University of Utah Hospitals and Clinics Preferred Drug List

Total Page:16

File Type:pdf, Size:1020Kb

University of Utah Hospitals and Clinics Preferred Drug List University of Utah Hospitals and Clinics Preferred Drug List This Preferred Drug List (PDL) is a list of frequently prescribed medications and does not include all drugs covered under your pharmacy drug‐ benefit. Inclusion of a drug does not guarantee coverage. Drugs that are not listed may be non-covered or excluded drugs. • Most non specialty, generic drugs are covered at the generic tier and are preferred, if available. High cost generic drugs are covered at a higher tier than other generics as noted in this list. • Please note that additional coinsurance will apply if a member requests a brand name medication when a generic alternative is available. • The Affordable Care Act (ACA) requires that certain drugs be provided without cost to the member, such as generic oral contraceptives and most recommended vaccinations. Drugs noted by * are considered preventive and may be covered at a different benefit level than listed. Limits may apply. • Most specialty medications require prior authorization and are covered under one of the specialty drugs tiers. Generic and brand name antiretroviral medications with no generics available are covered on the specialty tier without a prior authorization. • Quantity Limits (QL), Step Therapy (ST), and Prior Authorization (PA) may also apply and are noted below. Preferred Brands Non- Preferred Preferred and Non- Preferred Generics Specialty Limits Preferred Brands (T1) (T4) Generics (T3) (T2) ANALGESICS NON-STEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDS) AND COMBINATIONS Oral celecoxib, diclofenac/ER oral, diclofenac/misoprostol, etodolac/ER, QL celecoxib fenoprofen, flurbiprofen, ibuprofen, indomethacin/ER, ketoprofen/ER, ketorolac, meclofenamate, mefenamic acid, meloxicam, nabumetone, naproxen (except Naprelan equivalent), oxaprozin, piroxicam, sulindac, tolmetin diclofenac gel, naproxen (Naprelan equivalent) Anaprox/DS, Arthrotec, Cambia, Celebrex, Daypro, EC-Naprosyn, ST, QL Feldene, Indocin, Mobic, Nalfon, Naprelan, Ponstel, Tivorbex, Voltaren/XR, Zipsor, Zorvolex Topical diclofenac solution ST, QL diclofenac gel, ketorolac gel ST, QL, PA ketorolac Flector, NaPro, Pennsaid, Rexaphenac cream, Solaraze, Voltaren, ST, QL Vopac OPIOIDS AND OPIOID COMBINATIONS acetaminophen/codeine, codeine, Endocet, Endodan, fentanyl, QL hydrocodone, hydrocodone/acetaminophen, hydrocodone/ibuprofen, hydromorphone/ER, levorphanol, meperidine, Meperitab, methadone, Methadose tablet, morphine/ER, oxycodone, oxycodone/acetaminophen, oxycodone/aspirin, oxycodone/ibuprofen, oxymorphone/ER, Reprexain, Roxicet, tramadol/ER, Xylon Oxycodone ER, Oxycontin QL meperidine/promethazine QL Abstral, Actiq, Butrans, Conzip, Demerol, Dilaudid, Dolophine, ST, QL Duragesic, Exalgo, Fentora, Hysingla ER, Kadian, Methadose concentrate/SF, MS Contin, Nucynta/ER, Opana/ER, Oxecta, Percocet, Percodan, Primlev, Roxicodone, Sublimaze, Subsys, Synapryn, Ultracet, Ultram/ER, Vicoprofen, Xartemis XR, Xtampza ER, Zohydro ER MISCELLANEOUS lidocaine patch, fentanyl patch QL lidocaine-menthol patch, fentanyl OT LOZ PA Fentanyl Lidoderm QL SALICYLATES aspirin*, choline-mag trisalicylate, diflunisal, salsalate Disalcid 1 Effective July 1, 2017 (Last updated July 2017) University of Utah Hospitals and Clinics Preferred Drug List T1 T2 T3 T4 Limits ANTIDOTES IRON OVERLOAD THERAPY Exjade, Ferriprox tab, Jadenu PA OPIOID ANTAGONISTS Narcan ANTI-INFECTIVE AGENTS ANTIBIOTICS Aminoglycosides neomycin, paromomycin Cephalosporins cefadroxil, cefdinir, cefpodoxime, cefprozil, ceftibuten, cefuroxime axetil, cephalexin cefditoren, cefixime Ceftin, Cedax, Spectracef, Suprax Macrolides azithromycin, clarithromycin, erythromycin Biaxin/XL, E.E.S., EryPed, Ery-Tab, PCE, Zithromax Dificid PA Miscellaneous clindamycin, First-Vancomycin, metronidazole, nitrofurantoin vancomycin oral capsules QL, ST Alinia, Ketek, Macrobid, Macrodantin, Mepron, Sivextro oral, Xifaxan QL Sivextro Penicillins amoxicillin, amoxicillin/clavulanate, ampicillin, dicloxacillin, penicillin VK Augmentin, Augmentin XR/ES, Moxtag Quinolones ciprofloxacin, levofloxacin, moxifloxacin Avelox, Cipro, Factive, Levaquin, Noroxin QL Sulfonamides sulfadiazine, TMP-SMX/DS Bactrim/DS Tetracyclines doxycycline, minocycline doxycycline DR Adoxa, Dynacin, Monodox, Periostat, Solodyn, Vibramycin, tetracycline ANTIFUNGALS fluconazole, flucytosine, griseofulvin suspension, ketoconazole, nystatin griseofulvin tablets, itraconazole, voriconazole PA itraconazole Ancobon, Bio-Statin, Diflucan, Grifulvin V, Gris-PEG, Lamisil oral Cresemba PA ANTIRETROVIRAL AGENTS Antiretrovials Adjuvants Tybost CCR5 Antagonists Selzentry 2 Effective July 1, 2017 (Last updated July 2017) University of Utah Hospitals and Clinics Preferred Drug List T1 T2 T3 T4 Limits Combinations abacavir-lamivudine- zidovudine, lamivudine-zidovudine Atripla, Complera, Descovy, Evotaz, Kaletra, Odefsey, Prezcobix, Stribild, Triumeq, Truvada Integrase Inhibitors Isentress, Tivicay, Vitekta Protease Inhibitors Aptivus, Crixivan, Invirase, Lexiva, Norvir, Prezista, Reyataz, Viracept RTI-Non-Nucleoside Analogues nevirapine/ER Edurant, Intelence, Rescriptor, Sustiva RTI-Nucleotide Analogues Viread RTI-Nucleotide Analogues-Purines abacavir, didanosine Videx oral solution, Ziagen RTI-Nucleoside Analogues-Pyrimidines lamivudine Emtriva RTI-Nucleoside Analogues-Thymidines zidovudine, stavudine ANTIVIRALS-GENERAL acyclovir, amantadine, famciclovir, rimantadine, valacyclovir QL Tamiflu QL Relenza QL Famvir, Flumadine, Sitavig, Valtrex, Zovirax oral ST, QL valganciclovir, Synagis PA ANTIVIRALS-HEPATITIS B adefovir, entecavir, lamuvidine (HBV) Tyzeka PA ANTIVIRALS-HEPATITIS C ribavirin Copegus, Moderiba, Rebetol, Ribasphere, RibaTab QL Peg-Intron PA ANTIVIRALS-HEPATITIS C COMBINATIONS Epclusa, Zepatier PA DRUGS FOR MALARIA atovaquone/proguanil, chloroquine, hydroxychloroquine, mefloquine, primaquine, quinine Aralen, Coartem, Daraprim, Malarone, Plaquenil, Qualaquin DRUGS FOR PARASITES ivermectin Albenza, Biltricide, Stromectol QL DRUGS FOR TUBERCULOSIS cycloserine, ethambutol, isoniazid, pyrazinamide, ribabutin, rifampin Myambutol, Mycobutin, Rifamate, Rifater 3 Effective July 1, 2017 (Last updated July 2017) University of Utah Hospitals and Clinics Preferred Drug List T1 T2 T3 T4 Limits ANTINEOPLASTIC AGENTS (CANCER) ORAL CHEMOTHERAPEUTIC AGENTS Alkylating Agents Haxalen, lomustine PA Androgen Biosynthesis Inhibitors Zytiga PA Antiadrenals Lysodren PA Antiandrogens Xtandi PA Antimetabolites capecitabine PA Antineoplastic Retinoids Panretin PA BRAF Kinase Inhibitors Tafinlar, Zelboraf PA Cyclin-Dependent Kinases (CDK) Inhibitors Ibrance PA Hedgehog Pathway Inhibitors Erivedge PA Histone Deacetylase Inhibitors Farydak, Zolinza PA Imidazotetrazines temozolomide QL Immunomodulators - Antileprotics Thalomid PA Immunomodulators - Antineoplastic Pomalyst PA Immunomodulators for Myelodysplastic Revlimid PA Interferons Alferon N, Intron-A, Sylatron PA LHRH Analogs Eligard PA MEK Inhibitors Mekinist PA Miscellaneous Antineoplastics Matulane PA mTOR Kinase Inhibitors Afinitor PA Multikinase Inhibitors Nexavar, Stivarga, Sutent PA Poly (ADP-ribose) Polymerase (PARP) Inhibitors Lynparza PA Phosphatidylinositol 3-Kinase (PI3K) Inhibitors Zydelig PA Selective Retinoid X Receptor Agonists Targretin Oral/Topical PA 4 Effective July 1, 2017 (Last updated July 2017) University of Utah Hospitals and Clinics Preferred Drug List T1 T2 T3 T4 Limits Topoisomerase I Inhibitors Hycamtin Oral PA Tyrosine Kinase Inhibitors Bosulif, Caprelsa, Cometriq, Gilotrif, Iclusig, imatinib mesylate, PA Imbruvica, Inlyta, Lenvima, Sprycel, Tarceva, Tasigna, Tykerb, Xalkori, Votrient, Zykadia HEMATOLOGIC AGENTS BLOOD CELL STIMULATORS ERYTHROPOIESIS-STIMULATING AGENTS (ESAs) Epogen PA GRANULOCYTE COLONY-STIMULATING FACTORS (G-CSF) Granix, Neulasta, Neupogen PA HEMATOPOIETIC GROWTH FACTORS - THROMBOPOIETIN AGONISTS Promacta PA STEM CELL MOBILIZERS Mozobil PA AUTOIMMUNE/IMMUNE/INFLAMMATORY ANTIPSORIATICS - SYSTEMIC Stelara PA INTERLEUKIN AGENTS Interleukin-1 Receptor Antagonists (IL-1Ra) Kineret PA Interleukin-6 Inhibitors Actemra Subcutaneous PA MISCELLANEOUS AUTOIMMUNE AGENTS Phosphodiesterase 4 (PDE4) Inhibitors Otezla PA Selective Costimulation Modulators Orencia PA TUMOR NECROSIS FACTOR AGENTS Anti-TNF-alpha - Monoclonal Antibodies Humira, Simponi PA Soluble Tumor Necrosis Factor Receptor Agents Enbrel PA ANTI-ANGINA isosorbide dinitrate, isosorbide mononitrate, nitroglycerin oral/transdermal Nitro-Bid Oint 2%, Nitrostat, Ranexa Minitran, Nitro-Dur, Nitrolingual, NitroMist QL ANTICOAGULANTS Antiplatelet cilostazol, clopidogrel, dipyridamole, ticlopidine Brilinta QL Aggrenox, Agrylin, Effient, Plavix, Pletal, Zontivity QL 5 Effective July 1, 2017 (Last updated July 2017) University of Utah Hospitals and Clinics Preferred Drug List T1 T2 T3 T4 Limits CARDIOVASCULAR AGENTS Antithrombotics Jantoven, warfarin Eliquis, enoxaparin, fondaparinux, Xarelto QL Fragmin, Iprivask, Pradaxa, Savaysa QL BLOOD PRESSURE THERAPY AND COMBINATIONS Ace Inhibitors benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, trandolapril Accupril, Aceon, Altace, Epaned, Lotensin, Mavik, Prinivil, Vasotec, Zestril Antiotensin antagonists (ARBs) candesartan, eprosartan, irbesartan, losartan, valsartan Atacand, Avapro, Benicar, Cozaar, Diovan, Edarbi, Micardis, Teveten ST, QL Antiadrenergic Agents - Central and Peripheral clonidine, doxazosin, prazosin, guanfacine,
Recommended publications
  • Folic Acid Antagonists: Antimicrobial and Immunomodulating Mechanisms and Applications
    International Journal of Molecular Sciences Review Folic Acid Antagonists: Antimicrobial and Immunomodulating Mechanisms and Applications Daniel Fernández-Villa 1, Maria Rosa Aguilar 1,2 and Luis Rojo 1,2,* 1 Instituto de Ciencia y Tecnología de Polímeros, Consejo Superior de Investigaciones Científicas, CSIC, 28006 Madrid, Spain; [email protected] (D.F.-V.); [email protected] (M.R.A.) 2 Consorcio Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, 28029 Madrid, Spain * Correspondence: [email protected]; Tel.: +34-915-622-900 Received: 18 September 2019; Accepted: 7 October 2019; Published: 9 October 2019 Abstract: Bacterial, protozoan and other microbial infections share an accelerated metabolic rate. In order to ensure a proper functioning of cell replication and proteins and nucleic acids synthesis processes, folate metabolism rate is also increased in these cases. For this reason, folic acid antagonists have been used since their discovery to treat different kinds of microbial infections, taking advantage of this metabolic difference when compared with human cells. However, resistances to these compounds have emerged since then and only combined therapies are currently used in clinic. In addition, some of these compounds have been found to have an immunomodulatory behavior that allows clinicians using them as anti-inflammatory or immunosuppressive drugs. Therefore, the aim of this review is to provide an updated state-of-the-art on the use of antifolates as antibacterial and immunomodulating agents in the clinical setting, as well as to present their action mechanisms and currently investigated biomedical applications. Keywords: folic acid antagonists; antifolates; antibiotics; antibacterials; immunomodulation; sulfonamides; antimalarial 1.
    [Show full text]
  • Infection Prevention in Combat-Related Injuries CPG ID: 24 APPENDIX B: POST-INJURY ANTIMICROBIAL AGENT SELECTION and DURATION BASED UPON INJURY PATTERN
    Infection Prevention in Combat-Related Injuries CPG ID: 24 APPENDIX B: POST-INJURY ANTIMICROBIAL AGENT SELECTION AND DURATION BASED UPON INJURY PATTERN INJURY PREFERRED AGENT(S) ALTERNATE AGENT(S) DURATION EXTREMITY WOUNDS (INCLUDES SKIN, SOFT TISSUE, BONE) Skin, soft tissue, no open fractures Cefazolin, 2 gm IV q6-8h†‡ Clindamycin (300-450 mg PO TID or 600 mg IV q8h) 1-3 days Skin, soft tissue, with open Cefazolin 2 gm IV q6-8h†‡§ Clindamycin 600 mg IV q8h 1-3 days fractures, exposed bone, or open joints THORACIC WOUNDS Penetrating chest injury without Cefazolin, 2 gm IV q6-8h†‡ Clindamycin (300-450 mg PO TID or 600 mg IV q8h) 1 day esophageal disruption Penetrating chest injury with Cefazolin 2 gm IVq 6-8h†‡ PLUS metronidazole 500 Ertapenem 1 gm IV x 1 dose, OR moxifloxacin 400 mg 1 day after definitive esophageal disruption mg IV q8-12h IV x 1 dose washout ABDOMINAL WOUNDS Penetrating abdominal injury with Cefazolin 2 gm IV q 6-8h†‡ PLUS metronidazole 500 Ertapenem 1 gm IV x 1 dose, OR moxifloxacin 400 mg 1 day after definitive suspected/known hollow viscus mg IV q8-12h IV x 1 dose washout injury and soilage; may apply to rectal/perineal injuries as well MAXILLOFACIAL AND NECK WOUNDS Open maxillofacial fractures, or Cefazolin 2 gm IV q6-8h†‡ Clindamycin 600 mg IV q8h 1 day maxillofacial fractures with foreign body or fixation device CENTRAL NERVOUS SYSTEM WOUNDS Penetrating brain injury Cefazolin 2 gm IV q6-8h.†‡ Consider adding Ceftriaxone 2 gm IV q24h. Consider adding 5 days or until CSF metronidazole 500 mg IV q8-12h if gross metronidazole 500 mg IV q8-12h if gross contamination with organic debris contamination with organic debris.
    [Show full text]
  • Sulfonamides and Sulfonamide Combinations*
    Sulfonamides and Sulfonamide Combinations* Overview Due to low cost and relative efficacy against many common bacterial infections, sulfonamides and sulfonamide combinations with diaminopyrimidines are some of the most common antibacterial agents utilized in veterinary medicine. The sulfonamides are derived from sulfanilamide. These chemicals are structural analogues of ρ-aminobenzoic acid (PABA). All sulfonamides are characterized by the same chemical nucleus. Functional groups are added to the amino group or substitutions made on the amino group to facilitate varying chemical, physical and pharmacologic properties and antibacterial spectra. Most sulfonamides are too alkaline for routine parenteral use. Therefore the drug is most commonly administered orally except in life threatening systemic infections. However, sulfonamide preparations can be administered orally, intramuscularly, intravenously, intraperitoneally, intrauterally and topically. Sulfonamides are effective against Gram-positive and Gram-negative bacteria. Some protozoa, such as coccidians, Toxoplasma species and plasmodia, are generally sensitive. Chlamydia, Nocardia and Actinomyces species are also sensitive. Veterinary diseases commonly treated by sulfonamides are actinobacillosis, coccidioidosis, mastitis, metritis, colibacillosis, pododermatitis, polyarthritis, respiratory infections and toxo- plasmosis. Strains of rickettsiae, Pseudomonas, Klebsiella, Proteus, Clostridium and Leptospira species are often highly resistant. Sulfonamides are bacteriostatic antimicrobials
    [Show full text]
  • 1.Why Are Sulfonamide Antibacterials Acidic?
    STUDY GUIDE 2: SYNTHETIC ANTIBACTERIALS: THE SULFONAMIDES: 1.Why are sulfonamide antibacterials acidic? Why are sulfonamides such as sulfisoxazole more acidic than sulfacetamide or sulfanilamide? Understand the relationship between resonance and acidity and be able to apply it relative acidity. 2. Why does the water solubility of the sulfonamides decrease as pH decreases as indicated in Table 1? DON'T MEMORIZE this table, just understand it. 3. What factors determine water solubility/lipophilicity 4. Do not memorize the drug structures shown in the chapter. You will not be asked to recall these from memory (see 24 below). 5. What bacterial enzyme does the sulfonamides inhibit to produce its chemotherapeutic effect? Why are they capable of inhibiting this enzyme? Specifically, how does this result in decreased bacterial DNA synthesis? Is this a static or cidal action? 6. What role does ionization and pKa play in mechanism of action and entry in target bacteria? 8. YOU NEED NOT MEMORIZE the folate biosynthetic scheme, but if given the structures of PABA and the DPAD precursor, you should be able to draw the structure of the DIHYDRO- PTEROATE product. 7. Why are the sulfonamides selectively toxic to bacterial cells versus mammalian cells (Selectivity)? 8. How and why do sulfonamides function as pseudo-substrates? 9. What are the known mechanisms of resistance to the sulfonamides? What is the MAJOR mechanism and how is it transferred to other bacteria? Which other antibacterial drug are sulfon- amide-resistant bacteria resistant to and why? 10. What gram positive and gram negative bacteria are the sulfonamides effective against. DON'T MEMORIZE TABLE 2.
    [Show full text]
  • Syntheses and Structural Studies of Metal Complexes of Sulfa Drugs
    SYNTHESES AND STRUCTURAL STUDIES OF METAL COMPLEXES OF SULFA DRUGS A thesis submitted to the Cardiff University By G. M. Golzar Hossain in candidature of the degree of Doctor of Philosophy August 2005 Department of Chemistry Cardiff University UMI Number: U584873 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. Dissertation Publishing UMI U584873 Published by ProQuest LLC 2013. Copyright in the Dissertation held by the Author. Microform Edition © ProQuest LLC. All rights reserved. This work is protected against unauthorized copying under Title 17, United States Code. ProQuest LLC 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, Ml 48106-1346 DECLARATION This work has not previously been accepted in substance for any degree and is not being concurrently submitted in candidature for any degree. Signed (Candidate) Date: O 3 / ^ 6 STATEMENT 1 This thesis is the result of my own investigations, except where otherwise stated. Other sources are acknowledged by in the appended bibliography. Signed (Candidate) Date: STATEMENT 2 I hereby give consent for my thesis, if accepted, to be available for photocopying and for inter-library loan, and for the title and summary to be made available to outside organisations. Signed (Candidate) Date: / 3 / o 3 / II <tm ^d ic a te < d t o JAfroza andJAsif III ACKNOWLEDGEMENTS This work would not have been completed without the encouragement and patience of my supervisors Professor Peter G.
    [Show full text]
  • Visão De Futuro Para Produção De Antibióticos: Tendências De Pesquisa, Desenvolvimento E Inovação
    UNIVERSIDADE FEDERAL DO RIO DE JANEIRO CRISTINA D’URSO DE SOUZA MENDES SANTOS VISÃO DE FUTURO PARA PRODUÇÃO DE ANTIBIÓTICOS: TENDÊNCIAS DE PESQUISA, DESENVOLVIMENTO E INOVAÇÃO Rio de Janeiro EQ/UFRJ 2014 CRISTINA D ’U RSO DE SOUZA MENDES SANTOS VISÃO DE FUTURO PARA A PRODUÇÃO DE ANTIBIÓTICOS: TENDÊNCIAS DE PESQUISA, DESENVOLVIMENTO E INOVAÇÃO Tese de Doutorado apresentada ao Programa de Pós-Graduação em Tecnologia de Processos Químicos e Bioquímicos, Escola de Química, Universidade Federal do Rio de Janeiro, como requisito parcial à obtenção do título de Doutor em Ciências, D.Sc. Orientadora: Profa. Adelaide Maria de Souza Antunes, D.Sc. Rio de Janeiro 2014 Santos, Cristina d’Urso de Souza Mendes. Visão de futuro para produção de antibióticos: tendências de pesquisa, desenvolvimento e inovação / Cristina d’Urso de Souza Mendes Santos. - Rio de Janeiro, 2014. 216 f.: il.; 29,7 cm. Tese (Doutorado em Ciências) – Universidade Federal do Rio de Janeiro, Escola de Química, Programa de Pós-Graduação em Tecnologia de Processos Químicos e Bioquímicos, Rio de Janeiro, 2014. Orientadora: Adelaide Maria de Souza Antunes. 1. Antibióticos. 2. P&D na Indústria Farmacêutica. 3. Prospecção Tecnológica. 4. Patentes. I. Antunes, Adelaide Maria de Souza. II. Universidade Federal do Rio de Janeiro. Escola de Química. III. Visão de futuro para a produção de antibióticos: tendências de pesquisa, desenvolvimento e inovação. iv v Dedico esta tese à minha mãe querida e amada, que está no céu comemorando esta vitória, que é mais dela do que minha. Dedico também à minha filhinha Malu que sem entender foi a minha maior motivação para concluir esta tese.
    [Show full text]
  • Stembook 2018.Pdf
    The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances FORMER DOCUMENT NUMBER: WHO/PHARM S/NOM 15 WHO/EMP/RHT/TSN/2018.1 © World Health Organization 2018 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances. Geneva: World Health Organization; 2018 (WHO/EMP/RHT/TSN/2018.1). Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data.
    [Show full text]
  • Pharmacogenomic Associations Tables
    Pharmacogenomic Associations Tables Disclaimer: This is educational material intended for health care professionals. This list is not comprehensive for all of the drugs in the pharmacopeia but focuses on commonly used drugs with high levels of evidence that the CYPs (CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4 and CYP3A5 only) and other select genes are relevant to a given drug’s metabolism. If a drug is not listed, there is not enough evidence for inclusion at this time. Other CYPs and other genes not described here may also be relevant but are out of scope for this document. This educational material is not intended to supersede the care provider’s experience and knowledge of her or his patient to establish a diagnosis or a treatment plan. All medications require careful clinical monitoring regardless of the information presented here. Table of Contents Table 1: Substrates of Cytochrome P450 (CYP) Enzymes Table 2: Inhibitors of Cytochrome P450 (CYP) Enzymes Table 3: Inducers of Cytochrome P450 (CYP) Enzymes Table 4: Alternate drugs NOT metabolized by CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4 or CYP3A5 enzymes Table 5: Glucose-6-Phosphate Dehydrogenase (G6PD) Associated Drugs and Compounds Table 6: Additional Pharmacogenomic Genes & Associated Drugs Table 1: Substrates of Cytochrome P450 (CYP) Enzymes Allergy Labetalol CYP2C19 Immunosuppressives Loratadine CYP3A4 Lidocaine CYP1A2 CYP2D6 Cyclosporine CYP3A4/5 Analgesic/Anesthesiology CYP3A4/5 Sirolimus CYP3A4/5 Losartan CYP2C9 CYP3A4/5 Codeine CYP2D6 activates Tacrolimus CYP3A4/5 Lovastatin
    [Show full text]
  • Mafenide Tied to Fungal Infections in Burn Patients
    48 Wound Healing S KIN & ALLERGY N EWS • July 2008 Mafenide Tied to Fungal Infections in Burn Patients BY PATRICE WENDLING placing the application of saline soaks for the annual meeting of the American Burn Nonsignificant differences between the Chicago Bureau 24 hours followed by silver sulfadiazine 1% Association. silver sulfadiazine and mafenide acetate cream (Silvadene) with only the applica- From 1998 to 2006, 42 patients were groups included mean total body surface C HICAGO — The use of topical tion of mafenide acetate 5% solution (Sul- treated twice daily with silver sulfadiazine, area burned (27% vs. 29%), inhalation in- mafenide acetate on burn wounds was as- famylon) as the topical antibiotic of choice and 69 with mafenide acetate solution. jury (14 vs. 25 patients), and mortality (6 sociated with a higher incidence of fungal for initial antimicrobial therapy. The silver sulfadiazine group was signifi- vs. 13 patients). infection than was silver sulfadiazine in a The change in burn wound treatment cantly younger than the mafenide acetate Univariate analysis showed that patients retrospective analysis of 111 patients. protocol was made in 2002 in an effort to group (mean age, 38 vs. 48 years), less like- receiving mafenide acetate solution had The chart review was initiated after improve patient outcomes, and has since ly to have a central line (16 vs. 43 patients), twice the rate of burn infection or sys- physicians at the regional burn center of been reversed, according to research co- and more likely to have shorter ICU stays temic fungal infection (48%) than did pa- Miami Valley Hospital, Dayton, Ohio, ob- ordinator Ryan Shapiro, on behalf princi- (4 vs.
    [Show full text]
  • SULFAMYLON (Mafenide Acetate, USP)
    SULFAMYLON® (Mafenide Acetate, USP) FOR 5% TOPICAL SOLUTION DESCRIPTION: Mafenide acetate, USP is a synthetic antimicrobial agent designated chemically as "-amino-p-toluenesulfonamide monoacetate. It has the following structural formula: H2NO2S CH2NH2 C CH3COOH C7H10N2O2S C C2H4O2 M.W. 246.29 Mafenide acetate, USP is a white, crystalline powder which is freely soluble in water. SULFAMYLON® For 5% Topical Solution is provided in packets containing 50 g of sterile mafenide acetate to be reconstituted in 1000 mL of Sterile Water for Irrigation, USP or 0.9% Sodium Chloride Irrigation, USP. After mixing, the solution contains 5% w/v of mafenide acetate. The solution is an antimicrobial preparation suitable for topical administration. The solution is not for injection. The 5% topical solution is to be stored at room temperature, 25E- 30E C (77E- 86EF) and should be used within 48 hours after mixing. CLINICAL PHARMACOLOGY Mechanism of Action: The mechanism of action of mafenide is not known, but is different from that of the sulfonamides. Mafenide is not antagonized by pABA, serum, pus or tissue exudates, and there is no correlation between bacterial sensitivities to mafenide and to the sulfonamides. Its activity is not altered by changes in the acidity of the environment. The osmolality of the 5% topical solution is approximately 340 mOsm/kg. NDA 19-832 Approved Labeling Page 2 Absorption and Metabolism: Applied topically, mafenide acetate diffuses through devascularized areas. Approximately 80% of a mafenide acetate dose is delivered to burned tissue over four hours following topical application of the 5% solution. Following application of mafenide acetate cream and solution, peak mafenide concentrations in human burned skin tissue occur at two and four hours, respectively.
    [Show full text]
  • Recent Updates on the Synthesis of Bioactive Quinoxaline-Containing Sulfonamides
    applied sciences Review Recent Updates on the Synthesis of Bioactive Quinoxaline-Containing Sulfonamides Ali Irfan 1,* , Sajjad Ahmad 2, Saddam Hussain 3, Fozia Batool 4, Haseeba Riaz 4, Rehman Zafar 5 , Katarzyna Kotwica-Mojzych 6 and Mariusz Mojzych 7,* 1 Department of Chemistry, Faculty of Physical Sciences, Government College University Faisalabad, 5-Km, Jhang Road, Faisalabad 38040, Pakistan 2 Department of Chemistry, UET Lahore, Faisalabad Campus, Faisalabad 37630, Pakistan; [email protected] 3 School of Biochemistry, Minhaj University Lahore, Lahore 54000, Pakistan; [email protected] 4 Department of Chemistry, Faculty of Sciences, The University of Lahore, Sargodha Campus, 10 Km, Lahore Road, Sargodha 40100, Pakistan; [email protected] (F.B.); [email protected] (H.R.) 5 Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Riphah International University, Islamabad 44000, Pakistan; [email protected] 6 Department of Histology, Embryology and Cytophysiology, Medical University of Lublin, Radziwiłłowska 11, 20-080 Lublin, Poland; [email protected] 7 Department of Chemistry, Siedlce University of Natural Sciences and Humanities, 3-go Maja 54, 08-110 Siedlce, Poland * Correspondence: [email protected] (A.I.); [email protected] or [email protected] (M.M.) Abstract: Quinoxaline is a privileged pharmacophore that has broad-spectrum applications in the fields of medicine, pharmacology and pharmaceutics. Similarly, the sulfonamide moiety is of con- siderable interest in medicinal chemistry, as it exhibits a wide range of pharmacological activities. Therefore, the therapeutic potential and biomedical applications of quinoxalines have been enhanced Citation: Irfan, A.; Ahmad, S.; by incorporation of the sulfonamide group into their chemical framework. The present review Hussain, S.; Batool, F.; Riaz, H.; Zafar, R.; Kotwica-Mojzych, K.; Mojzych, M.
    [Show full text]
  • USP Class Example Part D Eligible Drugs* Salt/Ester
    USP Medicare Model Guidelines v6.0 Page 1 of 30 Example Part D USP Category USP Class Salt/Ester Eligible Drugs* Analgesics Nonsteroidal Anti-inflammatory Drugs Celecoxib Diclofenac Potassium Diflunisal Etodolac Fenoprofen Calcium Flurbiprofen Ibuprofen Indomethacin Ketoprofen Ketorolac Tromethamine Meclofenamate Mefenamic Acid Meloxicam Nabumetone Naproxen Oxaprozin Piroxicam Sulindac Tolmetin Opioid Analgesics, Long-acting Hydromorphone Fentanyl Levorphanol Tartrate Methadone Hydrochloride Morphine Sulfate Oxycodone Hydrochloride Oxymorphone Hydrochloride Tramadol Hydrochloride Opioid Analgesics, Short-acting Butorphanol Tartrate Codeine Phosphate Fentanyl Citrate Hydromorphone Hydrochloride Meperidine Hydrochloride Nalbuphine Hydrochloride Oxycodone Hydrochloride Oxymorphone Hydrochloride Pentazocine Lactate Tapentadol Tramadol Hydrochloride Anesthetics Local Anesthetics Lidocaine Hydrochloride Lidocaine and Prilocaine Anti-Addiction/ Substance Abuse Treatment Agents Alcohol Deterrents/Anti-craving Acamprosate Calcium Disulfiram Naltrexone Hydrochloride Opioid Dependence Treatments Buprenorphine Buprenorphine/Naloxone Naltrexone Hydrochloride Opioid Reversal Agents * This list is illustrative of Part D eligible drugs only, and does not infer CMS coverage USP Medicare Model Guidelines v6.0 Page 2 of 30 Example Part D USP Category USP Class Salt/Ester Eligible Drugs* Naloxone Hydrochloride Smoking Cessation Agents Bupropion Hydrochloride Nicotine Varenicline Tartrate Antibacterials Aminoglycosides Amikacin Sulfate Gentamicin Sulfate
    [Show full text]