www.impactjournals.com/oncotarget/ Oncotarget, 2017, Vol. 8, (No. 17), pp: 27820-27838 Research Paper Multi-targeting therapeutic mechanisms of the Chinese herbal medicine QHD in the treatment of non-alcoholic fatty liver disease Qin Feng1,2,3,*, Wensheng Liu2,3,*, Susan S. Baker2,3, Hongshan Li4, Cheng Chen1, Qian Liu1, Shijie Tang5, Lingyu Guan5, Maria Tsompana6, Rafal Kozielski8,9, Robert D. Baker2,3, Jinghua Peng1, Ping Liu1, Ruixin Zhu5, Yiyang Hu1, Lixin Zhu2,3,7 1Institute of Liver Disease, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China 2Digestive Diseases and Nutrition Center, Women and Children’s Hospital of Buffalo, Buffalo, NY, USA 3Department of Pediatrics, The State University of New York at Buffalo, Buffalo, New York, USA 4Ningbo No.2 Hospital, Ningbo, Zhejiang Province, China 5Department of Bioinformatics, Tongji University, Shanghai, China 6Center of Excellence in Bioinformatics and Life Sciences, The State University of New York at Buffalo, Buffalo, New York, USA 7Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China 8Women and Children’s Hospital of Buffalo, Buffalo, NY, USA 9Department of Pathology, The State University of New York at Buffalo, Buffalo, New York, USA *These authors contributed equally to this work Correspondence to: Lixin Zhu, email:
[email protected] Yiyang Hu, email:
[email protected] Keywords: NAFLD, lipid synthesis, anti-oxidant, gut microbiome, Treg Received: December 28, 2016 Accepted: February 08, 2017 Published: February 18, 2017 Copyright: Feng et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.