Norflex, Tablet

Total Page:16

File Type:pdf, Size:1020Kb

Norflex, Tablet NORFLEX™ Orphenadrine citrate 100 mg tablets Consumer Medicine Information What is in this leaflet Your doctor may have prescribed allergies to any other medicines, NORFLEX for another purpose. foods, preservatives or dyes This leaflet answers some common Ask your doctor if you have any any heart problems questions about NORFLEX tablets. questions about why this medicine any liver or kidney problems. However it does not contain all the has been prescribed for you. Tell your doctor if you are available information. Your doctor pregnant or intend to become and pharmacist have more information about this medicine. pregnant or you are breast-feeding or plan to breast-feed. If you have any questions about Before you take NORFLEX that are not answered NORFLEX Your doctor or pharmacist can discuss the risks and benefits by this leaflet, please ask your involved. doctor or pharmacist. When you must not take it If you are not sure whether to start All medicines have risks and Do not take NORFLEX if: taking this medicine, talk to your benefits. Your doctor has weighed the risks of you taking NORFLEX you have had an allergic doctor. reaction to orphenadrine citrate against the benefits before or to any of the ingredients Taking other medicines prescribing it for you. listed at the end of this leaflet. If you are worried about taking Tell your doctor or pharmacist if you have any of the following: this medicine please talk to your you are taking any other doctor or pharmacist. glaucoma medicines, including any that you buy without a prescription from Keep this leaflet with your (high pressure in the eye) your pharmacy, supermarket or medicine as you may want to read intestinal blockage, stomach health-food shop. it again. ulcer or oesophageal disease Some medicines and NORFLEX may enlarged prostate or bladder interfere with each other. These obstruction include: What NORFLEX is myasthenia gravis anticholinergics (medicines used used for (a condition in which the muscles to relieve stomach cramps or become weak and tire easily) spasms) The name of your medicine is the expiry date on the bottle has medicines used to treat NORFLEX. passed depression The active ingredient in NORFLEX the packaging shows signs of dextropropoxyphene is orphenadrine citrate, which is a tampering. other central nervous system skeletal muscle relaxant. It acts in the Do not give this medicine to a child (CNS) depressant drugs, central nervous system to produce its under the age of 12 years. including alcohol. muscle relaxant effects. Safety and effectiveness in children Examples of CNS depressants are NORFLEX is used to help relax younger than 12 years have not been antihistamines or medicines for certain muscles in your body and to hayfever, other allergies or colds; relieve the pain and discomfort established. sedatives or tranquilizers; caused by sprains, strains or other Before you start to take it narcotic analgesics; barbiturates; injury to your muscles. medicines for seizures; Tell your doctor or pharmacist if NORFLEX is also used to treat anaesthetics, including some you have: tension headache and persistent dental anaesthetics; and other hiccoughs. muscle relaxants. NORFLEX™ 1 You may need different amounts of even if there are no signs of NORFLEX is a prescription your medicines, or you may need to discomfort or poisoning. medicine and has been prescribed for take different medicines. Your doctor You may need urgent medical you only. or pharmacist has more information attention. Do not take NORFLEX to treat on medicines to be careful with or Symptoms of an overdose may any other complaints unless your avoid while taking NORFLEX. include excitement, confusion and doctor tells you to. delirium leading to coma, convulsions, rapid heart rate, dilated pupils and difficulty passing urine. How to take NORFLEX Side Effects Follow all directions given to you All medicines can cause unwanted by your doctor or pharmacist side effects. Sometimes they are carefully. While you are taking NORFLEX serious, most of the time they are not. They may differ from the Tell your doctor if you experience information contained in this leaflet. Things you must do any of the following side effects If you do not understand the and they bother you: Tell all doctors, dentists and instructions on the bottle ask your dry mouth. doctor or pharmacist for help. pharmacists who are treating you that you are taking NORFLEX. nausea, vomiting How much to take If you become pregnant while abdominal or stomach cramps or pain Take NORFLEX tablets only as taking this medicine, tell your directed by your doctor or doctor immediately. blurred vision, unusually enlarged pharmacist. Be careful driving or operating pupils or other changes to your vision. Your doctor will prescribe the correct machinery until you know how the dose for you. medicine affects you. headache The usual dose of NORFLEX for In some people NORFLEX may tremor or shaking adults is one tablet twice a day. cause blurred vision, drowsiness, dizziness, short periods of dizziness, or to become drowsy, lightheadedness, fainting Take one tablet in the morning and dizzy, lightheadedness or to faint, or the other tablet in the evening. be less alert than usual. It may also drowsiness Do not change the dose unless your cause muscle weakness. If you have muscle weakness doctor tells you to do so. any of these symptoms do not drive feeling confused or agitated or operate machinery or do anything seeing, feeling or hearing things If you forget to take your else that could be dangerous. that are not there medicine If you experience dry mouth when rash, itchiness or other skin If you miss a dose of this medicine taking NORFLEX and your dry conditions. and remember within an hour or so mouth continues for more than 2 of the missed dose, take it right weeks speak to your dentist. Tell your doctor immediately or go away. If you do not remember until Continued dryness of the mouth can to hospital if any of the following side effects occur: later, skip the missed dose and take increase the chance of dental disease, the next dose when you would including tooth decay, gum disease shortness of breath; troubled normally. and fungal infections. breathing; tightness in chest and/or wheezing and skin rash Do not take a double dose. For temporary relief of dry mouth use sugarless gum or sweets, melt sores, ulcers or white spots on If you take too much some ice in your mouth or use a lips or in mouth; swollen and/or (overdose) saliva substitute. painful glands; unusual bruising or bleeding; unusual tiredness or If you or someone else has taken Things you must not do weakness. too much NORFLEX contact your doctor or pharmacist, or the Do not give NORFLEX to anyone These are serious side effects and may need urgent medical attention. Poisons Information Centre (0800 else even if they have the same Serious side effects are rare. POISON or 0800 764 766). Do this condition as you. NORFLEX™ 2 Tell your doctor or pharmacist if ethylcellulose you notice anything which is lactose. making you unwell. This medicine does not contain Other side effects not listed above gluten or preservatives. may also occur in some people. Sponsor After taking NORFLEX NORFLEX is supplied in New Zealand by: Storage iNova Pharmaceuticals (New Keep NORFLEX in a cool dry Zealand) Limited c/- Simpson Grierson place where the temperature stays 88 Shortland Street below 30°C. Auckland 1141 Do not store it or any other Toll free number: 0508 375 394 medicine in the bathroom or near a This leaflet was prepared in May sink. Do not leave it on a window 2018 sill or in the car. Heat and dampness can destroy some medicines. ™ = Trademark Keep all medicines where children cannot reach them. A locked cupboard at least 1.5 metres above the ground is a good place to store medicines. Disposal If your doctor tells you to stop taking this medicine, or if it has passed its 'Use By' date ask your pharmacist what to do with any tablets that are left over. Product Description What it looks like NORFLEX are white tablets with N/X on one side and no markings on the other side. It comes in bottles containing 100 tablets. Ingredients Each NORFLEX tablet contains orphenadrine citrate 100 mg. It also contains: magnesium stearate colloidal anhydrous silica NORFLEX™ 3 .
Recommended publications
  • Orphenadrine Hydrochloride 50Mg/5Ml Oral Solution Rare (Affect More Than 1 in 10,000 People) N Forgetting Things More Than Usual
    Uncommon (affect more than 1 in 1000 people) n Constipation Package Leaflet: Information for the user n Greater sensitivity to things around you or feeling nervous n Feeling light-headed and an unusual feeling of excitement (elation) n Difficulty sleeping or feeling tired. Orphenadrine Hydrochloride 50mg/5ml Oral Solution Rare (affect more than 1 in 10,000 people) n Forgetting things more than usual. Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. Reporting of side effects n Keep this leaflet. You may need to read it again. If you get any side effects, talk to your doctor, n If you have any further questions, ask your doctor pharmacist or nurse. This includes any possible side or pharmacist. effects not listed in this leaflet. You can also report n This medicine has been prescribed for you only. side effects directly (see details below). By reporting Do not pass it on to others. It may harm them, even side effects you can help provide more information on if their signs of illness are the same as yours. the safety of this medicine. n If you get any side effects, talk to your doctor or United Kingdom pharmacist. This includes any possible side effects not listed in this Yellow Card Scheme leaflet. See section 4. Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or What is in this leaflet: Apple App Store. 1. What Orphenadrine Hydrochloride Oral Solution is and what is it used for 2.
    [Show full text]
  • Risk Based Requirements for Medicines Handling
    Risk based requirements for medicines handling Including requirements for Schedule 4 Restricted medicines Contents 1. Introduction 2 2. Summary of roles and responsibilities 3 3. Schedule 4 Restricted medicines 4 4. Medicines acquisition 4 5. Storage of medicines, including control of access to storage 4 5.1. Staff access to medicines storage areas 5 5.2. Storage of S4R medicines 5 5.3. Storage of S4R medicines for medical emergencies 6 5.4. Access to storage for S4R and S8 medicines 6 5.5. Pharmacy Department access, including after hours 7 5.6. After-hours access to S8 medicines in the Pharmacy Department 7 5.7. Storage of nitrous oxide 8 5.8. Management of patients’ own medicines 8 6. Distribution of medicines 9 6.1. Distribution outside Pharmacy Department operating hours 10 6.2. Distribution of S4R and S8 medicines 10 7. Administration of medicines to patients 11 7.1. Self-administration of scheduled medicines by patients 11 7.2. Administration of S8 medicines 11 8. Supply of medicines to patients 12 8.1. Supply of scheduled medicines to patients by health professionals other than pharmacists 12 9. Record keeping 13 9.1. General record keeping requirements for S4R medicines 13 9.2. Management of the distribution and archiving of S8 registers 14 9.3. Inventories of S4R medicines 14 9.4. Inventories of S8 medicines 15 10. Destruction and discards of S4R and S8 medicines 15 11. Management of oral liquid S4R and S8 medicines 16 12. Cannabis based products 17 13. Management of opioid pharmacotherapy 18 14.
    [Show full text]
  • Prescription Regulations Summary Chart Who Hold an Approval to Prescribe Methadone from Their
    Products included in the Triplicate Prescription Program* This is a reference list provided for convenience. While all generic medication names appear, only sample brand names are provided and it should not be viewed as an all-inclusive listing of all trade names of drugs included in the Triplicate Prescription Program. BUPRENORPHINE METHADONE BuTrans, Suboxone** Metadol, Methadose - May only be prescribed by physicians Prescription regulations summary chart who hold an approval to prescribe methadone from their BUTALBITAL PREPARATIONS provincial regulatory body*** Summary of federal and provincial laws governing prescription drug ordering, Fiorinal, Fiorinal C ¼ & C ½, Pronal, Ratio-Tecnal, records, prescription requirements, and refills Ratio-Tecnal C ¼ & C ½, Trianal, Trianal C ½ METHYLPHENIDATE Biphentin®, Foquest®, and Concerta® brands are excluded Revised 2019 BUTORPHANOL from TPP prescr ip t i o n p a d req u ir e m e n t s (generic versions Butorphanol NS, PMS-Butorphanol, Torbutrol (Vet), of these products require a triplicate presc ription) Torbugesic (Vet) Apo-Methyphenidate, PHL-Methylphenidate, PMS- Prescription regulations DEXTROPROPOXYPHENE Methylphenidate, PMS-Methylphenidate ER, Ratio- None identified Methylphenidate, Ritalin, Ritalin SR, Sandoz- According to the Standards of Practice for Pharmacists and Pharmacy Technicians: Methylphenidate SR, Teva-Methylphenidate ER-C FENTANYL/SUFENTANIL/ALFENTANIL 6.4 Neither a pharmacist nor a pharmacy technician may dispense a drug or blood product under a Alfentanil Injection,
    [Show full text]
  • Choice of Drugs in the Treatment of Rheumatoid Arthritis
    RHEUMATOLOGY IN GENERAL PRACTICE 7 Those with predominant but never exclusive involvement of the terminal finger joint, usually associated with changes in the nail of the same finger; they are serologically negative. There may be a swollen finger with loss of the skin markings-a sort of dactylitis, again serologically negative. (2) Those with a much more severe process which produces loss of movement in the spine and changes in the sacroiliac joints much the same as those in ankylosing spondylitis; unlike ankylosing spondylitis, it produces severe deformity often with ankylosis in peripheral joints. Many of the finger joints become deformed and ankylosed. (3) Those cases indistinguishable from rheumatoid arthritis although the majority are sero-negative. The Stevens Johnson syndrome produces acute effusions, particularly in large joints. It is sometimes associated with the rash of erythema multiforme, always with ulceration in the mouth and genital tract; the mouth ulcers are accompanied by sloughing, unlike those of Beh9et's syndrome which we come to next. BehCet's syndrome, originally described as a combination of orogenital ulceration with relapsing iritis, is now expanded to include skin lesions, other eye lesions, lesions of the central nervous system, thrombophlebitis migrans, and arthropathy (occurring in 64 per cent). The onset is acute, often affecting only a single joint and settling without residual trouble. Choice of drugs in the treatment of rheumatoid arthritis Dr Dudley Hart, M.D., F.R.C.P. (Consultant physician, Westminster Hospital and Medical School) There are many potential drugs for the treatment of rheumatoid disease, but what are we treating in this disorder? Pain in rheumatoid arthritis is but one of the symp- toms.
    [Show full text]
  • Pharmacogenetics of Ketamine Metabolism And
    Pharmacogenetics of Ketamine Metabolism and Immunopharmacology of Ketamine Yibai Li B.HSc. (Hons) Discipline of Pharmacology, School of Medical Sciences, Faculty of Health Sciences, The University of Adelaide September 2014 A thesis submitted for the Degree of PhD (Medicine) Table of contents TABLE OF CONTENTS .............................................................................................. I LIST OF FIGURES ....................................................................................................IV LIST OF TABLES ......................................................................................................IV ABSTRACT ............................................................................................................... V DECLARATION .......................................................................................................VIII ACKNOWLEDGEMENTS ..........................................................................................IX ABBREVIATIONS .....................................................................................................XI CHAPTER 1. INTRODUCTION .................................................................................. 1 1.1 A historical overview of ketamine ........................................................................................ 1 1.2 Structure and Chemistry ....................................................................................................... 3 1.3 Classical analgesic mechanisms of ketamine ...................................................................
    [Show full text]
  • Literature Review of Prescription Analgesics in the Causal Path to Pain
    Literature Review: Opioids and Death compiled by Bill Stockdale ([email protected]) This review is the result of searches for the terms opioid/opioid-related-disorders and death/ADE done in the PubMed database. This bibliography includes selected articles from the 1,075 found by searching during May, 2008, which represent key findings in the study of opioids. Articles for which there is no abstract are excluded. Also case reports and initial clinical trial reports are excluded. This is a compendium of all articles and do not lead to a specific target. There are three major topics developed in the literature as shown in this table of contents; • Topic One: Opioids in Causal Path to Death (page 1) o Prescription Drug Deaths (page 1) o Illicit Drug Deaths (page 30) o Neonatal Deaths (page 49) • Topic Two: Deaths in Palliative Care and Pain Treatment (page 57) • Topic Three: Pharmacology, Psychology, Origins of Abuse Relating to Death (page 72) • Bibliography (page 77) The three topics are presented below; each is followed in chronological order. Topic One: Opioids in Causal Path to Death Prescription Drug Deaths Karlson et al. describe differences in treatment of acute myocardial infarction, including different opioid use among men and women. The question whether women and men with acute myocardial infarction (AMI) are treated differently is currently debated. In this analysis we compared pharmacological treatments and revascularization procedures during hospitalization and during 1 year of follow-up in 300 women and 621 men who suffered an AMI in 1986 or 1987 at our hospital. During hospitalization, the mean dose of morphine (+/- SD) during the first 3 days was higher in men compared to women (14.5 +/- 15.7 vs.
    [Show full text]
  • PCF4 Revised Monographs (Since Publication September 2011 to July 2014)
    www.palliativedrugs.com PCF4 revised monographs (since publication September 2011 to July 2014) Monograph Chapter number Date updated 5HT3 antagonists Chapter 04 Correction Apr-13 5HT3 antagonists Chapter 04 Jun-14 Adjuvant analgesics Chapter 05 Jun-14 Alfentanil Chapter 05 May-14 Amitriptyline Chapter 04 Oct-13 Anaemia Chapter 09 Apr-14 Analgesic drugs and fitness to drive Chapter 19 Jun-14 Anaphylaxis Chapter 27 May-13 Anaphylaxis Chapter 27 Correction Oct-13 Anaphylaxis Chapter 27 Jul-14 Antacids Chapter 01 Sep-12 Antacids Chapter 01 Minor update Jun-14 Antibacterials in palliative care Chapter 06 Sep-12 Antibacterials in palliative care Chapter 06 Minor update Apr-14 Anticoagulants Chapter 02 Minor update Aug-13 Anticoagulants (new) Chapter 02 New May-13 Antidepressants Chapter 04 Oct-13 Anti-emetics Chapter 04 Jun-14 Anti-epileptics pre-synaptic calcium channel blockers Chapter 04 Discontinued May-14 Anti-epileptics sodium channel blockers Chapter 04 Discontinued May-14 Anti-epileptics Chapter 04 Merged monograph May-14 Antifibrinolytics Chapter 02 Aug-13 Antihistaminic antimuscarinic anti-emetics Chapter 04 Jun-14 Antimuscarinics Chapter 01 Correction Apr-13 Antimuscarinics Chapter 01 Apr-14 Antipsychotics Chapter 04 Jun-14 Antitussives Chapter 03 Mar-14 Artificial saliva Chapter 11 Jun-14 Ascorbic acid Chapter 09 Nov-12 Baclofen Chapter 10 Jun-14 Barrier products Chapter 12 Apr-14 Benzodiazepines Chapter 04 Jun-14 Bisphosphonates Chapter 07 Merged monograph Jun-14 Buprenorphine Chapter 05 Jun-13 Buprenorphine Chapter 05 Jun-14
    [Show full text]
  • Topical Treatments of Skin Pain Associated with Hidradenitis Supprurativa
    UC Davis Dermatology Online Journal Title Topical treatments of skin pain: a general review with a focus on hidradenitis suppurativa with topical agents Permalink https://escholarship.org/uc/item/4m57506k Journal Dermatology Online Journal, 20(7) Author Scheinfeld, Noah Publication Date 2014 DOI 10.5070/D3207023131 License https://creativecommons.org/licenses/by-nc-nd/4.0/ 4.0 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Volume 20 Number 7 July 2014 Review Topical treatments of skin pain: a general review with a focus on hidradenitis suppurativa with topical agents Noah Scheinfeld MD JD Dermatology Online Journal 20 (7): 3 Assistant Clinical Professor of Dermatology Weil Cornel Medical College Correspondence: Noah Scheinfeld 150 West 55th Street NYC NY 10019 (212) 991-6490 [email protected] Abstract Hidradenitis Supprurativa (HS) is a painful chronic follicular disease. Few papers have addressed pain control for this debilitating condition. Possible topical agents include tricyclic antidepressants, opioids, anticonvulsants, NSAIDs, NMDA receptor antagonists, local anesthetics and other agents. The first line agents for the topical treatment of the cutaneous pain of HS are diclonefac gel 1% and liposomal xylocaine 4% and 5% cream or 5% ointment. The chief advantage of topical xylocaine is that is quick acting i.e. immediate however with a limited duration of effect 1-2 hours. The use of topical ketamine, which blocks n- methyl-D-aspartate receptors in a non-competitive fashion, might be a useful tool for the treatment of HS pain. Topical doxepin, which available in a 5% commercially preparation (Zonalon®) , makes patients drowsy and is not useful for controlling the pain of HS .
    [Show full text]
  • Chapter 151 – Antidepressants
    Crack Cast Show Notes – Skin and Soft Tissue Infections www.canadiem.org Chapter 151 – Antidepressants Key Concepts ❏ Although rarely used for depression, MAOIs are used in the treatment of Parkinson’s disease ❏ Because serious symptoms can occur after a lengthy latent period, patients with reported MAOI overdose should be admitted for 24 hours, regardless of symptoms. Symptoms are characterized by tachycardia, hypertension, and CNS changes, and later cardiovascular collapse. ❏ The primary manifestations of TCA toxicity are seizures, tachycardia, and intraventricular conduction delay. IV sodium bicarbonate should be administered for QRS prolongation. ❏ DO NOT USE PHYSOSTIGMINE IN TCA OVERDOSE ❏ SSRIs are comparatively benign in overdose. ❏ SNRI ingestions can result in seizures, tachycardia, and occasionally intraventricular conduction delay. ❏ The hallmark feature of serotonin syndrome is lower extremity rigidity (spasticity) with spontaneous or inducible clonus, especially at the ankles. ❏ Serotonin syndrome is primarily treated with supportive care, including discontinuation of the offending agent, and benzodiazepines. Sign Post 1) List 7 pharmacodynamic effects of cyclic antidepressants and describe the physiologic result 2) What are the ECG findings associated with TCA toxicity and what are their implications 3) Describe the management of TCA toxicity 4) What are the diagnostic criteria for Serotonin Syndrome? 5) How can you discern between NMS and Serotonin Syndrome? 6) What are the common meds causing Serotonin Syndrome? 7) Describe the management of Serotonin Syndrome 8) What is the primary risk of toxicity in Bupropion? 9) What are the 3 mechanisms by which MAOI toxicity can occur? And what is the clinical syndrome? 10) List 5 foods and 5 classes of meds that can interact to cause MAOI toxicity 11) Describe the management of MAOI toxicity.
    [Show full text]
  • The Effect of Antidepressive Drugs and Some Related Compounds on the Levels of Adenine Nucleotides, Inorganic Phosphate and Phosphocreatine in the Rat Brain by J
    Brit. J. Pharmacol. (1963), 20, 462-470. THE EFFECT OF ANTIDEPRESSIVE DRUGS AND SOME RELATED COMPOUNDS ON THE LEVELS OF ADENINE NUCLEOTIDES, INORGANIC PHOSPHATE AND PHOSPHOCREATINE IN THE RAT BRAIN BY J. J. LEWIS AND G. R. VAN PETTEN From the Experimental Pharmacology Division, Institute of Physiology, University of Glasgow (Received January 11, 1963) The effects upon levels of adenine nucleotides, phosphocreatine and inorganic phosphate of iproniazid, isoniazid, phenelzine, pheniprazine, tranylcypromine, harmine, imipramine, amitriptyline, orphenadrine, diphenhydramine and cocaine have been studied. With the exception of harmine and diphenhydramine, each of these compounds increased the brain level of adenosine triphosphate and, with the exception of imipramine and cocaine, the level of adenosine diphosphate decreased. Harmine had no effect on levels of adenine nucleotides and, in the case of diphenhydramine, the level of adenosine diphosphate increased and the level of adenosine triphosphate tended to decrease. There appears to be a relationship between the ability of the drugs to cause behavioural signs of central nervous stimulation and to produce an increase in the adenosine triphosphate/diphosphate ratio. This effect may be a factor in the action of antidepressive drugs. Many attempts have been made to explain the mechanism of action of anti- depressive drugs on the basis of their ability to inhibit monoamine oxidase, and thereby to increase the effective concentrations in the brain of its substrates, nor- adrenaline and 5-hydroxytryptamine, which have been postulated to act there as transmitters. Major difficulties arise, however, when an attempt is made to correlate the increase in the brain level of a particular amine produced by a drug with its antidepressive activity.
    [Show full text]
  • Treatment for Acute Pain: an Evidence Map Technical Brief Number 33
    Technical Brief Number 33 R Treatment for Acute Pain: An Evidence Map Technical Brief Number 33 Treatment for Acute Pain: An Evidence Map Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 5600 Fishers Lane Rockville, MD 20857 www.ahrq.gov Contract No. 290-2015-0000-81 Prepared by: Minnesota Evidence-based Practice Center Minneapolis, MN Investigators: Michelle Brasure, Ph.D., M.S.P.H., M.L.I.S. Victoria A. Nelson, M.Sc. Shellina Scheiner, PharmD, B.C.G.P. Mary L. Forte, Ph.D., D.C. Mary Butler, Ph.D., M.B.A. Sanket Nagarkar, D.D.S., M.P.H. Jayati Saha, Ph.D. Timothy J. Wilt, M.D., M.P.H. AHRQ Publication No. 19(20)-EHC022-EF October 2019 Key Messages Purpose of review The purpose of this evidence map is to provide a high-level overview of the current guidelines and systematic reviews on pharmacologic and nonpharmacologic treatments for acute pain. We map the evidence for several acute pain conditions including postoperative pain, dental pain, neck pain, back pain, renal colic, acute migraine, and sickle cell crisis. Improved understanding of the interventions studied for each of these acute pain conditions will provide insight on which topics are ready for comprehensive comparative effectiveness review. Key messages • Few systematic reviews provide a comprehensive rigorous assessment of all potential interventions, including nondrug interventions, to treat pain attributable to each acute pain condition. Acute pain conditions that may need a comprehensive systematic review or overview of systematic reviews include postoperative postdischarge pain, acute back pain, acute neck pain, renal colic, and acute migraine.
    [Show full text]
  • United States Patent (19) 11 Patent Number: 4,780,463 Sunshine Et Al
    United States Patent (19) 11 Patent Number: 4,780,463 Sunshine et al. (45) Date of Patent: Oct. 25, 1988 (54). ANALGESIC, ANTI-INFLAMMATORY AND Ailments of the Musculoskeletal Apparatus), Investiga SKELETAL MUSCLE RELAXANT tion Medica Internactional, pp. 475-478, (1983), and COMPOSITIONS COMPRISING English translation thereof. NON-STEROIDAL ANTI-NFLAMMATORY Socialist Republic of Romania Description of Inven DRUGS AND MUSCULOSKELETAL tion, 82,717, copy of patent and English translation RELAXANTS AND METHODS OF USING thereof. SAME Rego, "Mio-Relaxantes No Tratamento Das Lom 75 Inventors: Abraham Sunshine, New York; balgias Aguda E Da Lombo-Ciaticas Recentes', Mus Eugene M. Laska, Larchmont; cle Relaxants in the Treatment of Acute Lumbalgias Carole E. Siegel, Mamaroneck, all of and Recent Lumbo-Sciatica Cases, Acta N.Y. Reumatologica Portuguesa, II, 2:363-364, (1974), copy of the original and English translation thereof. 73 Assignee: Analgesic Associates, Larchmont, Schror, "Analgetisch-antiphlogistische Therapie Von N.Y. Schmerzzustanden des Bewegungsapparates', Anal 21 Appl. No.: 114,751. gesic-Antiphlogistic Therapy of Locomotor System Pain), Therapiewoche, 28, 5657-5663, (1978), copy of the 22 Filed: Oct. 30, 1987 original and English translation thereof. Schar, "Medikamentose Behandling von Lumboishial Related U.S. Application Data gien', Drug Treatment of the Lumbago-Sciatic Syn 60 Division of Ser. No. 815,502, Jan. 2, 1986, Pat. No. drome, Schweiz. Rundschau Med., (Praxis), vol. 68, No. 4,722,938, which is a continuation of Ser. No. 686,380, 5, pp. 141-142, (Jan. 30, 1979), copy of original article Dec. 26, 1984, abandoned. and English translation thereof. 51) int. Cl.' ..................... A61K 31/19; A61K 31/44; Kolodny and Klipper, "Bone and Joint Diseases in the A61K 3/54; A61K 31/195; A61K 31/205 Elderly', Hospital Practice, pp.
    [Show full text]