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Health safari project implemented at NDMC Schools Bright field image of HeLa cells Anti-microbial peptides grown in normal from wasp venom culture media Annual National Facility for Rice leaffolder Marine Cyanobacterial culture Report Repository 2011-2012 Protein Nano Betanodavirus assay medicine prototype kit Droplet based digital microfluidic platform Annual Report 2011-2012 Department of Biotechnology Ministry of Science & Technology Government of India CONTENTS Chapter – 1 : Overview 1- 34 Chapter – 2 : Human Resource Development 35-48 Teaching 35 Training Programmes 38 Fellowships 39 DBT Scholarships and Awards 43 Rapid Grant for young Investigators Scheme 45 DBT-CREST Award 46 Biotechnology Entrepreneurship Student Teams 46 Biotech Popularization and Promotion 47 Chapter – 3 : Biotech Facilities, Technology platforms & Research Resources 49-60 Centres of Excellence 49 Programme Support 52 Long term R&D Projects 55 Biotech Facilities and Research Resources 55 BUILDER Scheme 57 Chapter – 4 : Research and Development 61-168 Agricultural Biotechnology 61 Biofertiliser Biotechnology 77 Biopesticides and Crop Management 79 Bioresource Development and Utilization 83 Plant Biotechnology 92 Medicinal and Aromatics Plants 101 Animal Biotechnology-Production 103 Animal Health 109 Aquaculture and Marine Biotechnology 112 Seribiotechnology 119 Basic Research in Modern Biology 112 Contents Annual Report : 2011-12 Medical Biotechnology 127 Stem Cell Research 134 Bioengineering 136 Human Genetics and Genome Analysis 140 Environmental Biotechnology 143 Nanoscience and Nanobiotechnology 151 RNAi Technology platforms 155 Energy Bioscience Programme 159 Chapter – 5 : Biotechnology Programmes for Societal Development 169-185 Programmes for SC and ST Population 169 Programmes for Rural Development 174 Programmes for Women 180 Chapter – 6 : Biotech Product & Process Development 187-208 Small Business Innovation Research Initiative 187 Biotechnology Industry Partnership Programme 191 Biotechnology Industry Research Assistance Council 194 Biotech Product and Process Development 195 Biotechnological Approaches for Food and Nutritional Security 198 Biosafety Issues 202 Patent Facilitation Cell 208 Chapter – 7 : Biotechnology Information System Network 209-219 Chapter – 8 : Biotechnology Parks and Incubators 221-223 Chapter – 9 : International Collaboration 225-244 Chapter – 10 : Autonomous Institutions 245-284 National Institute of Immunology 245 National Centre for Cell Science 246 National Brain Research Centre 249 Centre for DNA Fingerprinting and Diagnostics 251 National Institute of Plant Genome Research 258 Annual Report : 2011-12 Contents Institute of Life Sciences 261 Institute of Bioresources and Sustainable Development 263 Rajiv Gandhi Centre for Biotechnology 265 Institute for Stem Cell Science and Regenerative Medicine 268 Translational Health Science and Technology Institute 270 National Institute of Biomedical Genomics 272 Regional Centre for Biotechnology 273 National Agri-Food Biotechnology Institute 275 National Institute of Animal Biotechnology 283 Bioclusters 283 Chapter – 11 : Public sector Undertakings 285-286 Chapter – 12 : International Centre for Genetic Engineering 287-291 and Biotechnology Chapter – 13 : Promotion of Biotechnology in the North Eastern 293-298 States of India Chapter – 14 : New Legislations & Regulations 299-300 Chapter – 15 : Administration and Finance 301-305 Annexures I – VII 307-330 Abbreviations 331-339 Chapter 1 OVERVIEW Rs. 23 crore in 1986-87 to Rs.1426.92 crore Preamble in 2011-12. The department moved with the progress from its single institute, National The year 2011-12 has been very significant Institute of Immunology, New Delhi to 14 in the life of the Department of autonomous institutions covering the areas Biotechnology. This year the department was of plant, human sciences, industrial rated as one of the Toppers amongst the biotechnology, stem cell science and first three Ministries/Department, by the regenerative medicine, translational health Cabinet Secretariat in the Government’s science, biomedical genomics, agri-food Performance Review. The department has biotechnology and animal biotechnology. completed 25 years of its existence and is The department is also committed to celebrating the Silver Jubilee this year. It is provide nearly two-thirds of its budget to therefore a right occasion for reflection. Universities and non-DBT institutes. The department has grown into a major India needs to increase quality Ph.Ds atleast national research and development agency by three folds. The generation of Ph.Ds and presently providing nearly two-thirds of the scientific publications from India are showing research and development support in the a major upward trend and high quality life science sector. The department’s initial publication are increasing in number. The emphasis was on creating an institutional biotechnology industry has consistently framework for biological science and maintained growth of approximately 28% biotechnology, human resources at Ph.D. and in the last decade and nearly 46 products Post Doctoral levels, creating and nurturing have been commercialized by the biotech scientific and technology leaders in the industry in the country. Our regulatory country. The performance of department system has matured in its quality and supported universities and academia transparency and so has the ability to manage institutions in this field have been par- intellectual property, technology transfer, excellence. The budgetary allocation of the entrepreneurship and academia-industry department has increased from around relationship. 1 Overview Annual Report : 2011-12 From a few simple generic schemes, we for establishing a science based totally now have a large and diverse portfolio of autonomous, biotechnology regulatory schemes to support people, institutions and authority; initiation of special programmes universities, to promote excellence, to initiate to create interdisciplinary life science centres and effectively manage R&D networks in universities with 50% of our R&D nationally and globally. While nurturing expenditure in the university system. New basic and interdisciplinary science, DBT has initiatives in system biology, plant genomics effectively intervened to make a difference and molecular breeding, human and animal to the health sector, agriculture sector and vaccines, prospecting of bioresource for in catalysing and supporting development drugs, stem cell research and regenerative and diffusion of affordable technologies. medicine, food fortification for nutritionally The DBT’s critical role in these sectors is deprived segments of the population; to sustain high-end science, technology affordable health technology in implant and innovation and industry-academia inter- devices using the biodesign approach are action, complementing the efforts of agencies other key elements. like ICAR and ICMR. A device to manage faecal incontinence has The department has implemented over 90% been developed by the Fellows of the first of the recommendations of the national batch of the Stanford-India Biodesign biotechnology development strategy, built Programme implemented by DBT at AIIMS excellence in basic and interdisciplinary and IIT Delhi in collaboration with Stanford science, and produced and nurtured human University, USA. resources for innovation. Highlights of this are: establishment of seven new institutes The goals set in the biotechnology strategy designed to do both basic science and of a globally connected nationally relevant affordable technology; three new bioscience biotechnology sector are on its way of being clusters in Faridabad, Mohali and Bangalore; fulfilled with a remarkable increase in our full operationalization of two highly global partnership with almost every major acclaimed schemes of SBIRI and BIPP/ biotechnology nation covering North America, BIRAC for supporting partnership. Europe, Scandinavia, Australia, Canada, Russia and Cuba. The global partnership has Other highlights include Public-Private been strategically done to use and leverage Partnership, with about a 120 such projects India’s cost arbitrage for giving affordable in operation today, the cabinet approval solutions to our people. The effect of these 2 Annual Report : 2011-12 Overview developments was visible in the last year The department has signed an MOU with when Indian biotechnology industry recorded the partner institutions for creating “Bio- approximately 25% growth and crossed US Cluster Board”, a legal entity for its $4 billion despite global recession. management and to synergize their intellectual strength and facilities to create The public private partnership and the a seamless campus. New schemes in North- increased availability of quality human Eastern region were implemented for resources, the ready access to research students from North East region for RA resources and our sophistication in fellowship and Biotech Industrial Training managing technology transfer resulted in a Programme offering industrial training to major push towards product development. fresh B.Tech/M.Sc./M.Tech students in Some of this includes commercialization of biotechnology in industry for a period of 6 three new influenza vaccines, bivalent polio months. This program is being implemented vaccine and pentavalent vaccine, by the Biotech Consortium India Limited meningococcal–B vaccine, low cost (BCIL) New Delhi. Through a special diagnostic for several infectious diseases, programme DBT has supported
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