DOCSLIB.ORG

Nuclear Magnetic Resonance Imaging Technology: a Clinical, Industrial, and Policy Analysis

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Nuclear Magnetic Resonance Imaging Technology: a Clinical, Industrial, and Policy Analysis Nuclear Magnetic Resonance Imaging Technology: A Clinical, Industrial, and Policy Analysis September 1984 NTIS order #PB85-146207 — HEALTH TECHNOLOGY CASE STUDY 27: Nuclear Magnetic Resonance Imaging Technology A Clinical, Industrial, and Policy Analysis SEPTEMBER 1984 This case study was performed as a part of OTA’s Assessment of Federal Policies and the Medical Devices Industry Prepared for OTA by: Earl P. Steinberg, M. D., M.P.P. Assistant Professor, Johns Hopkins School of Medicine and John Hopkins School of Hygiene and Public Health; Senior Associate, Office of Medical Practice Evaluation; also w/Henry J. Kaiser Family Foundation Faculty Scholar in General Internal Medicine and Alan B. Cohen, Sc.D. Associate Director, Center for Hospital Finance and Management; also w/Assistant Professor of Health Policy and Management, Johns Hopkins School of Hygiene and Public Health f I OTA Case Studies are documents containing information on a specific medical technology or area of application that supplements formal OTA assessments. The material is not normally of as immediate policy interest as that in an OTA Report, nor does it present options for Congress to consider. CONGRESS OF THE UNITED STATES Office of Technology Assessment Washington, D C 20510 Recommended Citation: Health Technology Case Study 27: Nuclear Magnetic Resonance Imaging Technology: A Clinical, Industrial, and Policy Analysis (Washington, DC: U.S. Congress, Office of Tech- nology Assessment, OTA-HCS-27, September 1984). This case study was performed as part of OTA’s assessment of Federal Policies and the Medical Devices Industry. Library of Congress Catalog Card Number 84-601123 For sale by the Superintendent of Documents, U.S. Government Printing Office, Washington, D.C. 20402 Preface Nuclear Magnetic Resonance Imaging Tech- tion (preventive, diagnostic, therapeutic, and nology: A Clinical, Industrial, and Policy Anal- rehabilitative); ysis is Case Study 27 in OTA’s Health Technology examples of types of technologies by physical Case Study Series. This case study has been prepared nature (drugs, devices, and procedures); in connection with OTA’s project on Federal examples of technologies in different stages Policies and the Medical Devices Industry, re- of development and diffusion (new, emerg- quested by the Senate Committee on Labor and ing, and established); Human Resources and endorsed by the Senate examples from different areas of medicine Committee on Veterans’ Affairs. A listing of other (e.g., general medical practice, pediatrics, case studies in the series is included at the end of radiology, and surgery); this preface. examples addressing medical problems that are important because of their high frequen- OTA case studies are designed to fulfill two cy or significant impacts (e. g., cost); functions. The primary purpose is to provide examples of technologies with associated high OTA with specific information that can be used costs either because of high volume (for low- in formin general conclusions regardin broader g g cost technologies) or high individual costs; policy issues. The first 19 cases in the Health Tech- examples that could provide information ma- nology Case Stud Series, for example, were con- y terial relating to the broader policy and meth- ducted in conjunction with OTA’s overall project odological issues being examined in the on The Implications of Cost-Effectiveness Anal- particular overall project; and ysis of Medical Technology. By examining the 19 examples with sufficient scientific literature. cases as a group and looking for common prob- lems or strengths in the techniques of cost-effec- Case studies are either prepared by OTA staff, tiveness or cost-benefit analysis, OTA was able commissioned by OTA and performed under con- to better analyze the potential contribution that tract by experts (generally in academia), or writ- those techniques might make to the management ten by OTA staff on the basis of contractors’ of medical technology and health care costs and papers. quality. OTA subjects each case study to an extensive The second function of the case studies is to review process. Initial drafts of cases are reviewed provide useful information on the specific tech- by OTA staff and by members of the advisory nologies covered. The design and the funding lev- panel to the associated project. For commissioned els of most of the case studies are such that they cases, comments are provided to authors, along should be read primarily in the context of the as- with OTA’s suggestions for revisions. Subsequent sociated overall OTA projects. Nevertheless, in drafts are sent by OTA to numerous experts for many instances, the case studies do represent ex- review and comment. Each case is seen by at least tensive reviews of the literature on the efficacy, 30 reviewers, and sometimes by 80 or more out- safety, and costs of the specific technologies and side reviewers. These individuals may be from as such can stand on their own as a useful contri- relevant Government agencies, professional so- bution to the field. cieties, consumer and public interest groups, med- ical practice, and academic medicine. Academi- Case studies are prepared in some instances be- cians such as economists, sociologists, decision cause they have been specifically requested by analysts, biologists, and so forth, as appropriate, congressional committees and in others because also review the cases. they have been selected through an extensive re- view process involving OTA staff and consulta- Although cases are not statements of official tions with the congressional staffs, advisory panel OTA position, the review process is designed to to the associated overall project, the Health Pro- satisfy OTA’s concern with each case study’s gram Advisory Committee, and other experts in scientific quality and objectivity. During the vari- various fields. Selection criteria were developed ous stages of the review and revision process, to ensure that case studies provide the following: therefore, OTA encourages, and to the extent possible requires, authors to present balanced in- Ž examples of types of technologies by func- formation and recognize divergent points of view. 111,.. Health Technology Case Study Seriesa — . ——. —. .-. —.. ————...— ——— —— . Case Study Case Study Series Case study title; author(s); Series Case study title; author(s); number OTA publication numberb number OTA publication numberb 1 Formal Analysis, Policy Formulation, and End-Stage 14 Cost Benefit/Cost Effectiveness of Medical Renal Disease; Technologies: A Case Study of Orthopedic Joint Richard A. Rettig (OTA-BP-H-9(1)) C Implants; 2 The Feasibility of Economic Evaluation of Judith D. Bentkover and Philip G. Drew Diagnostic Procedures: The Case of CT Scanning; (OTA-BP-H-9(14)) Judith L. Wagner (OTA-BP-H-9(2)) 15 Elective Hysterectomy: Costs, Risks, and Benefits; 3 Screening for Colon Cancer: A Technology Carol Korenbrot, Ann B. Flood, Michael Higgins, Assessment; Noralou Roos, and John P. Bunker David M. Eddy (OTA-BP-H-9(3)) (OTA-BP-H-9(15)) 4 Cost Effectiveness of Automated Multichannel 16 The Costs and Effectiveness of Nurse Practitioners; Chemistry Analyzers; Lauren LeRoy and Sharon Solkowitz Milton C. Weinstein and Laurie A. Pearlman (OTA-BP-H-9(16)) (OTA-BP-H-9(4)) 17 Surgery for Breast Cancer; 5 Periodontal Disease: Assessing the Effectiveness and Karen Schachter Weingrod and Duncan Neuhauser Costs of the Keyes Technique; (OTA-BP-H-9(17)) Richard M. Scheffler and Sheldon Rovin 18 The Efficacy and Cost Effectiveness of (OTA-BP-H-9(5)) Psychotherapy; 6 The Cost Effectiveness of Bone Marrow Transplant Leonard Saxe (Office of Technology Assessment) Therapy and Its Policy Implications; (OTA-BP-H-9(18)) d Stuart O. Schweitzer and C. C. Scalzi 19 Assessment of Four Common X-Ray Procedures; (OTA-BP-H-9(6)) Judith L. Wagner (OTA-BP-H-9(19))e 7 Allocating Costs and Benefits in Disease Prevention 20 Mandatory Passive Restraint Systems in Programs: An Application to Cervical Cancer Automobiles: Issues and Evidence; Screening; Kenneth E. Warner (OTA-BP-H-15(20))f Bryan R. Luce (Office of Technology Assessment) 21 Selected Telecommunications Devices for Hearing- (OTA-BP-H-9(7)) Impaired Persons; 8 The Cost Effectiveness of Upper Gastrointestinal Virginia W. Stern and Martha Ross Redden Endoscopy; (OTA-BP-H-16(21)) g Jonathan A. Showstack and Steven A. Schroeder 22 The Effectiveness and Costs of Alcoholism (OTA-BP-H-9(8)) Treatment; 9 The Artificial Heart: Cost, Risks, and Benefits; Leonard Saxe, Denise Dougherty, Katharine Esty, Deborah P. Lubeck and John P. Bunker and Michelle Fine (OTA-HCS-22) (OTA-BP-H-9(9)) 23 The Safety, Efficacy, and Cost Effectiveness of 10 The Costs and Effectiveness of Neonatal Intensive Therapeutic Apheresis; Care; John C. Langenbrunner (Office of Technology Peter Budetti, Peggy McManus, Nancy Barrand, Assessment) (OTA-HCS-23) and Lu Ann Heinen (OTA-BP-H-9(1O)) 24 Variation in Length of Hospital Stay: Their 11 Benefit and Cost Analysis of Medical Interventions: Relationship to Health Outcomes; The Case of Cimetidine and Peptic Ulcer Disease; Mark R. Chassin (OTA-HCS-24) Harvey V. Fineberg and Laurie A. Pearlman 25 Technology and Learning Disabilities; (OTA-BP-H-9(11)) Candis Cousins and Leonard Duhl (OTA-HCS-25) 12 Assessing Selected Respiratory Therapy Modalities: 26 Assistive Devices for Severe Speech Impairments; Trends and Relative Costs in the Washington, D.C. Judith Randal (Office of Technology Assessment) Area; (OTA-HCS-26) Richard M. Scheffler and Morgan Delaney 27 Nuclear
Load more

Recommended publications
  • A Compound for Use in Imaging Procedures Original Research Article
    J of Nuclear Medicine Technology, first published online September 3, 2015 as doi:10.2967/jnmt.115.162404 A compound for use in imaging procedures Original research article Mulugeta Semework, Ph.D., Postdoctoral Research Scientist Columbia University Department of Neuroscience 1051 Riverside Drive, Unit 87 New York, N.Y. 10032 e-mails: [email protected] [email protected] Tel: 678-362-3554, Fax: 646-774-7649 Sources of support: NINDS training grant from 2T32MH015174-35 (to Dr. Rene Hen); Support from NEI grant 1 R01 EY014978-06 (to Dr. Michael E. Goldberg); Supplement grant through NEI grant 3 R01 EY014978-06; Brain & Behavior Research Foundation (NARSAD) 2013 Young Investigator Award; generous scan time, technical and expert support from New York State Psychiatric Institute MRI unit, PET Center at Columbia University Medical Center Department of Radiology, Department of Radiology of the Center for Neurobiology and Behavior, of Columbia University/Neurological Institute and the radiology department of NY- Presbyterian Hospital. Word count: 5073 (including references) Short running title: Imaging compound 1 Abstract Numerous research and clinical interventions, such as targeted drug deliveries or surgeries, finding blood clots, abscess, lesions, etc., require accurate localization of various body parts. Individual differences in anatomy make it hard to use typical stereotactic procedures that rely upon external landmarks and standardized atlases. For instance, it is not unusual to make misplaced craniotomies in brain surgery. This project was thus carried out to find a new and easy method to correctly establish the relationship between external landmarks and medical scans of internal organs, such as specific brain regions.
    [Show full text]
  • Medical Instruments/Equipment Catalogue
    MEDICAL INSTRUMENTS/EQUIPMENT CATALOGUE Addis Ababa, Ethiopia December, 2008 WHO Ethiopia 1 TABLE OF CONTENTS Page No. Acknowledgements ………………………………………………..II Forward…………………………………………………………….III Introduction………………………………………………………..IV Diagnostic Instruments…………………………………………….1 Laboratory instruments……………………………………............14 Imaging instruments………………………………………………..30 General Surgery instruments………………………………………..32 ENT instruments……………………………………………………55 Ophthalmic instruments……………………………………………..73 Cardiovascular and thoracic instruments..………………………….110 Dental instruments…………………………………………………131 Orthopedic instruments……………………………………………..148 Rectal instruments…………………………………………………..175 Gynecology instruments…………………………………………….179 Physiotherapy ………………………….……………………………196 Hospital Equipments…………………………………………………203 Catalogue index………………………………………………………210 i ACKNOWLEDGEMENTS The Pharmaceutical Fund and Supply Agency (PFSA) of Ethiopia would like to extend its gratitude to the World Health Organization (WHO) for its technical support and for meeting all the financial expenses associated with the preparation and printing of this Catalogue. PFSA acknowledges the contribution of Sister Mebrat Ashine (from PFSA), Mr Bekele Tefera (National Professional Officer for Essential Drugs and Medicines policy of WHO office) and Mr Ashenafi Hussein (from PFSA) who jointly prepared this catalogue with great commitment and effort. PFSA also thanks all those who contributed directly or indirectly for the preparation of this catalogue. ii F0RWARD The day to day health care activities
    [Show full text]
  • Molecular Imaging of Inflammatory Disease
    biomedicines Review Molecular Imaging of Inflammatory Disease Meredith A. Jones 1,2, William M. MacCuaig 1,2, Alex N. Frickenstein 1,2, Seda Camalan 3 , Metin N. Gurcan 3, Jennifer Holter-Chakrabarty 2,4, Katherine T. Morris 2,5 , Molly W. McNally 2, Kristina K. Booth 2,5, Steven Carter 2,5, William E. Grizzle 6 and Lacey R. McNally 2,5,* 1 Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK 73019, USA; [email protected] (M.A.J.); [email protected] (W.M.M.); [email protected] (A.N.F.) 2 Stephenson Cancer Center, University of Oklahoma, Oklahoma City, OK 73104, USA; [email protected] (J.H.-C.); [email protected] (K.T.M.); [email protected] (M.W.M.); [email protected] (K.K.B.); [email protected] (S.C.) 3 Department of Internal Medicine, Wake Forest Baptist Health, Winston-Salem, NC 27157, USA; [email protected] (S.C.); [email protected] (M.N.G.) 4 Department of Medicine, University of Oklahoma, Oklahoma City, OK 73104, USA 5 Department of Surgery, University of Oklahoma, Oklahoma City, OK 73104, USA 6 Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA; [email protected] * Correspondence: [email protected] Abstract: Inflammatory diseases include a wide variety of highly prevalent conditions with high mortality rates in severe cases ranging from cardiovascular disease, to rheumatoid arthritis, to chronic obstructive pulmonary disease, to graft vs. host disease, to a number of gastrointestinal disorders. Many diseases that are not considered inflammatory per se are associated with varying levels of inflammation.
    [Show full text]
  • Scintillator Requirements for Medical Imaging
    Lawrence Berkeley National Laboratory Lawrence Berkeley National Laboratory Title Scintillator requirements for medical imaging Permalink https://escholarship.org/uc/item/5pc245ds Author Moses, William W. Publication Date 1999-09-01 eScholarship.org Powered by the California Digital Library University of California Accepted by the International Conference on Inorganic Scintillators and Their Applications: SCINT99 LBNL-4580 Scintillator Requirements for Medical Imaging* William W. Moses Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720 USA Scintillating materials are used in a variety of medical imaging devices. This paper presents a description of four medical imaging modalities that make extensive use of scintillators: planar x-ray imaging, x-ray computed tomography (x-ray CT), SPECT (single photon emission computed tomography) and PET (positron emission tomography). The discussion concentrates on a description of the underlying physical principles by which the four modalities operate. The scintillator requirements for these systems are enumerated and the compromises that are made in order to maximize imaging performance utilizing existing scintillating materials are discussed, as is the potential for improving imaging performance by improving scintillator properties. Keywords: Medical Imaging, Planar X-Ray, X-Ray CT, SPECT, PET 1. Introduction The first medical image is arguably the x-ray image that Röntgen took of his wife’s hand in 1895. While Roentgen used photographic film to convert the x-rays into a form observable by the human eye, within one year powdered phosphor materials such as CaWO4 replaced photographic film as the x-ray conversion material [1, 2], and have been an integral part of medical imaging devices ever since.
    [Show full text]
  • Radiology in the Next Hundred Years Alexander R
    26 World Health • 48th Yeor, No. 3, Moy-J une 1995 Radiology in the next hundred years Alexander R. Margulis f we review the for brain tu­ accomplish­ mours, while I ments of interventional imaging during radiology is the last 100 years making advances since Rontgen's with the intro­ discovery of duction of X-rays, we must catheters through conclude that the femoral progress was artery to carry initially slow but radiotherapy to gained speed, an affected with momentous organ. Indeed advances in interventional technology. The radiology, which relatively early in the beginning breakthroughs used only fluo­ were the image roscopy with Coronary angiography examination. A radiation-opaque dye injected into the body outlines intensifier and arteries and shows up any obstruction on the screen. television view- television view­ ing for imaging ing, which made interventional control, is today also employing radiology possible and transformed ultrasound, CT and now magnetic gastrointestinal fluoroscopy into an To be able to prosper in the resonance imaging. objective, detailed, data-gathering future, medical imaging must discipline. Radiology benefited from continue to decrease in the spin-off of space exploration and . Threat to progress Cold War defence technology, result­ mvasJVeness, mcrease m ing in breakthroughs in computers, The explosive progress in imaging, electronics, the move from tubes to sensitivity and specificity and however, has also coincided with the transistors to printed circuits on general rise in the cost of medicine, boards to silicone chips, miniaturiza­ - more than anything else - producing a reaction which is threat­ tion, telecommunications and fine­ remain affordable and ening further progress.
    [Show full text]
  • RIDER Database Resource: Plans for a Public-Private Partnership
    RIDER Database Resource and Plans for a Public-Private Partnership Table of Contents 1. RIDER Database: Executive Summary. 1.1 RIDER Goals 1.2 Progress Report and time lines for future plans 1.3 Clarification of the Goals of the Federal Trans-Agency Oncology Biomarker Qualification Initiative (OBQI) and the RIDER Project 2. Introduction: Goals of the White Paper. 3. Clinical and Historical Background 3.1 Lung Cancer 3.2 RECIST Criteria 4. RIDER Pilot Project: Progress Report (2004-06). 4.1 Goals of the Pilot Project 4.2 Initial Development of Image Archive (caBIG) 4.3 Data Transfer Strategies: (RSNA: MIRC) 4.4 Initial Progress on Data Collection 4.5 RIDER: Progress on Boundary Identification of Nodules: 4.6 RIDER Support for RIDER Pilot for FY 06 4.7 NCI-NIBIB supported FDA Fellowship and visiting scientists. 4.8 NIST Collaboration on Imaging Standards 5. RIDER: Plans for the Demonstration Project 5.1 Imaging Data Collection: Acquisition Parameters 5.2 Populating the Database: Case Selection Criteria 5.3 Rider Database Design: Initial Research plans. 5.4 Multi Site Project Infrastructure 5.4.2 Process Model 5.4.3 Validation Software Tools 5.5 Meta Data and Data Management Tools 5.5.1 Multi Site Process Model 5.5.2 Interoperability with CaBIG 5.3.3 Patient Confidentiality 5.6 Standardized Methods for Software Performance 5.7 Engagement and Scientific Role of Industry Stake Holders 5.7.1 Potential Image Date Sources: Industry Drug Trials 5.7.2 Correlation of change Analysis Data with Clinical Outcome 5.7.3 Device and Software Industry: Acceptance of Standards.
    [Show full text]
  • US5322682.Pdf
    ||||||||||||| US005322682A United States Patent (19) 11 Patent Number: 5,322,682 Bartzokis et al. (45) Date of Patent: Jun. 21, 1994 54 METHOD FOR QUANTITATIVELY "Dashed Hopes for MRImaging of the Head and Neck MEASURING AND MAPPING STORED . ." Editorials from the Neuroradiology Section, RON IN TSSUE USING MRI Dept. of Radiology, Hospital of the University of Penn (75) Inventors: George Bartzokis; Carolanne K. sylvania, Radiology 1991; 184:25-26. Phelan, both of Los Angeles, Calif. "T-Relaxometry-A Critical Investigation . ," Thomas Tolxdorff et al., SMRM 1988, p. 33. 73 Assignee: The Regents of the University of "T2 Values in the Human Brain: Comparison with California, Oakland, Calif. Quantitative Assays of Iron and Ferritinl' Julian C. (21) Appl. No.: 926,245 Chen, M.D. et al. Radiology 1989, pp. 521-526. "Field Strength in Neuro-MRImaging: A Comparison 22 Filed: Aug. 6, 1992 of 0.5T and 1.5T' Clifford R. Jack, Jr., et al., Journal of 51) Int. Cl...................... G01N 24/08; A61K 33/26; Computer Assisted Tomography, vol. 14, No. 4, 1990, GO1V 3/00 pp. 505-513. 52 U.S. C. ..................................... 424/9; 128/653.2; (List continued on next page.) 128/653.4; 436/173; 324/300; 324/307; 324/308; 424/646 Primary Examiner-Glennon H. Hollrah 58) Field of Search ................. 424/9, 646; 128/653.2, Assistant Examiner-Gary E. Hollinden 128/653.4, 654; 436/173; 324/300, 307, 308 Attorney, Agent, or Firm-Daniel L. Dawes (56) References Cited U.S. PATENT DOCUMENTS (57) ABSTRACT 4,477,777 10/1984 Gordon ............................... 324/300 The invention provides a specific measure of iron stores 4,735,796 4/1988 Gordon ..................................
    [Show full text]
  • Ultrasound.Pdf
    Ultrasound J. Cornwall, Chair H. Abarbanel W. DaIly S. FIatte R. Westervelt May 1996 JSR-95-145 Approved for Public Release. Distribution Unlimited. DTIC QUALITY llJSPEOTED a JASON The MITRE Corporation 1820 Dolley Madison Boulevard Mclean, Virginia 22102-3481 (703) 883-6997 Form Approved REPORT DOCUMENTATION PAGE OMB No. 0704·0188 Public reporting burden for this collection of Information estimated to average t hour per response, Including the time for review Instruellons, searc hlng existing data sources, gathering and maintaining the data needed, and complellng and reviewing the collection of Information. Send comments regarding this burden estimate or any other aspect of this coIleellon 01 Information, Including suggestions for reducing this burden. to Washington Headquarters Services. Directorate for Information Operalions and Reports, 1215 Jefferson Davis Highway. Sulle 1204. Arlington, VA 22202·4302. and to the Office of Management and Budget. Paperwork Reduellon ProJeel (0704'()188). Washington, DC 20503. 1. AGENCY USE ONLY (Leave blank) 12. REPORT DATE r' REPORT TYPE AND DATES COVERED May 1996 4. TITLE AND SUBTITLE S. FUNDING NUMBERS ULTRASOUND 6. AUTHOR(S) 07-95-8534-A4 H. Abarbanel, J. Cornwall, W. Dally, S. Flatte, R. Westervelt 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER The MITRE Corporation JASON Program Office, Z561 1820 Dolley Madison Blvd JSR-95-145 McLean, Virginia 22102 9. SPONSORINGIMONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSORINGIMONITORING AGENCY REPORT NUMBER DARPA/TIO 3701 North Fairfax Drive, Arlington, Va 22030-1714 JSR-95-145 11. SUPPLEMENTARY NOTES 12a. DISTRIBUTION/AVAILABILITY STATEMENT 12b. DISTRIBUTION CODE Approved for Public Release.
    [Show full text]
  • Micro-Imaging of the Mouse Lung Via MRI Wei Wang Washington University in St
    Washington University in St. Louis Washington University Open Scholarship All Theses and Dissertations (ETDs) 5-24-2012 Micro-imaging of the Mouse Lung via MRI Wei Wang Washington University in St. Louis Follow this and additional works at: https://openscholarship.wustl.edu/etd Recommended Citation Wang, Wei, "Micro-imaging of the Mouse Lung via MRI" (2012). All Theses and Dissertations (ETDs). 733. https://openscholarship.wustl.edu/etd/733 This Dissertation is brought to you for free and open access by Washington University Open Scholarship. It has been accepted for inclusion in All Theses and Dissertations (ETDs) by an authorized administrator of Washington University Open Scholarship. For more information, please contact [email protected]. WASHINGTON UNIVERSITY IN ST. LOUIS Department of Physics Dissertation Examination Committee: Jason Woods, Chair Joseph Ackerman Mark Conradi David Gierada Kenneth Kelton Dmitriy Yablonskiy Micro-imaging of the Mouse Lung via MRI by Wei Wang A dissertation presented to the Graduate School of Arts and Sciences of Washington University in partial fulfillment of the requirements for the degree of Doctor of Philosophy May 2012 Saint Louis, Missouri Abstract Quantitative measurement of lung microstructure is of great significance in assessment of pulmonary disease, particularly in the earliest stages. Conventional stereological assessment of ex-vivo fixed tissue specimens under the microscope has a long and successful tradition and is regarded as a gold standard, but the invasive nature limits its applications and the practicality of use in longitudinal studies. The technique for diffusion MRI-based 3He lung morphometry was previously developed and validated for human lungs, and was recently extended to ex-vivo mouse lungs.
    [Show full text]
  • Clefs CEA N°62
    No. 62 clefsAutumn 2014 Exploring the brain No. 62 Autumn 2014 clefs Exploring the brain 3 Foreword, 5 The complexity of the nervous by Gilles Bloch system: a challenge for neuroscience, by Philippe Vernier Exploring the brain I. NON-INVASIVE EXPLORATION OF THE BRAIN Clefs CEA No. 62 – AUTUMN 2014 6 Introduction, by Denis Le Bihan Main cover picture Representations of 38 bundles of cerebral white matter (one colour per bundle) taken 8 Cerebral imaging: from the first in vivo atlas of human brain a never-ending story, connections. Each one is an assembly of by Denis Le Bihan, images acquired from 78 subjects in the CONNECT/Archi neuroimaging database, Claude Comtat, which was set up at NeuroSpin, using Virginie van Wassenhove cross-sections that are sagittal (vertical; and Isabelle Texier the sections scan the subject from left to right), coronal (vertical; the sections 9 Magnetoencephalography, scan the subject from front to back) and by Virginie van Wassenhove transversal (horizontal). D. Duclap, B. Schmitt, A. Lebois, 10 Positron emission tomography P. Guevara, D. Le Bihan, J.-F. Mangin, 17 C. Poupon/CEA-NeuroSpin 13 Optical imaging, by Anne Planat-Chrétien, Inset top: MIRCen histology platform. Brain Vincent Poher, 18 Very low field detectors, slices marked by different specific Jean-Marc Dinten by Myriam Pannetier-Lecœur indicators are being examined with a and Isabelle Texier microscope. C. Dupont/CEA 14 Magnetic resonance imaging 22 The FLI imaging research bottom: Preparation of a infrastructure, by Régine Trébossen radiopharmaceutical in a shielded hot 17 Looking to the future, and Franck Lethimonnier cell in the Frédéric Joliot Hospital Service (SHFJ).
    [Show full text]
  • 1 ∗A Novel TOF-PET MRI Detector for Diagnosis and Follow up Of
    ∗A novel TOF-PET MRI detector for diagnosis and follow up of the prostate cancer F. Garibaldi1,2,*, S. Beging9, R. Canese3, G. Carpinelli3, N. Clinthorne4, S. Colilli1,2, L. Cosentino5, P. Finocchiaro5, F. Giuliani1,2, M. Gricia1,2, M. Lucentini1,2, S. Majewski6, E. Monno7, P. Musico8, F. Santavenere1,2, J.Tödter9, H. Wegener9, K. Ziemons9 1. INFN Roma Piazzale Aldo Moro 1 – Rome - Italy 2. ISS - National Center of Innovative Technologies for the Public Health - Viale Regina Elena 299 – 00161 – Rome – Italy 3. ISS - Cell Biology and Neurosciences Department-Rome - Viale Regina Elena 299 – 00161 – Rome – Italy 4. Div. Nuclear Medicine / Dept. Radiology, University of Michigan, Ann Arbor, Michigan, USA 48109-5610 5. INFN LNS – Vis S. Sofia 62 – 95125 Catania 6. University of Virginia, Charlottesville, Virginia, USA 7. ENEA- Centro ricerche di Brindisi – S.S. 7 Appia km 706,00 - 72100 Brindisi 8. INFN Genova – Via Dodecaneso 33 - 16146 Genova - Italy 9. FH Aachen University of Applied Sciences Heinrich-Mußmann-Strasse 1 52428 Jülich | Germany Abstract Prostate cancer is the most common disease in men and the second leading cause of death from cancer. Generic large imaging instruments used in cancer diagnosis have sensitivity, spatial resolution, and contrast inadequate for the task of imaging details of a small organ such as the prostate. In addition, multimodality imaging can play a significant role merging anatomical and functional details coming from simultaneous PET and MRI. Indeed, multi-parametric PET/MRI was demonstrated to improve diagnosis, but it suffers from too many false positives. In order to address the above limits of the current techniques, we have proposed, built and tested, thanks to the TOPEM project funded by Italian National Institute of Nuclear Phisics a prototype of an endorectal PET-TOF/MRI probe.
    [Show full text]
  • Nuclear Magnetic Resonance Imaging Technology: a Clinical, Industrial, and Policy Analysis
    Nuclear Magnetic Resonance Imaging Technology: A Clinical, Industrial, and Policy Analysis September 1984 NTIS order #PB85-146207 — HEALTH TECHNOLOGY CASE STUDY 27: Nuclear Magnetic Resonance Imaging Technology A Clinical, Industrial, and Policy Analysis SEPTEMBER 1984 This case study was performed as a part of OTA’s Assessment of Federal Policies and the Medical Devices Industry Prepared for OTA by: Earl P. Steinberg, M. D., M.P.P. Assistant Professor, Johns Hopkins School of Medicine and John Hopkins School of Hygiene and Public Health; Senior Associate, Office of Medical Practice Evaluation; also w/Henry J. Kaiser Family Foundation Faculty Scholar in General Internal Medicine and Alan B. Cohen, Sc.D. Associate Director, Center for Hospital Finance and Management; also w/Assistant Professor of Health Policy and Management, Johns Hopkins School of Hygiene and Public Health f I OTA Case Studies are documents containing information on a specific medical technology or area of application that supplements formal OTA assessments. The material is not normally of as immediate policy interest as that in an OTA Report, nor does it present options for Congress to consider. CONGRESS OF THE UNITED STATES Office of Technology Assessment Washington, D C 20510 Recommended Citation: Health Technology Case Study 27: Nuclear Magnetic Resonance Imaging Technology: A Clinical, Industrial, and Policy Analysis (Washington, DC: U.S. Congress, Office of Tech- nology Assessment, OTA-HCS-27, September 1984). This case study was performed as part of OTA’s assessment of Federal Policies and the Medical Devices Industry. Library of Congress Catalog Card Number 84-601123 For sale by the Superintendent of Documents, U.S.
    [Show full text]