 2013), “Metabolite profiling of jaboticaba (Myrciaria cauliflora) and other dark-colored fruit juices.”

GRANTS Over the course of 15 years at CUNY, Dr. Kennelly has brought in about $4,500,000 (direct and indirect costs) in grants from federal, state, and private funding agencies to support his research in natural products research. A few recent examples appear below.

Fulbright Scholar, The Chinese University of Hong Kong. “Modern Traditional Chinese Medicine as Practiced in Hong Kong” (10/2014-3/2015). Edward J. Kennelly, Scholar.

Edward J. Kennelly—curriculum vitae 11

National Institutes of Health—National Center for Complementary and Alternative Medicine, “DNA and phytochemical fingerprinting of Actaea species” (5/2006-6/2008), $250,000, (Research grant). Edward J. Kennelly, PI, Timothy Motley, The New York Botanical Garden, CoPI.

National Institutes of Health—National Institute of General Medical Sciences, SCORE Program “Plant polyphenols for chronic obstructive pulmonary disease” (9/2008-8/2013), $700,000 (Research grant). Edward J. Kennelly, PI.

Chinese Ministry of Education, “Academic Innovation Base on Ethnobiology and Technologies for Sustainable Use of Biological Resources” (1/1/2008-12/31/2017). Chinese sponsored grant to have foreign experts work with researchers at Minzu University (Beijing) to conduct studies on how minority groups in China use plants. Edward J. Kennelly (Foreign Expert)

PSC-CUNY Ritualistic, Use of Theobroma cacao in Mayan Culture. (6/1/2013-5/31/2013) Study of chocolate residues in ancient Mayan vessels. Edward J. Kennelly, PI.

Edward J. Kennelly—curriculum vitae 12