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Poster Session 3 - Themes 2, 4 and 5 14:00 - 14:45 Thursday, 17Th October, 2019 Liffey B (Level 1) Presentation Type Poster Presentation

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Poster Session 3 - Themes 2, 4 and 5 14:00 - 14:45 Thursday, 17Th October, 2019 Liffey B (Level 1) Presentation Type Poster Presentation Poster Session 3 - Themes 2, 4 and 5 14:00 - 14:45 Thursday, 17th October, 2019 Liffey B (Level 1) Presentation type Poster presentation There are 5 poster presentations in the poster session. The posters are numbered as P3-Station Number-Presentation Number e.g. P3-32-02 refers to the second presentation at Station 32. The timings for all poster presentations within the session are as follows and these timings will be adhered to, even in the event of a poster withdrawal: Presentation 01: 14:00 - 14:07 Presentation 02: 14:08 - 14:15 Presentation 03: 14:16 - 14:23 Presentation 04: 14:24 - 14:31 Presentation 05: 14:32 - 14:39 P3-20-01 Effect of folic acid supplementation during pregnancy on brain health of the child at 11 years: the FASSTT Offspring trial Aoife Caffrey1, Kristina Pentieva1, Helene McNulty1, Pramod Gaur2, Joel B Talcott3, Caroline Witton3, Anthony Cassidy4, Marian McLaughlin4, Diane J Lees-Murdock5, Rachelle E Irwin5, Colum P Walsh5, Girijesh Prasad2 1Nutrition Innovation Centre for Food and Health (NICHE), Ulster University, Coleraine, United Kingdom. 2Intelligent Systems Research Centre, Ulster University, Derry~Londonderry, United Kingdom. 3Aston Brain Centre, Aston University, Birmingham, United Kingdom. 4Psychology Research Institute, Ulster University, Coleraine, United Kingdom. 5Genomic Medicine Research Group, Ulster University, Coleraine, United Kingdom Abstract Periconceptional folic acid (FA) has an established role in the prevention of neural tube defects (NTDs), leading to global recommendations for FA supplementation before and in early pregnancy. However, it is unclear whether there are any benefits for offspring brain health arising from continued maternal FA supplementation beyond the first trimester. The aim of this study was to investigate the role of maternal folate nutrition during pregnancy in relation to cognitive performance and brain function in the offspring at 11 years. The children of mothers who had participated in a randomised trial of Folic Acid Supplementation in the Second and Third Trimesters (FASSTT) were investigated, providing a unique opportunity to examine offspring brain health in relation to maternal folate (the FASSTT Offspring trial; n=68). Cognitive performance was assessed using the Wechsler Intelligence Scale for Children, Fourth UK Edition (WISC-IV). The WISC-IV measures Full Scale IQ and specific domains of cognitive performance: Verbal Comprehension, Perceptual Reasoning, Working Memory and Processing Speed. Brain function was measured using magnetoencephalography (MEG) in a subset of the child participants (n=33). The results showed no significant difference in Full Scale IQ between the children of mothers who had received folic acid versus placebo during pregnancy (P=0.993). Processing Speed subtest scores were however significantly higher in the folic acid group compared with placebo (Symbol Search: P=0.046 and Cancellation: P=0.011). The application of MEG analysis showed that at rest, there were differences in brain functioning with significantly lower overall power at Broad band [1–48Hz] (P=0.041) and a trend (not significant) towards lower power in all other frequency bands (Theta, Mu, Beta, Low Gamma and High Gamma) in children from the FA group compared with placebo. Results for the responses to the language task (congruent and incongruent sentences) in children from the FA group showed significantly lower power within the Theta band [4–8Hz] and significantly higher power within high frequency bands i.e. Beta [13–30 Hz] and High Gamma [49–70 Hz]. This suggested more efficient language processing abilities in these children compared to children of mothers in the placebo group. The findings provide scientific evidence that continuing FA supplementation beyond the periconceptional period that is protective against NTDs, may be beneficial for brain health in the offspring. Furthermore, this study demonstrates that MEG is a useful tool for objective assessment of functional brain activity in healthy children in response to nutrition intervention. Conflict of Interest There is no conflict of interest P3-20-02 Pre and postoperative deficiencies in iron, ferritin and B12 vitamin among portuguese patients undergoing bariatric surgery Mariana Santos Lopes1, Bruno MPM Oliveira2,3, Olga Neves2,4, Diva Melim5, Paula Freitas6,7, AMTCO Group5, Flora Correia1,5 1Faculdade de Ciências da Nutrição e Alimentação da Universidade do Porto , Porto, Portugal. 2Faculdade de Ciências da Nutrição e Alimentação da Universidade do Porto, Porto, Portugal. 3LIAAD, INESC TEC, Porto, Portugal. 4Sociedade Portuguesa de Ciências da Nutrição e Alimentação, Porto, Portugal. 5Centro Hospitalar São João, E.P.E, Porto, Portugal. 6Departamento de Endocrinologia, Diabetes e Metabolismo, Centro Hospitalar São João, E.P.E, Porto, Portugal. 7Faculdade de Medicina da Universidade do Porto, Porto, Portugal Abstract Introduction: According to the World Health Organization obesity it's the result of an abnormal or excessive body fat accumulation, which presents a high risk for the health. Bariatric surgery appears as an alternative to the conventional treatment for the morbid obese individuals. However, this type of intervention causes changes in the anatomy and physiology of the gastrointestinal tract, which may lead to the development of nutritional deficiencies in patients, in particular anemia. Aim: To evaluate micronutrient deficiencies in patients submitted to bariatric surgery in preoperative and postoperative periods, in particular iron, ferritin, and B12 vitamin. Methods: In this longitudinal study, we evaluated, retrospectively and prospectively, patients who attended the nutrition appointment at a central hospital. We completed a preexisting database containing anthropometric and biochemical data, adding biochemical data, at various periods: pre at 6th, 12th, 18th, 24th, 30th and 36th months post-surgery. Results: from the 121 patients submitted to bariatric surgery, 79,3% were female. The prevalence or iron deficiency reached 15%, ferritin deficiency reached almost 10% and B12 vitamin deficiency reached 18%. Furthermore there were deficiencies in other nutrients, e.g., vitamin D, magnesium and zinc. There was more than 85% adhesion to take the multivitamin supplementation and frequent use of specific supplementation. Conclusion: The prevalence of nutritional deficiencies is high, with a tendency to persist over time even with use of multivitamin supplementation, leading to the need for complementary supplementation, in particular to prevent the risk of anemia. Hence, periodic and long term monitoring is fundamental. Key words: obesity, bariatric surgery, nutritional deficiencies, anemia, supplementation Conflict of Interest There is no conflict of interest. P3-20-03 The effect of consuming boarfish (Capros aper) protein hydrolysate on glycated haemoglobin and BMI in overweight adults. William Crowe1, Judith Baird2, Christopher McLaughlin2, Padraigin Harnedy3, Dick Fitzgerald3, Finbarr O'Harte2, Philip Allsopp2, Emeir McSorley2 1Queen's University of Belfast, Belfast, Ireland. 2Ulster University, Coleraine, Ireland. 3University of Limerick, Limerick, Ireland Abstract Boarfish (Capros aper) is an underutilised pelagic fish species found in abundance in Irish waters. Research previously undertaken has shown a favourable effect of boarfish derived protein hydrolysate (BFH) consumption on glycaemic control in diabetic murine models. This study aims to investigate the effect of daily BFH consumption on glycated haemoglobin and body mass index (BMI) in overweight human participants. A randomised parallel placebo-controlled human intervention study was undertaken to investigate the effect of consuming BFH (3.5g/day) for 12 weeks. Participants (n=40) that met the following inclusion criteria were recruited; aged between 18-65 years, non-smoker, not currently pregnant or lactating, BMI > 25.0 kg/m2, free from illness. Participants were randomly assigned to consume either BFH or cellulose capsules for 12 weeks. Measures taken at baseline and post-intervention (week 12) included fasting measures of: glycated haemoglobin, glucose, insulin, leptin, glucagon like peptide (GLP-1), adiponectin as well as lipid profile. Height and weight were also recorded at both timepoints. Analysis of covariance (ANCOVA) controlling for baseline values as well as other covariates (age & BMI), was used to compare differences between groups over time. Consumption of BFH (3.5g/day) for 12 weeks had no significant effect on glucose, insulin, leptin, glucagon like peptide (GLP-1), adiponectin, high density lipoprotein (HDL), total cholesterol, triglycerides, low density lipoprotein compared with control. No significant difference in glycated haemoglobin change over time (P=0.123) was noted following consumption of placebo (2.5% increase) in comparison to those consuming the boarfish treatment (1.5% reduction). This study showed that 3.5g of BFH per day did not elicit an effect on any of the markers of metabolic health. Previous studies investigating the effect of protein consumption on metabolic health have used higher concentrations than were utilized in this study, however using similar concentrations in this study was not plausible given the lack of organoleptic acceptability of the BFH. Addressing the organoleptic properties of BFH may enable future studies to increase the dose of BFH to a level that may be more efficacious than the current study. Conflict of Interest no P3-20-04 The adipose-derived Nerve Growth Factor
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