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Disease Transmission by Misfolded Prion-Protein Isoforms, Prion-Like Amyloids, Functional Amyloids and the Central Dogma

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Disease Transmission by Misfolded Prion-Protein Isoforms, Prion-Like Amyloids, Functional Amyloids and the Central Dogma biology Review Disease Transmission by Misfolded Prion-Protein Isoforms, Prion-Like Amyloids, Functional Amyloids and the Central Dogma Martin L. Daus Received: 16 July 2015; Accepted: 28 December 2015; Published: 4 January 2016 Academic Editor: Chris O'Callaghan ZBS6-Proteomics and Spectroscopy, Robert Koch-Institute, Seestrasse 10, 13353 Berlin, Germany; [email protected]; Tel.: +49-30-187-542-844; Fax: +49-30-187-542-664 Abstract: In 1982, the term “prions” (proteinaceous infectious particles) was coined to specify a new principle of infection. A misfolded isoform of a cellular protein has been described as the causative agent of a fatal neurodegenerative disease. At the beginning of prion research scientists assumed that the infectious agent causing transmissible spongiform encephalopathy (TSE) was a virus, but some unconventional properties of these pathogens were difficult to bring in line with the prevailing viral model. The discovery that prions (obviously devoid of any coding nucleic acid) can store and transmit information similarly to DNA was initially even denoted as being “heretical” but is nowadays mainly accepted by the scientific community. This review describes, from a historical point of view, how the “protein-only hypothesis” expands the Central Dogma. Definition of both, the prion principle and the Central Dogma, have been essential steps to understand information storage and transfer within and among cells and organisms. Furthermore, the current understanding of the infectivity of prion-proteins after misfolding is summarized succinctly. Finally, prion-like amyloids and functional amyloids, as found in yeast and bacteria, will be discussed. Keywords: prion; Central Dogma; protein misfolding; amyloid; prion-like amyloids; functional amyloids 1. Introduction Prions (proteinaceous infectious particles, PrPTSE (TSE = transmissible spongiform encephalopathy)) are the causative agents of fatal neurodegenerative diseases as bovine spongiform encephalopathy (BSE) in cattle, scrapie in sheep, chronic wasting disease (CWD) in cervids and Creutzfeldt-Jakob disease in humans [1,2]. In a process that can occur sporadically, by genetic mutations or by the uptake of prions, the cellular prion protein (PrPC) is structurally transferred in a misfolded (then pathogenic) isoform (PrPTSE)[3]. In a self-propagating process, more disease-associated, transmissible PrPTSE becomes accumulated in the central nervous system causing progressive spongiform changes [4]. Prions are pathogens that fundamentally differ from bacteria, viruses or fungi as they are thought to consist essentially of host encoded prion protein lacking a coding nucleic acid. PrPTSE is characterized by an increased β-sheet content and tends to form highly ordered amyloid structures [5]. Similarly to prion diseases, neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease are neuropathologically characterized by the aggregation and deposition of misfolded endogenous proteins in the central nervous system. Albeit proteins from different neurodegenerative diseases differ in terms of amino acid sequences and native folds, their disease-associated proteins form extracellular amyloid deposits or intracellular amyloid-like inclusions. Principally, amyloids need not to be related to diseases but can also be beneficial as in bacteria (functional amyloids) or yeast (prion-like proteins) where they contribute to cell stability or Biology 2016, 5, 2; doi:10.3390/biology5010002 www.mdpi.com/journal/biology Biology 2016, 5, 2 2 of 6 Biology 2016, 5, 2 2 of 6 bacteria (functional amyloids) or yeast (prion-like proteins) where they contribute to cell stability or act as inheritable elements [6,7]. [6,7]. Amyloids Amyloids can can be trans transferredferred from from cell to to cell cell or or even even from from organism organism to organism. organism. At At least least in in case case of of prion prion diseases, diseases, amyloids amyloids can can transfer transfer disease disease by bythe the transmission transmission of specific,of specific, structurally structurally altered, altered, isoforms isoforms of ofcellular cellular proteins. proteins. The The discovery discovery of of functional functional amyloids, amyloids, prion-like proteins andand prionsprions (including(including different different strains strains as as outlined outlined below) below revealed) revealed the the necessity necessity to toexpand expand the theCentral Central Dogma Dogmaof of transcription transcription and and subsequent subsequent translation translation beingbeing thethe dominantdominant ways of information transfer in and between livingliving cells and organisms (Figure(Figure1 1).). Figure 1. Information transfer between differentdifferent macromolecules. According According to to the Central Dogma formulated by by Watson Watson and Crick, DNA in in transc transcribedribed into into RNA RNA and and then then translated translated into into protein protein ( (11).). Reverse transcriptase also allows the transfer of information from RNA to DNA.DNA. An information transfer from protein backback toto nucleicnucleic acidacid isis precludedprecluded (2(2).). Prions Prions transfer transfer information information in in a self-replicating manner manner from from protein protein to to protein protein by by a a distinct misfolded misfolded protein protein conformation conformation ( (33).). PrPC,, cellular cellular prion prion protein; PrP TSE, ,misfolded misfolded isoform isoform of of the the prion prion-protein-protein (TSE = transmissible spongiform encephalopathy). 2. Expanding Expanding the the CentralCentral Dogma Dogma When the double helix structure of of DNA (deoxyribonucleic acid) acid) had had been been discovered discovered by by F. F. Crick Crick and J. J. Watson Watson in in 1953, 1953, a amacrom macromoleculeolecule as as hereditary hereditary material material was was manifes manifestedted [8]. [At8]. this At thistime time it was it wasunclear unclear how howgenetic genetic information information is encoded is encoded in inDNA DNA and and how how this this information information is is transferred transferred to proteins. Also Also the the funct functionion of of RNA RNA (ribonucleic (ribonucleic acid) acid) in in gene gene expression expression remained remained to to be be resolved. resolved. Eight years later Crick published the hypothesis that a transfer of information from nucleic acid to nucleic acid or from nucleic acid to protein may be possible [9]. [9]. T Thishis brilliant idea still holds true in what we call transcription and translation today. Finally, it was statedstated thatthat ““DNADNA makes RNA makes protein”. TheThe discoverydiscovery of of RNA-viruses RNA-viruses and and reverse revers transcriptasee transcriptase revealed revealed that the that information the information transfer transferfrom DNA from to RNADNA needsto RNA not needs to be not unidirectional. to be unidirectional. But according But according to the Central to the Dogma Centralit wasDogma proposed it was proposedthat “once informationthat “once information has passed into has proteinpassed itinto cannot protein get it out cannot again ”[get8 out]. Information again” [8]. Information transfer from transfer protein fromback toprotein nucleic back acid to and nucleic from proteinacid and to from protein protein was precluded.to protein Aswas a transferprecluded. of informationAs a transfer from of informationprotein to protein from protein was proposed to protein by was the proposed prion-hypothesis, by the prion-hypot and functionalhesis, amyloidsand functional and prion-likeamyloids andproteins prion-like (as described proteins below) (as described were discovered, below) were the Centraldiscovered, Dogma the(even Central after Dogma minor (even revision after by minor Crick revisionin 1970 [ 9by]) hadCrick to in be 1970 expanded [9]) had (Figure to be1 expanded). Since S. (Figure Prusiner 1). has Since been S. awarded Prusiner thehas Nobel been awarded Price for thethe Nobelprion hypothesis Price for the in 1997,prion the hypothesis idea that ain misfolded 1997, the isoformidea that of a a misfolded cellular protein isoform can of transfer a cellular information protein canonto transfer other cellular information prion proteinsonto other in acellular self-replicating prion proteins manner in becamea self-replicating more and manner more accepted became [10 more,11]. and more accepted [10,11]. 3. Prions as Information Carriers within and among Cells and Organisms 3. Prions as Information Carriers within and among Cells and Organisms Many biological processes are driven by changes in protein conformation but prions are unique pathogensMany asbiological they transmit processes disease are bydriven a distinct by changes self-replicating in protein misfolded conformation isoform but of prions the cellular are unique prion pathogensprotein [12 –as15 they]. They transmit display disease a pathological, by a distinctβ-sheet self-replicating rich conformation misfolded that isoform tends toof aggregation.the cellular prionThe cellular protein form [12–15]. of the They prion display protein displaysa pathological, a different β-sheet secondary rich conformation structure with that a low tendsβ-sheet to aggregation.content. PrP TheC is cellul not infectious,ar form of the soluble prion in protein mild detergentsdisplays a anddifferent sensitive secondary to protease structure digestion. with a Accordinglow β-sheet to content. a misfolding PrPC process,is not infectious, designated soluble
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