DOCSLIB.ORG

Part 1 (Topic #1-8) Content

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Part 1 (Topic #1-8) Content Pathological physiology Part 1 (topic #1-8) Content. № Name topic Page Introduction. Pathophysiology as a science and medical disciplines. 1. 3 Subject, tasks and methods of studying pathological physiology. 2. HEALTH AND DISEASE. General nosology. GENERAL pathogenesis. 6 3. Pathological reactions, pathological process, pathological condition 14 4. Sanogenesis. 22 5. Environmental factors 26 6. The damaging effect of mechanical factors 27 7. Pathogenic effect of low temperatures. Hypothermia 29 8. Pathogenic effects of heat. Overheating. Heatstroke. 30 9. Sunstroke. The cause and pathogenesis of sunstroke. 31 10. Action barometric pressure 33 11. Poisoning with oxygen, nitrogen. 35 12. Pathogenic action of electric current 37 13. The damaging effects of ionizing radiation 40 14. The damaging effect of rays of the solar spectrum 45 15. The action of chemical factors 47 16. The action of biological factors 48 17. Action space flight factors. Gravity Pathophysiology. 49 18. The role of psychogenic factors in the pathology 54 19. Pathogenic action of sound and noise 55 20. The damaging effect of laser radiation 57 TYPES OF DAMAGE ON DIFFERENT LEVELS OF MULTICELLULAR 21. 58 ORGANISMS 22. DAMAGE TO CELLS 61 23. GENERAL MECHANISMS OF CELL DAMAGE 63 24. CHARACTERISTICS TYPICAL FORMS OF CELL DAMAGE 71 25. The death of cells 75 26. ADAPTATION OF CELLS IN THEIR DAMAGE 79 27. REACTIVITY OF THE BODY 85 28. The Resistance 88 29. Carbohydrate metabolism disorders 94 30. HYPOGLYCEMIA 99 31. HYPERGLYCEMIA 103 32. Diabetes 105 33. Pathophysiology of metabolism. Disturbance of the water-salt metabolism 119 34. Hypohydration 120 35. HYPERHYDRATION 123 36. EDEMA 125 2 Introduction. Pathophysiology as a science and medical disciplines. Subject, tasks and methods of studying pathological physiology. Pathophysiology - the doctrine of the bodily functions of the patient (pathos - injury, illness). Pathophysiology - is a medical discipline that studies the most general laws of occurrence, development and outcome of the disease and the pathological process that studies the principles of their treatment, as well as the problems of methodology obtained about the disease or pathological process knowledge. Pathophysiology refers to medical and biological sciences, combining biological sciences (biology, biochemistry, anatomy, histology, physiology, etc.) With clinical disciplines (internal medicine, pediatrics, surgery, neurology, etc.). Pathophysiology - this section of the medicine - a science that has as its main task, on the one hand, maintaining and promoting human health and on the other - the prevention of diseases and treatment of patients. The very same medicine arose at the intersection of the natural and social sciences (disciplines) and consists of health sciences and the science of the disease (pathology). Below is a chart showing the pathophysiology place among other medical and biological and clinical disciplines. Natural Sciences Social Sciences ↓ ↓ Medicine ↓ ↓ Science Health Sciences diseases (anatomy, physiology, (pathological anatomy, pathophysiology, histology, hygiene), surgery, pediatrics) Pathological physiology exists in two related conditions. I. Pathological physiology as a science. The study of pathological physiology as a science by scientists pathophysiology. Tasks Pathophysiology as a science. 1. The study etiology of disease. Etiology (aitia - reason) - is the study of the causes and conditions of the disease. 2. The study of the pathogenesis of the disease. Pathogenesis - a mechanism of the disease (the mechanism of injury and the mechanism of protection at illness). 3. The study of mechanisms of disease outcome (recovery mechanisms, mechanisms of dying). 4. Development of the principles of treatment of the disease (etiotropic, pathogenetic, sanogenetic, symptomatic). 5. Prevention of diseases, as well as the methodology, obtained knowledge about the disease (disease of comprehension received knowledge from the standpoint of philosophy: the formation of hypotheses, theories, concepts of illness, etc.). II. Pathological physiology as a medical discipline The object and purpose of pathophysiology as a medical discipline. 1. General nosology - the general doctrine of the disease (the general laws of occurrence, development and outcome of the disease). Topics included in the first section: - The introduction, the subject methods; - A disease in historical terms; - General nosology; - Disease-causing environmental factors; - Common pathogenesis; - The doctrine of the reactivity of the organism, allergic reactivity, immunological reactivity, heredity and disease. 3 2. General typical pathological processes (inflammation, fever, tumor process, extreme conditions, etc.). Topics included in the second section: - Standard peripheral circulatory disorders; - Inflammation, - Fever, - Extreme condition (shock, collapse, coma) - Lack of oxygen (hypoxia) - Typical metabolic disorders, - Stress and distress, - Neoplastic process. 3. Typical pathological processes of organs and systems (heart arrhythmia, heart failure, respiratory failure, anemia, kidney failure and others.). Topics included in the third section: - Typical disorders of the nervous system, - Typical disorders of the endocrine system, - Typical disorders of the cardiovascular system, - Typical disorders of the blood system, - Typical disorders of the respiratory system, - Typical digestive disorders, - Typical of the liver, - Typical renal impairment. Sometimes artificially first two sections are combined together and called "general pathophysiology," the third section is even more artificial (formally) called "private pathophysiology." However, in all three sections examine general patterns of disease. The challenges facing students in the study of the pathophysiology of both medical disciplines. 1. To study the general laws of occurrence, development and outcome of the disease. 2. Prepare yourself to the perception of the disease process in the hospital - at the bedside. 3. Remember - every disease always has: its specific causes and conditions, its pathogenesis, knowledge of which is necessary for an accurate diagnosis for proper treatment of any disease. 4. Remember that effective treatment can only be based on the principles of causal, pathogenetic, sanogenetic and symptomatic treatment of the disease. 5. Remember - the doctor all their knowledge, their experience, should devote a lifetime to the service of the interests of the sick person's health. The basic method of pathophysiology - method pathophysiological experiment. Its essence - the modeling of disease or pathological process in an experiment to study. Types pathophysiological experiments: 1. Method pathophysiological experiment - modeling of human disease in animal experiments. 2. Method pathophysiological experiment on humans ("natural experiment" - on volunteers), Pathophysiological features of the experiment is that it consists of three phases: 1. Physiological phase - study of healthy body functions. 2. Pathophysiological phase - modeling of disease or pathological process and the study of functions on the background of the disease. 3. Phase experimental therapy - the use of experimental therapy and follow-up restoration functions. Auxiliary research methods in pathophysiological experiment: 1. Physiological, 4 2. Morphological, 3. Biochemical, 4. Immunological, 5. Physico-chemical, 6. Physical, 7. Mathematical, 8. Clinical, 9. Comparative evolutionary method, 10. The method of studying isolated organs and tissues in culture in vitro. Clinical Pathophysiology - learning clinically in patients. 5 HEALTH AND DISEASE Health and disease are two major forms of life. The states of health and disease can often replace each other over the individual life of the animal and the human. Aristotle considered health and illness qualitatively different categories. Norm and health To understand the nature of the disease it is important to define what a normal, healthy life (normal, health), beyond which there is a disease. There are different views on the concepts of "normal" and "health". It should be emphasized that these concepts are very closely related to each other. Norm - the more general concept that defines many of the processes and phenomena of living organisms. It expresses particular qualitative state of a living organism as a whole in every single moment of his existence. Norma (from the Greek norm - a way of knowing) is a term that is very close to the concept of "health", but not exhaustive, the term altogether. In medical practice very often use the expression "normal temperature", "Normal electrocardiogram", "normal weight and height", "normal composition of blood," etc. In this case, it refers to the rate as a statistical mean value of the measurement data from a large number of healthy individuals (average rate). The average rate takes into account race, age and gender characteristics, but it can not take into account all possible genotypes. You can be healthy on the basic parameters of the structure and functions of the body, but have a deviation from the norm for some individual characteristics, such as growth, mental abilities, peculiarities of behavior in society, and others. On the other hand, you can be patient and at the same time have outstanding intellectual abilities. All this speaks of the relativity of the terms "normal" and "health" and some conventions of the scope of their assessment for each individual. By definition, GI Tsaregorodtsev "rate - is a set of harmonic ratio and structural
Load more

Recommended publications
  • The Importance of the Vagus Nerve for Biopsychosocial Resilience
    Neuroscience and Biobehavioral Reviews 125 (2021) 1–10 Contents lists available at ScienceDirect Neuroscience and Biobehavioral Reviews journal homepage: www.elsevier.com/locate/neubiorev Review article Mental health during the COVID-19 pandemic and beyond: The importance of the vagus nerve for biopsychosocial resilience Josefien Dedoncker a,b,*, Marie-Anne Vanderhasselt a,b,c, Cristina Ottaviani d,e, George M. Slavich f a Department of Head and Skin – Psychiatry and Medical Psychology, Ghent University Hospital, Ghent, Belgium b Ghent Experimental Psychiatry (GHEP) Lab, Ghent, Belgium c Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium d Department of Psychology, Sapienza University of Rome, Rome, Italy e Neuroimaging Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy f Cousins Center for Psychoneuroimmunology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA ARTICLE INFO ABSTRACT Keywords: The COVID-19 pandemic has led to widespread increases in mental health problems, including anxiety and COVID-19 depression. The development of these and other psychiatric disorders may be related to changes in immune, Coronavirus disease endocrine, autonomic, cognitive, and affective processes induced by a SARS-CoV-2 infection. Interestingly, many Lifestyle interventions of these same changes can be triggered by psychosocial stressors such as social isolation and rejection, which Psychiatric disorders have become increasingly common due to public policies aimed at reducing the spread of SARS-CoV-2. The Social stress Transcutaneous vagus nerve stimulation present review aims to shed light on these issues by describing how viral infections and stress affect mental health. First, we describe the multi-level mechanisms linking viral infection and life stress exposure with risk for psychopathology.
    [Show full text]
  • Physiological Responses to Prolonged Bed Rest and Fluid
    c6 NASA Tscht ~icalMemorandum 81324 Physiological Responses to Prolonged Bed Rest and Fluid Immersion in Man: A CompendiumI of Research (1974-1980)- John E. Greenleaf, Lori Silverstein, Judy Bliss, Vicki Langenheim, Heidi Rossow and Clinton Chao (NASA-Tl-81324) PHYSIOLOGICAL RESPONSES TO N 82- l885b PROLONGED BED REST AND FLUID IfltlERSION IN 111: A COlPEYDIUl OF RESEARCH (1974 - 1980) (NASA) 112 p HC A06/r!F 201 CSCL 06s Unclas January 1982 National Aeronautics arid Space Admin~strat~on 7-.v,-3-./",--- T ,pl.---r--r . -- .-- T, ~ -- m?+-_ " &-rr--T. -,-- -".- - --- * --- - Jill. I NASA Techniml Memorandum 81324 I i Physiological Responses to Prolonged Bed Rest and Fluid Immersion in Man: A Compendium of Research (1974-1 980) John E. Greenleaf Lori Si lverstein Judy Bliss Vicki Langenhcim Heidi Rossow Clinton Chao, Ames Research Center, Moffett Field, California National Aorona ,~csand Space Administration Amos Ramwch canter Moffett Field, California 94035 TABLE OF CONTENTS BED REST ...................................................................... 1 References and Abstracb ........................................................ 3 Additional Selected Bibliography .................................................. 55 Subjactlndex ................................................................. 58 AuthorIndcx ................................................................. 71 IMMERSION ..................................................................... 75 References and Abstracts .......................................................
    [Show full text]
  • Serum Lipid Antibodies Are Associated with Cerebral Tissue Damage in Multiple Sclerosis
    Serum lipid antibodies are associated with cerebral tissue damage in multiple sclerosis Rohit Bakshi, MD ABSTRACT Ada Yeste, PhD Objective: To determine whether peripheral immune responses as measured by serum antigen Bonny Patel, MSc arrays are linked to cerebral MRI measures of disease severity in multiple sclerosis (MS). Shahamat Tauhid, MD Methods: In this cross-sectional study, serum samples were obtained from patients with Subhash Tummala, MD relapsing-remitting MS (n 5 21) and assayed using antigen arrays that contained 420 antigens Roya Rahbari, PhD including CNS-related autoantigens, lipids, and heat shock proteins. Normalized compartment- Renxin Chu, MD specific global brain volumes were obtained from 3-tesla MRI as surrogates of atrophy, including Keren Regev, MD gray matter fraction (GMF), white matter fraction (WMF), and total brain parenchymal fraction Pia Kivisäkk, MD, PhD (BPF). Total brain T2 hyperintense lesion volume (T2LV) was quantified from fluid-attenuated Howard L. Weiner, MD inversion recovery images. Francisco J. Quintana, PhD Results: We found serum antibody patterns uniquely correlated with BPF, GMF, WMF, and T2LV. Furthermore, we identified immune signatures linked to MRI markers of neurodegeneration (BPF, GMF, WMF) that differentiated those linked to T2LV. Each MRI measure was correlated with a Correspondence to specific set of antibodies. Strikingly, immunoglobulin G (IgG) antibodies to lipids were linked to Dr. Quintana: brain MRI measures. Based on the association between IgG antibody reactivity and each unique [email protected] MRI measure, we developed a lipid index. This comprised the reactivity directed against all of the lipids associated with each specific MRI measure. We validated these findings in an additional independent set of patients with MS (n 5 14) and detected a similar trend for the correlations between BPF, GMF, and T2LV vs their respective lipid indexes.
    [Show full text]
  • Peripheral Blood Parameters As a Marker of Nonspecific Adaptive Response of the Body in Acute Infectious Diseases with Tonsillitis Syndrome
    Vol. 8 Núm. 22/Septiembre - octubre 2019 649 Artículo de investigación Peripheral blood parameters as a marker of nonspecific adaptive response of the body in acute infectious diseases with tonsillitis syndrome Параметры периферической крови как маркеры неспецифического адаптационного ответа при острых инфекционных заболеваниях с синдромом тонзиллита Recibido: 12 de julio del 2019 Aceptado: 25 de agosto del 2019 Written by: Plakhotnikova S.V.285 Santalova G.V. 286 Gasilina E.S.287 Zhirnov V.A.288 Davydkin I.L.289 Osadchuk A.M.290 Osadchuk M.A.291 Trushin M.V.292 Abstract Абстрак Evaluation of nonspecific adaptive response of Целью настоящего исследования явилась the body in children with acute infectious оценка неспецифической адаптационной diseases associated with tonsillitis syndrome was реакции организма у детей с острыми the aim of this research. This prospective study инфекционными заболеваниями, included clinical, anamnestic and laboratory ассоциированными с синдромом тонзиллита. examination of children with acute infectious Данное проспективное исследование diseases with tonsillitis syndrome. A systemic включало клинико-анамнестическое и multiple factor analysis was conducted лабораторное обследование детей с острыми (significance level р<0.05). The evaluation of инфекционными заболеваниями с синдромом peripheral blood parameters (specific gravity of тонзиллита. Проведен системный lymphocytes and indices of reactive protective многофакторный анализ (уровень значимости potential (RPP) - specific immune lymphocytic- р<0,05). Оценка
    [Show full text]
  • Identification of Naturally Occurring Fatty Acids of the Myelin Sheath That Resolve Neuroinflammation
    RESEARCH ARTICLE MULTIPLE SCLEROSIS Identification of Naturally Occurring Fatty Acids of the Myelin Sheath That Resolve Neuroinflammation Peggy P. Ho,1* Jennifer L. Kanter,1,2* Amanda M. Johnson,1,2 Hrishikesh K. Srinagesh,1 Eun-Ju Chang,2,3 Timothy M. Purdy,2,3 Keith van Haren,1,2,3 William R. Wikoff,4 Tobias Kind,4 Mohsen Khademi,5 Laura Y. Matloff,1 Sirisha Narayana,1,2 Eun Mi Hur,1 Tamsin M. Lindstrom,2,3 Zhigang He,6 Oliver Fiehn,4 Tomas Olsson,5 Xianlin Han,7 May H. Han,1 Lawrence Steinman,1*† William H. Robinson2,3*† Lipids constitute 70% of the myelin sheath, and autoantibodies against lipids may contribute to the demyelination that characterizes multiple sclerosis (MS). We used lipid antigen microarrays and lipid mass spectrometry to identify bona fide lipid targets of the autoimmune response in MS brain, and an animal model of MS to explore the role of the identified lipids in autoimmune demyelination. We found that autoantibodies in MS target a phosphate group in phosphatidylserine and oxidized phosphatidylcholine derivatives. Administration of these lipids ameliorated Downloaded from experimental autoimmune encephalomyelitis by suppressing activation and inducing apoptosis of autoreactive T cells, effects mediated by the lipids’ saturated fatty acid side chains. Thus, phospholipids represent a natural anti-inflammatory class of compounds that have potential as therapeutics for MS. INTRODUCTION tory responses in the CNS and that this protective mechanism is com- http://stm.sciencemag.org/ In multiple sclerosis (MS), aberrant adaptive immune responses target promised in MS, because these guardian lipids are attacked by the and destroy the myelin sheath.
    [Show full text]
  • Blood-Brain Barrier Protein Recognized by Monoclonal Antibody
    Proc. Natl. Acad. Sci. USA Vol. 84, pp. 8169-8173, November 1987 Neurobiology Blood-brain barrier protein recognized by monoclonal antibody (immunocytochemistry/peroxidase-antiperoxidase/Langerhans cells/experimental allergic encephalomyelitis/retina) NANCY H. STERNBERGER AND LUDWIG A. STERNBERGER Departments of Anatomy, Neurology and Pathology, University of Maryland School of Medicine, Baltimore, MD 21201 Communicated by Berta Scharrer, August 7, 1987 ABSTRACT An IgGi mouse monoclonal antibody pro- body is a useful probe for studying macromolecules related to duced in response to immunization with rat brain homogenate blood-brain barrier function. reacted with endothelial cells in the central and peripheral nervous system. Because antibody reactivity was associated MATERIALS AND METHODS with endothelia that have a selective permeability barrier, the antibody was called anti-endothelial-barrier antigen (anti- Monoclonal Antibody Production. Monoclonal antibodies EBA). Paraffin sections of Bouins'-fixed rat tissue were used were produced from BALB/c mice immunized with rat brain for initial screening and subsequent characterization of anti- homogenates as described (12) by using the procedure of body reactivity. The antibody was generally unreactive with Kohler and Milstein (13). Immunocytochemistry on paraffin endothelial cells in other organs and with nonendothelial cells sections was used to select hybridomas producing antibodies in or outside of the nervous system. Antibody binding was to endothelia. greatly reduced or absent in endothelia of the area postrema Immunocytochemistry. Lewis or Sprague-Dawley rats and choroid plexus, sites known to possess fenestrated blood were perfused with Bouins' fixative. Organs were postfixed vessels. In developing rat brain, anti-EBA binding to some in the same fixative overnight, dehydrated, and embedded in microvessels was seen at 3 days postnatally.
    [Show full text]
  • Neuroprotective Natural Antibodies to Assemblies of Amyloidogenic Peptides Decrease with Normal Aging and Advancing Alzheimer’S Disease
    Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer’s disease M. Britschgia, C. E. Olina, H. T. Johnsa, Y. Takeda-Uchimuraa, M. C. LeMieuxb, K. Rufibachc, J. Rajadasa, H. Zhanga, B. Tomookad, W. H. Robinsond,e, C. M. Clarkf, A. M. Fagang, D. R. Galaskoh, D. M. Holtzmang, M. Juteli, J. A. Kayej, C. A. Lemerek, J. Leszekl,G.Lim,n, E. R. Peskindm,n, J. F. Quinnj, J. A. Yesavagea,e, J. A. Ghisoo, and T. Wyss-Coraya,e,1 Departments of aNeurology and Neurological Sciences and dMedicine, Stanford University School of Medicine, Stanford, CA 94305; bDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305-5025; cInstitute of Social and Preventive Medicine, Biostatistics Unit, University of Zurich, CH-8001 Zurich, Switzerland; eGeriatric Research Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304; fDepartment of Neurology, Alzheimer’s Disease Center, and Institute on Aging, University of Pennsylvania, Philadelphia, PA 19104; gDepartment of Neurology, Washington University, St. Louis, MO 63110; hDepartment of Neurosciences, University of California at San Diego, La Jolla, CA 92093; iDepartment of Internal Medicine and Allergology, Wroclaw Medical University, 50-417 Wroclaw, Poland; jLayton Aging and Alzheimer’s Disease Center, Oregon Health Sciences University, Portland, OR 97201; kBrigham and Women’s Hospital and Center for Neurologic Diseases, Harvard Medical School, Boston, MA 02115; lDepartment of Psychiatry, Wroclaw Medical University, 51-622 Wroclaw, Poland; mAlzheimer’s Disease Research Center, University of Washington, Seattle, WA 98108; nVeterans Affairs Puget Sound Health Care System, Seattle, WA 98108; and oDepartments of Pathology and Psychiatry, New York University Langone Medical Center, New York, NY 10016 Edited by L.
    [Show full text]
  • Body Visual Discontinuity Affects Feeling of Ownership and Skin
    www.nature.com/scientificreports OPEN Body visual discontinuity affects feeling of ownership and skin conductance responses Received: 18 June 2015 1,3,* 1,2,* 3 Accepted: 26 October 2015 Gaetano Tieri , Emmanuele Tidoni , Enea Francesco Pavone & Salvatore Maria 1,2 Published: 25 November 2015 Aglioti When we look at our hands we are immediately aware that they belong to us and we rarely doubt about the integrity, continuity and sense of ownership of our bodies. Here we explored whether the mere manipulation of the visual appearance of a virtual limb could influence the subjective feeling of ownership and the physiological responses (Skin Conductance Responses, SCRs) associated to a threatening stimulus approaching the virtual hand. Participants observed in first person perspective a virtual body having the right hand-forearm (i) connected by a normal wrist (Full-Limb) or a thin rigid wire connection (Wire) or (ii) disconnected because of a missing wrist (m-Wrist) or a missing wrist plus a plexiglass panel positioned between the hand and the forearm (Plexiglass). While the analysis of subjective ratings revealed that only the observation of natural full connected virtual limb elicited high levels of ownership, high amplitudes of SCRs were found also during observation of the non-natural, rigid wire connection condition. This result suggests that the conscious embodiment of an artificial limb requires a natural looking visual body appearance while implicit reactivity to threat may require physical body continuity, even non-naturally looking, that allows the implementation of protective reactions to threat. Protective physiological reactions to events threatening our body depend not only on the recognition of the threat itself but also on the correct representation of our body and its attribution to ourselves.
    [Show full text]
  • Brain-Reactive Igg Correlates with Autoimmunity in Mothers of a Child with an Autism Spectrum Disorder
    Molecular Psychiatry (2013) 18, 1171–1177 & 2013 Macmillan Publishers Limited All rights reserved 1359-4184/13 www.nature.com/mp IMMEDIATE COMMUNICATION Brain-reactive IgG correlates with autoimmunity in mothers of a child with an autism spectrum disorder L Brimberg1, A Sadiq1, PK Gregersen2 and B Diamond1 It is believed that in utero environmental factors contribute to autism spectrum disorder (ASD). The goal of this study was to demonstrate, using the largest cohort reported so far, that mothers of an ASD child have an elevated frequency of anti-brain antibodies and to assess whether brain reactivity is associated with an autoimmune diathesis of the mother. We screened plasma of 2431 mothers of an ASD child from Simon Simplex Collection and plasma of 653 unselected women of child-bearing age for anti-brain antibodies using immunohistology on mouse brain. Positive and negative plasma from mothers with an ASD child were analyzed for anti-nuclear antibodies and for autoimmune disorders. Mothers of an ASD child were four times more likely to harbor anti-brain antibodies than unselected women of child-bearing age (10.5 vs 2.6%). A second cohort from The Autism Genetic Resource Exchange with multiplex families displayed an 8.8% prevalence of anti-brain antibodies in the mothers of these families. Fifty-three percent of these mothers with anti-brain antibodies also exhibited anti-nuclear autoantibodies compared with 13.4% of mothers of an ASD child without anti-brain antibodies and 15% of control women of child-bearing age. The analysis of ASD mothers with brain-reactive antibodies also revealed an increased prevalence of autoimmune diseases, especially rheumatoid arthritis and systemic lupus erythematosus.
    [Show full text]
  • Icalm: Wearable Sensor and Network Architecture for Wirelessly Communicating and Logging Autonomic Activity
    1 iCalm: Wearable Sensor and Network Architecture for Wirelessly Communicating and Logging Autonomic Activity R. Fletcher, Member, IEEE , K. Dobson, M. S. Goodwin, H. Eydgahi, O. Wilder-Smith, D. Fernholz, Y. Kuboyama, E. Hedman, M. Z. Poh, R. W. Picard , Fellow, IEEE treatment or service can adapt to the patient’s individual Abstract —Widespread use of affective sensing in healthcare affective state and state-influenced needs. For example, a applications has been limited due to several practical factors such majority of relapses in smoking are linked to stress, and stress as lack of comfortable wearable sensors, lack of wireless management is a strong contributing factor of successful standards, and lack of low-power affordable hardware. In this paper, we present a new low-cost, low-power wireless sensor cessation [2, 3]. A wearable, autonomic device that is platform implemented using the IEEE 802.15.4 wireless standard, unobtrusive, low-cost, and comfortable enough for continuous and describe the design of compact wearable sensors for long-term wear, might help the wearer who wants to quit smoking to see measurement of electrodermal activity, temperature, motor whether and when stress is affecting his or her behavior – activity and photoplethysmography. We also illustrate the use of perhaps influencing use of tobacco or drugs, over-eating, or this new technology for continuous long-term monitoring of other health problems. Help might then be customized for better autonomic nervous system and motion data from active infants, children, and adults. We describe several new applications managing that affective state and its causes, perhaps even at a enabled by this system, discuss two specific wearable designs for moment well timed to the triggering event [4].
    [Show full text]
  • Survival Research Project Paper
    i Message from the Director The Federal Law Enforcement Training Center (FLETC) is pleased to present the “Survival Scores Research Project” as part of our continuing effort to develop and provide new information and strategies to enhance law enforcement training. Additionally, the FLETC is committed to sharing this information with the law enforcement community. The dramatic impact of stress on performance is well recognized in the law enforcement profession, but has not been well documented from a research perspective. This latest research will enhance the growing pool of knowledge in this area, and aid in identifying training mechanisms to optimize the effectiveness of law enforcement officers’ responses in stressful encounters. This research-based project offers a new perspective on the future of law enforcement training. This novel approach combines the numerous disciplines that are integrated in the law enforcement profession and applies them in a highly stressful environment. The first hand documentation of the stress response provided new and insightful information that can be directly applied to our training programs. I would like to thank our distinguished research colleagues from the University of South Florida and Walter Reed Army Institute of Research for their valuable insight and assistance in performing this research. I would also like to thank our partner organizations at the FLETC who provided support and students for this project. The FLETC remains dedicated to exploring new technologies and evaluating training practices as we continue to focus on our responsibility of preparing law enforcement officers to meet their ever- evolving responsibilities. ii Survival Scores Research Project FLETC Research Paper April 2004 Table of Contents Research Abstract i Foreword ii Introduction: Officer Survival: Responding Under Stress 1 1.
    [Show full text]
  • Immunity – a Significant Pathogenic Factor As Well As an Integral Part of the Psychoneuroendocrine-Immune Regulations
    Physiol. Res. 67: 165-173, 2018 https://doi.org/10.33549/physiolres.933656 REVIEW Immunity – a Significant Pathogenic Factor as Well as an Integral Part of the Psychoneuroendocrine-Immune Regulations F. VOŽEH1,2 1Department of Pathophysiology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic, 2Laboratory of Neurodegenerative Disorders, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic Received April 20, 2017 Accepted November 10, 2017 On-line January 5, 2018 Summary Introduction Immunity plays an important role in the reactivity of the organism and, in this context, is an essential factor in the Currently, there is no doubt that immunity plays pathogenesis of many diseases. Basically, there is no system or a significant role in the pathogenesis of many diseases. organ in the body, whose dysfunction is not related to immunity Essentially, there is no system or organ in the body the consequences. In addition, there are also multisystem diseases impairment of which would not have immunity simultaneously involving multiple body systems. They are not consequences. Additionally, there are other diseases always caused by weak immunity, but also often by modified named multisystem diseases that affect multiple systems immune reactions known as overshooting. The essence of all in the body at the same time. Yet is it not always a matter these diseases is a change in the reactivity of the organism of weak immunity, but also modified, often so-called where immunity plays an important role. The immunity as such is overshooting immune responses that particularly are then part of the systems of neuroendocrine-immune regulation, recently on the rise.
    [Show full text]