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Celebrating Israeli Leaders in Cardiology

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Celebrating Israeli Leaders in Cardiology Celebrating Israeli Leaders in Cardiology • Dedication – Clinician-scientists – Building the profession in Israel – Excellence • Leaders • Collaborative investigators DAN GILON DAN GILON • Professor of Medicine (Cardiology), Hadassah-Hebrew University Medical Center • Director, Non-Invasive Cardiology, Heart Institute • Vice-Dean of the Faculty of Medicine DAN GILON • Leading investigator, IRAD Intl Registry of Acute Aortic Dissection • MVP and stroke – breaking old beliefs • 3D echo and hemodynamics of AS & MS • Cardiac function in the oldest old • New mechanism of myopathy – transcription factor MITF loss (E Razin) • ACC Young Investigator winner EHUD SCHWAMMENTHAL EHUD SCHWAMMENTHAL • Director, Cardiac Rehabilitation, and Director, Cardiac Outpatient Clinic, Sheba Medical Center, Tel Hashomer • Director of Echocardiography, Muenster University (before aliyah) • Professor of Medicine, Tel Aviv University • Founder, Ventor Technologies LTD, and CTO, Medtronic Embracer TAVI • Founder and CEO, Magenta Medical EHUD SCHWAMMENTHAL • Original mechanisms and hemo- dynamics of valve disease at rest and with exercise – MR and obstruction in HCM, ischemic MR, MS • Quantification of valve regurgitation • Innovative development of cardiac devices based on physical principles • Kellerman Young Investigator Award • Neufeld Young Investigator Award • AHA Young Investigator Award ALIK SAGIE • Director of Echocardiography Unit, Rabin Medical Center • Director, Valvular Clinic, Cardiology, Rabin Medical Center ALIK SAGIE • Professor of Medicine, Tel Aviv University • Director of Echocardiography Unit, Rabin Medical Center • Director, Valvular Clinic, Cardiology, Rabin Medical Center ALIK SAGIE – Main Research Contributions • TR: Evaluations, mechanisms and importance in rheumatic disease and mechanism of functional TR • Long-term progression of heart valve diseases • Thrombolytic therapy for prosthetic valve thrombosis • Mitral annulus and aortic valve calcifi- cation as windows to atherosclerosis • Value of exercise echo and intraop TEE Noah Liel–Cohen Director of the Echocardiography Lab Soroka University Medical Center Ben Gurion University of the Negev, Beer Sheva, Israel Chair, Israeli Working Group on Echocardiography (4 years); ACC Young Investigator Award Israeli Echocardiography Research Group Assaf Harophe MC Carmel MC Hadassah MC Haemek MC Hillel Yaffe MC Kaplan MC Rabin MC Rambam MC Shaare Zedek MC Sheba MC Soroka MC Journal of the American Society of Echocardiography 23, 3, 258-264 March 2010 Editorial comment Division of Cardiology, Emory University, Atlanta GA; 2D strain echocardiography in the Cardiac arrhythmia research laboratory directed by Dr. Yoram Etzion A novel type of bipolar electrode – effect of pacing site on cardiac synchrony. Synchronized LV contraction Bi-Ventricular pacing induces favorable Left Ventricle mechanics 10 (n = 7) (n = 7) 8 ** 6 De- Synchronized LV contraction 4 2 SD of Global peak Strain peak of Global SD 0 No RVa BIV Pacing Pacing Pacing Soroka University Medical Center, Ben-Gurion University, Beer Sheva, Israel; Hadassah University Hospital, Jerusalem, Israel; Rambam Medical Center, Haifa, Israel; Sheba Medical Center, Tel Aviv, Israel; Asaff Harofeh Medical Center, Zerifin, Israel; Shaare Zedek Medical Center, Jerusalem, Israel; Rabin Medical Center, Petah Tikva, Israel; Kaplan Medical Center, Rehovot, Israel; Editorial by Hillel-Yaffe Medical Center, Hadera, Israel. Linda D. Gillam Ongoing study Principal Investigator Avinoam Shiran M.D. Carmel Medical Center UTILITY OF 2D STRAIN IN TRIAGE OF PATIENTS WITH CHEST PAIN IN THE EMERGENCY DEPARTMENT Enrolled so far over 600 patients in 10 sites Ronen Beeri, MD ,FACC Ronen Beeri, MD ,FACC • Hadassah-Hebrew University Medical Center: – Associate Professor of Medicine • Massachusetts General Hospital & Harvard Medical School: – 2000-2002 Research fellow – 2002- Visiting Scientist In ischemic (post-infarction) MR, how can we separate the effects of MR and MI on the LV? RONEN BEERI Circulation 2007; JACC 2008 Hadassah-Hebrew University Hospital Massachusetts General Hospital No MR MR Diastole A C MI MI Systole B D Ronen Beeri Akt: Anti-apoptotic signal Early MR repair reverses LV remodeling MI Late MR repair fails to reverse LV remodeling MR + MI AAV.SERCA2a limits LV remodeling 0 1 3 months Ronen Beeri • Awards and Prizes: – The Shafarman Memorial Fund - outstanding research – The Eisenberg Fund - research in treatment and prevention of heart diseases – 2002 The Prof. H. Neufeld Memorial Research Award (USA-Israel Binational Science Foundation) – 2007 The Louis Chor Research Award – 2013 The Michel Mirowski Excellence in Cardiology Award – Grants: BSF, NHLBI, NIBIB, AHA, Israel Cancer Association Research Interests • Cardiac Gene and Cell Therapy – Development of closed-chest delivery systems for myocardial gene therapy . – Cardiac resident stem cells from the left atrial appendage (LAA) • Functional Imaging Using Echo • Finite–Element Modeling of the Heart 24 Mordehay Vaturi MD Staff cardiologist at the Echocardiography Unit and Valve Clinic, Department of Cardiology, Rabin Medical Center, Beilinson Hospital, Petah Tikva. Senior lecturer of cardiology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv. Research fellowship at MGH between 2003-2005 25 Mordehay Vaturi MD Contributions on impact of TR on heart failure and prognosis. Original observation on mechanism of TR in PHTN Role of EPCs in valve disease progression Chaim Yosefy MD Director, Non-Invasive Cardiology Unit, Barzilai Medical Center Campus, Ashkelon, Associate Professor of Cardiology, Ben Gurion University School of Medicine. 67 papers and Over 100 national and International Presentations covering 2 fields of interest: 1) 3D Echocardiography 2) Prevention of CV Disease Chaim Yosefy MD Director, Non-Invasive Cardiology Unit, Barzilai Medical Center Campus, Ashkelon, Associate Professor of Cardiology, Ben Gurion University School of Medicine. Extensive publications and presentations: 1) Echocardiography focus on the contribution of 3D Echo. Better understanding of: PISA (JASE) Vena Contracta (JASE) MR Mechanism in Apical MI (CIRCULATION) MVP Genetic Project. Working closely with Prof. Beeri on the other subjects in Ronen’s Introduction. Running the European annual courses of the 3D Echo – First Israel 3D Echo Course, Ashkelon 2) Prevention of CV Disease In the last 4 years Chairman of Working Group for Cardiovascular Epidemiology and Preventive Cardiology, Israel Heart Society. Focus on Hypertension diagnosis and treatment: 24 H ABPM , Fish Oil, Patient / Doctor Education Projects (NEJM , Int J of Cardiology, Hypertension). Major contribution to 4 guidelines of the Israel Heart Society in the field of CV prevention (Atherosclerosis, Aspirin, Diet, Physical Exercise). Started as a pioneer (in 1982 as a Medical Student) developing a country wide Health education project in Schools by Medical Students (PERACH PROJECT) and thus received the Citation from the Minister of Health (1988). Ronen Durst First Israel Heart Society Valve Disease Meeting, Israel, 2012, in association with the Leducq MITRAL network Awards Awards and Honors 1995 Israeli Defense Force Chief of Staff IDF chief of staff award for excellence as an officer under fire 1998 Golomb award Highest Israeli Defense System award for contribution for the security of Israel 2002 Stich award‐ faculty research award Recent origin and spread of a common Lithuanian mutation (G197delLDLR) causing Familial Hypercholesterolemia positive selection in not always necessary to account for disease incidence among Ashkenazi Jews Funding 1999‐2000 Berman Fund “Myocardial preconditioning induced by heat acclimation via altered angioitensin II receptor expression” 2002‐2003 Hebrew University Hadassah Joint Fund “The effect of polygenic polymorphism of the SCAP SREBP pathway on plasma lipid level variability in familial hypercholesterolemia” 2003 Women's Health fund “The effect of polygenic polymorphism of the SCAP SREBP pathway on plasma lipid level variability in FH females” 2004Young investigator award –Hebrew University “Cardioprotective effect of cannabinoids against myocardial ischemia.” 2005 2006 Phillips Medical Systems “Characterization of plaque tissue and vulnerability using dual energy CT scanner” 2006 MSD training fellowship “Cardiac imaging fellowship” 2007 American Physician Fellowship “Cardiac imaging fellowship” . 2008 ECOR award for young investigators “Cardiac genetic fellowship” 2011 European Union “Marie Curie” reintegration grant “Genetics of mitral valve prolapse” 2012 BSF “Epigenetic mechanisms on Differential effect of diet strategies on dynamics of fat depots –The CENTRAL randomized control intervention trial” 2013 ISF (Morasha) “In search of a cholesterol lowering gene in an FH family” Clinical accomplishment Establishing the MRI and CT cardiac • imaging service at Hadassah. .
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