NCBIOTECH Company Directory
ncbiotech.org/directory NC’s Life Science Transformation
The 34 years of work by the North Carolina Biotechnology Center has proven to be transformative for the state – especially for its manufacturing workforce. As employment in the state’s furniture, textile and tobacco factories tumbled over the past three decades, the number of people working in pharmaceutical and medicine manufacturing has grown from a few dozen to about 21,000 today. And pharmaceutical manufacturing is just one important segment of North Carolina’s transformational life science community. It doesn’t include the thousands of people in high-tech agriculture, or medical device commercialization, or contract research and development – a life science ecosystem totaling 63,000-plus workers at more than 700 companies statewide. The annual NCBiotech Company Directory print edition aggregates information on these 700+ companies, while the online version includes nearly 2,300 supporting companies such as patent law firms specializing in life science work. They bring the direct and indirect life science workforce total to 260,000.
Survey Shows Commuters Statewide What isn’t so obvious is the fact that today there are life That took a lot of teamwork, including some science and/or support companies in 85 of North fabulous support from human resources and Carolina’s 100 counties. Also, even if your county other key people at 58 companies across the state, doesn’t yet have one of these companies, people from mostly life science firms. your county are likely to be working for one. Some of them have a hefty commute, to be sure. But it’s worth it to Data from just these 58 companies, scattered them, because it’s satisfying, rewarding work that is often across 24 counties, show their collective available even to people with an associate’s degree from a 26,000 employees are commuting from their community college training program. homes in 93 North Carolina counties. We know this, in part, because NCBiotech completed its The “good factory jobs” look a lot different in 2018 first statewide Employee Commuting Study in 2018. than in 1984 when the Biotech Center was born. This directory, the only one of its kind, is a snapshot of Adhezion Biomedical LLC (Hudson) develops and produces cyanoacrylate-based NC’s 700+ life science companies. medical adhesive, wound care and microbial barrier products for connective tissue (human 13C Molecular Inc. (Fayetteville) provides Accord Healthcare Inc. (Durham) develops skin). The company’s manufacturing and stable-isotope labeled and native compounds and manufactures generic pharmaceuticals. research facility is located in Hudson. to the pharmaceutical and biomedical Their portfolio includes therapeutics in adhezion.com industries via custom organic synthesis oncology, cardiology, neurology, nephrology, and sourcing through a consortium of urology, psychiatry, diabetes and pain Adroit Pharmaceutical Development LLC manufacturers. management. The North Carolina location is (Durham) identifies new and improved 13cmolecular.com a sales office. formulations and process technologies. accord-healthcare.com Its primary focus is on inhalation and 1st Order Pharmaceuticals (Pittsboro) is dermatological product development. an early development-stage pharmaceutical AccuGenomics Inc. (Wilmington) develops adroitpharmdev.com company focused on developing neurology gene expression tests to diagnose and assets. monitor cancer treatment. Its technologies Advanced Animal Diagnostics Inc. 1storderpharma.com include Standardized Nucleic Acid (Morrisville) develops and commercializes diagnostics to detect and manage disease 410 Medical Inc. (Durham) is developing Quantification (SNAQ) for quantitative PCR states, reproductive, nutritional and overall technology for rapid infusion of fluids for and Standardized RNA Sequencing (STARSEQ) health status of production animals. hospital, transport and military healthcare for NGS platform analysis. providers, enabling clinicians to quickly and accugenomics.com qscoutlab.com effectively resuscitate critically-ill patients. 410medical.com Achelios Therapeutics Inc. (Chapel Hill) Advanced Chemotherapy Technologies develops topical therapeutics for the Inc. (Raleigh), a UNC startup, has developed 908 Devices Inc. (Carrboro) develops and treatment of migraine and peripheral pain. a novel device for infusing chemotherapies makes chemical analysis products such as achelios.com directly into poorly-vascularized pancreatic handheld chemical detection tools, compact tumors. analyzers and separation devices. Actus Therapeutics (Chapel Hill) develops 908devices.com gene therapies for rare diseases including Advanced Laboratories Inc. (Clayton) Pompe disease and epilepsy. provides chemical and microbiological A&C American Chemicals Ltd. (Raleigh) actustherapeutics.com analysis of dietary supplements and food manufactures GMP excipients, APIs and products. process solutions for pharmaceutical and Adámas Nanotechnologies Inc. (Raleigh) advancedlabsinc.com biotechnology companies. The Raleigh develops and produces fluorescent location is a business development office. nanodiamond particles for life science, Aegis Surgical Ltd. (Durham) is developing acggp.com medical and industrial applications, including a less invasive access system that facilitates life science research, drug delivery, bioimaging, percutaneous transaortic transcatheter aortic A1 BioChem Labs LLC (Wilmington) offers anti-counterfeiting, oil additives and cosmetics. valve replacement (pTAo-TAVR). chemistry services to universities, pharma, adamasnano.com synecor.com/portfolio agrochemical and biotech industries. Services include custom synthesis of APIs and novel compounds, catalog compound services, AegisCN LLC (Durham) develops route screening, lead optimization and technologies and treatments targeting chemical sourcing. neurological diseases and inflammation. a1biochemlabs.com
aperioclinical.com | (888) 448-2969 | [email protected]
Dedicated to transparent interactions with clients, Aperio provides full, customizable clinical research services across multiple therapeutic areas as well as consulting in Quality Assurance, Strategic Resourcing, and Clinical Trial Technology. From start to close and every point in between, Aperio works with its partners to deliver outcomes that will improve patient care and save lives.
Received NCBiotech investment North Carolina Bioscience Companies | 1 Aerie Pharmaceuticals Inc. (Durham) Alcami Corporation (Durham and Almac Clinical Services LLC (Durham) discovers, develops and commercializes first- Wilmington) provides contract drug provides clinical trial material manufacturing, in-class therapies for the treatment of patients development and manufacturing services, packaging and distribution services. with glaucoma. including API manufacturing, formulation almacgroup.com/development- aeriepharma.com development, analytical chemistry and solid manufacturing/clinical-services/ dose and parenteral drug manufacturing for Aestas Pharma Inc. (Lewisville) develops both clinical and commercial markets. Almac Diagnostics LLC (Durham) offers novel diagnostic imaging and therapeutic alcaminow.com services for biomarker discovery, assay agents to enable the early detection of development/validation/testing and Alzheimer’s and Parkinson’s disease when Alderon BioSciences Inc. (Beaufort) companion diagnostic co-development. clinical signs are not yet pronounced. develops point-of-care diagnostics. Testing platforms include NGS, Microarray, aestaspharma.com qPCR and IHC. Regulatory and bioinformatics Alera Labs LLC (Research Triangle Park) services are also available. Affinergy LLC (Morrisville) develops peptide- provides contract research analytical almacgroup.com/diagnostics based technologies, including diagnostic chemistry, in vitro toxicology, GLP products, research tools and therapeutic drug analysis and preformulation services to ALP Life Sciences Inc. (Black Mountain) monitoring products for use by clinicians and pharmaceutical, biotech and medical device develops diagnostics and therapeutics for researchers. companies. liver diseases and related inflammatory affinergy.com aleralabs.com diseases. alplifesciences.com AgBiome Inc. (Research Triangle Park) uses See Us Online its proprietary Genesis platform to collect, Alpha Nano Tech LLC (Research Triangle Park) provides nanoparticle and exosome isolate and analyze microbes for use in the Search the NCBiotech characterization services. discovery and development of biologicals Company Directory at alphanano.tech and traits for protecting crops. ncbiotech.org/directory agbiome.com AlphaSyx Therapeutics Inc. (Winston- Agile Sciences Inc. (Raleigh) is developing ALG Therapeutics LLC (Chapel Hill) Salem) is developing novel medicines that a mechanistic approach for the treatment develops pharmaceutical products for pain target cholinergic receptors to prevent of antibiotic-resistant, life-threatening disorders. and treat diseases of inflammation, initially infections. neuroinflammation resulting in Postoperative agilesci.com Algaen Corp. (Winston-Salem) uses Cognitive Decline (POCD). microalgae to develop, produce and alphasyx.com AimMax Therapeutics Inc. (Research market products and technologies for the Triangle Park) researches and develops nutraceutical, pharmaceutical and bio-energy Alterna Therapeutics Inc. (Durham) biopharmaceuticals for the treatment of industries. develops therapeutics to treat diabetes and infection, inflammation and pain through algaen.com obesity. in-licensing or co-development with strategic partners. Alganomics LLC (Southport) is researching Altis BioSystems (Chapel Hill) is developing aimmaxrx.com and developing algae-culturing systems to a stem cell technology that recreates the create bioproducts, including biofuels. human intestinal epithelium in a 2D or 3D Ajinomoto North America (Raleigh) layer of intestinal stem and differentiated manufactures pharmaceutical-grade amino Alion Science and Technology Inc. cells, which can be used for compound acids and custom-blended amino acid (Research Triangle Park) provides toxicology screening, microbiome research and disease mixtures. research, animal husbandry, inhalation modeling. ajiaminoscience.com engineering and biochemistry services. Alion altisbiosystems.com operates four bioscience research laboratories Akros Medical Inc. (Durham) develops in the Triangle. American Distillation Inc. (Leland) orthopedic medical devices. alionscience.com manufactures industrial-grade ethyl alcohol akrosmedical.com and offers contract manufacturing services Allergy Partners Extract Laboratory such as distillation, dehydration, reaction, (Asheville) produces extracts that are carbon treating and blending. used to treat allergic disease, asthma and americandistillation.net immunology. allergypartners.com
2 | ncbiotech.org/directory AnelleO (Chapel Hill) is developing a 3D printed intravaginal ring that can be used as a platform for treating a wide range of women’s NCBiotech Funding Programs: health conditions. Anémot Therapeutics Inc. (Chapel Hill) Life Science Lifelines develops therapeutics for acute and chronic inflammation. Its lead product is being developed for severe RSV infections, cystic fibrosis and other diseases of lung injury.
Annias Immunotherapeutics Inc. (Chapel Hill) is developing an immunotherapeutic platform to recognize tumor cells, including glioblastoma, breast, prostate and colorectal cancers. anniasimmuno.com
Antech Diagnostics Inc. (Morrisville) provides clinical and veterinary hematology analysis, clinical chemistry, urinalysis and coagulation testing. antechglp.com
Apeirolux Pharmaceutical Inc. (Research Triangle Park) is developing a tumor-cell selective topical skin cream for the treatment of skin cancer.
Appealing Products Inc. (Raleigh) develops products for forensics and personal protection from toxic materials such as inorganics, gases and poisons in foods, Learn how our funding programs help boost North Carolina’s life science sector at animal feeds and liquids. ncbiotech.org/funding appealingproducts.com
Apple Pharms Ingredients Inc. (Asheville) discovers natural bioactive ingredients and functional foods for nutritional and medicinal 15 T.W. Alexander Drive | Post Office Box 13547 | Research Triangle Park, NC 27709-3547 purposes. Apple Pharms also provides 919-541-9366 contract development and drug discovery Photo: shutterstock.com services. applepharms.com
Applied Catheter Technologies Inc. Amyris Inc. (Leland) converts plant sugars Andersen Products Inc. (Haw River) sells (Winston-Salem) develops drug-coated into hydrocarbon molecules and produces and services the Anprolene and EOGas medical devices that inhibit scar formation. specialty ingredients and consumer products. lines of 100% ethylene oxide gas sterilizers. The company’s first products under This site uses renewable biofarnesene to They also provide contract packaging and development are catheters for male urethral manufacture products such as biofuels, sterilization services for device manufacturers. stricture and devices that inhibit abdominal lubricants, cosmetics and other specialty anpro.com adhesions. chemicals. appliedcatheter.com amyris.com Andersen Scientific Inc. (Morrisville) provides contract ethylene oxide sterilization and validation services for packaging and devices. Andersen’s sterilization cycles include microbiological and other testing. ansci.us
Received NCBiotech investment North Carolina Bioscience Companies | 3 Applied LifeSciences & Systems Poultry Argos Therapeutics Inc. (Durham) develops ARSPIChem LLC (Research Triangle Inc. (Raleigh) develops automated bio- individualized immunotherapies for the Park) offers chemical product services to system solutions for detecting, targeting treatment of cancer and infectious diseases pharma, biotech industries, universities and and delivering vaccines to poultry. ALS-S using its Arcelis technology platform. research organizations to support drug technology aims to reduce the need for argostherapeutics.com discovery. Products and services include antibiotics by improving vaccination delivery. organic molecules, custom synthesis and als-s.com ARK Research LLC (Mebane) provides pharmaceutical screening libraries. contract research services supporting crop arspichem.com Arbiom Inc. (Durham) develops protection products. Services include GLP- technologies that convert residues from compliant regulated biotechnology trials, Artizan Biosciences Inc. (Durham) is agriculture and forestry into the intermediates efficacy testing and residues testing. developing a platform for identifying and required for the production of biofuels, arkresearch.com targeting pathogenic intestinal bacteria, biomaterials and green chemicals. The with a focus on inflammatory bowel disease Raleigh office is Arbiom’s application center. Array BioPharma Inc. (Morrisville) discovers, and potential applications in autoimmune arbiom.com develops and commercializes targeted, small- diseases, obesity, skin, lung and central molecule drugs to treat cancer. nervous system diseases. Arcato Laboratories Inc. (Durham) arraybiopharma.com develops specialty oral healthcare products. Arysta LifeScience North America LLC Its first product is a sustained-release ArrayXpress Inc. (Raleigh) applies (Cary) develops, manufactures and distributes medicated wax that treats oral discomfort bioinformatics to optimize bioprocesses, biological and chemical crop protection and caused by orthodontic appliances. increase diagnostic efficiency and provide plant nutrition products. arcatolabs.com contract research services, focusing on next- arystalifescience.com generation genomics. Archer Daniels Midland Co. (Southport) arrayxpress.com Ascent Bio-Nano Technologies Inc. makes citric acid and salts of citric acid used (Research Triangle Park) develops cell and in soft drinks, food products and detergents Arrevus Inc. (Raleigh) is developing designer particle separation research tools and medical at the manufacturing plant in Southport. They proline-rich antimicrobial peptide chaperone- devices. also make yeast mannan as an animal feed protein inhibitors (DCPs) to treat diseases ascentbionano.com ingredient. for which antibiotic resistance has clinical adm.com implications. Asinex (Winston-Salem) designs small- arrevus.com molecule libraries and provides lead Ardeal Pharma Inc. (Brevard) is a virtual optimization, custom synthesis and other pharma company developing patented Arrivo BioVentures LLC (Morrisville) chemistry services. The Winston-Salem stabilized sulforaphane for the dermal accelerates biologics and small molecules location is the company’s U.S. headquarters. pharmaceutical and cosmetic markets. from IND/phase one through proof-of- asinex.com concept, with biologics in development for Ardeal Research Institute (Brevard) is a dermatologic conditions and hearing loss. Asklepios BioPharmaceutical Inc. non-profit organization that develops drug arrivobio.com (Chapel Hill) develops protein- and cell-based discovery capabilities of the natural resources therapies using a proprietary technology in Western North Carolina. The Institute has platform called Biological Nano Particles collaboration agreements in place with (BNP). Brevard College and the N.C. Arboretum. askbio.com
bekbg.com | (919) 781-0054 | [email protected]
BE&K Building Group provides integrated construction services through advanced technologies. The company’s Biotech, Pharma + Life Science Center of Excellence has been based in the Triangle since 1982, delivering in-depth understanding of current Good Manufacturing Practices and regulatory compliance requirements. Contact Courtney Skunda for more information.
4 | ncbiotech.org/directory Aspir-Tek Inc. (Rocky Mount) makes Atrium Health Division of Therapeutic Avila Inc. (Durham) is developing rapid hair Aquaprin, an FDA-approved water-soluble Research and Development (Charlotte) removal pad technology for use prior to the aspirin. conducts clinical studies, patient-focused placement of defibrillator pads on victims of aspir-tek.com translational research and outcomes research. sudden cardiac arrest. carolinashealthcare.org/ fullpoweraed.com Asymchem Inc. (Morrisville) offers CMC research-clinical-trials and CDMO services, focused on developing Avioq Inc. (Research Triangle Park) develops processes for late-phase to commercial Attagene Inc. (Morrisville) has developed and manufactures FDA-approved and CE- APIs and HPAPIs, and small-molecule a pathway profiling technology to marked immunodiagnostic assays. Products manufacturing and development. Asymchem evaluate the impact of pharmaceuticals include HIV and HTLV assays, recombinant is USFDA- and TGA-inspected. and environmental chemicals on over 100 proteins and synthetic peptides and labware asymchem.com transcription factors and 48 nuclear receptors. supplies. Avioq also offers contract IVD attagene.com development and manufacturing. Asystbio Laboratories LLC (Chapel Hill) avioq.com uses next-generation DNA sequencing and Atticus LLC (Morrisville), a CSE Life Science proprietary algorithms to count mutations in Company, develops, manufactures and Avista Pharma Solutions (Durham) leukemic cells. markets post-patent fungicides, herbicides provides pharmaceutical, animal health and insecticides. and medical device clients with services ATEX Technologies Inc. (Pinebluff) designs atticusllc.com including API and drug product discovery, and manufactures custom implantable textile development and cGMP manufacturing and components and bio-resorbable structures Aurobindo Pharma USA Inc. (Durham) stand-alone analytical and microbiology for medical devices, as well as medical yarn is a generic drug manufacturer. Aurobindo testing support. and fabric. develops inhalation and dermatological avistapharma.com atextechnologies.com products from the company’s U.S. research and development headquarters in North Avoca Inc. (Merry Hill) develops and Atlantic Medical Inc. (Wrightsville Beach) Carolina. manufactures botanical extraction products develops nutraceutical products and devices aurobindousa.com and provides extraction services. Avoca to address ocular diseases. contracts with farmers to grow clary sage and Avazyme Inc. (Durham) provides field and also processes krill oil for omega-3 fatty acids. Atlas Regeneration Inc. (Winston-Salem) GLP laboratory testing for sectors including pharmachemlabs.com/divisions/avoca develops bioinformatics platforms for drug agchem, agbiotech, food and beverage discovery related to regenerative medicine producers and retailers, and brewers. Avolynt Inc. (Research Triangle Park) is and stem cell research. Atlas Regeneration Capabilities include mass spectrometry, developing a novel SGLT2 inhibitor for the also screens drugs in silico for drug immunochemistry, microbiology and treatment of nonalcoholic steatohepatitis repositioning. molecular biology. (NASH) and type 2 diabetes. atlasregeneration.com avazyme.com avolynt.com
Atox Bio Inc. (Chapel Hill) develops novel Avertica Inc. (Research Triangle Park) Aweve LLC (Raleigh) designs and immunomodulators to treat critically ill develops compounds and polymers for manufactures branded molded nano-particle patients. Initial focus is on patients with electronic device applications, including the delivery systems for the cosmeceutical Necrotizing Soft Tissue Infections. development of biomimetic and bio-based industry. atoxbio.com electronic materials. douglaswadams.com/aweve-llc.html averticainc.com
BATON Referral Network is a community of life science service providers who contribute services or provide preferential pricing for referrals coming through the BATON network database. ncbiotech.org/baton
Received NCBiotech investment North Carolina Bioscience Companies | 5 Azzur Labs LLC (Cary) provides analytical Bavarian Nordic Inc. (Morrisville) develops, BENANOVA Inc. (Raleigh) develops GXP-compliant testing services for the manufactures and commercializes cancer antimicrobial nanotechnology products for pharmaceutical, medical device, food and immunotherapies and vaccines for infectious the disinfectant, cosmetic and agricultural cosmetic industries. Programs include diseases. industries. environmental monitoring, cleaning bavarian-nordic.com benanova.com validations, biological indicator analysis and microbial identification. Baxter Healthcare Corp. (Marion) produces Benson Hill Biosystems Inc. (Research azzur.com/labs intravenous and peritoneal dialysis solutions Triangle Park) is an agricultural biotechnology at the Marion location, as well as empty company focused on the development of Baebies Inc. (Durham) develops and containers and component parts for other traits to increase crop yield, principally by delivers products and services based on Baxter facilities. improving photosynthesis. digital microfluidics and other technology to baxter.com bensonhillbio.com advance newborn screening and pediatric testing worldwide. Bayer (Research Triangle Park, Clayton and Bent Creek Institute Inc. (Asheville) baebies.com Pikeville) is a global enterprise with core conserves and develops plant biodiversity competencies in the life science fields of assets and maintains the North Carolina Banner Life Sciences LLC (High Point) health care and agriculture. Bayer’s Crop Arboretum’s Bent Creek Germplasm develops formulation technologies (gelcaps, Science division uses the tools of plant Repository. It also administers the U.S. tablets and sterile injectables) and licenses biotechnology to develop seeds and Botanical Safety Laboratory, a consortium of and markets prescription, over-the-counter products for crop protection and non- university botanical research sites. and nutritional products. agricultural and structural pest control. bentcreekinstitute.org bannerls.com Research Triangle Park serves as the North American Crop Science headquarters. The BestCo Inc. (Mooresville) manufactures Barbaresco Pharma LLC (Chapel Hill) is Clayton site performs pesticide and bee confectionery-based dosage forms for a target drug discovery company focused health research. The Pikeville site identifies, nonprescription drug products and dietary on obesity, cardiovascular and metabolic tests and develops new cotton and soybean supplements. diseases. varieties. bestco.com bayercropscience.us BaseTrace (Research Triangle Park) BindusChem LLC (Research Triangle Park) develops DNA-based industrial fluid tracers BD Diagnostics (Burlington, Durham and offers contract drug discovery and process for environmental monitoring and process Mebane) develops and commercializes chemistry projects for clients, synthesis optimization in the energy sector. molecular diagnostic products for various of small molecules for SAR study, focused basetrace.com cancers, including cervical, breast, ovarian arrays and scaffolds, as well as chemical and prostate. development, route scouting, process BASF Corp. (Research Triangle Park) bd.com/tripath optimization and validation. develops plant health products and binduschem.com seed treatments and conducts plant BD Technologies and Innovation biotechnology research with a focus on yield (Research Triangle Park) develops and quality traits in major crops. Business technologies for parenteral drug delivery, units in RTP include the crop protection and advanced diagnostics, smart medical devices, plant science groups. genomic research and supports external agriculture.basf.com/us/en.html innovation. The RTP site is BD’s corporate technology R&D and innovation center. bd.com/technologies
NCI-designated medical comprehensive schools 3 cancer centers 5 pharmacy schools
6 | ncbiotech.org/directory Bio Products Laboratory USA Inc. BioCytics Inc. (Huntersville) researches BioGreen Synergy Inc. (Greensboro) (Durham) manufactures and distributes and develops personalized cellular manufactures, grows and provides algae- plasma-derived products, including immunotherapy cancer therapies. based products for use in alternative intravenous immunoglobulin preparations, biocytics.com renewable energies, USDA, non-USDA and coagulation factors and albumin solution. chemical markets. The Durham office is the U.S. distributor for BioDelivery Sciences International Inc. biogreensynergy.com BPL products. (Raleigh) is a specialty pharmaceutical bpl-us.com company with a focus in the areas of pain BioIVT (Durham) provides control and management and addiction. The company’s disease state biological specimens, including BioAesthetics Corporation (Durham) is lead products utilize a buccal film delivery human and animal tissues, cell products, developing a nipple areolar complex graft system. blood and other biofluids. Its Durham that allows the patients’ cells to grow into the bdsi.com site develops cell-based drug toxicity- graft for use in breast reconstruction. testing products used in pharmaceutical bio-aesthetics.com BioDyne Water Reclamation Inc. (Raleigh) development, based on the company’s engineers and markets water reclamation proprietary hepatocyte technologies. BioAgilytix Labs Inc. (Durham) is a systems using biotreatment with its patented bioivt.com bioanalytical lab specializing in large- IBAC single vessel full-treatment systems. molecule bioanalysis, offering PK, biodynegroup.com BioKier Inc. (Chapel Hill) develops immunogenicity, biomarkers and cell-based proprietary drugs for diabetes and related assays in support of the development Biofluidica Inc. (Research Triangle Park) disorders. BioKier has identified a therapeutic and release testing of biologics and small- is developing novel instrumentation for opportunity based on gastric bypass surgery molecule therapeutics. the isolation and analysis of circulating and is developing a novel treatment for bioagilytix.com biomarkers, including circulating tumor cells, diabetes. in cancer patients. biokier.com BIoCI Systems Inc. (Raleigh) provides biofluidica.com sterilization validation services and other BioLink Life Sciences Inc. (Cary) provides contract laboratory testing services. Biogen (Research Triangle Park) discovers, contract product development support bioci.com develops and manufactures therapies for through custom synthesis and testing. serious neurological and neurodegenerative biolinkonline.com Biocomposites Inc. (Wilmington) develops, diseases. It operates biologics and oral solid manufactures and distributes synthetic tissue dose manufacturing facilities and a patient Biological Applied Research Inc. (Raleigh) regeneration products. The Wilmington office services contact center in RTP. provides efficacy testing of agricultural is a sales office. biogen.com chemicals such as fungicides and nematicides biocomposites.com on various crops, including fruit and BioGenomics LLC (Knightdale) provides vegetables. BioCryst Pharmaceuticals Inc. (Durham) pharmacogenomic testing to inform biologicalappliedresearch.com designs and develops novel, small-molecule prevention, diagnosis and treatment of oral drugs that block key enzymes to treat various diseases. BioMarck Pharmaceuticals Ltd. (Durham) rare diseases. The Durham location houses biogenomicsdx.com develops drugs to treat pulmonary diseases BioCryst’s clinical, regulatory and executive and disorders, such as chronic obstructive teams. pulmonary disease, ARDS, cystic fibrosis and biocryst.com lung cancer. biomarck.com 1 $1B land grant top-ranked college of annually from NIH since 2005 universities veterinary medicine
Received NCBiotech investment North Carolina Bioscience Companies | 7 bioMASON Inc. (Research Triangle Park) Biorg Inc. (Chapel Hill) is developing Bio-Val LLC (Cornelius) provides bioassay develops masonry material from a and commercializing organoid technology development, method validation, reagent nonpathogenic bacterium which induces for use in life science applications such production and characterization, feasibility cement materials in between aggregates as diagnostics, drug screenings and and medical writing services. such as sand. toxicology. biovalconsulting.com biomason.com biorg.com BioVendor LLC (Asheville) develops, BioMedomics Inc. (Durham) develops BioRxn LLC (Chapel Hill) develops manufactures and sells biological reagents point-of-care (POC) diagnostics, with a NMR-based metabolomic technology, and research products, including enzyme- focus on immunologically-based disease- including bioreactor and artificial liver linked immunosorbent assay (ELISA) kits, specific tests and advanced quantitative POC systems, for non-invasive monitoring of antibodies, proteins and other molecules for platforms. metabolic biomarkers. BioRxn also provides life science research. The Asheville site is the biomedomics.com conventional metabolomic services. U.S. headquarters. biorxn.com biovendor.com bioMérieux Inc. (Durham) develops in vitro products to diagnose infectious diseases, Biota Diagnostics LLC (Charlotte) Bioventus LLC (Durham) develops cancer and cardiovascular disease and offers pharmaceutical compound testing, and markets orthobiologic solutions for to detect microorganisms in agri-foods, dialysis and medical device testing and musculoskeletal healing and regeneration. pharmaceuticals and cosmetics. environmental analytical testing services. These include products for bone healing, biomerieux-usa.com biotadiag.com bone graft and knee osteoarthritis. bioventusglobal.com bioMONTR Labs (Research Triangle Park) Biotality (Durham) develops biological provides a broad range of CLIA-certified and natural products for crop protection. Its Biovet S.A. (Research Triangle Park) high-complexity laboratory testing, including first product is a proprietary organism that develops nutritional supplements, enzymes, assay/IVD protocol development, validation overproduces a fungicidal exudate, with pronutrients, digestives, antioxidants, design, performance evaluation testing, applications in the seed proctectant and preservatives, mycotoxin binders and drug trials and collaborative studies and post-harvest markets. flavoring for feed for poultry, ruminants, swine regulatory/quality control. agtechinventures.com/spin_offs.html and aquaculture. biomontr.com biovet-alquermes.com/index.php/en Biotech Restorations LLC (Denver) Bio-Pro Research LLC (Hickory) formulates bioremediation products for BioZyme Inc. (Apex) develops and sells manufactures and distributes bio-enzymatic the cleanup of petroleum and chlorinated substrates for metalloproteinases (MMPs and products for stain and odor removal. hydrocarbons including gasoline and diesel, ADAMs) which can be used in enzyme assays urineoff.com organochloride pesticides, PCBs and volatile and other diagnostic tests. organic chemicals in soil, sediment and biozyme-inc.com BioResource International Inc. (Durham) groundwater. designs, develops and manufactures biotechrestorations.com Blue Ridge Institute for Medical Research unique enzymes that help poultry and (Horse Shoe) researches small-molecule swine producers optimize animal nutrition BioTrackers Inc. (Charlotte) develops inhibitors of protein kinases and targeted and gut health. bacterial, or microbial, source tracking cancer therapies. briworldwide.com technology. brimr.org
North Carolina named best state for business. orbes, Best States for Business, 2 1
8 | ncbiotech.org/directory Boragen Inc. (Research Triangle Park) C Change Surgical LLC (Winston-Salem) Campbell University Pharmaceutical develops a chemistry platform that leverages develops, patents, manufactures and markets Education and Research Center the chemical properties of boron, with computerized electronic systems that control (Buies Creek) offers analytical, formulation, applications in crop protection and animal sterile surgical fluid temperature. R&D and training services to the pharma and health. cchangesurgical.com biotech industries, compounding pharmacies, boragenbio.com government agencies and other academic Calvert Laboratories Inc. (Cary) provides institutions. Braeburn Pharmaceuticals Inc. preclinical research and contract drug cphs.campbell.edu/centers-programs/ (Morrisville) manufactures and develops discovery and development services, such pharmaceutical-education-research-center/ pill-free drugs for neurological and psychiatric as lead identification and lead optimization disorders, including addiction, pain and services. Camras Vision Inc. (Research Triangle Park) schizophrenia. calvertlabs.com is developing an ocular implant to treat braeburnpharmaceuticals.com glaucoma. camrasvision.com BreStem Therapeutics Inc. (Raleigh) is Promote your company developing a stem cell therapy to treat in the next NCBiotech Cancer Advances Inc. (Durham), a pulmonary fibrosis. subsidiary of Cato Bioventures, develops brestem.com Company Directory immunomodulator therapeutics to treat gastrointestinal cancers. Brighton Development LLC (Cary) In print and online. canceradvancesinc.com develops sterilizing technologies and directory.ncbiotech.org/sponsor antimicrobial medical plastics. Cancer Genetics Inc. (Morrisville) offers diagnostic products and services that enable Brite Bio Inc. (Research Triangle Park) Camargo Pharmaceutical Services LLC precision medicine in the field of oncology. provides contract research services, including (Durham) provides contract drug This site performs clinical pharmacogenomic cell culture services, cell-based assays, development services, including formulation testing and provides biorepository services biomarker assay development, toxicological and testing, regulatory consulting, phase one under federally-designated clinical lab assays, bio-banking, drug target identification through four program development and API standards. and gene expression profiling and and clinical trial materials sourcing. cancergenetics.com characterization. camargopharma.com britebio.com Capture Pharmaceuticals Inc. Cambrex High Point (High Point) develops (Chapel Hill) develops oral treatments for Burleson Research Technologies Inc. and manufactures small-molecule APIs removing toxic or radioactive metals in (Morrisville) provides laboratory services to and intermediates for phase one through contaminated individuals. the biotechnology, pharmaceutical, chemical three clinical trials. It offers custom organic capturepharm.com manufacturing and health care industries synthesis, process development and cGMP with proof-of-concept, preclinical, clinical and manufacturing services. CardioEphEx LLC (Chapel Hill) develops toxicology studies. cambrex.com therapeutics for cardiovascular disease and brt-labs.com heart failure. The company’s research focuses on cardioprotection by targeting the Ephrin/ Eph receptor signaling pathway in the heart. cardioephex.com
Biomedical Partnership Center at NC State University | cassoreservations.wixsite.com/biomedicalpartnerctr (919) 223-9901 | [email protected] The Biomedical Partnership Center at North Carolina State University offers customized lab and office space for lease to life science companies. Tenant benefits include affiliate privileges from NCSU and collaborative research opportunities with the university’s colleges. Leasing and management by Capital Associates.
Received NCBiotech investment North Carolina Bioscience Companies | 9 CardioPharma Inc. (Wilmington) develops Cato Research Ltd. (Durham) provides Cellex Inc. (Research Triangle Park) develops, combinatorial products to treat cardiovascular contract research services, including manufactures and markets diagnostic tests disease. preclinical and clinical study design and suitable for point-of-care use. These tests use cardio-pharma.com management, regulatory assessments, a platform technology called Homogeneous data management and statistics, CMC Biochemiluminescence Assay (HBA), which CardioVascular and ExtraCorporeal program management, medical writing and enables assays that are highly sensitive and Technologies (Winston-Salem) provides submission of regulatory documents. easy-to-use. preclinical cardiac and implant surgical model cato.com cellex.us development and device evaluation, and applied life support technologies. Cedarlane Laboratories Ltd. (Burlington) CELLF-Bio LLC (Winston-Salem) is cvect.devhub.com manufactures and sells antibodies, proteins, developing a novel regenerative medicine- research reagents and cell separation media based therapy for fecal incontinence. Carolina Liquid Chemistries Corp. to the life science community. The Burlington, (Greensboro), an ISO-certified and FDA- N.C. site is a distribution office. CellSolutions LLC (Greensboro) develops registered medical device company, cedarlanelabs.com liquid-based preparation and evaluation specializes in clinical chemistry analyzers and systems for cytology applications. The reagents for clinical and reference labs. CLC CEI Labs Inc. (Cary) provides industrial company’s primary area of focus is women’s also offers instrument training, repair, QA and hygiene laboratory services such as asbestos health, including cervical cancer screening, technical support. testing, microbiology analysis and fungal precancer detection and evaluation of carolinachemistries.com analysis. infectious disease. ceilabs.com cellsols.com Carolina Yeast and Analytics LLC (Durham) isolates, propagates and sells yeast for Cell Microsystems Inc. Celplor LLC (Raleigh) provides molecular brewing, and provides yeast banking and (Research Triangle Park) develops, biology services, including stable cell line analytical testing services, including yeast manufactures and commercializes products generation, Southern blot analysis, Western viability, contamination testing, identification, and tools for the isolation, recovery and blot analysis, cDNA cloning and mouse tail IBUs, water testing and alcohol content. analysis of single cells. genotyping. carolinayeast.com cellmicrosystems.com celplor.com
Catalent Pharma Solutions LLC Celldom Inc. (Durham) is developing a CEM Corp. (Matthews) designs and develops (Morrisville) develops inhalation products and single-cell analysis platform for phenotyping microwave laboratory instrumentation and provides analytical testing, formulation and and genotyping rare events in biology. This scientific methods for life sciences, analytical other scientific services. platform has immediate touchpoints in drug laboratories and processing plants. catalent.com discovery and development, and future cem.com clinical applications. Cathtek Inc. (Winston-Salem) develops celldom.com Cenduit LLC (Durham) helps and manufactures catheters and related pharmaceutical, biotech and medical device accessories. Cellective BioTherapy Inc. companies control the processes of patient cathtek.com (Research Triangle Park) is developing cellular enrollment, patient randomization and and monoclonal antibody-based platforms drug supply through the use of Interactive for treating cancers, autoimmunity and Response Technology (IRT). immunodeficiency. cenduit.com cellectivebiotherapy.com
Business Retention Program NCBiotech taps a variety of tools to take your existing life science business to the next level, from finding qualified workers and new local suppliers to implementing energy-efficient processes. ncbiotech.org/resources/business-retention-program
10 | ncbiotech.org/directory Centre Ingredient Technology Inc. CHD Technologies Inc. (Charlotte) conducts Chesson Laboratory Associates Inc. (Rockingham) develops natural flavors and chemical process R&D for agricultural and (Durham) develops prescription and over- fragrance ingredients for the food, beverage pharmaceutical intermediates. Competencies the-counter polymer-based medical products and cosmetics industry using fermentation. include distillation, rectification, crystallization, for wound care and skin and nail care CIT also provides contract development, filtration and drying for batch and continuous products. toll manufacturing and biotransformation chemical manufacturing processes. chessonlabs.com services. chdtechnologies.com bioingredients.com Chiesi USA Inc. (Cary), the U.S. affiliate Chematron Inc. (Charlotte) manufactures of Chiesi Farmaceutici S.p.A, develops and Cereius Inc. (Durham) is developing novel textile chemicals and has the capability for commercializes products in the therapeutic radio-labeled therapeutics for treating solid contractual custom manufacture of specialty areas of respiratory, cardiovascular, tumor brain metastasis. chemicals. neonatology and cystic fibrosis. chematron.com chiesiusa.com Chaperone Therapeutics Inc. (Chapel Hill) develops disease-modifying Chem-Bac Laboratories Inc. (Charlotte) Chiltern International Inc. (Wilmington therapies for neurodegenerative and rare offers analytical testing, specializing in and Cary) conducts phase one through four diseases caused by protein misfolding. petroleum products, unknown polymer global clinical trials across a broad range of chaperonetherapeutics.com identifications and textiles. therapeutic areas, functional service provision chembac.com and contract staffing solutions. Charles River Laboratories (Hillsborough, chiltern.com Morrisville, Durham and Raleigh) provides ChemoGenics Biopharma LLC drug discovery and development process (Research Triangle Park) provides Chimerix Inc. (Durham) discovers, develops services. CRL’s Hillsborough location provides collaborative drug discovery, bioanalytical, and commercializes broad spectrum antivirals contract toxicologic pathology and histology formulation and scale-up services. Capabilities for the prevention and treatment of life- services at the Hillsborough location. The include medicinal chemistry, DMPK, threatening viral infections. Morrisville location provides in vivo and bioinformatics and preclinical models in chimerix.com in vitro oncology research service. CRL’s cancer, inflammation and metabolic diseases. Pathology Associates in Durham provides chemogenicsbiopharma.com Chirazyme (Washington) produces enzymes pathology and toxicology contract services. for stereospecific epoxidation intermediates criver.com ChemQ Bioscience LLC in pharmaceutical synthesis. (Research Triangle Park) develops and chirazyme.com Charter Medical Ltd. (Winston-Salem) markets novel liquid products, such as bio- designs and supplies single-use solutions for preservation media, tissue perfusion solutions Circassia Pharmaceuticals Inc. (Morrisville) cell growth, frozen storage and biological and liquid-based cytology processing kits. designs and develops products to aid in the fluid handling for the bioprocessing, cell vitroprep.com diagnosis and control of asthma, COPD and therapy and medical device industries. CML is allergy. FDA-registered and ISO 13485-certified. Chemring Detection Systems Inc. circassia.com chartermedical.com (Charlotte) develops and manufactures chemical and biological agent detection systems, as well as explosive detection systems. chemringds.com
$1.89B federal R&D spending per year in NC
Received NCBiotech investment North Carolina Bioscience Companies | 11 CivaTech Oncology Inc. (Durham) has Clintec USA (Durham) conducts clinical trials Cohesion Phenomics LLC (Spindale) developed targeted implantable radiation in oncology, rare diseases, anti-infectives, is a CLIA-certified molecular diagnostic devices to treat many cancer types. These cardiology, dermatology, gastroenterology, laboratory. Cohesion Phenomics also products provide a targeted, customized neurology, respiratory medicine and develops DNA sequencing tests for complex dose immediately during a surgical resection rheumatology. and single gene disorders within specific procedure or in outpatient therapies to treat clintec.com clinical areas such as cardiovascular disease. prostate cancer. cohesionphenomics.com civatechoncology.com Cloud Pharmaceuticals Inc. (Research Triangle Park) designs and Collaborations Pharmaceuticals Inc. CiVentiChem (Cary) provides contract develops novel drug molecules using (Raleigh) develops drugs for rare and development and manufacturing services. computational design for a wide range neglected diseases using machine learning Services include cGMP manufacturing of therapeutic areas including cancer, software, providing preclinical and clinical of APIs, GMP analytical services, process inflammation, CNS disorders and rare expertise to rare disease foundations, development, medicinal chemistry and diseases. academic scientists and companies custom synthesis. cloudpharmaceuticals.com developing clinical candidates. civentichem.com collaborationspharma.com Cmed Clinical Services (Durham) provides Clavé Biodesign Inc. (Cary) develops clinical services to drug development Columbia Life Systems Inc. (Chapel Hill) is cell-specific peptides which can be used organizations and manages early-phase developing a computer-controlled oxygen for therapeutic purposes related to cancer, studies (phase one through two b) with blender for therapeutic research. cardiovascular disease and ophthalmology a focus in oncology, infectious disease, as well as for diagnostic imaging and respiratory infection and cardiology. Concentrx Pharmaceuticals Inc. (Durham) biomarkers. cmedresearch.com develops inhaled prescription products for clavebiodesign.com asthma and COPD, including a unit dose CMP Pharma Inc. (Farmville) develops, disposable dry powder inhaler. Clinical Sensors Inc. (Research Triangle Park) manufactures and commercializes specialty concentrxpharma.com develops a near-patient test for early pharmaceuticals, focused on niche liquid and detection of sepsis based on nitric oxide topical products that solve unmet patient Contego Medical LLC (Raleigh) develops measurements from unprocessed blood. needs. embolic protection devices for cardiovascular clinicalsensors.com cmppharma.com and peripheral vascular procedures, designed to simplify catheter-based procedures. Clinipace Worldwide Inc. (Morrisville) Cognosci Inc. (Research Triangle Park) contegomedical.com provides full-service global clinical develops neurorestorative therapies for development services for drug and medical Alzheimer’s disease, multiple sclerosis, ConvaTec Inc. (Greensboro) develops device programs using its TEMPO eClinical traumatic brain injury, nerve crush and other and manufactures therapies for the platform, as well as regulatory and strategic disease and trauma indications. management of chronic conditions, with a consulting. cognosci.com focus on advanced wound care, ostomy care, clinipace.com continence and critical care and infusion Cohera Medical Inc. (Raleigh) develops devices. The Triad site is the company’s Global surgical adhesives for internal use for Quality headquarters. abdominoplasty procedures. convatec.com coheramedical.com
davos.com | (919) 607-0207 | [email protected]
DavosPharma specializes in supporting all aspects of the drug development spectrum, from IND-enabling activities required to get a new molecule from concept to clinic, to ton-scale manufacturing of APIs and drug product. This includes items such as custom chemistry, biology, toxicology, and pharmaceutical manufacturing services for APIs and dosage forms.
12 | ncbiotech.org/directory Cook Medical (Winston-Salem) develops Covance Inc. (Durham and Research Crop Microclimate Management Inc. and manufactures devices used in Triangle Park), the drug development (Apex) researches and develops technologies gastrointestinal endoscopy to diagnose and business of LabCorp, provides a wide to improve crop productivity by mitigating treat esophageal, gastric, pancreatic, biliary range of early-stage and late-stage product the impact of environmental stresses. and colonic disorders. development services primarily to the cropstress.com cookmedical.com pharmaceutical and biotechnology industries. The RTP location specializes in bioanalytical CSS-Dynamac (Durham) provides health Corning Life Sciences (Durham) and immunoanalytical services, specializing and safety services and scientific program manufactures pipettes, conical and round- in GLP-compliant LC/MS/MS bioanalytical support in the physical and life sciences. The bottomed tubes, cell inserts, tissue-culture services for all phases of drug discovery and Durham location provides environmental plates and ADME/Toxicology products. development. toxicity testing services. corning.com/worldwide/en/industries/ covance.com css-dynamac.com life-sciences.html Craft Technologies Inc. (Wilson) CTMG Inc. (Greenville and Raleigh) Cotton Incorporated (Cary) Cotton provides analytical and method development provides site-specific clinical research Incorporated’s Agricultural & Environmental services to measure nutritional components management services, including patient Research Division improves cotton cultivation in blood, tissues, dietary supplements, food recruitment, personnel, expertise and through genetic and biotechnology tools, and animal feed. systems. enhancing yield, quality and resistance of crafttechnologies.com ctmginc.com cotton varieties. cottoninc.com Creative PEGWorks (Chapel Hill) Curasan Inc. (Durham) develops, manufactures and supplies advanced manufactures and markets biomaterials for Countervail Corp. (Charlotte) develops and functional polymer products for bone and tissue regeneration. This location is commercializes products to protect against research. Main product lines include PEG, the U.S. headquarters for sales and marketing. and treat exposure to chemical weapons and polysaccharides, biodegradable polyester, curasaninc.com pesticide poisoning. copolymers, and PEGylation service. countervailcorp.com creativepegworks.com Curl Bio LLC (Durham) develops drugs for the interrelated set of disorders involving Couragen Biopharmaceutics LLC Creative Scientist Inc. (Research Triangle Park) Type 2 diabetes, obesity, fatty liver disease, (Durham) develops gene and protein therapy specializes in bioassay development, primary metabolic syndrome and associated products for preclinical and clinical use cell production and preclinical contract complications. for the treatment of genetic and chronic research services. They are also developing a curlbio.com diseases. Couragen also provides custom radiation sensitivity cell-based assay. adeno-associated virus vectors as a tool for cscientist.com Cygnus Technologies LLC (Southport) laboratory research. develops products and services for the CRL Suncare LLC (Winston-Salem) provides biopharma industry, including host cell services to sunscreen and dermatological protein ELISA kits, immunoassay reagents product manufacturers, including evaluation and custom development of antibodies and of sunscreen SPF and UVA protection. assays. suncarelab.com cygnustechnologies.com