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Research Highlights
Vol. 16, November 2016 Research Highlights Fishy approach reveals how things taste sweet or umami Okayama University have identified the protein conformational changes associated with sweet and umami taste recognition. Taste recognition occurs as specific protein receptors in the mouth interact with molecules in eaten food. The proteins responsible for tasting sweet and umami molecules are described as taste receptor type 1 (T1r) and are common to vertebrates in general, including fish, birds and mammals. It is known that the T1r family of variants interact with food molecules in paired up structures - “heterodimers” – Yamashita and colleagues identified the structure and to allow the distinction between umami, sweet, and other conformational changes in type 1 taste receptor proteins tastes. However, difficulties in producing and purifying these during the recognition of sweet and umami tastes proteins have inhibited attempts to directly investigate what interactions occur during sweet and umami taste recognition. Atsuko Yamashita and a team of researchers at RIKEN SPring-8 Center, the National Institute of Natural Science, the Graduate University for Advanced Studies (SOKENDAI), the Food Research Institute, Osaka University, Okazaki Institute for Integrative Biosciences, and Okayama University have now successfully demonstrated a way around these difficulties. They identified a fish known as medaka or “Japanese rice fish” as a suitable vertebrate model for investigating umami and sweet tastes. The researchers found they could produce – “express” – the ligand binding domain of the T1r2 and T1r3 proteins in medaka fish as functional heterodimeric proteins. They express the proteins in a glycosylated form, which is closer to the physiological state. The study identifies the conformational changes the proteins undergo during sweet and umami taste recognition for the first time. -
Pathogenic Mutations Identified by a Multimodality Approach in 117 Japanese Fanconi Anemia Patients
ERRATA CORRIGE Bone Marrow Failure Pathogenic mutations identified by a multimodality approach in 117 Japanese Fanconi anemia patients Minako Mori, 1,2 Asuka Hira, 1 Kenichi Yoshida, 3 Hideki Muramatsu, 4 Yusuke Okuno, 4 Yuichi Shiraishi, 5 Michiko Anmae, 6 Jun Yasuda, 7Shu Tadaka, 7 Kengo Kinoshita, 7,8,9 Tomoo Osumi, 10 Yasushi Noguchi, 11 Souichi Adachi, 12 Ryoji Kobayashi, 13 Hiroshi Kawabata, 14 Kohsuke Imai, 15 Tomohiro Morio, 16 Kazuo Tamura, 6 Akifumi Takaori-Kondo, 2 Masayuki Yamamoto, 7,17 Satoru Miyano, 5 Seiji Kojima, 4 Etsuro Ito, 18 Seishi Ogawa, 3,19 Keitaro Matsuo, 20 Hiromasa Yabe, 21 Miharu Yabe 21 and Minoru Takata 1 1Laboratory of DNA Damage Signaling, Department of Late Effects Studies, Radiation Biology Center, Graduate School of Biostudies, Kyoto University, Kyoto, Japan; 2Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; 3Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan; 4Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan; 5Laboratory of DNA Information Analysis, Human Genome Center, The Institute of Medical Science, University of Tokyo, Tokyo Japan; 6Medical Genetics Laboratory, Graduate School of Science and Engineering, Kindai University, Osaka, Japan; 7Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; 8Department of Applied Information Sciences, Graduate School of Information Sciences, Tohoku University, Sendai, Japan; 9Institute of Development, Aging, -
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Minamino et al. Arthritis Research & Therapy (2021) 23:96 https://doi.org/10.1186/s13075-021-02479-x RESEARCH ARTICLE Open Access Urinary sodium-to-potassium ratio associates with hypertension and current disease activity in patients with rheumatoid arthritis: a cross-sectional study Hiroto Minamino1,2*†, Masao Katsushima3†, Motomu Hashimoto4* , Yoshihito Fujita1*, Tamami Yoshida5, Kaori Ikeda1, Nozomi Isomura1, Yasuo Oguri1, Wataru Yamamoto6, Ryu Watanabe4, Kosaku Murakami3, Koichi Murata4,7, Kohei Nishitani4, Masao Tanaka4, Hiromu Ito4,7, Koichiro Ohmura3, Shuichi Matsuda7, Nobuya Inagaki1 and Akio Morinobu3 Abstract Background: Excessive salt intake is thought to exacerbate both development of hypertension and autoimmune diseases in animal models, but the clinical impact of excessive salt in rheumatoid arthritis (RA) patients is still unknown. We performed a cross-sectional study to clarify the associations between salt load index (urinary sodium- to-potassium ratio (Na/K ratio)), current disease activity, and hypertension in an RA population. Methods: Three hundred thirty-six participants from our cohort database (KURAMA) were enrolled. We used the spot urine Na/K ratio as a simplified index of salt loading and used the 28-Joint RA Disease Activity Score (DAS28- ESR) as an indicator of current RA disease activity. Using these indicators, we evaluated statistical associations between urinary Na/K ratio, DAS28-ESR, and prevalence of hypertension. Results: Urinary Na/K ratio was positively associated with measured systolic and diastolic blood pressure and also with prevalence of hypertension even after covariate adjustment (OR 1.34, p < 0.001). In addition, increased urinary Na/K ratio was significantly and positively correlated with DAS28-ESR in multiple regression analysis (estimate 0.12, p < 0.001), as was also the case in gender-separated and prednisolone-separated sub-analyses. -
Development and Practice of Training Program in Japanese Higher Education
Development and Practice of Training Program in Japanese Higher Education - Benefits of Professional Development Across Institutions - Eiko Shimizu, Otemon Gakuin University Natsuko Kishioka, Ritsumeikan University Mariko Mikuriya, Meisei University Megumi Yamasaki, Soka University Objectives of this presentation • To understand the characteristics and issues of higher education in Japan in regards to Academic Advising • To understand the staff development program without professional staff • To understand the benefits of professional development across institutions Characteristics of Higher Education in Japan 1. Lack of Professional Staff ➠ “multiple roles” assigned to an individual staff e.g. Learning Support + Academic Advising 2. ”Job Rotation” ➠ Staff will be assigned to a new unit every 3 to 5 years 3. Lack of systemic professional development opportunities ➠Professional development = OJT Professional Staff (Ministry of Education, 2015) Issues in Higher Education in Japan 1. No systemic approach in academic advising ➡ Depend on an individual faculty/staff 2. No continuity in supporting system 3. No clear competencies and assessment base 4. No sharing information within institution Professional Development Trials Trial 1 Academic Advising Salon: Informational Session X6 ○ Issues presented by practitionars Trial 2 Academic Advising Workshop: Analysing own institution ○ Understanding NACADA’s Competencies and CAS Self Assessment Guide ○ Developing a competency framework based on “senior” practitionars Trial 1: Academic Advising Salon Goal: Share information on Academic Advising and develop a network across higher education ・Share histories and theories on Academic Advising internationally ・Share information on professional dvelopment practices ・Identify skills shared among institutions ・Develop a network among practitionars Academic Advising Salon Date/Place Content Participa nts# October 21, 2017/Osaka Academic Advising in the U.S. -
FY2019 Results of Accreditation
Results of Accreditations Performed by the Japan University Accreditation Association April 10, 2020 Introduction In 2002, the Certified Evaluation and Accreditation System was introduced in Japan (enforced in 2004), obligating all higher education institutions (universities, junior colleges and technical colleges) to undergo an evaluation once every 7 years, and all professional graduate schools to undergo an evaluation once every 5 years as well. In each case, the evaluating agency certified by the Minister of Education, Culture, Sports, Science and Technology (MEXT) conducts the evaluation process, comprehensively assessing the level of education, and other areas. Since its establishment in 1947, the Japan University Accreditation Association (JUAA) has played a significant role in assuring the quality of higher education. On August 31, 2004, the JUAA was authorized by the Minister of MEXT as the first Certified Evaluation and Accreditation Agency for universities. Authorization for its Certified Evaluation and Accreditation later expanded to several other fields. The JUAA currently performs Certified Evaluation and Accreditation in 11 fields (university, junior college, law school, professional graduate business school, professional graduate public policy school, professional graduate school of public health, professional graduate school of intellectual property studies, professional graduate school of global communications, professional graduate school of digital contents, professional graduate school of global legal studies, and professional graduate school of public relations) and the accreditation for school of veterinary medicine. JUAA has just finalized the results of accreditations for FY 2019 as follows. FY 2019 University Accreditation (Certified Evaluation and Accreditation for University) Results On accepting applications for University Accreditation from 30 universities, the JUAA has undertaken the evaluative process. -
Visual-JW 2019 & WSE 2019
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34Th Annual Meeting of the Japan Shoulder Society
34TH ANNUAL MEETING OF THE JAPAN SHOULDER SOCIETY 1 F Wave Monitoring After Arthroscopic Shoulder Surgery gers may be used to evaluate the functions of the shoulder joint. It is IWATA Yoshio, Department of Orthopaedics, Uji Takeda Hospital also believed that people can perform approximately half of the ac- MORIHARA Toru, HAYASHIDA Tatsurou, OGURA Akiko, KUBO tions even if the diseased hand is on their dominant side. Toshikazu, Department of Orthopaedics, Kyoto Prefectural Univer- sity of Medicine, Graduate School of Medical Science HORII Motoyuki, Department of Orthopaedic Surgery, Kyoto Inter- 3 The Shoulder Function of Congenital Clavicle Anomalies disciplinary Institute Hospital of Community Medicine KENMOKU Tomonori, Department of Orthopaedics Surgery, Chiba KUROKAWA Masao, Department of Orthopaedic Surgery, Saisei- Univercity Graduate School of Medicine kai Suita Hospital SAISU Takashi, KAMEGAYA Makoto, Division of Orthopaedics Sur- The purpose of this study was to evaluate the modulation of excit- gery, Chiba Children’s Hospital ability of spinal motor neuron function. We investigated F waves af- MIKASA Motohiko, Matsudo Orthopaedic Hospital ter arthroscopic shoulder surgery. We evaluated 7 subjects who There was no report on the shoulder function of congenital clav- underwent an arthroscopic shoulder surgery. There were 5 men icle anomalies. Our purpose was to clarify the role of the clavicle, and 2 women; the mean age at the time of surgery was 33.6 years investigating the shoulder function in patients with clavicle defect old. In our study, F waves were recorded from the abductor pollicis or pseudoarthrosis. muscle after transcutaneous median nerve stimulation at bilateral Thirteen shoulders of 9 patients with congenital clavicle anoma- wrists. -
Japan Ryugaku Awards Special
6 | The Japan Times | Monday, November 30, 2020 Japan Ryugaku Awards special (Sponsored content) Schools lauded for COVID-19 response, support The number of international students At that time, many students at Japanese ties and Japanese language schools, as well ments, Takushoku University received Japan’s education. pass level N2 of the JLPT before enter- enrolled in Japanese universities and voca- language schools returned to their home as affiliated business representatives. the east grand prize, while the west grand The pandemic has severely disrupted ing a program conducted in Japanese. But tional schools is on the rise. In May 2019, countries. Since then, Japanese language This year, 176 Japanese language schools prize went to the University of Market- Japanese-language schools, which play some educators observe that students this number stood at 312,214, up from schools have selected award recipients submitted 469 votes to select 50 institu- ing and Distribution Sciences. In the cat- an important role in preparing students who have passed this exam may still have 164,000 in 2011, and the number of students based on numerous criteria. Providing tions across five categories: vocational egory for private science departments, to enroll in vocational schools and uni- trouble understanding their instructors who chose to work in Japan after graduat- easy-to-understand materials, establishing schools, private liberal arts departments, Tokyo University of Science received the versities. According to surveys conducted and classmates. Japanese language schools ing has more than doubled since 2013. separate tracks for international students, private science departments, public east grand prize and Kindai University, by Japanese language schools, approxi- generally teach their curriculum over two Supporting this influx of international simplifying application procedures and universities and graduate schools. -
Osaka City University 2021
Take a break with fun activities throughout the year University events & Award-Winning Research Facilities extracurricular activities Dance Award-Winning Research Facilities Boat race Center of Education and Research for Osaka City University Disaster Management (CERD) Advanced Mathematical Institute (OCAMI) Social Implementation of Disaster Knowledge. Wide Angle Mathematical Basis Focused on OCU Botanical Gardens Disaster-Resilient Communities. Knots and International Research Center in Rakugo ichiro Namb Mathematics & Mathematical Physics. Yo u Instagram Account @osakacityuniversity OSAKA CITY UNIVERSITY OCU distinguished professor emeritus and Why Osaka? Nobel Laureate in 2008 for his discovery of a Yama the mechanism of spontaneous broken Shiny naka Osaka offers you all you could want from a modern city: excellent food, convenient public 2021 transport, mountains nearby and a 35 minute commute to the city from the airport. Also, cost of symmetry in subatomic physics. ©京都大学iPS細胞研究所 living is relatively low, commuting times short and being in the middle of the culturally rich Kansai Director of the Center for iPS Cell Research and area with cities such as Kyoto and Nara means you will never run out of places to explore. Center for Health Science Innovation (CHSI) Application, Kyoto University and Nobel Laureate Research Center for Fatigue and Active Health. in 2012 for his discovery of iPS cells. Urban Health and Sports (RCUHS) Sightseeing Received his PhD at OCU in 1993. Promote a Healthy and Active Lifestyle in Modern Society. Spots Kiyomizu-dera Temple, Kyoto Shisendo Temple, Kyoto CENTRAL WESTERN HONSHU HONSHU HYOGO KYOTO Nambu Yoichiro Institute of Theoretical Pref. Pref. Kyoto SHIGA and Experimental Physics (NITEP) Nobuo Kamiya Urban Research Plaza (URP) Pref. -
Osaka---A Gastronomic Wonderland
Osaka---A Gastronomic Wonderland Osaka is said to be a culinary capital. Reading Japanese Cooking: A Simple Art, written by Shizuo Tsuji, founder of the Tsuji Culinary Institute, the British food journalist Michael Booth was amazed to learn that concepts currently in vogue in contemporary Western-style cooking, such as simplicity, letting the ingredients speak for themselves, and seasonal food, had been talked about so vividly in a book introducing Japanese cuisine written back in 1980. As a result of reading Tsuji’s book, Booth became profoundly interested in Japanese food and decided to make a three-month “foodie road trip” across Japan together with his family. He describes his experiences on that tour in a book titled Sushi and Beyond: What the Japanese Know about Cooking. In that book, Booth writes about food in Osaka. He notes that the respected French restaurant critic Francois Simon told him that Osaka was “his favorite food city in the world” and adds that “I have seen it [Osaka] name-checked in several interviews with top European and US chefs as a place they visit for inspiration.” The book goes on to describe how Booth himself relished his visit to the city, going not only to high-class restaurants but also okonomiyaki, kushikatsu, and other eateries frequented by ordinary folk. After reading Booth’s book, I smacked my lips and knew there was only one place to go---Osaka! IHCSA Café International Hospitality and Conference Service Association (IHCSA) Okonomiyaki (savory pancakes) The origin of okonomiyaki apparently goes way back to the Azuchi-Momoyama period (1568–1600), when the tea master Sen no Rikyu served similar confectionery at tea ceremonies. -
Japanese Universities That Offer Teacher-Training Programs
Japanese Universities that Offer Teacher-Training Programs Hokkaido University of Education – http://www.hokkyodai.ac.jp Hirosaki University - http://www.hirosaki-u.ac.jp/kokusai/index.html Iwate University – http://iuic.iwate-u.ac.jp/ Miyagi University of Education – http://www.miyakyo-u.ac.jp Fukushima University – http://www.fukushima-u.ac.jp/ Ibaraki University – http://www.ibaraki.ac.jp/ University of Tsukuba – www.kyouiku.tsukuba.ac.jp www.intersc.tsukuba.ac.jp Utsunomiya University – http://www.utsunomiya-u.ac.jp/ Gunma University – http://www.gunma-u.ac.jp Saitama University – http://www.saitama-u.ac.jp Chiba University – http://www.chiba-u.ac.jp Tokyo University of Foreign Studies – http://www.tufs.ac.jp Tokyo Gakugei University – http://www.u-gakugei.ac.jp/ Yokohama National University – http://www.ynu.ac.jp/english/ Niigata University – http://www.niigata-u.ac.jp/ Joetsu University of Education – http://www.juen.ac.jp/ Akita University – http://www.akita-u.ac.jp/english/ Toyama University – http://www.u-toyama.ac.jp Kanazawa University – http://www.kanazawa-u.ac.jp/e/index.html University of Fukui – http://www.u-fukui.ac.jp University of Yamanashi – http://www.yamanashi.ac.jp/ Shinshu University – http://www.shinshu-u.ac.jp/english/index.html Gifu University – https://syllabus.gifu-u.ac.jp/ Shizuoka University – http://www.shizuoka.ac.jp/ Aichi University of Education – http://www.aichi-edu.ac.jp/ http://www.aichi-edu.ac.jp/cie/ 1 Mie University – http://www.mie-u.ac.jp Shiga University – http://www.shiga-u.ac.jp/ -
IEFS Japan Annual Meeting 2017, Kyoto Univ
Conference on Institutions, Markets, and Market Quality - In Honor of Professor Makoto Yano on the occasion of his retirement from Kyoto University - IEFS Japan Annual Meeting 2017 Organizing Committee: Kazuo Nishimura (Kobe University), Fumio Dei (Kobe University), Masato Yodo (Kyoto University) and Koji Ito (Kyoto University) March 8, Thursday at Yamauchi Hall of Shiran Kaikan, Kyoto University ◇ Registration Open ◇ 12:30~ ◇ Opening Address ◇ 13:00~13:10 Opening Address, Satoshi Mizobata (Kyoto University) ◇ Session 1 ◇ Chair: Yoichiro Higashi (Okayama University) 13:10 ~13:40 Presentation, Youngsub Chun (Seoul National University) “Kidney Exchange with Immunosuppressants” 13:40~14:10 Presentation, Takayuki Oishi (Meisei University) “Intermediary Organizations in Labor Markets” ◇ Session 2 ◇ Chair: Naoto Jinji(Kyoto University) 14:20~14:50 Presentation, Yuichi Furukawa (Chukyo University) “Novelty Seeking as a Market Infrastructure for Innovation and Economic Growth” 14:50~15:20 Presentation, Yu Awaya (University of Rochester) “Communication and Cooperation in Repeated Games” 15:20~15:50 Presentation, Yoichi Sugita (Hitotsubashi University) “Wage Markdowns and FDI Liberalization” ◇ Session 3 ◇ Chair: Ryo Miyata (Ryukyu University) 16:00~16:30 Presentation, Atsumasa Kondo (Shiga University) “Deflation, Population Decline and Sustainability of Public Debt” 16:30~17:00 Presentation, Takakazu Honryo (University of Mannheim) “Strategic Stability of Equilibria in Multi-Sender Signaling Games” ◇ Session 4 ◇ Chair: Makoto Hanazono (Nagoya University)