DOCSLIB.ORG

Danmark

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

<1θ> DANMARK <1°> DK/EP 2448590 Τ3 (12) Oversættelse af europæisk patentskrift Patent- og Varemærkestyrelsen (51) Int.CI.: A 61 K 31/70 (2006.01) A 61 K 31/7008 (2006.01) A 61 K 31/7012 (2006.01) A61P 11/00(2006.01) (45) Oversættelsen bekendtgjort den: 2019-02-25 (80) Dato for Den Europæiske Patentmyndigheds bekendtgørelse om meddelelse af patentet: 2018-10-31 (86) Europæisk ansøgning nr.: 10793441.6 (86) Europæisk indleveringsdag: 2010-07-02 (87) Den europæiske ansøgnings publiceringsdag: 2012-05-09 (86) International ansøgning nr.: AU2010000846 (87) Internationalt publikationsnr.: WO2011000053 (30) Prioritet: 2009-07-03 AU 2009903123 (84) Designerede stater: AL AT BE BG CH CY CZ DE DK EE ES Fl FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR (73) Patenthaver: Australian Biomedical Company Pty Ltd, 34 Munro Avenue, Mt Waverley, Victoria 3149, Australien (72) Opfinder: JIN, Betty, 34 Munro Avenue, Mount Waverley, Victoria 3149, Australien JONES, Paul, Arthur, 47 Yongala Street, Balwyn, Victoria 3103, Australien SEAH, Ee, Ling, 11 Hill Edge Court, Lysterfield South, Victoria 3156, Australien WU, Wen, Yang, 34 Munro Avenue, Mount Waverley, Victoria 3149, Australien JENKINS, Peter, James, 6 Grand View Grove, Prahran East, Victoria 3181, Australien (74) Fuldmægtig i Danmark: Patentgruppen A/S, Arosgården, Åboulevarden 31,8000 Århus C, Danmark (54) Benævnelse: MEDICINSKE KULHYDRATER TIL BEHANDLING AF LUFTVEJSLIDELSER (56) Fremdragne publikationer: EP-A1-1 609 473 EP-A1-2 060 257 EP-A2- 0 429 430 W0-A1 -2006/127977 W0-A1 -2009/020641 WO-A2-02/101071 JP-A- 11 206 050 US-A- 5 834 423 US-A1-2002 022 601 US-A1-2007 259 094 US-A1-2009 209 488 US-B1-6 274 568 DATABASE WPI Week 200137 Thomson Scientific, London, GB; AN 2001-344214 XP002694489, & CN 1 156 026 A (UNIV NO 3 ARMY MEDICAL PLA) 6 August 1997 (1997-08-06) Fortsættes ... DK/EP 2448590 T3 KEPPLER O ET AL: "UDP-GIcNAc 2-epimerase: A regulator of cell surface sialylation", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 284, no. 5418, 21 May 1999 (1999-05-21), pages 1372-1376, XP002164157, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.284.5418.1372 DATABASE WPI Week 199710 Thomson Scientific, London, GB; AN 1997-103654 XP002694542, & JP 8 337532 A (TAKEDA CHEM IND LTD) 24 December 1996 (1996-12-24) NAKANO T. ET AL.: 'Sialic Acid in Human Milk: Composition and Functions' ACTA PAEDIATRICA TAIWANICA vol. 42, no. 1,2001, pages 11 -17, XP009079911 VAN ALPHEN L. ET AL.:'Blocking-of Fimbria-Mediated Adherence of Haemophilus influenzae by Sialyl Gangliosides' INFECTION AND IMMUNITY vol. 59, no. 12, 1991, pages 4473 - 4477, XP008150719 SCHROTEN H. ET AL.: 'Binding of Cloned S-Fimbriated E. coli to Human Buccal, Epithelial Cells - Different Inhibition of Binding by Neonatal Saliva and Adult Saliva' ZENTRALBLATT FUR BAKTERIOLOGIE vol. 274, no. 4, 1991, pages 514 - 518, XP008150727 SCHROTEN H. ET AL.: 'Fab-Independent Antiadhesion Effects of Secretory Immunoglobulin Aon S-Fimbriated Escherichia coli Are Mediated by Sialyloligosaccharides' INFECTION AND IMMUNITY vol. 66, no. 8,1998, pages 3971 - 3973, XP008150720 ARCASOY S.M. ET AL.: 'MUCI and Other Sialylglycoconjugates Inhibit Adenovirus- Mediated Gene Transfer to Epithelial Cells' AMERICAN JOURNAL OFRESPIRATORY CELL & MOLECULAR BIOLOGY vol. 17, no. 4, 1997, pages 422 - 435, XP002951404 SCHULTE B.A. ET AL.: 'Histochemical Methods for Characterizing Secretory and Cell Surface Sialoglycoconjugates' JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY vol. 33, no. 5, 1985, pages 427 -438, XP008150721 RUHL S. ET AL.: 'Identification of Polymorphonucluear Leukocyte and HL-60 Cell Receptors for Adhesins of Streptococcus gordonii and Actinomyces naeslundii' INFECTION AND IMMUNITY vol. 68, no. 11,2000, pages 6346 - 6354, XP008150722 DOSANJH A. ET AL.: 'Expression of DELTAF508 Cystic Fibrosis Treansmembrane Regulator (CFTR) Decreases Membrane Sialylation' OPEN RESPIRATORY MEDICINE JOURNAL vol. 3, May 2009, pages 79 - 84, XP008150728 DK/EP 2448590 T3 DESCRIPTION FIELD OF THE INVENTION [0001] This invention is related to a novel method and a group of carbohydrates of Formula (1) and/or (2), and their compositions for treating cough and related respiratory conditions including post viral/bacterial infections, acute/chronic bronchitis, COPD, and inflammatory conditions. BACKGROUND OF THE INVENTION [0002] In humans, the respiratory tract, with an area of a football field is the largest surface connecting the body with the outside world required for sufficient exchange of air; meanwhile, it is affected by many physical, chemical, and biological substances in the air to cause disorders including asthma, chronic obstructive pulmonary disease, inflammatory conditions of the lung and respiratory tract. Also, some genetic disorders such as cystic fibrosis are affected by the respiratory tract's connection with the outside world. Viruses and bacteria may enter the body and cause infections in the respiratory tract to occur. [0003] Cough is one of the common conditions that needs to be treated. However, the currently available treatments are only limited in symptom relief leaving the body to recover by itself and in many cases the recoveries are sluggish. [0004] In Australia, the sale of cough syrup is over $20 million a year. It is estimated that the worldwide market of cough syrup exceeds $1 billion per annum. [0005] Persistent cough sometimes with period of normality lasting for months or even years is attributed to bronchial asthma, occult reflex, or post viral/bacterial infections and smoking causing the airway to become hypersensitive/hyperreactive. Accordingly there is a need for an efficient treatment that can assist the body to recover after it has been affected by many physical, chemical, and biological substances in the air that can cause disorders in the respiratory system. [0006] The discussion of documents, acts, materials, devices, articles and the like is included in this specification solely for the purpose of providing a context for the present invention. It is not suggested or represented that any or all of these matters formed part of the prior art base or were common general knowledge in the field relevant to the present invention as it existed before the priority date of each claim of this application. SUMMARY OF THE INVENTION DK/EP 2448590 T3 [0007] The present application discloses in one embodiment a method of promoting restoration of a sialylglycoconjugate on the surface of a damaged respiratory cell of a subject to treat a respiratory condition in the subject, the method including the step of administering to the subject at least one pharmaceutically acceptable compound capable of accelerating sialylglycoconjugate biosynthesis. [0008] In one disclosed embodiment, the method provides a recovery of viability of the cell such that the cell is in a better condition for normal biological function to respond to factors which may affect the respiratory surface thereby leading to respiratory conditions such as but not limited coughs, post viral or bacterial infections, acute/chronic bronchitis, chronic obstructive pulmonary disease (COPD), cystic fibrosis and other respiratory inflammatory conditions. [0009] In another embodiment, the disclosure relates to the use of a compound selected from the group consisting of compounds of Formula (1) and Formula (2) and their pharmaceutically acceptable salts and derivatives and combinations thereof. The use is for the treatment or prevention of a respiratory condition as herein described. [0010] In other aspects ofthe invention there are provided compositions and pharmaceutical compositions comprising at least one pharmaceutically acceptable compound capable of accelerating sialylglycoconjugate biosynthesis for use in the treatment and prevention of respiratory conditions. [0011] The embodiments ofthe invention are as specified in the claims. [0012] It is also described therein a method of screening for a compound for the treatment of a respiratory condition, said method comprising: subjecting a cell having reduced sialylglycoconjugates on a surface of the cell to a test compound; and measuring recovery of sialylglycoconjugates on the surface of the cell after exposure of the test compound to the cell. [0013] Measurement of the recovery of sialylglycoconjugates on the surface of the cell can be determined by a measurement of the viability of the cell. [0014] In yet another aspect of the disclosure there is provided a method of treating or preventing a respiratory condition in a subject, the method including the step of administering to the subject at least one compound identified by the screening method. BRIEF DESCRIPTION OF THE FIGURES DK/EP 2448590 T3 [0015] Figure 1 shows the biosynthesis pathway of sialylglycoconjugates in living cell. DETAILED DESCRIPTION OF THE INVENTION [0016] From cell biology and molecular biology point of view, the hypersensitivity/hyperreactivity of the damaged respiratory tract may be caused by their damaged cell surface which then will be susceptible to the stimulation of irritants. For instance, applicants have found that the respiratory tract cells after viral or bacterial infection often lost terminal sialic acids on their surface sialylglycoconjugates. As a consequence, the viability of the "naked" cell was reduced. This then trigged an inflammatory response leading to bronchitis and cough. Without being limited by theory, it is postulated that restoration of the sialic acids on the cell surface may repair the respiratory
Recommended publications
  • (12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 De Juan Et Al

    (12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 De Juan Et Al

    US 200601 10428A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 de Juan et al. (43) Pub. Date: May 25, 2006 (54) METHODS AND DEVICES FOR THE Publication Classification TREATMENT OF OCULAR CONDITIONS (51) Int. Cl. (76) Inventors: Eugene de Juan, LaCanada, CA (US); A6F 2/00 (2006.01) Signe E. Varner, Los Angeles, CA (52) U.S. Cl. .............................................................. 424/427 (US); Laurie R. Lawin, New Brighton, MN (US) (57) ABSTRACT Correspondence Address: Featured is a method for instilling one or more bioactive SCOTT PRIBNOW agents into ocular tissue within an eye of a patient for the Kagan Binder, PLLC treatment of an ocular condition, the method comprising Suite 200 concurrently using at least two of the following bioactive 221 Main Street North agent delivery methods (A)-(C): Stillwater, MN 55082 (US) (A) implanting a Sustained release delivery device com (21) Appl. No.: 11/175,850 prising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more (22) Filed: Jul. 5, 2005 bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more Related U.S. Application Data bioactive agents Subretinally; and (60) Provisional application No. 60/585,236, filed on Jul. (C) instilling (e.g., injecting or delivering by ocular ion 2, 2004. Provisional application No. 60/669,701, filed tophoresis) one or more bioactive agents into the Vit on Apr. 8, 2005. reous humor of the eye. Patent Application Publication May 25, 2006 Sheet 1 of 22 US 2006/0110428A1 R 2 2 C.6 Fig.
  • List of Union Reference Dates A

    List of Union Reference Dates A

    Active substance name (INN) EU DLP BfArM / BAH DLP yearly PSUR 6-month-PSUR yearly PSUR bis DLP (List of Union PSUR Submission Reference Dates and Frequency (List of Union Frequency of Reference Dates and submission of Periodic Frequency of submission of Safety Update Reports, Periodic Safety Update 30 Nov. 2012) Reports, 30 Nov.
  • Genl:VE 1970 © World Health Organization 1970

    Genl:VE 1970 © World Health Organization 1970

    Nathan B. Eddy, Hans Friebel, Klaus-Jiirgen Hahn & Hans Halbach WORLD HEALTH ORGANIZATION ORGANISATION .MONDIALE DE LA SANT~ GENl:VE 1970 © World Health Organization 1970 Publications of the World Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyright Convention. Nevertheless governmental agencies or learned and professional societies may reproduce data or excerpts or illustrations from them without requesting an authorization from the World Health Organization. For rights of reproduction or translation of WHO publications in toto, application should be made to the Division of Editorial and Reference Services, World Health Organization, Geneva, Switzerland. The World Health Organization welcomes such applications. Authors alone are responsible for views expressed in signed articles. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Director-General of the World Health Organization concerning the legal status of any country or territory or of its authorities, or concerning the delimitation of its frontiers. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. © Organisation mondiale de la Sante 1970 Les publications de l'Organisation mondiale de la Sante beneficient de la protection prevue par les dispositions du Protocole n° 2 de la Convention universelle pour la Protection du Droit d'Auteur. Les institutions gouvernementales et les societes savantes ou professionnelles peuvent, toutefois, reproduire des donnees, des extraits ou des illustrations provenant de ces publications, sans en demander l'autorisation a l'Organisation mondiale de la Sante. Pour toute reproduction ou traduction integrate, une autorisation doit etre demandee a la Division des Services d'Edition et de Documentation, Organisation mondiale de la Sante, Geneve, Suisse.
  • PHARMACEUTICAL APPENDIX to the TARIFF SCHEDULE 2 Table 1

    PHARMACEUTICAL APPENDIX to the TARIFF SCHEDULE 2 Table 1

    Harmonized Tariff Schedule of the United States (2020) Revision 19 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2020) Revision 19 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names INN which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service CAS registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known.
  • Article (Published Version)

    Article (Published Version)

    Article Characterization of drug‐induced transcriptional modules: towards drug repositioning and functional understanding ISKAR, Murat, et al. Reference ISKAR, Murat, et al. Characterization of drug‐induced transcriptional modules: towards drug repositioning and functional understanding. Molecular Systems Biology, 2013, vol. 9, no. 1, p. 662 DOI : 10.1038/msb.2013.20 PMID : 23632384 Available at: http://archive-ouverte.unige.ch/unige:153825 Disclaimer: layout of this document may differ from the published version. 1 / 1 Molecular Systems Biology 9; Article number 662; doi:10.1038/msb.2013.20 Citation: Molecular Systems Biology 9:662 www.molecularsystemsbiology.com Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding Murat Iskar1, Georg Zeller1, Peter Blattmann2,3, Monica Campillos4,5, Michael Kuhn6, Katarzyna H Kaminska1,9, Heiko Runz3,7, Anne-Claude Gavin1, Rainer Pepperkok2,3, Vera van Noort1 and Peer Bork1,8,* 1 Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, 2 Cell Biology/Biophysics Unit, EMBL, Heidelberg, Germany, 3 Molecular Medicine Partnership Unit (MMPU), EMBL, University of Heidelberg, Heidelberg, Germany, 4 Institute for Bioinformatics and Systems Biology, Helmholtz Center Munich–German Research Center for Environmental Health (GmbH), Neuherberg, Germany, 5 German Center for Diabetes Research (DZD), Neuherberg, Germany, 6 Biotechnology Center, TU Dresden, Dresden, Germany, 7 Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany and 8 Max-Delbru¨ck-Centre for Molecular Medicine, Berlin, Germany 9Present address: International Institute of Molecular and Cell Biology in Warsaw, ul. Ks. Trojdena 4, 02-109 Warsaw, Poland * Corresponding author. Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, Heidelberg, Germany.
  • Etats Rapides

    Etats Rapides

    List of European Pharmacopoeia Reference Standards Effective from 2015/12/24 Order Reference Standard Batch n° Quantity Sale Information Monograph Leaflet Storage Price Code per vial Unit Y0001756 Exemestane for system suitability 1 10 mg 1 2766 Yes +5°C ± 3°C 79 ! Y0001561 Abacavir sulfate 1 20 mg 1 2589 Yes +5°C ± 3°C 79 ! Y0001552 Abacavir for peak identification 1 10 mg 1 2589 Yes +5°C ± 3°C 79 ! Y0001551 Abacavir for system suitability 1 10 mg 1 2589 Yes +5°C ± 3°C 79 ! Y0000055 Acamprosate calcium - reference spectrum 1 n/a 1 1585 79 ! Y0000116 Acamprosate impurity A 1 50 mg 1 3-aminopropane-1-sulphonic acid 1585 Yes +5°C ± 3°C 79 ! Y0000500 Acarbose 3 100 mg 1 See leaflet ; Batch 2 is valid until 31 August 2015 2089 Yes +5°C ± 3°C 79 ! Y0000354 Acarbose for identification 1 10 mg 1 2089 Yes +5°C ± 3°C 79 ! Y0000427 Acarbose for peak identification 3 20 mg 1 Batch 2 is valid until 31 January 2015 2089 Yes +5°C ± 3°C 79 ! A0040000 Acebutolol hydrochloride 1 50 mg 1 0871 Yes +5°C ± 3°C 79 ! Y0000359 Acebutolol impurity B 2 10 mg 1 -[3-acetyl-4-[(2RS)-2-hydroxy-3-[(1-methylethyl)amino] propoxy]phenyl] 0871 Yes +5°C ± 3°C 79 ! acetamide (diacetolol) Y0000127 Acebutolol impurity C 1 20 mg 1 N-(3-acetyl-4-hydroxyphenyl)butanamide 0871 Yes +5°C ± 3°C 79 ! Y0000128 Acebutolol impurity I 2 0.004 mg 1 N-[3-acetyl-4-[(2RS)-3-(ethylamino)-2-hydroxypropoxy]phenyl] 0871 Yes +5°C ± 3°C 79 ! butanamide Y0000056 Aceclofenac - reference spectrum 1 n/a 1 1281 79 ! Y0000085 Aceclofenac impurity F 2 15 mg 1 benzyl[[[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxy]acetate
  • UNIVERSITE DE NANTES Thomas Gelineau

    UNIVERSITE DE NANTES Thomas Gelineau

    UNIVERSITE DE NANTES __________ FACULTE DE MEDECINE __________ Année 2011 N° 139 THESE pour le DIPLÔME D’ÉTAT DE DOCTEUR EN MÉDECINE DES de médecine générale par Thomas Gelineau né le 29 janvier 1983 à Cholet __________ Présentée et soutenue publiquement le 06/12/2011 __________ LE RHUME DE L'ENFANT ET SON TRAITEMENT: DECISION PARTAGEE AVEC LES PARENTS D'APRES UN QUESTIONNAIRE __________ Président : Monsieur le Professeur Olivier MALARD Directeur de thèse : Madame le Professeur Jacqueline LACAILLE 1 Table des matières IIntroduction................................................................................................................ 7 IIDéfinition, état des connaissances...........................................................................8 1Le rhume.......................................................................................................................................8 APhysiopathologie............................................................................................................................. 8 aL'origine virale.................................................................................................................................... 8 bLa saisonnalité................................................................................................................................... 8 cL'âge de survenue.............................................................................................................................. 9 dLe sexe..................................................................................................................................................
  • General Pharmacology

    General Pharmacology

    GENERAL PHARMACOLOGY Winners of “Nobel” prize for their contribution to pharmacology Year Name Contribution 1923 Frederick Banting Discovery of insulin John McLeod 1939 Gerhard Domagk Discovery of antibacterial effects of prontosil 1945 Sir Alexander Fleming Discovery of penicillin & its purification Ernst Boris Chain Sir Howard Walter Florey 1952 Selman Abraham Waksman Discovery of streptomycin 1982 Sir John R.Vane Discovery of prostaglandins 1999 Alfred G.Gilman Discovery of G proteins & their role in signal transduction in cells Martin Rodbell 1999 Arvid Carlson Discovery that dopamine is neurotransmitter in the brain whose depletion leads to symptoms of Parkinson’s disease Drug nomenclature: i. Chemical name ii. Non-proprietary name iii. Proprietary (Brand) name Source of drugs: Natural – plant /animal derivatives Synthetic/semisynthetic Plant Part Drug obtained Pilocarpus microphyllus Leaflets Pilocarpine Atropa belladonna Atropine Datura stramonium Physostigma venenosum dried, ripe seed Physostigmine Ephedra vulgaris Ephedrine Digitalis lanata Digoxin Strychnos toxifera Curare group of drugs Chondrodendron tomentosum Cannabis indica (Marijuana) Various parts are used ∆9Tetrahydrocannabinol (THC) Bhang - the dried leaves Ganja - the dried female inflorescence Charas- is the dried resinous extract from the flowering tops & leaves Papaver somniferum, P album Poppy seed pod/ Capsule Natural opiates such as morphine, codeine, thebaine Cinchona bark Quinine Vinca rosea periwinkle plant Vinca alkaloids Podophyllum peltatum the mayapple
  • Cardiac Sigma Receptors – an Update

    Cardiac Sigma Receptors – an Update

    Physiol. Res. 67 (Suppl. 4): S561-S576, 2018 https://doi.org/10.33549/physiolres.934052 REVIEW Cardiac Sigma Receptors – An Update T. STRACINA1, M. NOVAKOVA1 1Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic Received March 25, 2018 Accepted September 12, 2018 Summary (Martin et al. 1976). The authors believed that sigma More than four decades passed since sigma receptors were first receptor represents an opioid receptor subtype, which mentioned. Since then, existence of at least two receptor mediates psychomimetic and stimulatory behavioral subtypes and their tissue distributions have been proposed. effects of N-allylnormetazocine (SKF-10047) in chronic Nowadays, it is clear, that sigma receptors are unique ubiquitous spinal dog. Subsequent binding studies in guinea pig and proteins with pluripotent function, which can interact with so rat showed that binding profile of sigma receptor differs many different classes of proteins. As the endoplasmic resident from any other known subtype of opioid receptor as well proteins, they work as molecular chaperones – accompany as other receptor classes (Su 1982, Tam 1983). Therefore, various proteins during their folding, ensure trafficking of the the sigma receptor was defined as novel receptor type maturated proteins between cellular organelles and regulate their (Su 1982). functions. In the heart, sigma receptor type 1 is more dominant. Cardiac sigma 1 receptors regulate response to endoplasmic Two subtypes of sigma receptor reticulum stress, modulates calcium signaling in cardiomyocyte Further research led to differentiation among at and can affect function of voltage-gated ion channels. They least two subtypes of sigma receptors. Based on their contributed in pathophysiology of cardiac hypertrophy, heart diverse ligand selectivity and stereospecificity, association failure and many other cardiovascular disorders.
  • Pharmaceutical Appendix to the Tariff Schedule 2

    Pharmaceutical Appendix to the Tariff Schedule 2

    Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. ABACAVIR 136470-78-5 ACIDUM LIDADRONICUM 63132-38-7 ABAFUNGIN 129639-79-8 ACIDUM SALCAPROZICUM 183990-46-7 ABAMECTIN 65195-55-3 ACIDUM SALCLOBUZICUM 387825-03-8 ABANOQUIL 90402-40-7 ACIFRAN 72420-38-3 ABAPERIDONUM 183849-43-6 ACIPIMOX 51037-30-0 ABARELIX 183552-38-7 ACITAZANOLAST 114607-46-4 ABATACEPTUM 332348-12-6 ACITEMATE 101197-99-3 ABCIXIMAB 143653-53-6 ACITRETIN 55079-83-9 ABECARNIL 111841-85-1 ACIVICIN 42228-92-2 ABETIMUSUM 167362-48-3 ACLANTATE 39633-62-0 ABIRATERONE 154229-19-3 ACLARUBICIN 57576-44-0 ABITESARTAN 137882-98-5 ACLATONIUM NAPADISILATE 55077-30-0 ABLUKAST 96566-25-5 ACODAZOLE 79152-85-5 ABRINEURINUM 178535-93-8 ACOLBIFENUM 182167-02-8 ABUNIDAZOLE 91017-58-2 ACONIAZIDE 13410-86-1 ACADESINE 2627-69-2 ACOTIAMIDUM 185106-16-5 ACAMPROSATE 77337-76-9
  • Marrakesh Agreement Establishing the World Trade Organization

    Marrakesh Agreement Establishing the World Trade Organization

    No. 31874 Multilateral Marrakesh Agreement establishing the World Trade Organ ization (with final act, annexes and protocol). Concluded at Marrakesh on 15 April 1994 Authentic texts: English, French and Spanish. Registered by the Director-General of the World Trade Organization, acting on behalf of the Parties, on 1 June 1995. Multilat ral Accord de Marrakech instituant l©Organisation mondiale du commerce (avec acte final, annexes et protocole). Conclu Marrakech le 15 avril 1994 Textes authentiques : anglais, français et espagnol. Enregistré par le Directeur général de l'Organisation mondiale du com merce, agissant au nom des Parties, le 1er juin 1995. Vol. 1867, 1-31874 4_________United Nations — Treaty Series • Nations Unies — Recueil des Traités 1995 Table of contents Table des matières Indice [Volume 1867] FINAL ACT EMBODYING THE RESULTS OF THE URUGUAY ROUND OF MULTILATERAL TRADE NEGOTIATIONS ACTE FINAL REPRENANT LES RESULTATS DES NEGOCIATIONS COMMERCIALES MULTILATERALES DU CYCLE D©URUGUAY ACTA FINAL EN QUE SE INCORPOR N LOS RESULTADOS DE LA RONDA URUGUAY DE NEGOCIACIONES COMERCIALES MULTILATERALES SIGNATURES - SIGNATURES - FIRMAS MINISTERIAL DECISIONS, DECLARATIONS AND UNDERSTANDING DECISIONS, DECLARATIONS ET MEMORANDUM D©ACCORD MINISTERIELS DECISIONES, DECLARACIONES Y ENTEND MIENTO MINISTERIALES MARRAKESH AGREEMENT ESTABLISHING THE WORLD TRADE ORGANIZATION ACCORD DE MARRAKECH INSTITUANT L©ORGANISATION MONDIALE DU COMMERCE ACUERDO DE MARRAKECH POR EL QUE SE ESTABLECE LA ORGANIZACI N MUND1AL DEL COMERCIO ANNEX 1 ANNEXE 1 ANEXO 1 ANNEX
  • Pharmaceutical Appendix to the Harmonized Tariff Schedule

    Pharmaceutical Appendix to the Harmonized Tariff Schedule

    Harmonized Tariff Schedule of the United States Basic Revision 3 (2021) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States Basic Revision 3 (2021) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names INN which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service CAS registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known.