NCBIOTECH Company Directory

ncbiotech.org/directory NC’s Life Science Transformation

The 34 years of work by the North Carolina Biotechnology Center has proven to be transformative for the state – especially for its manufacturing workforce. As employment in the state’s furniture, textile and tobacco factories tumbled over the past three decades, the number of people working in pharmaceutical and medicine manufacturing has grown from a few dozen to about 21,000 today. And pharmaceutical manufacturing is just one important segment of North Carolina’s transformational life science community. It doesn’t include the thousands of people in high-tech agriculture, or medical device commercialization, or contract research and development – a life science ecosystem totaling 63,000-plus workers at more than 700 companies statewide. The annual NCBiotech Company Directory print edition aggregates information on these 700+ companies, while the online version includes nearly 2,300 supporting companies such as patent law firms specializing in life science work. They bring the direct and indirect life science workforce total to 260,000.

Survey Shows Commuters Statewide What isn’t so obvious is the fact that today there are life That took a lot of teamwork, including some science and/or support companies in 85 of North fabulous support from human resources and Carolina’s 100 counties. Also, even if your county other key people at 58 companies across the state, doesn’t yet have one of these companies, people from mostly life science firms. your county are likely to be working for one. Some of them have a hefty commute, to be sure. But it’s worth it to Data from just these 58 companies, scattered them, because it’s satisfying, rewarding work that is often across 24 counties, show their collective available even to people with an associate’s degree from a 26,000 employees are commuting from their community college training program. homes in 93 North Carolina counties. We know this, in part, because NCBiotech completed its The “good factory jobs” look a lot different in 2018 first statewide Employee Commuting Study in 2018. than in 1984 when the Biotech Center was born. This directory, the only one of its kind, is a snapshot of Adhezion Biomedical LLC (Hudson) develops and produces cyanoacrylate-based NC’s 700+ life science companies. medical adhesive, wound care and microbial barrier products for connective tissue (human 13C Molecular Inc. (Fayetteville) provides Accord Healthcare Inc. (Durham) develops skin). The company’s manufacturing and stable-isotope labeled and native compounds and manufactures generic pharmaceuticals. research facility is located in Hudson. to the pharmaceutical and biomedical Their portfolio includes therapeutics in adhezion.com industries via custom organic synthesis oncology, cardiology, neurology, nephrology, and sourcing through a consortium of urology, psychiatry, diabetes and pain Adroit Pharmaceutical Development LLC manufacturers. management. The North Carolina location is (Durham) identifies new and improved 13cmolecular.com a sales office. formulations and process technologies. accord-healthcare.com Its primary focus is on inhalation and 1st Order Pharmaceuticals (Pittsboro) is dermatological product development. an early development-stage pharmaceutical AccuGenomics Inc. (Wilmington) develops adroitpharmdev.com company focused on developing neurology gene expression tests to diagnose and assets. monitor cancer treatment. Its technologies Advanced Animal Diagnostics Inc. 1storderpharma.com include Standardized Nucleic Acid (Morrisville) develops and commercializes diagnostics to detect and manage disease 410 Medical Inc. (Durham) is developing Quantification (SNAQ) for quantitative PCR states, reproductive, nutritional and overall technology for rapid infusion of fluids for and Standardized RNA Sequencing (STARSEQ) health status of production animals. hospital, transport and military healthcare for NGS platform analysis. providers, enabling clinicians to quickly and accugenomics.com qscoutlab.com effectively resuscitate critically-ill patients. 410medical.com Achelios Therapeutics Inc. (Chapel Hill) Advanced Chemotherapy Technologies develops topical therapeutics for the Inc. (Raleigh), a UNC startup, has developed 908 Devices Inc. (Carrboro) develops and treatment of migraine and peripheral pain. a novel device for infusing chemotherapies makes chemical analysis products such as achelios.com directly into poorly-vascularized pancreatic handheld chemical detection tools, compact tumors. analyzers and separation devices. Actus Therapeutics (Chapel Hill) develops 908devices.com gene therapies for rare diseases including Advanced Laboratories Inc. (Clayton) Pompe disease and epilepsy. provides chemical and microbiological A&C American Chemicals Ltd. (Raleigh) actustherapeutics.com analysis of dietary supplements and food manufactures GMP excipients, APIs and products. process solutions for pharmaceutical and Adámas Nanotechnologies Inc. (Raleigh) advancedlabsinc.com biotechnology companies. The Raleigh develops and produces fluorescent location is a business development office. nanodiamond particles for life science, Aegis Surgical Ltd. (Durham) is developing acggp.com medical and industrial applications, including a less invasive access system that facilitates life science research, drug delivery, bioimaging, percutaneous transaortic transcatheter aortic A1 BioChem Labs LLC (Wilmington) offers anti-counterfeiting, oil additives and cosmetics. valve replacement (pTAo-TAVR). chemistry services to universities, pharma, adamasnano.com synecor.com/portfolio agrochemical and biotech industries. Services include custom synthesis of APIs and novel compounds, catalog compound services, AegisCN LLC (Durham) develops route screening, lead optimization and technologies and treatments targeting chemical sourcing. neurological diseases and inflammation. a1biochemlabs.com

aperioclinical.com | (888) 448-2969 | [email protected]

Dedicated to transparent interactions with clients, Aperio provides full, customizable clinical research services across multiple therapeutic areas as well as consulting in Quality Assurance, Strategic Resourcing, and Clinical Trial Technology. From start to close and every point in between, Aperio works with its partners to deliver outcomes that will improve patient care and save lives.

Received NCBiotech investment North Carolina Bioscience Companies | 1 Aerie Pharmaceuticals Inc. (Durham) Alcami Corporation (Durham and Almac Clinical Services LLC (Durham) discovers, develops and commercializes first- Wilmington) provides contract drug provides clinical trial material manufacturing, in-class therapies for the treatment of patients development and manufacturing services, packaging and distribution services. with glaucoma. including API manufacturing, formulation almacgroup.com/development- aeriepharma.com development, analytical chemistry and solid manufacturing/clinical-services/ dose and parenteral drug manufacturing for Aestas Pharma Inc. (Lewisville) develops both clinical and commercial markets. Almac Diagnostics LLC (Durham) offers novel diagnostic imaging and therapeutic alcaminow.com services for biomarker discovery, assay agents to enable the early detection of development/validation/testing and Alzheimer’s and Parkinson’s disease when Alderon BioSciences Inc. (Beaufort) companion diagnostic co-development. clinical signs are not yet pronounced. develops point-of-care diagnostics. Testing platforms include NGS, Microarray, aestaspharma.com qPCR and IHC. Regulatory and bioinformatics Alera Labs LLC (Research Triangle Park) services are also available. Affinergy LLC (Morrisville) develops peptide- provides contract research analytical almacgroup.com/diagnostics based technologies, including diagnostic chemistry, in vitro toxicology, GLP products, research tools and therapeutic drug analysis and preformulation services to ALP Life Sciences Inc. (Black Mountain) monitoring products for use by clinicians and pharmaceutical, biotech and medical device develops diagnostics and therapeutics for researchers. companies. liver diseases and related inflammatory affinergy.com aleralabs.com diseases. alplifesciences.com AgBiome Inc. (Research Triangle Park) uses See Us Online its proprietary Genesis platform to collect, Alpha Nano Tech LLC (Research Triangle Park) provides nanoparticle and exosome isolate and analyze microbes for use in the Search the NCBiotech characterization services. discovery and development of biologicals Company Directory at alphanano.tech and traits for protecting crops. ncbiotech.org/directory agbiome.com AlphaSyx Therapeutics Inc. (Winston- Agile Sciences Inc. (Raleigh) is developing ALG Therapeutics LLC (Chapel Hill) Salem) is developing novel medicines that a mechanistic approach for the treatment develops pharmaceutical products for pain target cholinergic receptors to prevent of antibiotic-resistant, life-threatening disorders. and treat diseases of inflammation, initially . neuroinflammation resulting in Postoperative agilesci.com Algaen Corp. (Winston-Salem) uses Cognitive Decline (POCD). microalgae to develop, produce and alphasyx.com AimMax Therapeutics Inc. (Research market products and technologies for the Triangle Park) researches and develops nutraceutical, pharmaceutical and bio-energy Alterna Therapeutics Inc. (Durham) for the treatment of industries. develops therapeutics to treat diabetes and , inflammation and pain through algaen.com obesity. in-licensing or co-development with strategic partners. Alganomics LLC (Southport) is researching Altis BioSystems (Chapel Hill) is developing aimmaxrx.com and developing algae-culturing systems to a stem cell technology that recreates the create bioproducts, including biofuels. human intestinal epithelium in a 2D or 3D Ajinomoto North America (Raleigh) layer of intestinal stem and differentiated manufactures pharmaceutical-grade amino Alion Science and Technology Inc. cells, which can be used for compound acids and custom-blended amino acid (Research Triangle Park) provides toxicology screening, microbiome research and disease mixtures. research, animal husbandry, inhalation modeling. ajiaminoscience.com engineering and biochemistry services. Alion altisbiosystems.com operates four bioscience research laboratories Akros Medical Inc. (Durham) develops in the Triangle. American Distillation Inc. (Leland) orthopedic medical devices. alionscience.com manufactures industrial-grade ethyl alcohol akrosmedical.com and offers contract manufacturing services Allergy Partners Extract Laboratory such as distillation, dehydration, reaction, (Asheville) produces extracts that are carbon treating and blending. used to treat allergic disease, asthma and americandistillation.net immunology. allergypartners.com

2 | ncbiotech.org/directory AnelleO (Chapel Hill) is developing a 3D printed intravaginal ring that can be used as a platform for treating a wide range of women’s NCBiotech Funding Programs: health conditions. Anémot Therapeutics Inc. (Chapel Hill) Life Science Lifelines develops therapeutics for acute and chronic inflammation. Its lead product is being developed for severe RSV infections, cystic fibrosis and other diseases of lung injury.

Annias Immunotherapeutics Inc. (Chapel Hill) is developing an immunotherapeutic platform to recognize tumor cells, including glioblastoma, breast, prostate and colorectal cancers. anniasimmuno.com

Antech Diagnostics Inc. (Morrisville) provides clinical and veterinary hematology analysis, clinical chemistry, urinalysis and coagulation testing. antechglp.com

Apeirolux Pharmaceutical Inc. (Research Triangle Park) is developing a tumor-cell selective topical skin cream for the treatment of skin cancer.

Appealing Products Inc. (Raleigh) develops products for forensics and personal protection from toxic materials such as inorganics, gases and poisons in foods, Learn how our funding programs help boost North Carolina’s life science sector at animal feeds and liquids. ncbiotech.org/funding appealingproducts.com

Apple Pharms Ingredients Inc. (Asheville) discovers natural bioactive ingredients and functional foods for nutritional and medicinal 15 T.W. Alexander Drive | Post Office Box 13547 | Research Triangle Park, NC 27709-3547 purposes. Apple Pharms also provides 919-541-9366 contract development and drug discovery Photo: shutterstock.com services. applepharms.com

Applied Catheter Technologies Inc. Amyris Inc. (Leland) converts plant sugars Andersen Products Inc. (Haw River) sells (Winston-Salem) develops drug-coated into hydrocarbon molecules and produces and services the Anprolene and EOGas medical devices that inhibit scar formation. specialty ingredients and consumer products. lines of 100% ethylene oxide gas sterilizers. The company’s first products under This site uses renewable biofarnesene to They also provide contract packaging and development are catheters for male urethral manufacture products such as biofuels, sterilization services for device manufacturers. stricture and devices that inhibit abdominal lubricants, cosmetics and other specialty anpro.com adhesions. chemicals. appliedcatheter.com amyris.com Andersen Scientific Inc. (Morrisville) provides contract ethylene oxide sterilization and validation services for packaging and devices. Andersen’s sterilization cycles include microbiological and other testing. ansci.us

Received NCBiotech investment North Carolina Bioscience Companies | 3 Applied LifeSciences & Systems Poultry Argos Therapeutics Inc. (Durham) develops ARSPIChem LLC (Research Triangle Inc. (Raleigh) develops automated bio- individualized immunotherapies for the Park) offers chemical product services to system solutions for detecting, targeting treatment of cancer and infectious diseases pharma, biotech industries, universities and and delivering vaccines to poultry. ALS-S using its Arcelis technology platform. research organizations to support drug technology aims to reduce the need for argostherapeutics.com discovery. Products and services include antibiotics by improving delivery. organic molecules, custom synthesis and als-s.com ARK Research LLC (Mebane) provides pharmaceutical screening libraries. contract research services supporting crop arspichem.com Arbiom Inc. (Durham) develops protection products. Services include GLP- technologies that convert residues from compliant regulated biotechnology trials, Artizan Biosciences Inc. (Durham) is agriculture and forestry into the intermediates efficacy testing and residues testing. developing a platform for identifying and required for the production of biofuels, arkresearch.com targeting pathogenic intestinal bacteria, biomaterials and green chemicals. The with a focus on inflammatory bowel disease Raleigh office is Arbiom’s application center. Array BioPharma Inc. (Morrisville) discovers, and potential applications in autoimmune arbiom.com develops and commercializes targeted, small- diseases, obesity, skin, lung and central molecule drugs to treat cancer. nervous system diseases. Arcato Laboratories Inc. (Durham) arraybiopharma.com develops specialty oral healthcare products. Arysta LifeScience North America LLC Its first product is a sustained-release ArrayXpress Inc. (Raleigh) applies (Cary) develops, manufactures and distributes medicated wax that treats oral discomfort bioinformatics to optimize bioprocesses, biological and chemical crop protection and caused by orthodontic appliances. increase diagnostic efficiency and provide plant nutrition products. arcatolabs.com contract research services, focusing on next- arystalifescience.com generation genomics. Archer Daniels Midland Co. (Southport) arrayxpress.com Ascent Bio-Nano Technologies Inc. makes citric acid and salts of citric acid used (Research Triangle Park) develops cell and in soft drinks, food products and detergents Arrevus Inc. (Raleigh) is developing designer particle separation research tools and medical at the manufacturing plant in Southport. They proline-rich antimicrobial peptide chaperone- devices. also make yeast mannan as an animal feed protein inhibitors (DCPs) to treat diseases ascentbionano.com ingredient. for which antibiotic resistance has clinical adm.com implications. Asinex (Winston-Salem) designs small- arrevus.com molecule libraries and provides lead Ardeal Pharma Inc. (Brevard) is a virtual optimization, custom synthesis and other pharma company developing patented Arrivo BioVentures LLC (Morrisville) chemistry services. The Winston-Salem stabilized sulforaphane for the dermal accelerates biologics and small molecules location is the company’s U.S. headquarters. pharmaceutical and cosmetic markets. from IND/phase one through proof-of- asinex.com concept, with biologics in development for Ardeal Research Institute (Brevard) is a dermatologic conditions and hearing loss. Asklepios Inc. non-profit organization that develops drug arrivobio.com (Chapel Hill) develops protein- and cell-based discovery capabilities of the natural resources therapies using a proprietary technology in Western North Carolina. The Institute has platform called Biological Nano Particles collaboration agreements in place with (BNP). Brevard College and the N.C. Arboretum. askbio.com

bekbg.com | (919) 781-0054 | [email protected]

BE&K Building Group provides integrated construction services through advanced technologies. The company’s Biotech, Pharma + Life Science Center of Excellence has been based in the Triangle since 1982, delivering in-depth understanding of current Good Manufacturing Practices and regulatory compliance requirements. Contact Courtney Skunda for more information.

4 | ncbiotech.org/directory Aspir-Tek Inc. (Rocky Mount) makes Atrium Health Division of Therapeutic Avila Inc. (Durham) is developing rapid hair Aquaprin, an FDA-approved water-soluble Research and Development (Charlotte) removal pad technology for use prior to the aspirin. conducts clinical studies, patient-focused placement of defibrillator pads on victims of aspir-tek.com translational research and outcomes research. sudden cardiac arrest. carolinashealthcare.org/ fullpoweraed.com Asymchem Inc. (Morrisville) offers CMC research-clinical-trials and CDMO services, focused on developing Avioq Inc. (Research Triangle Park) develops processes for late-phase to commercial Attagene Inc. (Morrisville) has developed and manufactures FDA-approved and CE- APIs and HPAPIs, and small-molecule a pathway profiling technology to marked immunodiagnostic assays. Products manufacturing and development. Asymchem evaluate the impact of pharmaceuticals include HIV and HTLV assays, recombinant is USFDA- and TGA-inspected. and environmental chemicals on over 100 proteins and synthetic peptides and labware asymchem.com transcription factors and 48 nuclear receptors. supplies. Avioq also offers contract IVD attagene.com development and manufacturing. Asystbio Laboratories LLC (Chapel Hill) avioq.com uses next-generation DNA sequencing and Atticus LLC (Morrisville), a CSE Life Science proprietary algorithms to count mutations in Company, develops, manufactures and Avista Pharma Solutions (Durham) leukemic cells. markets post-patent fungicides, herbicides provides pharmaceutical, animal health and insecticides. and medical device clients with services ATEX Technologies Inc. (Pinebluff) designs atticusllc.com including API and drug product discovery, and manufactures custom implantable textile development and cGMP manufacturing and components and bio-resorbable structures Aurobindo Pharma USA Inc. (Durham) stand-alone analytical and microbiology for medical devices, as well as medical yarn is a generic drug manufacturer. Aurobindo testing support. and fabric. develops inhalation and dermatological avistapharma.com atextechnologies.com products from the company’s U.S. research and development headquarters in North Avoca Inc. (Merry Hill) develops and Atlantic Medical Inc. (Wrightsville Beach) Carolina. manufactures botanical extraction products develops nutraceutical products and devices aurobindousa.com and provides extraction services. Avoca to address ocular diseases. contracts with farmers to grow clary sage and Avazyme Inc. (Durham) provides field and also processes krill oil for omega-3 fatty acids. Atlas Regeneration Inc. (Winston-Salem) GLP laboratory testing for sectors including pharmachemlabs.com/divisions/avoca develops bioinformatics platforms for drug agchem, agbiotech, food and beverage discovery related to regenerative medicine producers and retailers, and brewers. Avolynt Inc. (Research Triangle Park) is and stem cell research. Atlas Regeneration Capabilities include mass spectrometry, developing a novel SGLT2 inhibitor for the also screens drugs in silico for drug immunochemistry, microbiology and treatment of nonalcoholic steatohepatitis repositioning. molecular biology. (NASH) and type 2 diabetes. atlasregeneration.com avazyme.com avolynt.com

Atox Bio Inc. (Chapel Hill) develops novel Avertica Inc. (Research Triangle Park) Aweve LLC (Raleigh) designs and immunomodulators to treat critically ill develops compounds and polymers for manufactures branded molded nano-particle patients. Initial focus is on patients with electronic device applications, including the delivery systems for the cosmeceutical Necrotizing Soft Tissue Infections. development of biomimetic and bio-based industry. atoxbio.com electronic materials. douglaswadams.com/aweve-llc.html averticainc.com

BATON Referral Network is a community of life science service providers who contribute services or provide preferential pricing for referrals coming through the BATON network database. ncbiotech.org/baton

Received NCBiotech investment North Carolina Bioscience Companies | 5 Azzur Labs LLC (Cary) provides analytical Bavarian Nordic Inc. (Morrisville) develops, BENANOVA Inc. (Raleigh) develops GXP-compliant testing services for the manufactures and commercializes cancer antimicrobial nanotechnology products for pharmaceutical, medical device, food and immunotherapies and vaccines for infectious the disinfectant, cosmetic and agricultural cosmetic industries. Programs include diseases. industries. environmental monitoring, cleaning bavarian-nordic.com benanova.com validations, biological indicator analysis and microbial identification. Baxter Healthcare Corp. (Marion) produces Benson Hill Biosystems Inc. (Research azzur.com/labs intravenous and peritoneal dialysis solutions Triangle Park) is an agricultural biotechnology at the Marion location, as well as empty company focused on the development of Baebies Inc. (Durham) develops and containers and component parts for other traits to increase crop yield, principally by delivers products and services based on Baxter facilities. improving photosynthesis. digital microfluidics and other technology to baxter.com bensonhillbio.com advance newborn screening and pediatric testing worldwide. Bayer (Research Triangle Park, Clayton and Bent Creek Institute Inc. (Asheville) baebies.com Pikeville) is a global enterprise with core conserves and develops plant biodiversity competencies in the life science fields of assets and maintains the North Carolina Banner Life Sciences LLC (High Point) health care and agriculture. Bayer’s Crop Arboretum’s Bent Creek Germplasm develops formulation technologies (gelcaps, Science division uses the tools of plant Repository. It also administers the U.S. tablets and sterile injectables) and licenses biotechnology to develop seeds and Botanical Safety Laboratory, a consortium of and markets prescription, over-the-counter products for crop protection and non- university botanical research sites. and nutritional products. agricultural and structural pest control. bentcreekinstitute.org bannerls.com Research Triangle Park serves as the North American Crop Science headquarters. The BestCo Inc. (Mooresville) manufactures Barbaresco Pharma LLC (Chapel Hill) is Clayton site performs pesticide and bee confectionery-based dosage forms for a target drug discovery company focused health research. The Pikeville site identifies, nonprescription drug products and dietary on obesity, cardiovascular and metabolic tests and develops new cotton and soybean supplements. diseases. varieties. bestco.com bayercropscience.us BaseTrace (Research Triangle Park) BindusChem LLC (Research Triangle Park) develops DNA-based industrial fluid tracers BD Diagnostics (Burlington, Durham and offers contract drug discovery and process for environmental monitoring and process Mebane) develops and commercializes chemistry projects for clients, synthesis optimization in the energy sector. molecular diagnostic products for various of small molecules for SAR study, focused basetrace.com cancers, including cervical, breast, ovarian arrays and scaffolds, as well as chemical and prostate. development, route scouting, process BASF Corp. (Research Triangle Park) bd.com/tripath optimization and validation. develops plant health products and binduschem.com seed treatments and conducts plant BD Technologies and Innovation biotechnology research with a focus on yield (Research Triangle Park) develops and quality traits in major crops. Business technologies for parenteral drug delivery, units in RTP include the crop protection and advanced diagnostics, smart medical devices, plant science groups. genomic research and supports external agriculture.basf.com/us/en.html innovation. The RTP site is BD’s corporate technology R&D and innovation center. bd.com/technologies

NCI-designated medical comprehensive schools 3 cancer centers 5 pharmacy schools

6 | ncbiotech.org/directory Bio Products Laboratory USA Inc. BioCytics Inc. (Huntersville) researches BioGreen Synergy Inc. (Greensboro) (Durham) manufactures and distributes and develops personalized cellular manufactures, grows and provides algae- plasma-derived products, including immunotherapy cancer therapies. based products for use in alternative intravenous immunoglobulin preparations, biocytics.com renewable energies, USDA, non-USDA and coagulation factors and albumin solution. chemical markets. The Durham office is the U.S. distributor for BioDelivery Sciences International Inc. biogreensynergy.com BPL products. (Raleigh) is a specialty pharmaceutical bpl-us.com company with a focus in the areas of pain BioIVT (Durham) provides control and management and addiction. The company’s disease state biological specimens, including BioAesthetics Corporation (Durham) is lead products utilize a buccal film delivery human and animal tissues, cell products, developing a nipple areolar complex graft system. blood and other biofluids. Its Durham that allows the patients’ cells to grow into the bdsi.com site develops cell-based drug toxicity- graft for use in breast reconstruction. testing products used in pharmaceutical bio-aesthetics.com BioDyne Water Reclamation Inc. (Raleigh) development, based on the company’s engineers and markets water reclamation proprietary hepatocyte technologies. BioAgilytix Labs Inc. (Durham) is a systems using biotreatment with its patented bioivt.com bioanalytical lab specializing in large- IBAC single vessel full-treatment systems. molecule bioanalysis, offering PK, biodynegroup.com BioKier Inc. (Chapel Hill) develops immunogenicity, biomarkers and cell-based proprietary drugs for diabetes and related assays in support of the development Biofluidica Inc. (Research Triangle Park) disorders. BioKier has identified a therapeutic and release testing of biologics and small- is developing novel instrumentation for opportunity based on gastric bypass surgery molecule therapeutics. the isolation and analysis of circulating and is developing a novel treatment for bioagilytix.com biomarkers, including circulating tumor cells, diabetes. in cancer patients. biokier.com BIoCI Systems Inc. (Raleigh) provides biofluidica.com sterilization validation services and other BioLink Life Sciences Inc. (Cary) provides contract laboratory testing services. Biogen (Research Triangle Park) discovers, contract product development support bioci.com develops and manufactures therapies for through custom synthesis and testing. serious neurological and neurodegenerative biolinkonline.com Biocomposites Inc. (Wilmington) develops, diseases. It operates biologics and oral solid manufactures and distributes synthetic tissue dose manufacturing facilities and a patient Biological Applied Research Inc. (Raleigh) regeneration products. The Wilmington office services contact center in RTP. provides efficacy testing of agricultural is a sales office. biogen.com chemicals such as fungicides and nematicides biocomposites.com on various crops, including fruit and BioGenomics LLC (Knightdale) provides vegetables. BioCryst Pharmaceuticals Inc. (Durham) pharmacogenomic testing to inform biologicalappliedresearch.com designs and develops novel, small-molecule prevention, diagnosis and treatment of oral drugs that block key enzymes to treat various diseases. BioMarck Pharmaceuticals Ltd. (Durham) rare diseases. The Durham location houses biogenomicsdx.com develops drugs to treat pulmonary diseases BioCryst’s clinical, regulatory and executive and disorders, such as chronic obstructive teams. pulmonary disease, ARDS, cystic fibrosis and biocryst.com lung cancer. biomarck.com 1 $1B land grant top-ranked college of annually from NIH since 2005 universities veterinary medicine

Received NCBiotech investment North Carolina Bioscience Companies | 7 bioMASON Inc. (Research Triangle Park) Biorg Inc. (Chapel Hill) is developing Bio-Val LLC (Cornelius) provides bioassay develops masonry material from a and commercializing organoid technology development, method validation, reagent nonpathogenic bacterium which induces for use in life science applications such production and characterization, feasibility cement materials in between aggregates as diagnostics, drug screenings and and medical writing services. such as sand. toxicology. biovalconsulting.com biomason.com biorg.com BioVendor LLC (Asheville) develops, BioMedomics Inc. (Durham) develops BioRxn LLC (Chapel Hill) develops manufactures and sells biological reagents point-of-care (POC) diagnostics, with a NMR-based metabolomic technology, and research products, including enzyme- focus on immunologically-based disease- including bioreactor and artificial liver linked immunosorbent assay (ELISA) kits, specific tests and advanced quantitative POC systems, for non-invasive monitoring of , proteins and other molecules for platforms. metabolic biomarkers. BioRxn also provides life science research. The Asheville site is the biomedomics.com conventional metabolomic services. U.S. headquarters. biorxn.com biovendor.com bioMérieux Inc. (Durham) develops in vitro products to diagnose infectious diseases, Biota Diagnostics LLC (Charlotte) Bioventus LLC (Durham) develops cancer and cardiovascular disease and offers pharmaceutical compound testing, and markets orthobiologic solutions for to detect microorganisms in agri-foods, dialysis and medical device testing and musculoskeletal healing and regeneration. pharmaceuticals and cosmetics. environmental analytical testing services. These include products for bone healing, biomerieux-usa.com biotadiag.com bone graft and knee osteoarthritis. bioventusglobal.com bioMONTR Labs (Research Triangle Park) Biotality (Durham) develops biological provides a broad range of CLIA-certified and natural products for crop protection. Its Biovet S.A. (Research Triangle Park) high-complexity laboratory testing, including first product is a proprietary organism that develops nutritional supplements, enzymes, assay/IVD protocol development, validation overproduces a fungicidal exudate, with pronutrients, digestives, antioxidants, design, performance evaluation testing, applications in the seed proctectant and preservatives, mycotoxin binders and drug trials and collaborative studies and post-harvest markets. flavoring for feed for poultry, ruminants, swine regulatory/quality control. agtechinventures.com/spin_offs.html and aquaculture. biomontr.com biovet-alquermes.com/index.php/en Biotech Restorations LLC (Denver) Bio-Pro Research LLC (Hickory) formulates bioremediation products for BioZyme Inc. (Apex) develops and sells manufactures and distributes bio-enzymatic the cleanup of petroleum and chlorinated substrates for metalloproteinases (MMPs and products for stain and odor removal. hydrocarbons including gasoline and diesel, ADAMs) which can be used in enzyme assays urineoff.com organochloride pesticides, PCBs and volatile and other diagnostic tests. organic chemicals in soil, sediment and biozyme-inc.com BioResource International Inc. (Durham) groundwater. designs, develops and manufactures biotechrestorations.com Blue Ridge Institute for Medical Research unique enzymes that help poultry and (Horse Shoe) researches small-molecule swine producers optimize animal nutrition BioTrackers Inc. (Charlotte) develops inhibitors of protein kinases and targeted and gut health. bacterial, or microbial, source tracking cancer therapies. briworldwide.com technology. brimr.org

North Carolina named best state for business. orbes, Best States for Business, 21

8 | ncbiotech.org/directory Boragen Inc. (Research Triangle Park) C Change Surgical LLC (Winston-Salem) Campbell University Pharmaceutical develops a chemistry platform that leverages develops, patents, manufactures and markets Education and Research Center the chemical properties of boron, with computerized electronic systems that control (Buies Creek) offers analytical, formulation, applications in crop protection and animal sterile surgical fluid temperature. R&D and training services to the pharma and health. cchangesurgical.com biotech industries, compounding pharmacies, boragenbio.com government agencies and other academic Calvert Laboratories Inc. (Cary) provides institutions. Braeburn Pharmaceuticals Inc. preclinical research and contract drug cphs.campbell.edu/centers-programs/ (Morrisville) manufactures and develops discovery and development services, such pharmaceutical-education-research-center/ pill-free drugs for neurological and psychiatric as lead identification and lead optimization disorders, including addiction, pain and services. Camras Vision Inc. (Research Triangle Park) schizophrenia. calvertlabs.com is developing an ocular implant to treat braeburnpharmaceuticals.com glaucoma. camrasvision.com BreStem Therapeutics Inc. (Raleigh) is Promote your company developing a stem cell therapy to treat in the next NCBiotech Cancer Advances Inc. (Durham), a pulmonary fibrosis. subsidiary of Cato Bioventures, develops brestem.com Company Directory immunomodulator therapeutics to treat gastrointestinal cancers. Brighton Development LLC (Cary) In print and online. canceradvancesinc.com develops sterilizing technologies and directory.ncbiotech.org/sponsor antimicrobial medical plastics. Cancer Genetics Inc. (Morrisville) offers diagnostic products and services that enable Brite Bio Inc. (Research Triangle Park) Camargo Pharmaceutical Services LLC precision medicine in the field of oncology. provides contract research services, including (Durham) provides contract drug This site performs clinical pharmacogenomic cell culture services, cell-based assays, development services, including formulation testing and provides biorepository services biomarker assay development, toxicological and testing, regulatory consulting, phase one under federally-designated clinical lab assays, bio-banking, drug target identification through four program development and API standards. and gene expression profiling and and clinical trial materials sourcing. cancergenetics.com characterization. camargopharma.com britebio.com Capture Pharmaceuticals Inc. Cambrex High Point (High Point) develops (Chapel Hill) develops oral treatments for Burleson Research Technologies Inc. and manufactures small-molecule APIs removing toxic or radioactive metals in (Morrisville) provides laboratory services to and intermediates for phase one through contaminated individuals. the biotechnology, pharmaceutical, chemical three clinical trials. It offers custom organic capturepharm.com manufacturing and health care industries synthesis, process development and cGMP with proof-of-concept, preclinical, clinical and manufacturing services. CardioEphEx LLC (Chapel Hill) develops toxicology studies. cambrex.com therapeutics for cardiovascular disease and brt-labs.com heart failure. The company’s research focuses on cardioprotection by targeting the Ephrin/ Eph receptor signaling pathway in the heart. cardioephex.com

Biomedical Partnership Center at NC State University | cassoreservations.wixsite.com/biomedicalpartnerctr (919) 223-9901 | [email protected] The Biomedical Partnership Center at North Carolina State University offers customized lab and office space for lease to life science companies. Tenant benefits include affiliate privileges from NCSU and collaborative research opportunities with the university’s colleges. Leasing and management by Capital Associates.

Received NCBiotech investment North Carolina Bioscience Companies | 9 CardioPharma Inc. (Wilmington) develops Cato Research Ltd. (Durham) provides Cellex Inc. (Research Triangle Park) develops, combinatorial products to treat cardiovascular contract research services, including manufactures and markets diagnostic tests disease. preclinical and clinical study design and suitable for point-of-care use. These tests use cardio-pharma.com management, regulatory assessments, a platform technology called Homogeneous data management and statistics, CMC Biochemiluminescence Assay (HBA), which CardioVascular and ExtraCorporeal program management, medical writing and enables assays that are highly sensitive and Technologies (Winston-Salem) provides submission of regulatory documents. easy-to-use. preclinical cardiac and implant surgical model cato.com cellex.us development and device evaluation, and applied life support technologies. Cedarlane Laboratories Ltd. (Burlington) CELLF-Bio LLC (Winston-Salem) is cvect.devhub.com manufactures and sells antibodies, proteins, developing a novel regenerative medicine- research reagents and cell separation media based therapy for fecal incontinence. Carolina Liquid Chemistries Corp. to the life science community. The Burlington, (Greensboro), an ISO-certified and FDA- N.C. site is a distribution office. CellSolutions LLC (Greensboro) develops registered medical device company, cedarlanelabs.com liquid-based preparation and evaluation specializes in clinical chemistry analyzers and systems for cytology applications. The reagents for clinical and reference labs. CLC CEI Labs Inc. (Cary) provides industrial company’s primary area of focus is women’s also offers instrument training, repair, QA and hygiene laboratory services such as asbestos health, including cervical cancer screening, technical support. testing, microbiology analysis and fungal precancer detection and evaluation of carolinachemistries.com analysis. infectious disease. ceilabs.com cellsols.com Carolina Yeast and Analytics LLC (Durham) isolates, propagates and sells yeast for Cell Microsystems Inc. Celplor LLC (Raleigh) provides molecular brewing, and provides yeast banking and (Research Triangle Park) develops, biology services, including stable cell line analytical testing services, including yeast manufactures and commercializes products generation, Southern blot analysis, Western viability, contamination testing, identification, and tools for the isolation, recovery and blot analysis, cDNA cloning and mouse tail IBUs, water testing and alcohol content. analysis of single cells. genotyping. carolinayeast.com cellmicrosystems.com celplor.com

Catalent Pharma Solutions LLC Celldom Inc. (Durham) is developing a CEM Corp. (Matthews) designs and develops (Morrisville) develops inhalation products and single-cell analysis platform for phenotyping microwave laboratory instrumentation and provides analytical testing, formulation and and genotyping rare events in biology. This scientific methods for life sciences, analytical other scientific services. platform has immediate touchpoints in drug laboratories and processing plants. catalent.com discovery and development, and future cem.com clinical applications. Cathtek Inc. (Winston-Salem) develops celldom.com Cenduit LLC (Durham) helps and manufactures catheters and related pharmaceutical, biotech and medical device accessories. Cellective BioTherapy Inc. companies control the processes of patient cathtek.com (Research Triangle Park) is developing cellular enrollment, patient randomization and and monoclonal -based platforms drug supply through the use of Interactive for treating cancers, autoimmunity and Response Technology (IRT). immunodeficiency. cenduit.com cellectivebiotherapy.com

Business Retention Program NCBiotech taps a variety of tools to take your existing life science business to the next level, from finding qualified workers and new local suppliers to implementing energy-efficient processes. ncbiotech.org/resources/business-retention-program

10 | ncbiotech.org/directory Centre Ingredient Technology Inc. CHD Technologies Inc. (Charlotte) conducts Chesson Laboratory Associates Inc. (Rockingham) develops natural flavors and chemical process R&D for agricultural and (Durham) develops prescription and over- fragrance ingredients for the food, beverage pharmaceutical intermediates. Competencies the-counter polymer-based medical products and cosmetics industry using fermentation. include distillation, rectification, crystallization, for wound care and skin and nail care CIT also provides contract development, filtration and drying for batch and continuous products. toll manufacturing and biotransformation chemical manufacturing processes. chessonlabs.com services. chdtechnologies.com bioingredients.com Chiesi USA Inc. (Cary), the U.S. affiliate Chematron Inc. (Charlotte) manufactures of Chiesi Farmaceutici S.p.A, develops and Cereius Inc. (Durham) is developing novel textile chemicals and has the capability for commercializes products in the therapeutic radio-labeled therapeutics for treating solid contractual custom manufacture of specialty areas of respiratory, cardiovascular, tumor brain metastasis. chemicals. neonatology and cystic fibrosis. chematron.com chiesiusa.com Chaperone Therapeutics Inc. (Chapel Hill) develops disease-modifying Chem-Bac Laboratories Inc. (Charlotte) Chiltern International Inc. (Wilmington therapies for neurodegenerative and rare offers analytical testing, specializing in and Cary) conducts phase one through four diseases caused by protein misfolding. petroleum products, unknown polymer global clinical trials across a broad range of chaperonetherapeutics.com identifications and textiles. therapeutic areas, functional service provision chembac.com and contract staffing solutions. Charles River Laboratories (Hillsborough, chiltern.com Morrisville, Durham and Raleigh) provides ChemoGenics Biopharma LLC drug discovery and development process (Research Triangle Park) provides Chimerix Inc. (Durham) discovers, develops services. CRL’s Hillsborough location provides collaborative drug discovery, bioanalytical, and commercializes broad spectrum antivirals contract toxicologic pathology and histology formulation and scale-up services. Capabilities for the prevention and treatment of life- services at the Hillsborough location. The include medicinal chemistry, DMPK, threatening viral infections. Morrisville location provides in vivo and bioinformatics and preclinical models in chimerix.com in vitro oncology research service. CRL’s cancer, inflammation and metabolic diseases. Pathology Associates in Durham provides chemogenicsbiopharma.com Chirazyme (Washington) produces enzymes pathology and toxicology contract services. for stereospecific epoxidation intermediates criver.com ChemQ Bioscience LLC in pharmaceutical synthesis. (Research Triangle Park) develops and chirazyme.com Charter Medical Ltd. (Winston-Salem) markets novel liquid products, such as bio- designs and supplies single-use solutions for preservation media, tissue perfusion solutions Circassia Pharmaceuticals Inc. (Morrisville) cell growth, frozen storage and biological and liquid-based cytology processing kits. designs and develops products to aid in the fluid handling for the bioprocessing, cell vitroprep.com diagnosis and control of asthma, COPD and therapy and medical device industries. CML is allergy. FDA-registered and ISO 13485-certified. Chemring Detection Systems Inc. circassia.com chartermedical.com (Charlotte) develops and manufactures chemical and biological agent detection systems, as well as explosive detection systems. chemringds.com

$1.89B federal R&D spending per year in NC

Received NCBiotech investment North Carolina Bioscience Companies | 11 CivaTech Oncology Inc. (Durham) has Clintec USA (Durham) conducts clinical trials Cohesion Phenomics LLC (Spindale) developed targeted implantable radiation in oncology, rare diseases, anti-infectives, is a CLIA-certified molecular diagnostic devices to treat many cancer types. These cardiology, dermatology, gastroenterology, laboratory. Cohesion Phenomics also products provide a targeted, customized neurology, respiratory medicine and develops DNA sequencing tests for complex dose immediately during a surgical resection rheumatology. and single gene disorders within specific procedure or in outpatient therapies to treat clintec.com clinical areas such as cardiovascular disease. prostate cancer. cohesionphenomics.com civatechoncology.com Cloud Pharmaceuticals Inc. (Research Triangle Park) designs and Collaborations Pharmaceuticals Inc. CiVentiChem (Cary) provides contract develops novel drug molecules using (Raleigh) develops drugs for rare and development and manufacturing services. computational design for a wide range neglected diseases using machine learning Services include cGMP manufacturing of therapeutic areas including cancer, software, providing preclinical and clinical of APIs, GMP analytical services, process inflammation, CNS disorders and rare expertise to rare disease foundations, development, medicinal chemistry and diseases. academic scientists and companies custom synthesis. cloudpharmaceuticals.com developing clinical candidates. civentichem.com collaborationspharma.com Cmed Clinical Services (Durham) provides Clavé Biodesign Inc. (Cary) develops clinical services to drug development Columbia Life Systems Inc. (Chapel Hill) is cell-specific peptides which can be used organizations and manages early-phase developing a computer-controlled oxygen for therapeutic purposes related to cancer, studies (phase one through two b) with blender for therapeutic research. cardiovascular disease and ophthalmology a focus in oncology, infectious disease, as well as for diagnostic imaging and respiratory infection and cardiology. Concentrx Pharmaceuticals Inc. (Durham) biomarkers. cmedresearch.com develops inhaled prescription products for clavebiodesign.com asthma and COPD, including a unit dose CMP Pharma Inc. (Farmville) develops, disposable dry powder inhaler. Clinical Sensors Inc. (Research Triangle Park) manufactures and commercializes specialty concentrxpharma.com develops a near-patient test for early pharmaceuticals, focused on niche liquid and detection of sepsis based on nitric oxide topical products that solve unmet patient Contego Medical LLC (Raleigh) develops measurements from unprocessed blood. needs. embolic protection devices for cardiovascular clinicalsensors.com cmppharma.com and peripheral vascular procedures, designed to simplify catheter-based procedures. Clinipace Worldwide Inc. (Morrisville) Cognosci Inc. (Research Triangle Park) contegomedical.com provides full-service global clinical develops neurorestorative therapies for development services for drug and medical Alzheimer’s disease, multiple sclerosis, ConvaTec Inc. (Greensboro) develops device programs using its TEMPO eClinical traumatic brain injury, nerve crush and other and manufactures therapies for the platform, as well as regulatory and strategic disease and trauma indications. management of chronic conditions, with a consulting. cognosci.com focus on advanced wound care, ostomy care, clinipace.com continence and critical care and infusion Cohera Medical Inc. (Raleigh) develops devices. The Triad site is the company’s Global surgical adhesives for internal use for Quality headquarters. abdominoplasty procedures. convatec.com coheramedical.com

davos.com | (919) 607-0207 | [email protected]

DavosPharma specializes in supporting all aspects of the drug development spectrum, from IND-enabling activities required to get a new molecule from concept to clinic, to ton-scale manufacturing of APIs and drug product. This includes items such as custom chemistry, biology, toxicology, and pharmaceutical manufacturing services for APIs and dosage forms.

12 | ncbiotech.org/directory Cook Medical (Winston-Salem) develops Covance Inc. (Durham and Research Crop Microclimate Management Inc. and manufactures devices used in Triangle Park), the drug development (Apex) researches and develops technologies gastrointestinal endoscopy to diagnose and business of LabCorp, provides a wide to improve crop productivity by mitigating treat esophageal, gastric, pancreatic, biliary range of early-stage and late-stage product the impact of environmental stresses. and colonic disorders. development services primarily to the cropstress.com cookmedical.com pharmaceutical and biotechnology industries. The RTP location specializes in bioanalytical CSS-Dynamac (Durham) provides health Corning Life Sciences (Durham) and immunoanalytical services, specializing and safety services and scientific program manufactures pipettes, conical and round- in GLP-compliant LC/MS/MS bioanalytical support in the physical and life sciences. The bottomed tubes, cell inserts, tissue-culture services for all phases of drug discovery and Durham location provides environmental plates and ADME/Toxicology products. development. toxicity testing services. corning.com/worldwide/en/industries/ covance.com css-dynamac.com life-sciences.html Craft Technologies Inc. (Wilson) CTMG Inc. (Greenville and Raleigh) Cotton Incorporated (Cary) Cotton provides analytical and method development provides site-specific clinical research Incorporated’s Agricultural & Environmental services to measure nutritional components management services, including patient Research Division improves cotton cultivation in blood, tissues, dietary supplements, food recruitment, personnel, expertise and through genetic and biotechnology tools, and animal feed. systems. enhancing yield, quality and resistance of crafttechnologies.com ctmginc.com cotton varieties. cottoninc.com Creative PEGWorks (Chapel Hill) Curasan Inc. (Durham) develops, manufactures and supplies advanced manufactures and markets biomaterials for Countervail Corp. (Charlotte) develops and functional polymer products for bone and tissue regeneration. This location is commercializes products to protect against research. Main product lines include PEG, the U.S. headquarters for sales and marketing. and treat exposure to chemical weapons and polysaccharides, biodegradable polyester, curasaninc.com pesticide poisoning. copolymers, and PEGylation service. countervailcorp.com creativepegworks.com Curl Bio LLC (Durham) develops drugs for the interrelated set of disorders involving Couragen Biopharmaceutics LLC Creative Scientist Inc. (Research Triangle Park) Type 2 diabetes, obesity, fatty liver disease, (Durham) develops gene and protein therapy specializes in bioassay development, primary metabolic syndrome and associated products for preclinical and clinical use cell production and preclinical contract complications. for the treatment of genetic and chronic research services. They are also developing a curlbio.com diseases. Couragen also provides custom radiation sensitivity cell-based assay. adeno-associated virus vectors as a tool for cscientist.com Cygnus Technologies LLC (Southport) laboratory research. develops products and services for the CRL Suncare LLC (Winston-Salem) provides biopharma industry, including host cell services to sunscreen and dermatological protein ELISA kits, immunoassay reagents product manufacturers, including evaluation and custom development of antibodies and of sunscreen SPF and UVA protection. assays. suncarelab.com cygnustechnologies.com

aeihDrham metro area rane 4th among 16 U.S. life sciences clusters. JLL, “Life Sciences Outlook,” 2017

Received NCBiotech investment North Carolina Bioscience Companies | 13 DaVINCI Biomedical Research Products Inc. (Garner) is an AAALAC-accredited contract lab that performs GLP and non-GLP Book your next meeting at NCBiotech’s preclinical animal studies. DaVINCI specializes in regenerative medicine, cardiovascular, award-winning Hamner Conference Center orthopedic and medical device applications. davincibiomed.com

Deep Blue Medical Advances Inc. (Durham) develops a surgical mesh for hernia repair and other medical device technologies from Duke University. deepbluemedical.com

Dermavant Sciences (Durham), a part of the Roivant family of companies, develops therapies for the treatment of skin diseases. dermavant.com

Dharma Laboratories LLC (Morrisville) Professional staff. Easy access. Simply elegant. develops dosage forms, including oral solids, ncbiotech.org/hcc liquids, injectables, topicals and specialty products. dharmapdlabs.com

Dignify Therapeutics LLC (Research Triangle Park) develops bladder and bowel drug therapies for spinal cord- injured, multiple sclerosis and similar patient populations with voiding dysfunction. dignifytherapeutics.com

Dina Pharmaceuticals Inc. (Raleigh) is developing a treatment for Levodopa- Induced Dyskinesia (LID) associated with Parkinson’s disease. located within the dinapharma.com

15 T.W. Alexander Drive | Post Office Box 13547 | Research Triangle Park, NC 27709-3547 DMC Limited (Durham) is developing 919-541-9366 | Reservations: ncbiotech.org/hcc-reservation synthetic metabolic valve technology for rapid engineering of microbial hosts for the Photo: Jim Sink production of specialty chemicals, flavors, fragrances, nutraceuticals, natural products, pharmaceuticals and APIs. dmcbio.com Cytex Therapeutics Inc. (Durham) develops David H. Murdock Research Institute bio-artificial devices to treat osteoarthritis and (Kannapolis) provides collaborators with other musculoskeletal diseases. genomics, proteomics, metabolomics, light DMK Pharmaceuticals Inc. (Holly Springs) develops small-molecule analgesics that have cytextherapeutics.com microscopy, NMR, clinical chemistry, cellular biology and immunology services. DHMRI reduced side effects, such as abuse potential, respiratory depression, nausea, vomiting and Daily Manufacturing Inc. (Rockwell) focuses on human health, nutrition and itching, that are currently associated with manufactures vitamins, minerals and herbals. agriculture. marketed analgesics. The company also manufactures products for dhmri.org other supplement companies with their own Dole Nutrition Institute Research brand names. Laboratory (Kannapolis) conducts research daily-mfg.com on phytochemicals found in fruits and vegetables. transforming-science.com/ dole-nutrition-research-laboratory 14 | ncbiotech.org/directory Dova Pharmaceuticals Inc. (Durham) Edison Agrosciences Inc. (Research EMSL Analytical Inc. (Morrisville, Charlotte develops treatments for orphan diseases. Triangle Park) is an agricultural biotechnology and Kernersville) provides analytical services, Its lead compound is being developed as a company that engineers yield improvements including microbiology, asbestos, metals, treatment for thrombocytopenia in patients and the plant-based production of industrial indoor air quality and food testing. with chronic liver disease. materials, with a primary focus on the emsl.com dova.com development of alternative rubber crops in sunflower. EN-CAS Analytical Laboratories Drumetix Laboratories LLC (Greensboro) edisonagrosciences.com (Winston-Salem) provides GLP-compliant provides bioanalytical support for drug analytical chemistry contract services for metabolism, pharamacokinetics and EG-GILERO (Asheboro) provides contract agrochemical, veterinary and bioanalytical toxicokinetic (DMPK, ADME) studies, as well design, development, manufacturing and research. EN-CAS has experience with as LC-MS/MS analysis of small-molecule commercialization for medical devices and preclinical and clinical trials support, biomarkers, such as neurotransmitters, drug delivery devices. The Asheboro site is a pesticides, herbicides and veterinary drugs. all-trans retinoic acid and creatinine. manufacturing facility. en-cas.com drumetix.com eg-gilero.com EncepHeal Therapeutics Inc. DSK Biopharma Inc. (Morrisville) provides (Winston-Salem) develops neurotherapeutics custom synthesis and medicinal chemistry See Us Online to treat substance abuse and mental health services. DSK develops and supplies fine disorders through working partnerships with chemicals, APIs and intermediates, scaffolds, Search the NCBiotech academic institutions, private companies and Company Directory at inhibitors, amino acids, carbohydrates, foundations and government agencies. ncbiotech.org/directory peptides, coupling reagents and other encepheal.com compounds. dskbiopharma.com Ei, A Pharmaceutical SolutionWorks ENCO Pharmaceutical Development Inc. (Kannapolis) develops and manufactures (Cary) provides comprehensive product Dualogics LLC (Chapel Hill) researches and liquid, semisolid and powder prescription and development services to the pharmaceutical develops bispecific antibody products based nonprescription skin-care and animal health and medical device market. on their proprietary OrthoMab platform. products. encopharma.com dualogics.com eisolutionworks.com Endacea Diagnostics Inc. Duke Clinical Research Institute (Durham) Eisai Inc. (Raleigh) discovers, develops and (Research Triangle Park) is developing is an academic clinical research organization markets pharmaceuticals in neurology and EndaTox IVD, an in vitro sepsis diagnostic, that coordinates research projects including oncology-critical care. This site supports and EndaTox Test, an assay to measure LPS small pilot studies, multinational clinical trials, global partnerships, quality assurance and endotoxin in biological and non-biological major national patient registries and landmark supply chain for the company. samples. outcomes research. us.eisai.com endacea.com dcri.org Elanco Animal Health (Greensboro) Endacea Inc. (Research Triangle Park) DuPont Pioneer - Kinston Research Center researches, develops and commercializes develops A1 adenosine receptor antagonists (Kinston) conducts research on the animal health products for pet owners, as drug candidates for renal impairment conventional and transgenic development farmers and veterinarians. and inflammation, including sepsis and of corn, soybeans and other crops, with an elanco.us asthma. emphasis on drought-resistant products. endacea.com pioneer.com Element Genomics Inc. (Durham) is developing a high-throughput platform for EnDev Laboratories (Kannapolis) offers Ecoblend LLC (Pittsboro) develops and understanding gene regulatory elements topical research and development services manufactures organic weed and pest control in order to identify new drug targets for for therapeutic skin care and prescription products. common diseases. dermatological products. Services include ecoblend.green elementgenomics.com formulation and process development, analytical development, technology transfer Emergo Therapeutics Inc. (Durham) is and regulatory solutions. repurposing drugs for the treatment of acute endevlabs.com inflammation.

Received NCBiotech investment North Carolina Bioscience Companies | 15 EnSolve Biosystems Inc. (Raleigh) Environmental Testing Solutions Inc. Eppin Pharma Inc. (Chapel Hill) is produces proprietary biologically-based (Asheville) offers microbiological and developing a non hormonal male oral treatment systems to address oily bilge chemical testing for drinking water and contraceptive. water, groundwater, process waste streams wastewater and aquatic biomonitoring eppinpharma.com and scrubber water. They also manufacture toxicity testing. bioenzymatic degreasers/detergents and oil- etsnclab.com Eton Bioscience Inc. (Research Triangle Park) spill cleanup products. specializes in DNA sequencing and offers ensolve.com Envisia Therapeutics Inc. (Durham) other services such as gene and peptide discovers and develops novel therapies to synthesis, mutagenesis and mammalian cell Entegrion Inc. (Durham) develops biologic address significant unmet medical needs in expression. and medical device technologies to enhance ophthalmology. etonbio.com the safety and availability of the human blood envisiatherapeutics.com supply. The company also provides blood Eurofins Agroscience Services Inc. supply-related contract R&D services to the Enzerna Biosciences Inc. (Chapel Hill) is (Mebane) provides contract research services, U.S. Department of Defense. developing molecular tools for reversible, product development consulting and entegrion.com precise manipulation of gene expression, technical support to the crop protection, using technologies that create sequence- agricultural biotechnology and pest control ENTEX Technologies Inc. (Chapel Hill) specific RNA binding proteins. Enzerna also industries. provides advanced biological and filtration offers mitochondrial toxicity models and eurofins.com/agroscienceservices.aspx wastewater treatment that can be testing. customized for various industries. Evecxia Inc. (Durham) is developing a entexinc.com EpiCypher Inc. (Research Triangle Park) natural serotonin precursor for treatment- develops and manufactures novel products resistant depression. EntoGenetics Inc. (Charlotte) engineers and tools for epigenetics and chromatin evecxia.com the production of spider silk at a commercial biology, focused on enabling drug discovery scale through the genetic transformation of research and development. Exela Pharma Sciences LLC (Lenoir) silkworms. Spider silk is a very strong fiber epicypher.com develops and manufactures injectable, that has applications in the biomedical, ophthalmic and inhalation pharmaceuticals. defense and textile industries. EpiZyme Inc. (Morrisville) discovers, The Lenoir site is a sterile manufacturing entogenetics.com develops and plans to commercialize facility, compliant with cGMP and other FDA innovative personalized therapeutics for regulations. ENVIGEN Pharmaceuticals Inc. (Raleigh) patients with genetically defined cancers. exelapharma.com develops classes of small drug-like molecules epizyme.com to treat life-threatening diseases including Exodos Life Science Partners (Chapel Hill) cancer, HIV/AIDS and neurological disorders. EPL Inc. (Durham) provides GLP-compliant advances product concepts through the envigenpharma.com toxicologic pathology and related 505(b)(2) process to early clinical proof- services including necropsy, histology, of-principle and sale. Exodus specializes in immunohistochemistry, pathology topical formulations for the treatment of pain evaluation, EM, stereology, pathology peer and inflammation. reviews, specimen storage and consultation. exodosls.com epl-inc.com

Entrepreneur Resources NCBiotech gives businesses access to a variety of resources such as financial planning tools, funding sources, incubators, accelerators, lab space and more. ncbiotech.org/resources/entrepreneur-resources

16 | ncbiotech.org/directory Eydis Bio Inc. (Research Triangle Park) is Fervent Pharmaceuticals LLC (Greenville) Flexcell International Corp. (Burlington) developing a platform of tethered molecules develops a nonhormonal product, FP-101, to designs and manufactures products for that enable detection and ablation of treat vasomotor symptoms associated with cytomechanics research, studying cellular malignant tumors. menopause. responses to mechanical forces such as ferventpharma.com tension or compression. Eyedesis Biosciences LLC (Chapel Hill) is flexcellint.com developing a small-molecule macrophage FHI 360 (Durham) is a nonprofit human inhibitor for the treatment of neovascular age development organization that focuses on Fluidigm Corp. (Research Triangle Park) related macular degeneration. family planning, reproductive health and HIV/ develops and manufactures microfluidic AIDs by advancing locally-driven solutions. systems consisting of instruments, software, f(x) Immune Diagnostics Inc. (Candler) The laboratory in Durham offers medical integrated fluidic circuits, high-performance provides advanced testing services to device and pharmaceutical testing services. assays for gene expression and genotyping, developers of immuno-therapeutics and fhi360.org and primers for sample preparation for next- vaccines using its proprietary technologies. generation sequencing. The company’s pipeline includes related FibroStatin Inc. (Raleigh) develops fluidigm.com clinical diagnostics, point-of-care and treatments for drug resistant cancer and companion assays and systems. organ fibrosis using its proprietary GPBP FMC Agricultural Solutions fx-immune.com technology that has identified a novel and (Research Triangle Park), a unit of FMC Corp., preferred pathway for inhibiting the cell develops biological crop protection products. Fair Products Inc. (Cary) manufactures epithelial-to-mesenchymal transition (EMT). The RTP location conducts research on plant- and distributes tobacco crop care products fibrostatin.com microbe interactions. including insecticides, sucker control, ripeners fmccrop.com and fertilizers. First Flight Biosciences Inc. (Cary) provides fairproductsinc.com contract drug discovery research services, Foothills Bio-Energies (Lenoir) produces including lead optimization in preclinical drug biodiesel from virgin agri-based feedstock. Falcon Therapeutics Inc. (Durham) is discovery, assay development, compound incominginc.com/operations/ developing personalized neural stem cell profiling, high-throughput screening, in vivo therapies to treat glioblastoma and other pharmacology, DMPK and bioanalytics. Foundation Medicine Inc. (Morrisville) cancers. firstflightbioscience.com develops clinical assays for solid tumors, falcontherapeutics.com hematologic malignancies and sarcomas and FLAG Therapeutics Inc. (Raleigh) matches patients with targeted therapies Fennec Pharmaceuticals Inc. develops cancer therapeutics using new and clinical trials. The Morrisville location is a (Research Triangle Park) develops classes of small molecules which have testing laboratory. cancer therapeutics. Its lead product selective dual activity: antiangiogenesis and foundationmedicine.com under development is Eniluracil, an oral chemotherapeutic. dihydropyrimidine dehydrogenase inhibitor flagtherapeutics.com Frenova Renal Research (Durham) to improve the tolerability and effectiveness provides phase one through four drug of oncology drugs. Fleming Laboratories Inc. (Charlotte) and device clinical development services fennecpharma.com manufactures animal pharmaceuticals. exclusively for renal research. Services include renal clinical program development, maintenance of a renal research site network and bioinformatics and analytics. frenovarenalresearch.com

Raleigh ranked 2nd best-performing large city based on opportunities for prosperity and innovation. ilen, est-Performing ities,

Received NCBiotech investment North Carolina Bioscience Companies | 17 Fresenius Kabi USA LLC (Wilson) Galaxy Diagnostics Inc. (Morrisville) offers GeneCentric Therapeutics Inc. manufactures medical devices and sterile molecular and serology testing for zoonotic (Research Triangle Park) develops molecular injection- and infusion-based drug-delivery and vector-borne infectious diseases for diagnostic assays to enable oncologists products. human and veterinary medicine and to and their patients to make informed, fresenius-kabi.com support clinical research studies. individualized treatment decisions. galaxydx.com genecentric.com FUJIFILM Diosynth Biotechnologies USA Inc. (Morrisville) provides biologics contract Gateway Bio Inc. (Durham) is developing a Geneffects LLC (Mebane) provides development and manufacturing. Services rapid onset anticoagulant. proteogenomic analyses of data and has include cell line development, process developed a proteogenomic search software and analytical development, clinical and GBM Pharma Inc. (Durham) develops drugs called Peppy. commercial manufacturing and bioprocess for the treatment of glioblastoma multiforme. geneffects.com research and development. fujifilmdiosynth.com GEM Tox Consultants & Labs Inc. Geneformation Technology Inc. (Belmont) (Greenville) conducts research focused is a cytogenetics company that develops and FusionBio Inc. (Chapel Hill) develops novel on cancer biotechnology, food safety and commercializes cell culture technology for treatments for immune-mediated diseases, toxicology, with a special emphasis on cancer peripheral blood, bone marrow and amniotic including cancer and autoimmunity. biomarker discovery and validation. fluid. fusionbiology.com gemtoxlabs.com geneformation.com

G&W Laboratories LLC (Lincolnton) Gene Facelift LLC (Winston-Salem) develops Genemart Bioscience Inc. (Cary) manufactures OTC and prescription a cosmetic gene therapy in a topical cream manufactures antibodies, recombinant hydrocortisone, antifungal and permethrin formulation to reduce wrinkles, regenerate proteins, ELISA kits and critical assays. products as creams, ointments, liquids and collagen and restore aging skin. The delivery Genemart also provides contract R&D, process suppositories. platform will be used to develop wound development and manufacturing services gwlabs.com healing drugs. to the biopharmaceutical and academic lab genefacelift.com communities. G1 Therapeutics Inc. (Research Triangle Park) develops small- Gene Master LLC (Cary) provides contract Genencine Therapeutics LLC (Durham) molecule therapies to address significant biomedical research services such as develops mRNA vaccines for the prevention unmet needs in oncology. genotyping and vector construction. Gene and treatment of cancer, viral diseases and g1therapeutics.com Master helps design and perform biological autoimmune diseases, as well as mRNA experiments. therapeutic drugs for genetic diseases. Gaia Herbs Inc. (Brevard) grows and ncgenemaster.com genencine.com produces certified organic herbal products, including liquid extracts, functional powders Genebiology Inc. (Research Triangle Park) General Biosystems Inc. (Morrisville) and herbal teas. All growing, manufacturing, identifies, patents and develops new provides gene synthesis, molecular biology, processing, researching, packaging and parenteral formulations of approved drugs and protein expression and purification distribution takes place in its North Carolina for unmet medical needs using the 505b2 services. facilities. regulatory pathway. generalbiosystems.com gaiaherbs.com genebiology.com

life science Ph.D.s conferred per year in NC

18 | ncbiotech.org/directory Generys Biopharmaceuticals Corp. Glenmark Pharmaceuticals Inc., USA Grid Therapeutics LLC (Durham) is (Chapel Hill) develops drugs, formulations (Monroe) discovers small-molecule drugs and developing cancer therapeutics that apply and generics for unmet medical needs. biologics in the areas of oncology, respiratory a platform that develops human-derived Generys also offers therapeutic pipeline disease and dermatology, and manufactures antibodies to the treatment of multiple portfolio consulting and management and distributes APIs and generics. The cancer types. services on a contract basis. Monroe site manufactures oral solids, gridtherapeutics.com generysbiopharma.com injectables and topicals. glenmarkpharma.com Grifols (Research Triangle Park and Clayton) Genetron Health Technologies Inc. develops and produces plasma-derived (Research Triangle Park) provides mutation Global Lyme Diagnostics LLC medicines to treat chronic and acute detection assays using its liquid biopsy (Research Triangle Park) develops solutions to conditions in the therapeutic areas of platform, as well as various genetic accurately diagnose Lyme disease in humans immunology, pulmonology, hematology, assays to support both clinical and basic and domestic animals. thrombolytics and neurology. Grifols’ research. Genetron also offers custom assay Clayton plant is the company’s primary development. Global Vaccines Inc. (Durham) is a manufacturing facility, producing proteins us.genetronhealth.com not-for-profit company that develops to treat rare diseases including immune vaccines against developing-country diseases deficiencies and genetic emphysema. GENEWIZ Inc. (Research Triangle Park) such as HIV/AIDS, polio, dengue fever, malaria grifols.com provides custom DNA sequencing, gene and viral diarrhea (rotavirus). synthesis, genomics, next-generation globalvaccines.org GSK (Research Triangle Park and Zebulon) sequencing and molecular biology in a GLP/ develops and manufactures vaccines, cGMP regulatory environment. Glycan Therapeutics Inc. (Raleigh) is medicines and consumer healthcare products genewiz.com developing a synthetic heparin and synthetic for the treatment of infectious and respiratory carbohydrates to aid researchers investigating diseases, central nervous system disorders, Genova Diagnostics Inc. (Asheville) multiple therapeutic areas. immuno-inflammation, diabetes and cancer. performs diagnostics and molecular genetics glycantherapeutics.com GlaxoSmithKline manufactures solid-dose testing under federally-designated clinical products, including tablets and capsules, lab standards to support physicians in Goldsboro Laboratories LLC (Goldsboro) at its Zebulon facility. The plant also does personalized chronic disease treatment and develops and manufactures vaccines for granulation, drying and packaging, and prevention. the swine, poultry and cattle divisions of contract manufacturing of antibiotics for gdx.net Goldsboro Milling Company. other companies. gsk.com Genoverde Biosciences Inc. (Raleigh) Greenlight Biosciences is developing a cell wall gene platform (Research Triangle Park) has developed a GTCAllison LLC (Mocksville) researches technology used to increase biomass cell-free bioprocessing method for the low- and develops diagnostic tests for animal production in non food crops. cost production of RNA for use in research in pathogens. genoverde.com vaccine development, pandemic preparation, gtcallison.com crop management and crop pesticides. greenlightbiosciences.com Guerbet LLC (Raleigh) manufactures contrast media used in diagnostic imaging Greenwich Biosciences (Raleigh) develops tests. cannabinoid prescription medicines and guerbet-us.com other plant-based pharmaceuticals. greenwichbiosciences.com

63,000+ NC life science workers

Received NCBiotech investment North Carolina Bioscience Companies | 19 Gusto Global LLC (Charlotte) discovers and Healthspan Diagnostics LLC (Durham) Hemoglobin Diagnostics LLC develops microbiome therapeutics for next- develops biomarkers of aging for clinical (Research Triangle Park) develops diagnostic generation immune-modulation. use to help physicians predict risk of tests for clinically relevant hemoglobin chemotherapy-induced toxicities and variants for use in screening, confirmations Gyrus Pharmaceuticals Inc. (Chapel Hill) surgery-associated adverse events in various and point-of-care facilities. is developing treatments for serious patient groups. diseases of the central nervous system healthspandiagnostics.com HemoSonics LLC (Durham) is developing using proprietary therapeutic agents and an in vitro diagnostic platform that measures nanoparticles for noninvasive delivery Heat Biologics Inc. (Durham) develops the evolving stiffness of forming blood to the CNS. combination therapies for the treatment clots within a consumable test cartridge. Its gyruspharma.com of cancer. Heat Biologics is focused on technology assists with the management of T cell-stimulating therapeutic platform coagulation dysfunctions at the point of care. Hammock Pharmaceuticals Inc. (Charlotte) technologies used in combination with hemosonics.com licenses and develops women’s health checkpoint inhibitors. and urology products. It is developing a heatbio.com HepatoSys Inc. (Cornelius) develops metronidazole and clindamycin vaginal technologies for functional restoration of gel for the treatment of bacterial vaginosis donor livers for use in transplantation and and a urology product for the treatment of Promote your company research, focusing on methods for expanding radiation cystitis. in the next NCBiotech availability of quality human hepatocytes for hammockpharma.com Company Directory research and toxicity testing. hepatosys.com Happy Jack Inc. (Snow Hill) manufactures insecticides and pharmaceutical preparations In print and online. Heteroz LLC (Durham) supplies building to treat dogs. directory.ncbiotech.org/sponsor blocks and screening compounds for happyjackinc.com research and development and provides custom synthesis of organic and inorganic HDH Pharma Inc. (Morrisville) offers HeiQ ChemTex Inc. (Concord) develops and compounds for the chemical, pharmaceutical contract chemistry research services to the manufactures specialty chemicals for the and agrochemical industries. biopharma industry, including medicinal and carpet, textiles, paper, coated fabrics, oil field heteroz.com process chemistry; organic synthesis; CMC recovery and specialty surfactants industries. analytical and bioanalytical services; and Its product Bac-Shield contains a natural High Point Clinical Trials Center API intermediate, inhibitor and screening microbial extracted from snow crab shells. (High Point) conducts phase one and two compound provision. chemtexlaboratories.com clinical research studies to test emerging hdhpharma.com drugs for pharmaceutical companies. Hemo Bioscience Inc. (Morrisville) is hpctrialscenter.com Health Decisions Inc. (Durham) is a global an FDA-registered, ISO 13485-accredited clinical research organization that specializes manufacturer of blood-typing reagents and HIPRA Scientific USA LLC (Raleigh) in applying adaptive principles to both trial diagnostics for the blood-banking industry. researches and develops vaccines, diagnostics design and operations. hemobioscience.com and pharmaceuticals for animal health. healthdec.com hipra.com Hemodynamic Therapeutics (Durham) develops a small-molecule combination therapy for obesity-related hypertension. hemodynamictx.com

Raleigh, Charlotte, Durham and Wilmington placed in the top 20 best places for business and careers. orbes, The est Places for usiness and areers,

20 | ncbiotech.org/directory HOMS LLC (Pittsboro) develops, Hyperbranch Medical Technology Inc. Immunolight LLC (Belville) develops manufactures and markets natural products (Durham) is a biosurgical device company immune modulating photopheresis for pest management. focused on the design, development and technology to treat cancer tumors. homs.com manufacture of resorbable surgical sealants immunolight.com for general and specialty surgery use. Hongene Biotechnology USA Inc. hyperbranch.com ImmunoReagents Inc. (Raleigh) (Morrisville) develops and manufactures manufactures primary and secondary bioreagents such as nucleosides, nucleotides Icagen Inc. (Durham) partners with global polyclonal antibodies used in research and in and phosphoramidite products. pharmaceutical and biotech companies to vitro diagnostics for the pharmaceutical and hongeneusa.com generate high-quality, advanced leads, with veterinary markets. expertise in kinases, GPCR’s, ion channels and immunoreagents.com Howard Associates LLC transporters. (Research Triangle Park) offers preclinical icagen.com Inanovate Inc. (Raleigh) has developed a contract research to the pharma industry, patented blood analysis system (the Bio-ID) primarily on rodent models to predict the ICON Clinical Research LLC (Durham) for diagnostic tests. The first application of efficacy of experimental compounds for provides drug development and clinical the Bio-ID is a new blood test to detect breast CNS diseases and to predict side effects. services, from compound selection to phase cancer recurrence at a stage when it may still The company also offers science editing one through four clinical studies, in areas be cured. and writing. including oncology, cardiovascular and inanovate.com biosimilars. HRF Inc. (Raleigh) is a plasma center that iconplc.com Indexus Biomedical LLC (Morrisville) provides human blood plasmas for bioscience designs, develops and manufactures research. Ideal Health Biotechnology LLC instrument systems, reagents and assays for hrfinc.com (Kannapolis) researches and develops in vitro diagnostics, initially focusing on the dietary supplements made from plant-based hematology and immunology markets. HTX Technologies LLC (Chapel Hill) compounds, including products derived from indexusbiomed.com develops tissue imaging and molecular grape seed extract and algae for digestion, imaging technologies, with a primary eye disease and diabetes. Indicus Pharma LLC (Raleigh) develops focus on sample preparation and mass generic formulations in oral solid dosage spectrometry imaging. IDEXX Reference Laboratories Inc. forms, parenterals and ophthalmics. Products htximaging.com (Greensboro) provides animal health are manufactured at a partner facility in India. diagnostic products and services for use indicuspharma.com Humacyte Inc. (Morrisville) develops in small animals, equine, poultry and dairy a technology platform that isolates and livestock. It also provides microbiology-based IngateyGen LLC (Elizabeth City) develops grows stable investigational human tissue water testing products. and produces hypoallergenic peanuts replacements with potential regenerative idexx.com/corporate/home.html and fortified and enriched peanuts and medicine, vascular and nonvascular surgery yams through genomic and proteomic applications. ImmunogeniX Research LLC (Asheville) technologies. humacyte.com provides a cryonics biorepository for storage ingateygen.com of patient tumor cell samples, with the Huvepharma Inc. (Maxton) manufactures goal of using those cells in tumor vaccine Coccidiosis vaccines for in ovo and post-hatch immunology. vaccination of poultry. immunogenixresearch.com huvepharma.com

hipp-usa.com | (919) 755-1033 | [email protected]

HIPP Engineering & Consulting specializes in technology transfer, process scale-up and facilities design for cGMP/cGLP driven fields. We provide planning, design, project management, and start-up services for FDA and EMA regulated industries. Our talent acquisition division can provide short-term or long-term on-site engineering services.

Received NCBiotech investment North Carolina Bioscience Companies | 21 NC’s Evolving Sectors

North Carolina’s life science landscape, like its geographical and biological diversity, is unusually active and varied. Still, our life science foundation contains three sturdy pillars: human health, agricultural bioscience and industrial biotechnologies. As life science and related technologies evolve, they bring new opportunities. Sometimes the cutting edges of new discoveries begin to overlap and form even more possibilities at these points of convergence. Where North Carolina has potential for real strength in such convergence, NCBiotech works to transform them into new opportunities for the state. NCBiotech staff experts continually evaluate and encourage the best life science ideas from our partners across the state and around the globe. Then, as appropriate, they’ll establish focused initiatives to explore the possibilities for capitalizing on them.

22 | ncbiotech.org/directory Agriculture Contract Research Organizations Medical Devices North Carolina is a place where agricultural North Carolina is the birthplace of this world- From medical engineering labs to global tradition and 21st century science meet to changing industry and remains its global manufacturers of medical devices, North create unmatched research and business epicenter, because we have the scientific Carolina is rich in breakthrough technologies opportunities. minds to create new drugs and diagnostics, that enable faster, more precise, and less Here, virtually any ag tech company, and to help meet testing milestones to get expensive options for diagnosing and treating researcher, investor or holder of intellectual life-saving medicines to patients. medical conditions in animals and people. property will find unique opportunities for North Carolina is home to 150+ CROs North Carolina is home to companies transforming ideas into products. employing more than 24,000 people within developing everything from nanoscale This is evident in our 100+ ag tech companies the state and tens of thousands of others medical devices that can transport and treat, and hundreds of world-class ag tech scientists, around the world. These companies support all the way up to large robotic systems to including global thought leaders working in pharmaceutical, biotech and medical help surgeons create big changes through our colleges and universities. device companies and research institutions small incisions. And the state’s diagnostic with a wide range of services, including expertise includes tabletop “labs” for on-farm biopharmaceutical development, biologic early mastitis detection, all the way to quick assay development, commercialization, and efficient cancer and digestive disease preclinical and clinical research and clinical detection for humans. trials management.

Bio Defense Human Therapeutics Precision Health The NCBiotech Bio Defense program expands Human therapeutics, including North Carolina’s Imagine tailoring medical care to an the life science base of North Carolina’s $38 world-leading biomanufacturing facilities and individual’s unique characteristics, including billion defense economy. workforce enable new high-speed production susceptibility to disease and response to Our Bio Defense outreach goes far beyond of vaccines and other life-saving therapies. treatments. It’s possible with the tools of concerns over bioterrorism. NCBiotech and Huge global pharmaceutical companies are precision health. partners – North Carolina’s small companies, drawn to North Carolina for many reasons. North Carolina possesses the capacity in researchers and military representatives – are One of the biggest is our highly educated and its research and healthcare institutions, thinking more broadly. We work to provide uniquely skilled workforce. biomedical research and development vaccines for soldiers, to protect the food Adding to North Carolina’s rich life science capabilities, and information technology supply, and to find how best to deploy novel environment, our prestigious research companies to become a global leader in technologies that will protect our soldiers and universities every year spawn exciting precision health. heal those who sustain wounds in battle. new entrepreneurial ventures, many with NCBiotech and a seminal group of committed NCBiotech funding support. partners are working to develop the state’s full potential in this important area.

North Carolina Bioscience Companies | 23 Ingredion Inc. (Winston-Salem) Innovative Neurophysiology Inc. Invitrox Technologies, a division of manufactures ingredients for foods, (Durham) designs and develops advanced AIDIA Investment Group Inc. beverages and drugs from corn, tapioca, tools, equipment and methodology for (Research Triangle Park) detects wheat and potatoes. neuroscience research. microparticles (MP) in biologic fluids for ingredion.com inphysiology.com the development of novel diagnostics and personalized drug monitoring by providing Initos Pharmaceuticals LLC (Chapel Hill) is InovaChrom LLC (Candler) offers synthetic laboratory services to pharma, CRO and developing a platform delivery technology APIs, extracts and natural products, as academic clients. for nucleic acid therapeutics to develop well as identification, separation, isolation invitroxtechnologies.com agents to enhance intracellular delivery of and purification of organic compounds to oligonucleotides, peptides and proteins. industry and research universities. IProbeLabs Inc. (Research Triangle Park) inovachrom.com offers medicinal chemistry services, including Inivata Inc. (Research Triangle Park) design, structure optimization, structural- develops a noninvasive liquid biopsy Intarcia Therapeutics Inc. activity relationship (SAR) analysis and diagnostic using the precision of circulating (Research Triangle Park) is developing a preclinical studies of active pharmaceutical tumor DNA (ctDNA) analysis for improving continuous subcutaneous delivery system ingredients and drug leads. cancer detection and assessing individual for the treatment of Type 2 diabetes. The RTP response to treatment. location discovers and develops peptide IQVIA (Durham) provides technology- inivata.com therapeutic drugs to augment Intarcia’s drug enabled healthcare services to help biotech, delivery platform. medical device and pharmaceutical InnaVasc Medical Inc. (Durham) designs intarcia.com companies develop new therapies, identify and develops products for vascular access. unmet treatment needs and understand The company’s first technology is an Integrated Laboratory Systems Inc. the safety, effectiveness and value of arteriovenous graft (AVG) modification (Morrisville) provides GLP toxicology, pharmaceutical products. that facilitates graft access and safety in histopathology, molecular biology and iqvia.com hemodialysis. research and development services to innavasc.com government and commercial clients in IRIS BioMed LLC (Chapel Hill) is developing agro-chemical, biopharmaceutical and a wavelength-encodable compound that Innocrin Pharmaceuticals Inc. (Durham) environmental industries. delivers therapeutic agents to diseased sites discovers and develops a novel small- ils-inc.com with spatial and temporal precision. Potential molecule CYP17 lyase inhibitor that can applications include cancer, auto-immune be taken orally to treat castration-resistant Intelligent Implant Systems LLC diseases and vascular disorders. prostate cancer. (Charlotte) designs and develops all-sterile irisbiomed.com innocrinpharma.com medical devices for the spine, including single-use instrument sets. Isagro USA Inc. (Morrisville), a wholly- Innovate Biopharmaceuticals Inc. intelligentimplantsystems.com owned subsidiary of Isagro SpA, sells and (Raleigh) is developing novel medicines for markets crop protection products. autoimmune/inflammatory disease. InTox Biotech (Middlesex) provides The Morrisville office is a sales office. innovatebiopharma.com research and consulting in the areas of isagro-usa.com pesticide toxicology, immuno- and nucleic acid-based diagnostics, molecular biology, Isolere Bio Inc. (Durham) is developing a genomics, human and animal environmental chromatography-free purification technique risk assessment, forensic toxicology and for monoclonal antibodies that uses a novel arthropod control. affinity-phase separation based technology.

inds-inc.com | (734) 929-5392 | [email protected]

Specialized, complementary expertise to provide you nonclinical drug development support from target selection to product registration. Our team consists of board certified toxicologists, veterinarians, and information technology and business operations experts with more than 100 years of combined experience in the .

24 | ncbiotech.org/directory ISTARI Oncology Inc. (Durham) is Katharos Inc. (Apex) is developing a King Bio Inc. (Asheville) develops and developing immunotherapies for cancer phosphate-selective adsorption blood manufactures water-based homeopathic treatment. filtering medical device to treat high blood medicines and supplements for human and phosphate levels in end-stage renal disease companion-animal health. King Bio also JABB of the Carolinas Inc. (Pine Level) hemodialysis patients. provides contract manufacturing services. develops and manufactures fungal pesticides gust.com/companies/katharos_inc drkings.com and biopesticide products. Products are distributed through its partner company, KBI Biopharma Inc. (Durham, Research KlearOptix Inc. (Kannapolis) develops Terregena. Triangle Park) offers contract development advanced contact lens technology, including terregena.com and biopharmaceutical manufacturing bandage lenses for healing, intraocular lenses services such as formulation, analytical for cataract surgery and new materials for soft JC Med LLC (Kannapolis) develops algae- method development, stability services, lenses. based supplements and point-of-care process development and recombinant transforming-science.com/klear-optix diagnostics for evaluating insulin sensitivity. protein API manufacturing. KBI’s headquarters jcmed-usa.com are in Durham, and its process development Knightpoint Group LLC (Cary) offers facility is in Research Triangle Park. contract development and manufacturing Jericho Sciences LLC (Research Triangle Park) kbibiopharma.com services, specializing in parenteral and is developing antiviral therapeutics and respiratory drug delivery products. corresponding personalized diagnostics for Kepley Biosystems Inc. (Greensboro) Knightpoint Group is also developing a the clinical management of HIV-1 infection. employs nanotechnology to develop platform autoinjector technology to deliver jerichosciences.com applications that have commercial potential emergency drugs. in the life science sector. They are currently JLA International Inc. (Edenton) provides developing a synthetic crustacean bait. Kowa Research Institute Inc. (Morrisville), testing and analytical services for the food kepleybiosystems.com a division of Kowa Company Ltd., develops and beverage industry. It also provides therapeutic drugs for the treatment of technical consulting services. KeraNetics LLC (Winston-Salem) develops cardio-metabolic diseases such as diabetes jlaglobal.com and commercializes keratin-based and atherosclerosis, pain and sensory organ biomaterials for therapeutic and regenerative disorders. Kaio Therapy LLC (Raleigh) develops medical applications. kowaus.com immunotherapy technology to treat solid keranetics.com tumors. Krenitsky Pharmaceuticals Inc. kaiotherapy.com KindHeart Inc. (Chapel Hill) develops, (Chapel Hill) discovers and develops drug markets, sells and rents cardiac and thoracic candidates, with a focus on disorders of the KaryoLogic Inc. (Durham) provides real tissue surgical simulators. Simulators nervous system. chromosome analysis services to research are used for training for new technology, kpi-pharma.com laboratories. Services include G-band including robotic surgery, hemostasis and karyotyping of human and mouse stem cell sealants. KXTbio Inc. (Cary) develops and and cancer cell lines. kindheart.com commercializes reagents and assays for two karyologic.com major classes of drug targets, GTPases and G protein-coupled receptors. kxtbio.com

Jobs Board More than 63,000 North Carolinians have life science jobs. Here’s the most comprehensive listing of opportunities statewide. A one-stop shop to find a job or list an opening. ncbcjobs.ncbiotech.org

Received NCBiotech investment North Carolina Bioscience Companies | 25 Laboratory Corporation of America Leaf Technologies (Durham) provides yeast LigaTrap Technologies (Raleigh) develops (Burlington, Research Triangle Park, strains and fermentation solutions for fuel affinity chromatography resins and Morrisville and Kannapolis) provides clinical ethanol and bio-based chemical producers. purification buffers, ELISA kits and reagents, and anatomical laboratory services, including Leaf Technologies is a business unit of and recombinant proteins. LigaTrap also clinical trials testing services, and offers a Lesaffre. provides services including custom protein broad range of genomic and esoteric tests. leaftechnologies.com purification and analytical assay development. LabCorp’s Center for Occupational Testing in ligatrap.com Morrisville provides urine, hair, oral fluid and LeafPro LLC (Wilson) develops new point-of-collection drugs-of-abuse testing technologies for producing naturally Lindy Biosciences LLC (Durham) develops services. LabCorp’s Center for Molecular occurring proteins and coproducts from protein therapeutic formulations for non- Biology and Pathology in RTP provides plant biomass. standard formulations such as suspension laboratory testing services, focused in leafprobioproducts.com formulations (for high-concentration delivery diagnostic genetics, oncology and pathology. of antibodies), encapsulation (for sustained/ The LabCorp Biorepository is a state-of- Leica Microsystems Inc. (Morrisville) controlled release) or dry powder pulmonary the-art biorepository that has the capacity manufactures microscopes and scientific delivery. to house 15 million samples. In addition, instruments for the analysis of microstructures lindybio.com LabCorp has dozens of specimen collection and nanostructures. Its Morrisville site facilities across the state. develops optical coherence tomography Liquidia Technologies Inc. (Morrisville) labcorp.com imaging systems for ophthalmology utilizes PRINT technology, a particle preclinical research and surgery. engineering and manufacturing technology, LANXESS Solutions US Inc. (Gastonia) leica-microsystems.com/products/ to develop products in several areas manufactures specialty chemicals and crop optical-coherence-tomography-oct including pulmonary, pain, dermatology, protection products. ophthalmology and oral health. lanxess.com LemnaTec Corp. (Research Triangle Park) liquidia.com offers noninvasive sensor-based phenotyping Laudiss Labs LLC (Winston-Salem) uses of plants and other organisms for academia Locus Biosciences Inc. advanced proprietary platform technologies and industry. (Research Triangle Park) is developing for quantitative DNA and protein testing of lemnatec.com next-generation CRISPR technology for GMOs, foodborne pathogens and mycotoxins programmed cell death to kill target bacteria. in food and feed. LifeNet Health (Research Triangle Park) This platform enables the development laudiss.com provides transplant solutions, including of therapeutics for disease areas ranging cellular therapy research, organ procurement from resistant bacterial infections to the LCMS Limited (Durham) provides LC/ and bioimplant. The North Carolina facility microbiome. MS/MS services for the identification and isolates liver cells and adult stem cells for locus-bio.com quantification of compounds like proteins, applications in drug discovery and toxicity biomarkers, peptides and mAb’s. LCMS testing. Lonza RTP (Morrisville) provides bioscience specializes in detecting cross contamination lifenethealth.org products and services ranging from cell from manufacturing in food and drugs and culture and discovery technologies for provides custom training. LifeScape Biosciences Inc. (Charlotte) research to quality control tests and software lcmslimited.com develops prescription and nonprescription that ensures product quality. Its RTP site (OTC) pharmaceutical products and medical produces hepatocytes for use in drug foods made from FDA-designated “generally research. regarded as safe” (GRAS) substances. lonza.com lifescapebio.com

North Carolina ranked #6 for NIH funding awarded in 2017. esearch America,

26 | ncbiotech.org/directory LotusBioEFx LLC (Chapel Hill) develops Mallinckrodt Pharmaceuticals (Raleigh) Mayne Pharma USA (Raleigh and Greenville) venous catheters impregnated with manufactures acetaminophen, the active manufactures oral and topical dosage nanoscale clusters of metal alloys to inhibit ingredient in Tylenol, at its pharmaceutical branded and generic pharmaceuticals. Mayne formation of bacterial biofilms. facility in Raleigh. Pharma also provides contract development mallinckrodt.com and manufacturing services. The Raleigh Lucerno Dynamics LLC (Cary) is location is the company’s U.S. headquarters, commercializing a noninvasive device for MAPA Bioanalysis (High Point) is vTv and the Greenville site is Mayne’s contract quality assurance and control in nuclear Therapeutics’ bioanalytical lab, providing pharmaceutical development and medicine imaging. Future applications of bioanalytical and biomarker analysis for manufacturing division. the technology include immunotherapy and preclinical and clinical programs from drug maynepharma.com chemotherapy assessment. discovery to phase three. lucernodynamics.com mapabioanalysis.com MD Scientific LLC (Charlotte) developed the EndoTool Glucose Management System Lumedica Inc. (Durham) is developing a MARBIONC Development Group LLC and is currently developing a drug to prevent retinal optical coherence tomography (OCT) (Wilmington) is a nonprofit organization kidney and heart injury from iodinated system for point-of-care use. that develops and markets new products contrast agents. lumedicasystems.com and technologies derived from marine and mdscientific.com aquatic organisms. Lundbeck NA Ltd. (Charlotte) is a marbionc.org MDxHealth Inc. (Hillsborough) develops pharmaceutical development company epigenetic technologies to personalize the that acquires and develops products for Marble Labs LLC (Winston-Salem) provides diagnosis and treatment of cancer. the treatment of various human diseases, contract testing, process development, mdxhealth.com including central nervous system disorders. laboratory services and FDA and international lundbeck.com/us regulatory expertise to biotechnology MED-EL Corporation USA (Durham) companies. researches and develops cochlear MAA Laboratories Inc. (Raleigh) is implant technology. The Durham location reformulating and commercializing existing Marius Pharmaceuticals LLC (Raleigh) manufactures cochlear implants and is also proprietary anti-cancer small molecules, develops therapeutic treatments, with a focus the North American headquarters. with the purpose of enhancing therapeutic on oral testosterone replacement therapies medel.com/us efficiency for targeted drug delivery and for adult men. mitigating undesirable effects of currently mariuspharma.com Medicago USA Inc. (Durham) develops approved drugs. vaccines based on proprietary manufacturing maalaboratories.com Mastezellen Bio Inc. (Research Triangle Park) technologies and virus-like particles. The is developing therapeutics for the treatment vaccines are manufactured using a transient Magstim Inc. (Morrisville) develops of diseases and disorders with mast cell protein expression system in Nicotiana transcranial magnetic stimulators as a involvement. benthamiana, a close relative of tobacco. treatment for nerve and brain disorders. medicago.com magstim.com Maverick Synfuels (Research Triangle Park) converts biomass, municipal waste and natural gas into petroleum-free fuels and chemicals. maverickbiofuels.com

lfrep.com | (919) 299-1073 | [email protected]

Longfellow Real Estate Partners is the largest life science real estate developer in the Carolinas. Longfellow acquires, invests in, and develops laboratories and high-tech office space for life science and technology organizations, universities, medical centers and research institutes. We also provide leasing, facilities, property management and project management services.

Received NCBiotech investment North Carolina Bioscience Companies | 27 Medical Murray (Charlotte) is a contract Meridian Laboratory Corp. (Charlotte) Microban International Ltd. (Huntersville) developer and manufacturer of medical provides CLIA-certified and COLA-accredited develops and manufactures antimicrobial, devices with a focus on minimally-invasive patient testing services, as well as testing of odor control and surface modification systems, permanent implants, injection water quality for use in dialysis. technologies used in consumer, industrial and molding and specialty materials meridianlaboratory.com medical products. Microban also provides (e.g. bioabsorbables and nitinol). contract bacterial and fungal testing in BSL-2 medicalmurray.com Meryx Inc. (Chapel Hill) is developing test labs. small-molecule, orally-bioavailable RTK microban.com MedKoo Biosciences Inc. (Morrisville) inhibitors that inhibit growth and initiate anti- manufactures, sells and distributes small- tumor immunity in hematologic and solid MicroElastic Ultrasound Systems Inc. molecule anticancer chemical reagents and malignancies. (Durham) is developing an ultrasound device kinase inhibitors for oncology research and meryxpharma.com to measure the progression or regression of provides drug discovery contract research graft-versus-host-disease (GVHD). services. microelastic.com medkoo.com See Us Online Midatech Pharma US Inc. (Raleigh) Search the NCBiotech MedPharm (Durham), through its U.S. develops and commercializes oncology Company Directory at subsidiary MP Pharma Services, provides ncbiotech.org/directory treatments and supportive care. contract topical and transdermal product midatechpharma.com research and development. medpharm.com Merz North America Inc. (Raleigh) develops Midnight Pharma LLC (Morrisville) is and commercializes treatment solutions in developing a treatment for insomnia. MEDTOX Diagnostics Inc. (Burlington) aesthetics and neurosciences. manufactures and distributes instant drugs merzusa.com Mimetics LLC (Durham) provides a suite of abuse testing devices for use by the of biocomputation algorithms for analyzing government, hospital and medical centers Metabolon Inc. (Morrisville) develops cellular-level networks from gene expression and workplace markets. metabolomics tools for life sciences data. medtoxdiagnostics.com research, including precision medicine, mimeticsbiosci.com population health initiatives and academic Medyn Bioscience LLC (Durham) provides studies. Its technology is used for biomarker Minu LLC (Chapel Hill) researches and customized reagents for diagnostic testing identification, diagnostic test development develops ophthalmology products. and recombinant virus antigens for in vitro and genomics research. diagnosis. MedynBio also conducts research metabolon.com Mirimichi Green Express LLC of blood diseases and disorders. (Castle Hayne) manufactures nontoxic medynbio.com Metalytics LLC (Morrisville) develops landscape products, including turf and tree software technologies and provides sample care products, seed and soil enhancers and Melinta Therapeutics Inc. (Chapel Hill) analysis services to assess cellular metabolism protectants, and weed and grass control develops antibiotics for treating drug- in order to optimize cell-based manufacturing herbicides. resistant bacterial infections. of biochemicals, drugs and foods. mirimichigreen.com melinta.com metalytics.bio Mispro Biotech Services Corp. Merakris Therapeutics LLC Micell Technologies Inc. (Durham) (Research Triangle Park) provides contract (Research Triangle Park) develops develops combination-product therapies research, vivarium space, remote animal biotherapeutic technologies derived from for interventional cardiology. Micell markets husbandry services and remote facility stem cells that promote homeostasis in MiStent, a drug-eluting stent, in Europe and management. damaged tissue. certain other regions. misprobiotech.com merakris.com micell.com Mlinzi Vaccines LLC (Raleigh) is developing Merck & Co. Inc. (Durham and Wilson) Microbac Laboratories Inc. and commercializing customizable, manufactures elements of Varivax, a chicken (Wilson and Fayetteville) offers chemical portable, 3D architected structures for rapid pox vaccine, and other vaccine products at and microbiological testing services for the regeneration of affected tissue. its Durham facility. Merck’s Wilson facility agrochemical, pharmaceutical, tobacco and mlinzi.com produces patented prescription products consumer products industries at its laboratory and performs granulation and tableting in Wilson. Microbac offers microbiological operations. testing and sampling services for wastewater, merck.com environmental and food safety purposes at its laboratory in Fayetteville. microbac.com

28 | ncbiotech.org/directory Molecules in Action LLC (Chapel Hill) provides custom molecular modeling, virtual drug screening, molecular simulations and consulting services. Is your life science company looking for moleculesinaction.com short-term office space? MOLTOX (Boone) manufactures reagents, assay kits and other products for genetic toxicology research and testing, as well as Let us help you find your first square products for industrial microbiology and quality control. foot in North Carolina, a global life moltox.com science leader.

Momentum Research Inc. (Durham) The North Carolina Biotechnology Center’s manages and directs phase one through four Landing Pad offers both prime office space clinical research projects and specializes in and an array of professional services to cardiovascular clinical trials management. cushion your landing as you establish your momentum-research.com company in North Carolina’s renowned life science hub, the Research Triangle Park. MonomerChem Inc. (Durham) provides contract drug development services, Learn more at ncbiotech.org/landingpad including custom synthesis, medicinal chemistry, lead optimization and synthesis of reference standards and metabolites. customsynthesis.com

Monsanto Co. (Mount Olive) operates a crops research station in Mount Olive. monsanto.com

Mucodel Pharma LLC (Greensboro) develops technologies for enhancing drug delivery via mucosal routes of administration. Its first candidate is a buccal gel for emergency treatment of opioid overdose. exonal.com

Mucommune LLC (Chapel Hill) researches improved protection against infectious 15 T.W. Alexander Drive | Post Office Box 13547 | Research Triangle Park, NC 27709-3547 diseases transmitted at mucosal surfaces. 919-541-9366 Mucommune’s current focus is a method to prevent sexually transmitted infections using Photo: Jim Sink monoclonal antibodies encapsulated in a polymeric capsule. Mycosynthetix Inc. (Hillsborough) manages NanoCor Therapeutics Inc. (Chapel Hill) Mycorrhiza Biotech LLC (Burlington) a large collection of fungal isolates and develops an intracellular genetic protein develops products and services to improve discovers novel fungal metabolites for human therapy for the treatment of chronic heart plant production. They specialize in fungi and and animal health and compounds for failure. allied organisms for diverse applications in agricultural applications. nanocortherapeutics.com agri-business. mycosynthetix.com mycorrhizabiotech.com NanoDiagnostic Technology LLC NanoBiologiX Inc. (Chapel Hill) develops (Kannapolis) develops nanotechnology- targeted chemotherapeutics to treat cancer based portable analytical devices for onsite using nanotechnology. rapid and sensitive detection of toxic nanobiologix.com chemical exposure and diseases at the point of care.

Received NCBiotech investment North Carolina Bioscience Companies | 29 NanoMedica LLC (Winston-Salem) NeuroAnalytics LLC (Durham) provides Noah’s Inc. (Charlotte) cultivates algal provides ultrasensitive detection reagents testing and analysis of tobacco products. biomass for the manufacture of astaxanthin and nanotechnology-based drug discovery extract, used as an antioxidant, fortifier services and tools to biopharmaceutical NeuroNano Pharma Inc. (Raleigh) is and carotenoid additive in nutraceutical companies as well as DNA and RNA developing polymer-based therapeutics for ingredients, cosmetic ingredients, and for the sequencing services. CNS diseases and cancer. fish, animal, food and beverage industries. nanomedica.com neuronanopharma.com North Carolina Clinical Research (Raleigh) NanoVector Inc. (Raleigh) is NeuroPro Therapeutics Inc. (Bahama) is conducts phase one through four trials at commercializing a plant virus nanoparticle to developing new drugs to treat epilepsy and its outpatient clinical research facility. Study develop a family of targeted-delivery, small- other CNS disorders. indications include allergy (seasonal and molecule cancer drugs. perennial), asthma, COPD, vaccine, migraine nanovectorinc.com NeuroTronik Inc. (Durham) develops and bioequivalent studies. medical technology for the treatment of nccr.com Natland International Corp. (Morrisville) acute heart failure syndrome. provides contract research synthesis of North Carolina Microbiology Laboratory pharmaceuticals and custom organic Nexgen Biosciences (Raleigh) is developing (Lincolnton) offers microbiology testing chemicals. next-generation anti-infective therapeutics services for the indoor air quality and wood natland.com effective against antibiotic-resistant strains of products industries. Services include fungal micro-organisms. identification, bacterial identification and Natural Discoveries Inc. (High Point) nexgen-bio.com product decay resistance characterization. provides biologically-active natural ncmlab.com products from remote areas of the world Nicox Ophthalmics (Research Triangle Park) for analysis, research and manufacturing to develops a nictric oxide-donating research NovaCyte LLC (Winston-Salem) isolates the pharmaceutical, agricultural and natural platform and products to help maintain vision cells from donor corneas to grow products industries. and improve ocular health. replacement corneal tissue on a scaffold as natdiscov.com nicox.com a bioengineered equivalent to the current standard of care. Natural Products & Glycotechnology NIRvana Sciences Inc. novacytellc.com Research Institute Inc. (Pittsboro) (Research Triangle Park) is commercializing develops new methods for the synthesis red and near-infrared fluorescent dyes for use Novan Inc. (Durham) develops therapies of oligosaccharides to be used in the in diagnostics and imaging applications. for dermatological conditions using its nitric development of vaccines or diagnostic nirvanasciences.com oxide-releasing nanoparticle technology. tools and also in improved synthesis of novan.com ribonucleotides. Nitta Gelatin NA Inc. (Morrisville and Fayetteville) manufactures NovaTarg Inc. (Research Triangle Park) Nature’s Pearl Corp. (Advance) food, pharmaceutical and technical gelatin, discovers and develops new medicines to manufactures nutraceutical and and is the maker of beMatrix Low Endotoxin treat metabolic diseases and cancer. cosmeceutical products from muscadine Gelatin. beMatrix is used in the fields of novatarg.org grape seeds and skins. Its products are regenerative medicine, medical devices and manufactured in a cGMP facility and have scientific research. been studied in clinical trials for efficacy. nitta-gelatin.com naturespearlproducts.com

Jobs Network All North Carolina life science professionals are welcome to the free monthly NCBiotech Jobs Network meetings to hone interview skills, meet recruiters and learn about job opportunities. ncbiotech.org/jobsnetwork

30 | ncbiotech.org/directory Novella Clinical, a Quintiles company Novozymes North America Inc. Nutrigene Sciences LLC (Kannapolis) (Morrisville and Wilmington) provides full- (Franklinton) researches, develops and develops genetic tests and nutrition-based, service, global clinical research organization manufactures enzymes, microorganisms medical foods to treat genetically-caused (CRO) services focused on oncology, and biopharmaceutical ingredients used metabolic disorders. dermatology and medical device and in industries including agriculture, baking, nutrigenesci.com diagnostics companies. biofuels, brewing, detergents, food, feed and novellaclinical.com textiles. The Franklinton site manufactures Oak-Bark Corp. (Riegelwood) develops and enzymes. manufactures semi-bulk and bulk chemicals, Novex Innovations LLC (Winston-Salem) is novozymes.com specializing in organosulfur products. a contract development and manufacturing oak-bark.com organization (CDMO) supporting small Nu Chemie LLC (Charlotte) is developing and startup life science companies in and commercializing nanomaterials for drug Ocis Biotechnology Inc. (Wilmington) the development of their products, from delivery and water soluble and traceable develops implantable custom hydrogel concept through manufacturing and bioconjugation reagents. NuChemie also medical devices for surgical implantation commercialization. provides custom synthesis services. and injection that produce time-released novexinnovations.com nuchemie.com biologics for tissue regeneration. ocisbiotech.com Novo Nordisk Pharmaceutical Industries LP NuBioPharma LLC (Sanford) develops (Clayton) manufactures insulin, GLP-1 and formulates novel liquid OliVentures Inc. (Raleigh) is developing products and prefilled delivery devices for the with child-friendly flavors for debilitating olive oil polyphenol and omega-3 fatty treatment of diabetes at its Clayton site. orphan diseases. Therapeutic areas include acid supplements and products to support novonordisk-us.com gout, pulmonary arterial hypertension and cardiovascular, breast and joint health. thrombocythemia. oliventuresinc.com Novoclem Therapeutics (Durham) uses a nubiopharma.com nitric oxide technology for the treatment of OncoTAb Inc. (Charlotte) develops and cystic fibrosis and other respiratory diseases. Nufarm Americas Inc. (Morrisville) commercializes diagnostic blood tests novoclem.com manufactures and markets insecticides, designed to detect breast cancer and fungicides, plant growth regulators and develops an immunotherapy for the Novozymes BioAg (Morrisville and Durham) herbicides. This site serves as Nufarm’s treatment of pancreatic cancer. develops microbial-based biofertility, primary research and development facility in oncotab.com biocontrol and bioyield enhancer products the United States. for agriculture. The Morrisville site focuses on nufarm.com Oncotide Pharmaceuticals Inc. (Durham) fermentation and production technology. The discovers and develops immunotherapeutic Durham site focuses on product research and NuPulseCV (Raleigh) is developing an drugs that directly activate tumor development. implantable cardiovascular left ventricular suppressors, the same tumor suppressors novozymes.com assist device to treat people suffering from activated by checkpoint inhibitor antibodies. congestive heart failure. Oncotide has also developed a companion nupulsecv.com diagnostic. oncotide.com Nutra-Pharma Manufacturing Corp. of N.C. (Lexington) manufactures vitamins, supplements and other wellness products.

NC medical and 9 pharmacy schools

Received NCBiotech investment North Carolina Bioscience Companies | 31 OncoTrap Inc. (Chapel Hill) is developing Ostrea Bio Inc. (Chapel Hill) develops Patrin Pharma Inc. (Salisbury) develops a nucleic acid delivery platform for therapies for the treatment of lysosomal pharmaceutical products, primarily accommodating nucleic acid-based storage diseases. oral dosage forms for gastrointestinal, therapeutics, designed to deliver therapeutic ostreabio.com cardiovascular, antiviral, antibacterial and genes to tumor sites. central nervous system indications. oncotrap.com Pace Analytical Services Inc. patrinpharma.com (Huntersville, Asheville, Eden and Raleigh) OnSite Remediation LLC (Cary) develops provides environmental testing services, Pearl Therapeutics Inc. (Durham), and uses naturally-occurring microbes, analytical services and field sampling. a subsidiary of AstraZeneca, develops mechanical separators, coalescing units pacelabs.com combination therapies and formulations of and filtration systems for the removal of inhaled drugs for chronic respiratory diseases contaminants from water and soil. Panaceutics Inc. (Research Triangle Park) such as asthma and COPD. onsiteremediation.com creates and sells customized nutritional astrazeneca.com/our-focus-areas/ supplement formulas in personalized pearl-therapeutics.html OpAns LLC (Durham) provides analytical gel-packs. services to support discovery, preclinical, panaceutics.com Pfizer Inc. (Chapel Hill, Rocky Mount, toxicology and clinical studies. Sanford) in Chapel Hill develops gene opans.com PAREXEL International Corp. (Durham) therapies to treat rare genetic central nervous provides drug-development and launch system (CNS) and neuromuscular diseases, Oriel Therapeutics Inc., a Sandoz services, including clinical development, including Giant Axonal Neuropathy (GAN), company (Durham) operates as Sandoz’ integrated advanced technologies, regulatory Canavan Disease, Friedreich’s Ataxia and product development center, which develops affairs consulting and commercialization Duchenne Muscular Dystrophy (DMD). respiratory products as generic alternatives to services. Pfizer’s Rocky Mount facility manufactures patented drugs for asthma and COPD. It also parexel.com injectable hospital products. The facility also develops and commercializes pre-metered provides contract manufacturing services such as aseptic filling, lyophilization and unit and multi-dose dry powder delivery Parion Sciences Inc. (Durham) develops terminal sterilization. Pfizer’s Sanford facility systems. therapies to treat defects of the innate manufactures clinical trial and commercial us.sandoz.com mucosal defense system in respiratory and drug substance materials for conjugate ophthalmology diseases. vaccines. Ortho Dermatologics, a division of parion.com pfizer.com Valeant Pharmaceuticals International Inc. (Raleigh) manages and markets Valeant’s Path BioAnalytics Inc. (Chapel Hill) PharmaChemCore Inc. (Carrboro) provides prescription dermatology portfolio, which develops rheological assays for testing custom design, synthesis and production includes acne, anti-fungal and anti-infective trans-mucosal drug delivery systems, of novel organic compounds, including products. mucolytic compounds, inhaled medications pharmaceutical intermediates and active ortho-dermatologics.com for respiratory diseases, antimicrobials and pharmaceutical ingredients (APIs). The treatments for diseases that impact the company also offers organic reagents Osmotica Pharmaceutical Corp. body’s mucosal layers. including organo-catalysts. (Wilmington) specializes in drug-delivery pathbioanalytics.com pharmachemcore.com technologies and neurology-based therapies, including a treatment for Parkinson’s disease. Pathfinder Pharmaceuticals Inc. (Durham) osmotica.com specializes in early stage drug discovery, with a focus on cancer therapy. pathfinderpharma.com

North Carolina won the Prosperity Cup for the most competitive state for the fourth year. ite election agazine Prosperity up,

32 | ncbiotech.org/directory PharmaDirections Inc. (Cary) provides PhotonMD Inc. (Morrisville) is developing Pique Therapeutics Inc. (Durham) develops virtual drug development services with photomedicine devices for aesthetic therapeutic vaccines for the treatment of primary competencies including discovery, applications and to treat chronic autoimmune cancer. formulation, CMC, DMPK, toxicology, and inflammatory diseases and other piquetherapeutics.com regulatory and global project management conditions. across all functions. photonmedical.com Pisgah Labs Inc. (Pisgah Forest) pharmadirections.com manufactures active pharmaceutical Physcient Inc. (Durham) develops new ingredients on a contract basis. Pisgah PharmAgra Labs Inc. (Brevard) conducts surgical tools designed to decrease tissue Labs’ cGMP facility includes an aseptic contract research and development in damage. Physcient is developing a dissector manufacturing suite. organic chemistry for industries including that differentiates between tissue types for pharma/biotech and electronics. PharmAgra laparoscopic, thoracic, endoscopic, plastic Plakous Therapeutics LLC (Winston-Salem) also offers cGMP services including clinical and general surgery. is developing biotherapeutics from post- trial materials supply and low-volume API physcient.com delivery placenta to promote regenerative manufacturing. healing for diseases including osteoarthritis, pharmagra.com Physicians Laboratories (Kernersville) necrotizing enterocolitis, wound healing and produces and distributes Revival Soy protein tissue engraftment. Pharmgate Animal Health LLC products and diet products. plakoustherapeutics.com (Wilmington) develops and markets soy.com medicines and vaccines for the control of Plant Health Care Inc. (Raleigh) develops disease in livestock and poultry in North Phytonix Corp. (Black Mountain) and provides novel biological products and America. develops and commercializes technologies technologies to promote plant health and pharmgateah.com and manufacturing processes that increase crop yields. photosynthetically convert CO2, with solar planthealthcare.com Pharm-Olam International energy and water, into low-cost chemicals (Research Triangle Park) provides phase one and fuels like n-butanol. Plant Impact Inc. (Morrisville) researches through four clinical research services to the phytonix.com and develops crop enhancement products, pharmaceutical, biotech and medical device including foliar sprays and seed coatings. industries. PhytoPharmacon Inc. (Garner) offers The RTP office directs research and is the pharm-olam.com high-throughput screening, lab and pilot company’s North American headquarters for scale extract processing, downstream lead sales, marketing and technical support. Phenogen Sciences Inc. (Charlotte) processing and purification and full-scale plantimpact.com provides predictive testing and risk supply of natural products for the food, assessment tools that help physicians nutraceutical, cosmetic and pharma research PlantResponse Biotech Inc. proactively manage patient health. and industries. (Research Triangle Park) develops solutions phenogensciences.com phytopharmacon.com to different types of botanical stress for crop management. PHITONEX Inc. (Durham) is developing Piedmont Animal Health LLC (Greensboro) plantresponse.com molecular-scale optical devices with an initial develops, licenses and markets animal application to flow cytometry. health therapeutics with a focus on major phitonex.com companion-animal categories. piedmontanimalhealth.com

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Received NCBiotech investment North Carolina Bioscience Companies | 33 Plureon Corp. (Winston-Salem) develops a Practichem LLC (Morrisville) develops Premier Research (Research Triangle Park) technology platform based on pluripotent biotech tools for research, including provides clinical development services for stem cells extracted from amniotic fluid chromatography instruments that can biotech and specialty pharma companies, and placenta. These cells may be used in be controlled remotely, and associated with a focus on analgesia, CNS, medical regenerative medicine and other therapies. consumables, including protein device, oncology, pediatric and rare disease plureon.com chromatography, flash and preparative research. chromatography and sample loading premier-research.com Polarean Inc. (Durham) designs and technology. manufactures equipment for production of practichem.com Procter & Gamble (Greensboro) hyperpolarized xenon or helium gas for use in manufactures Vicks and other over-the- MRI. Investigational uses include identifying Praetego Inc. (Raleigh) is developing counter products at this facility. early diagnoses of respiratory diseases as well prophylactic therapies for surgical and pg.com as monitoring progression and therapeutic critical care patients. Its lead candidate is an response. intravenous formulation to protect against Promethera Biosciences LLC (Durham) polarean.com the development of acute kidney injury (AKI) develops, produces and markets cell following cardiac surgery. therapeutic products, including human liver Polyzen Inc. (Apex) is a contract praetego.com cells, to treat liver diseases. manufacturer that designs, develops, and promethera.com manufactures polymer-based medical Precise Bio Inc. (Winston-Salem) grows live devices. Polyzen has polymer processing and vital complicated organs for transplant PSI CRO (Durham) offers full-service contract capabilities for prototyping and volume using 3D bio-printing. research services supporting phase one production. precise-bio.com through phase four clinical trials globally polyzen.com across multiple therapeutic areas. Precision BioSciences Inc. (Durham) psi-cro.com Powered Research LLC utilizes a proprietary genome-editing method (Research Triangle Park) provides contract called ARCUS to treat cancers and genetic Pulmonix LLC (Greensboro) conducts phase research services to life sciences companies diseases, and enable the development of two to phase four clinical trials in pulmonary, using both established and novel nonclinical safer, more productive food sources. asthma, sleep and critical care medicine. models. precisionbiosciences.com pulmonixresearch.com poweredresearch.com Precision PlantSciences Inc. (Durham) Puratec LLC (Raleigh) is developing an PPD (Wilmington and Morrisville) a develops Precision Biosciences’ technology, antimicrobial Foley catheter. global contract research organization, called Directed Nuclease Editor, to site- provides comprehensive, integrated drug specifically insert or remove traits at a user- Purdue Pharma Manufacturing LP development, laboratory and lifecycle defined location in the genome of row crops, (Durham and Wilson) develops management services to pharmaceutical, biofuel feedstocks and other plants. pharmaceuticals to treat pain. The Durham biotechnology, medical device, academic and precisionbiosciences.com location is an oral solid dosage manufacturing government organizations. plant. The Wilson plant manufactures, ppdi.com Premex Innovation Labs (Durham) packages and distributes oral solid-dose develops, manufactures and markets tablets and is the company’s distribution PRA Health Sciences (Raleigh) provides nutritional ingredients for animals. This center for prescription products. clinical research and trial services for all location conducts research on feed additives purduepharma.com phases of clinical development. for animal nutrition. prahs.com premex.co/en/nutrition

700+ life science companies across North Carolina

34 | ncbiotech.org/directory Q² Solutions (Morrisville) offers clinical QuarTek Corp. (Asheboro) develops Rappta Therapeutics Inc. (Cary) is trials lab services to biopharma, device and nanotechnology processes with applications developing compounds to activate a potent diagnostics customers. Services include in antimicrobials, advanced textiles, tumor suppressor protein and induce central laboratories, bioanalytical, ADME, nanosensors, diagnostics and biofuels. The apoptosis in cancer cells. genomics, biomarkers and companion company also provides accelerator services rappta.com diagnostics to support drug discovery and for startup nanotechnology companies. precision medicine. quartekcorp.com Recipharm Laboratories Inc. (Morrisville) q2labsolutions.com provides contract inhalation, injectable and QuatroBio LLC (Morrisville) provides semi-solid product development. Services Qatch Technologies LLC (Durham) oversight and strategic direction to several include formulation development, analytical develops microfluidic sensor technology to closely held drug development companies. and stability testing, scale-up and tech measure blood coagulation in point-of-care transfer, and cGMP manufacturing for clinical diagnostic tests. trial material. qatchtech.com recipharm.com/locations/ Promote your company research-triangle-park QOL Medical LLC (Raleigh) commercializes in the next NCBiotech existing and complementary new orphan Company Directory Redbud Labs (Chapel Hill) develops and products for metabolic disease and pediatric manufactures microfluidic mixing chips that gastroenterology. use micro-electromechanical systems (MEMS) In print and online. qolmed.com technology called Redbud Posts. directory.ncbiotech.org/sponsor redbudlabs.com QPS Hepatic Biosciences (Research Triangle Park) specializes in RedHill Biopharma Inc. (Raleigh) develops hepatocyte research, drug metabolism, drug Qura Therapeutics LLC (Chapel Hill) is and commercializes orally-administered, transporter services and in vitro drug-drug discovering therapeutics for curing HIV/AIDS. small-molecule drugs for the treatment of interactions. Qura is a joint venture between GSK and UNC gastrointestinal and inflammatory diseases, qps.com Chapel Hill, and provides financial, material including cancer. Its Raleigh site is the and development support for the therapies company’s U.S. commercial headquarters. Qualicaps Inc. (Whitsett) manufactures that emerge from research at the UNC HIV redhillbio.com empty two-piece capsules (gelatin and Cure Center. hypromellose) and encapsulation equipment hivcurecenter.web.unc.edu/qura-therapeutics Regenerative Cell Solutions LLC under cGMP regulations for use by (Winston-Salem) develops tissue and organ pharmaceutical, OTC and dietary-supplement R&S Chemicals Inc. (Kannapolis) offers regeneration applications for veterinary manufacturers. research, development and manufacturing medicine, diagnostics and pharmaceutical qualicaps.com services for the chemical and pharmaceutical research and development. industries. Services include custom synthesis Quality Chemical Laboratories in organic synthesis, process chemistry, Relion Manufacturing Inc. (Asheville) (Wilmington) offers contract formulation medicinal chemistry and drug discovery and provides contract manufacturing, testing and development, manufacturing and analytical chemical research. packaging services for the pharmaceutical, and microbiological testing, including raw- randschemicals.com medical device and personal care industries. material and finished-product testing, stability relioninc.com testing, method development, validation and Radiant Neurosciences LLC custom synthesis. (Durham) develops medicines to treat qualitychemlabs.com neurodevelopmental disorders in children.

2,000+ NC postdoctoral fellows in the life sciences

Received NCBiotech investment North Carolina Bioscience Companies | 35 Renovion Inc. (Durham) develops therapies RF Wastewater (Raleigh) focuses on Roivant Sciences Inc. (Durham) acquires for lung transplant patients and chronic biological wastewater treatment, using drug candidates or partners with the inflammatory airway diseases including cystic lignocellulosic materials as biofilm media biopharma industry to complete the clinical fibrosis, asthma and COPD. for activated sludge system retrofits and development of shelved product candidates. renovion.com upgrades. Therapeutic areas include neurology, rfwastewater.com dermatology, hepatology, oncology, Rescindo Therapeutics Inc. (Durham) endocrinology and rare disease. discovers novel therapeutic targets and RFPi Inc. (Greenville) is developing a non- roivant.com drugs for human genetic disorders based on invasive surgical imaging platform technology humanized zebrafish in vivo modeling. licensed from East Carolina University. The RTI Health Solutions (Research Triangle Park) technology provides immediate view of is a nonprofit organization that provides Research Triangle Park Laboratories Inc. physiology and qualifies blood flow during biopharmaceutical companies clinical (Raleigh) provides contract analytical the procedure. research services and research and consulting laboratory services for the environmental, rfpi-co.com in health economics, outcomes research, pharmaceutical, biotechnology, dietary market access, and drug safety. supplements and manufacturing industries. Rho (Research Triangle Park) provides clinical rtihs.org rtp-labs.com development and contract research services to the biotechnology, pharmaceutical and RTI International (Research Triangle Park), Resinnate Therapeutics LLC (Durham) medical device industries. an independent, nonprofit institute, offers develops immunotherapies for the rhoworld.com scientific and technical expertise in social prevention and treatment of respiratory and laboratory sciences, engineering and infections. Ribometrix Inc. (Durham) is a platform international development to government resinnate.com therapeutics company discovering small- and commercial clients worldwide. molecule drugs that target functional RNA rti.org Retroject Inc. (Chapel Hill) is developing a structures to create new avenues to treat device to deliver glaucoma drugs to targeted human disease. RTI Surgical Inc. (Greenville) develops and sites in the eye. ribometrix.com provides surgical implants, including biologic, metal and synthetic implants. Reveris Therapeutics LLC (Chapel Hill) RiboWiz Scientific Inc. (Raleigh) uses a rtix.com/en_us develops novel therapeutics for triple proprietary platform to offer customized negative breast cancer (TNBC). software services and cloud-based SafeRay Spine LLC (Durham) develops reveris.com subscription licensing to accurately predict medical imaging devices that may help to and maximize protein production for life reduce radiation exposure and improve the Revivo Therapeutics Inc. (Durham) science companies. safety of fluoroscopy procedures. develops treatments for Alzheimer’s disease ribowiz.com lessray.com that targets both early symptoms and the progression of the disease. Rockwell Automation Life Sciences Salix Pharmaceuticals Inc. (Raleigh) revivotherapeutics.com (Cary) provides automation control, process develops and markets prescription optimization and execution systems for pharmaceutical products for the treatment of manufacturers. Rockwell’s Cary location is the gastrointestinal diseases. headquarters for the Americas’ life sciences salix.com division. rockwellautomation.com/global/ industries/life-sciences/overview.page

Exchange Groups Exchange groups are communities of academic, government and other life science professionals who gather for informational seminars, discuss their science, network, nd potential partners and create new ideas. ncbiotech.org/exchange-groups

36 | ncbiotech.org/directory Salzburg Therapeutics Inc. (Yadkinville) Sciteck Inc. (Fletcher) provides forensic drug Sentiens LLC (Charlotte) develops is developing systems that deliver activated testing services and diagnostic products. nutraceutical products targeting addictive forms of anticancer drugs, nucleic acid drugs Sciteck develops, manufactures and sells behavior. and nanoparticles directly to cancer cells. products for biotechnology, urinalysis, clinical sentiens.us sztipharm.com chemistry, toxicology, pharmaceuticals, treatment and safety applications. Sentinel Biomedical Inc. (Raleigh) develops Sandoz Inc., a Novartis Division (Wilson) sciteck.org and offers molecular diagnostics for the develops generic and biosimilar medicines. detection and monitoring of canine cancers. Its facility in Wilson manufactures oral-dosage ScitoVation LLC (Research Triangle Park) Sentinel also offers CRO services in the areas generic pharmaceuticals. supports and advances research on of molecular biology and genomics. us.sandoz.com the effects of chemical compounds on sentinelbiomedical.com human health. ScitoVation works with Sanesco International Inc. (Asheville) clients to develop safer pharmaceuticals, SePRO Research & Technology Campus develops clinical tools for healthcare food ingredients, agricultural chemicals, (Whitakers) acquires, develops, manufactures providers, such as neuroendocrine analytical commodity chemicals and consumer and markets products for aquatics and testing, nutritional support formulas products. horticulture. SePRO’s research and technology and patient-centered clinical review. The scitovation.com campus in Whitakers is the primary research NeuroLab division conducts research and and development site for the company. development of in vitro diagnostic tools. Seachaid Pharmaceuticals LLC (Mebane) sepro.com sanescohealth.com is a clinical-stage company that discovers and develops human therapeutics. Seqirus, a CSL Company (Holly Springs) Scientific Analytical Institute Inc. seachaid.com manufactures influenza vaccines using both (Greensboro) conducts environmental, indoor egg-based and cell-based technologies. air quality, forensic and materials testing. SeaTox Research Inc. (Wilmington) seqirus.com sailab.com develops bioassays for the detection of marine toxins and conducts pharmaceutical Serum Source International Inc. SciKon Innovation Inc. development through bioprospecting. (Charlotte) supplies animal serum for life (Research Triangle Park) creates life science seatoxresearch.com science cell culture research, contract products that replicate the performance research laboratory use, bioprocessing and of human organ systems using benchtop Select ImmunoGenomics Inc. (Apex) product development. microfluidic devices. Products simulate provides data analysis, predictive modeling serumsourceintl.com pharmacokinetics to evaluate human and reporting in support of genomic studies, responses to toxicants and drugs (exposure, biomarker development and biomarker Shattuck Labs Inc. (Research Triangle Park) metabolism, bioactivation). validation services. is a preclinical-stage immunotherapy scikoninnovation.com selectimmunogenomics.com company focused on utilizing its proprietary ARC (Agonist Redirected Checkpoint) Scioderm Inc., an Amicus Therapeutics SenGenix Inc. (Durham) develops point- technology to develop novel treatments Company (Durham) develops drugs to treat of-care blood diagnostic tests using for use in cancer, inflammation and orphan skin diseases with high unmet need. bioengineered fluorescently-responsive disease. sderm.com sensors. Testing is done with a finger stick, shattucklabs.com and results are available immediately. sengenix.com

Raleigh-Durham ranked #8 among the nation’s top biopharma clusters. N, Top .. iopharma lusters,

Received NCBiotech investment North Carolina Bioscience Companies | 37 Shefabone Inc. (Charlotte) is developing a SmartFlow Technologies Inc. (Apex) SonaCare Medical (Charlotte) develops resorbable bioactive bone graft material for provides TFF filtration, separation and minimally-invasive ultrasound technologies use in dental and maxillofacial bone defects. purification for the biotechnology, that ablate targeted soft tissue for the shefabone.com biopharmaceutical processing, biofuels, treatment of cancer. animal healthcare, dairy processing, enzyme sonacaremedical.com Shoaf Scientific Consultants Inc. manufacturing, food processing and (Lexington) provides research and wastewater industries. SonoVol Inc. (Durham) is developing development services in plant redox smartflow-tech.com preclinical imaging technology that can be bioenergetics, antimicrobial surface applied to the animal models that researchers technologies and molecular photochemical SmartGene Inc. (Raleigh) provides use to evaluate the efficacy and toxicity of studies in singlet oxygen and superoxide-free web-based software solutions for the new drugs before they enter clinical trials. radical anion as applied to aging. management, analysis and interpretation sonovol.com shoafbiochem.com of genetic sequences to identify and characterize bacteria, fungi and viruses. Southcot Inc. (Research Triangle Park) Shure Foods Inc. (Greenville) produces cold- Customers include diagnostic labs, medical prepares biological agents for the detection structured crab by treating the uncooked centers and sterile manufacturers. of tissue hypoxia at the cell level in normal crab meat with a protein binding agent. smartgene.com and malignant tissues. shurefoods.com hypoxyprobe.com Smithers Viscient LLC (Snow Camp) SightLife Surgical (Winston-Salem) provides environmental testing services for Southeastern Laboratories Inc. provides corneal endothelial cells for the pharmaceutical, veterinary, agriculture, (Goldsboro) provides research and laboratory transplantation, as well as related supplies chemical and personal-care industries. The support to water and wastewater-treatment and devices. It is an FDA-registered human company’s lab in Snow Camp conducts avian companies. SEL’s analytical services include tissue establishment. and wildlife toxicology testing. microbiological and chemical testing. sightlifesurgical.com smithersviscient.com selaboratories.com

SiNON Therapeutics (Research Triangle Park) SoBran BioScience (Browns Summit) Southern Research - Clean Technology is developing technology to treat neurological conducts preclinical small and large animal Development (Durham) develops and diseases by increasing the ability of drugs to contract research for academic, corporate and evaluates innovative technology solutions cross the Blood Brain Barrier (BBB). government clients. SoBran is GLP-compliant, to reduce energy consumption and sinontp.com AAALAC-accredited, OLAW-assured and ISO environmental impacts in various sectors 9001:2008-certified. from power generation to manufacturing to SipcamAdvan (Durham) develops and sobranbioscience.com transportation. manufactures herbicides, pesticides, southernresearch.org fungicides and biocides. Solutex NA LLC (Winston-Salem) makes sipcamadvan.com highly-refined omega-3 APIs for the SoyMeds Inc. (Charlotte) is developing a pharmaceutical and nutritional markets. seed-based expression platform that enables Smart Perfusion LLC (Denver) is developing The Winston-Salem location is a sales and production of protein-based targets that can an organ perfusion device that extends development office for the company. be used to diagnose and treat disease and the time an organ is viable ex vivo and solutex.us address other unmet needs in the healthcare that provides metrics to enable transplant industry. professionals to assess organ viability. soymeds.com

North Carolina ranked #5 in economic growth potential. usiness acilities, th Annual anings eport,

38 | ncbiotech.org/directory Spin-Darc LLC (Raleigh) is developing a StrideBio Inc. (Durham) develops Symmune Therapeutics LLC (Durham) rapid digital microbiology testing device engineered viral vectors for gene therapy develops immune targeted therapies for usable at point-of-care or in low-resource for the treatment of rare diseases. StrideBio’s chronic respiratory diseases and pulmonary settings. Applications include infectious technology engine utilizes structure-inspired disorders. disease diagnostics, food testing and water design to engineer AAV vectors which can symmune.com testing. escape pre-existing neutralizing antibodies spindarc.com (NAbs). SynapTech Labs (Morehead City) is stridebio.com developing a screening assay for neurologic Spirovation Inc. (Chapel Hill) is a specialty drugs. CRO with a focus on the development of Structure Medical Inc. (Mooresville) is a breakthrough drugs in respiratory medicine. contract manufacturer of orthopedic medical Synchrony Labs LLC (Durham) is an spirovation.com devices, including implantable orthopedic AAALAC-accredited large-animal, preclinical fracture fixation and spinal instrumentation contract research organization. It provides Spyryx Biosciences Inc. (Durham) is products. preclinical testing services, specializing in developing disease-modifying therapies for structuremedical.com models for safety, toxicology and efficacy obstructive lung disease based on the natural studies. fluid control mechanism in the lung. The Sun Dance Genetics LLC (Durham) has synchronylabs.com company’s initial focus is on cystic fibrosis. developed an improved and sustainable spyryxbio.com corn germplasm by transferring genes from a Syneos Health (Raleigh and Wilmington) wild relative (gamagrass) into corn. They also provides clinical research and commercialization Stallergenes Greer (Lenoir) develops developed high sugar gamagrass for efficient services across a variety of therapeutic areas. and distributes animal and human allergy bioenergy conversion. syneoshealth.com immunotherapy products and services. greerlabs.com Surgilūm LLC (Wilmington) designs, Syngenta Crop Protection LLC manufactures and markets medical (Greensboro and Research Triangle Park) Statera Environmental Inc. (Raleigh) instruments for use in cataract and refractive works to increase plant yield by developing develops innovative environmental surgery. products for disease, insect and weed control monitoring products and provides surgilum.com and drought tolerance. The Greensboro environmental technology consulting site is the North American headquarters services. Symberix Inc. (Durham) researches enzymes and performs crop protection product statera.org produced by the microbiome to develop development. The Innovation Center in drugs that would improve the efficacy of a Research Triangle Park is the company’s Sterigenics (EO) (Charlotte and Haw River) range of therapeutics. seeds center of excellence and includes the provides ethylene oxide sterilization and symberix.com Advanced Crop Lab. gamma radiation sterilization for medical and syngenta-us.com pharmaceutical products. Symmetry Biosciences Inc. sterigenics.com (Research Triangle Park) provides SynShark LLC (Leland) is developing contract research, specialized chemistry a method for extracting squalene from services and bioanalytic services to the tobacco. Squalene is a specialty chemical biotech, pharmaceutical, medical device, typically derived from shark livers used for agrochemical and fine chemical industries. vaccines and cosmetics. symmetrybiosciences.com synshark.com

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Received NCBiotech investment North Carolina Bioscience Companies | 39 Synteract Inc. (Morrisville) provides customized, full-service phase one through four clinical development services internationally across multiple therapeutic Do you want to improve your company’s areas. synteract.com competitive position? Synthon Pharmaceuticals Inc. (Durham) develops and manufactures generics, as well The Life Science Intelligence group at NCBiotech specializes in the intersection of as specialty pharmaceuticals and biosimilars bioscience innovation and business. By delivering targeted market and scientific insight, in key therapeutic areas of oncology and we connect entrepreneurs and companies with the analysis and resources needed to multiple sclerosis. The Durham location is a make strategic decisions. regulatory office. synthon.com We work across sectors, from agriculture to biopharma, from devices to diagnostics, and with companies at all stages of growth. Whether you have questions about market Synthonix Inc. (Wake Forest) designs, trends, your competitors’ R&D programs, or potential investors, Life Science Intelligence manufactures and markets molecules to aid in drug discovery. has the answers. synthonix.com Learn more at ncbiotech.org/lsi | Contact us at [email protected] T3D Therapeutics Inc. (Research Triangle Park) is developing a disease-modifying drug therapy for Alzheimer’s disease that may improve multiple disease defects. The drug also demonstrates potential as a therapy for nonalcoholic steatohepatitis (NASH). t3dtherapeutics.com

TAB Clinical Trials Inc. (Cary) provides global clinical trial support from pre-IND stage of development to postmarket approval for drugs and devices. TAB Clinical also provides drug safety and pharmacovigilance services in the U.S. and EU through a QPPV partner. tabclinical.com

Takeda Vaccines Inc. (Morrisville) develops 15 T.W. Alexander Drive | Post Office Box 13547 | Research Triangle Park, NC 27709-3547 vaccines, including norovirus, dengue and direct: 919-541-8880 seasonal influenza candidate vaccines. The Durham location is a manufacturing site. takeda.com

TARGET PharmaSolutions Inc. TearScience Inc. (Morrisville) develops Techverse Inc. (Cary) provides contract (Chapel Hill) is a clinical data information technologies to improve identification, chemistry R&D services for advanced energy company that assists in phase four clinical diagnosis, and treatment of Meibomian Gland technologies. Expertise includes membrane trials in the analysis of comparative Dysfunction. technologies for biotechnology applications; effectiveness and safety of therapeutic tearscience.com algae separation; and hydrogen generation, agents. separation, storage and fuel cells. targetpharmasolutions.com Technology Crops International techverseinc.com (Winston-Salem) designs, evaluates and TCRCure Biopharma Corp. (Durham) develops specialty plant-derived oils for food, Teleflex Medical (Morrisville) designs, discovers and develops novel therapeutic chemical, dietary supplement and personal manufactures and distributes medical targets in the field of cancer immunotherapy. care uses. The company manages the supply devices, surgical instruments and disposable chain from “soil to oil,” providing traceability, medical products. consistent demand and quality control. teleflex.com techcrops.com

40 | ncbiotech.org/directory Tem Systems Inc. (Research Triangle Park) TheraBionic LLC (Winston-Salem) is Trana Discovery Inc. (Cary) provides distributes the ROTEM delta blood hemostasis developing treatment approaches for a proprietary anti-infective discovery analyzer, developed by its parent company cancer based on the use of tumor-specific technology platform that enables its partners TEM International. modulation frequencies, with an initial focus to discover new treatments of bacterial, rotem-usa.com in hepatocellular carcinoma. viral and fungal infectious diseases in crops, therabionic.com animals and humans. Tenax Therapeutics Inc. (Morrisville) tranadiscovery.com develops and commercializes pharmaceutical Thermo Fisher Scientific (Durham, products for the critical care market. Greenville and High Point) provides contract TransEnterix Inc. (Morrisville) designs and tenaxthera.com development and commercial manufacturing develops flexible instruments and robotics for services for a full array of solid and sterile use in minimally-invasive surgery. TEO Systems Inc. (Greenville) develops dosage forms, including small-molecule API transenterix.com and sells optical and electronic devices and and biologic drug substances at its Durham systems, including a label-free flow cytometer location. The company manufactures TransViragen Inc. (Chapel Hill) provides in instrument for rapid analysis of biological cells sterile injectables (liquid and freeze-dried) vivo discovery research services, including and small particles. and solid-dose tablets and capsules in the generation and analysis of genetically Greenville. It also offers stability storage and modified rodents and cell lines. Tergus Pharma LLC (Durham) provides testing, and development of small-molecule transviragen.com topical and semi-solid development, APIs and large-molecule biologics in formulation, analysis and testing services, Greenville. Thermo Fisher’s High Point facility Treyco Environmental Solutions (Wilson) with expertise in IVRT method development. manufactures soft gel capsules. develops and manufactures products for The company has cGMP manufacturing, thermofisher.com cleaning and odor control that employ phase one through four clinical supplies and enzymes and microbes. Applications include logistics capabilities. Tidewater Agronomics Inc. (Belvidere) cleaning, degreasing and remediation. terguspharma.com conducts USDA-regulated biotech crop trials; treyco.net GLP trials in EPA Region 2; agronomic system TerMir Inc. (Raleigh) is developing an development; efficacy trials on chemistry, Triangle Biofuels Industries Inc. (Wilson) antibacterial agent to treat invasive citrus fertilizers and crop cultivars; pollinator studies makes biodiesel from vegetable oils obtained greening disease in US citrus. The product can and provides crop consulting services. from domestic sources. Target markets be applied via irrigation water or as a spray on tidewaterag.com are agricultural, marine, government and foliage application. commercial customers. termirsolutions.com TIRF Labs (Cary) develops, manufactures trianglebiofuels.com and markets a broad range of products based TerraStar Energy (Lumberton) provides on total internal reflection fluorescence Triangle BioSystems International turn-key systems to reduce waste and convert (TIRF), including add-on TIRF accessories for (Durham) develops, produces, markets it to biogas, electricity, liquid fuels and microscopy and spectroscopy, TIRF biosensors and supports biomedical signal processing solid and liquid fertilizers. Systems include and fluorescence illuminators. products that advance the research and anaerobic digestion, gasification, pyrolysis tirf-labs.com performance capabilities of its customers and boilers. in the neurophysiology and ultrasound terrastarenergy.com Tisucor LLC (Durham) develops and marketplace. sells human allograft products, including trianglebiosystems.com Tersus Environmental LLC (Wake Forest) demineralized cortical bone and amnion develops and markets technologies for membranes. Triangle Compounding Pharmacy (Cary) the remediation of soil and groundwater. tisucor.com is an FDA-registered 503B Outsourcing Facility Services include aerobic bioremediation, (cGMP) and PCAB-accredited pharmacy, bioaugmentation and cometabolic Toxicology Services Inc. (Chapel Hill) works specializing in compounding sterile and non- bioremediation. with small and mid-sized pharmaceutical sterile preparations of study medications, in tersusenv.com companies and CROs to plan, conduct and varied formulations, for clinical trials. summarize toxicology studies, including trianglecompounding.com Textile-Based Delivery Inc. (Conover) safety pharmacology and PK/ADME studies. develops and manufactures fabrics that toxicologyservices.net TriboFilm Research Inc. (Raleigh) develops integrate controlled release matrices, offering low-friction, thin-film coating and lubrication topical and transdermal dosing of active platforms for medical devices and for the ingredients. aerospace and marine industries. texdel.com tribofilmresearch.com

Received NCBiotech investment North Carolina Bioscience Companies | 41 Tryton Medical Inc. (Durham) develops US Botanical Safety Laboratory (Candler) Verdesian Life Sciences LLC (Cary) stent systems for the treatment of coronary provides natural products formulation and develops agricultural products with a focus in artery bifurcation lesions. botanical ingredient analytical testing. USBSL plant health, inoculants, seed treatment and cordis.com/en_us/cmp/ext/ is an FDA-registered laboratory operated by nutrition. tryton-side-branch-stent.html Bent Creek Institute and affiliated with The NC vlsci.com Arboretum Germplasm Repository. Twin City Bio LLC (Winston-Salem) botanical-safety.com Verge Therapeutics (Durham) manufactures cell therapy products that use develops therapeutics focused on metabolic a patient’s own cells to restore damaged UVision360 Inc. (Research Triangle Park) syndrome including nonalcoholic fatty kidney tissues by engrafting into, repairing or develops office-based hysteroscopy liver disease (NAFLD) and nonalcoholic replacing damaged tissues or organ. systems. steatohepatitis (NASH). uvision360.com vergetherapeutics.com TyraTech Inc. (Morrisville) develops and commercializes insect and parasite protection Vascular BioSciences Inc. (Durham) is a VERINETICS (Research Triangle Park) products for human and animal markets biopharmaceutical company developing develops products to prevent counterfeiting without the use of synthetic pesticides. solutions for difficult-to-treat cardiovascular of pharmaceuticals and other products, tyratech.com and inflammatory diseases. including both printed authentication and Tyton NC Biofuels LLC (Raeford) is a vascularbiosciences.com microparticle taggants. biorefinery that uses corn and energy verinetics.com tobacco as feedstock for ethanol production. Vascular Pharmaceuticals Inc. tytonbiofuels.com (Research Triangle Park) develops and Vertellus Specialties Inc. (Greensboro) commercializes therapeutic products to treat manufactures specialty chemicals for the UCB Biosciences Inc. (Raleigh) develops secondary complications of diabetes. agriculture, nutrition, pharmaceutical, medical therapeutics for the treatment of severe, life- and personal care markets. threatening neurological and inflammatory Velo Bio LLC (Morrisville) is developing vertellus.com diseases, including epilepsy, Parkinson’s an orphan drug for the treatment of severe disease, rheumatoid arthritis, Crohn’s disease, preeclampsia in pregnant women. Viamet Pharmaceuticals Inc. (Durham) psoriatic arthritis, lupus and osteoporosis. discovers and develops small-molecule ucb-usa.com Velosal Medical Inc. (Cary) develops compounds that target metalloenzymes medical devices for enhancing and in infectious disease, oncology and crop United Therapeutics Corp. improving patient care in the critical care protection. (Research Triangle Park) develops and and emergency markets. Its first product is a viamet.com commercializes products to treat video-guided laryngoscope for use in tracheal cardiopulmonary diseases, infectious intubations. ViiV Healthcare (Research Triangle Park), a diseases and cancer. velosal.com joint venture established by GSK and Pfizer, unither.com researches and develops new HIV medicines and advances care for people living with HIV. URO-1 Inc. (Winston-Salem) develops Veloxis Pharmaceuticals Inc. (Cary) surgical solutions for in-office procedures in develops drug delivery technology that viivhealthcare.com/us urology. Its first product is a system to inject increases the absorption and bioavailability botox into the bladder for the treatment of orally-administered drugs for transplant Vijaya Pharmaceuticals LLC of overactive bladder in such a way as to patients. (Research Triangle Park) provides medicinal prevent patients from developing urinary veloxis.com and synthetic organic chemistry services to incontinence. the pharmaceutical and allied industries. uro1medical.com vijayapharma.com

tnein otnities NCBiotech ctive connects Noth Coin ie science comnies nd nivesities ith side ie science entities seein to stenthen thei odct ieines nd otoios ncbiotech.org/partnering

42 | ncbiotech.org/directory ViraSource LLC (Durham) propagates West Pharmaceutical Services Inc. X-in8 Biologicals Corp. (Chapel Hill) and purifies BSL-1, BSL-2 viruses and (Kinston) manufactures packaging develops technologies to prevent and treat bacteriophages. ViraSource also provides components and delivery systems for ischemia reperfusion injury in the context of virus modifications and animal models of viral injectable drugs and healthcare products. organ transplant, myocardial infarction and infections and antiviral immune responses. westpharma.com stroke. virasource.com x-in8.com White Labs Inc. (Asheville) provides yeast ViraTree LLC (Research Triangle Park) supplies, lab services and consulting to Xona Microfluidics LLC acquires, authenticates, preserves, develops breweries, wineries and distilleries. (Research Triangle Park) develops and and distributes virological materials, whitelabs.com manufactures microfluidic platforms for information and technology for the neuroscience research. advancement of virus research. Wilmington Pharmaceuticals LLC xonamicrofluidics.com viratree.com (Wilmington) develops fast-dissolving dosage forms for established medicines. Yukon Medical LLC (Raleigh) designs Vital Plan Inc. (Cary) formulates and wilmingtonpharma.com and manufactures pharmaceutical drug produces therapeutically-dosed natural preparation and delivery devices with a focus supplements and herbal therapies for Worldwide Clinical Trials Inc. (Morrisville) on drug reconstitution. managing fibromyalgia, Lyme disease, chronic provides phase one through phase four drug yukonmedical.com fatigue and pain and hormonal imbalances. development services to the pharmaceutical vitalplan.com and biotechnology industries. Zenalux Biomedical Inc. (Durham) uses worldwide.com biophotonics to develop diagnostic tools, Vitrisa Therapeutics (Durham) discovers including an optical system for the clinical and develops ocular therapeutics with Xanofi Inc. (Raleigh) manufactures detection of cancer. the potential to address the underlying nanofibers which may be used in surgery, zenalux.com mechanisms of vision loss. wound care, regenerative medicine and other vitrisatherapeutics.com fields. Its first product, XanoMatrix, is a growth ZenBio Inc. (Research Triangle Park) provides platform that mimics native tissue structures contract research services and human tissues Vivelix Pharmaceuticals Corp. (Morrisville) in order to simulate in vivo conditions. and cells for drug discovery, especially in licenses, develops and commercializes xanofi.com the area of human metabolic disease and gastroenterology and hepatology treatments. dermatology. vivelix.com Xellia Pharmaceuticals USA LLC (Raleigh) zen-bio.com manufactures anti-infective treatments and vTv Therapeutics LLC (High Point) APIs, with an emphasis in lyophilized and Zenomics Inc. (Durham) is developing a discovers and develops drug candidates to liquid sterile manufacturing of small-molecule microneedle transdermal patch technology fill significant unmet medical needs such and biologic therapeutics. for diabetes, which is able to sense blood as Alzheimer’s disease, Type 2 diabetes and glucose levels and respond with appropriate inflammatory disorders. xellia.com concentrations of insulin. vtvtherapeutics.com Xenobiotic Detection Systems zenomicsbio.com Waters Agricultural Laboratories Inc. International Inc. (Durham) offers (Warsaw) provides various testing services, patented bioassays to facilitate assessment of Zinfandel Pharmaceuticals Inc. including soil, plant and water analysis as well environmental and human health risks. (Chapel Hill) uses pharmacogenetics to as microbiology, mycotoxin, aflatoxin and dioxins.com improve prediction of risk for Alzheimer’s heavy metals detection. disease and facilitate the development of watersag.com effective therapies.

NC life science support companies

Received NCBiotech investment North Carolina Bioscience Companies | 43 Zoetis Inc. (Durham) develops and manufactures vaccines and medications Thank You to Our Sponsors for animal health. The Durham, NC site develops and manufactures high-throughput automation biodevices for the poultry industry, including in ovo vaccination technology. zoetis.com

Zoion Pharma Inc. (Raleigh) develops drugs for veterinary disorders. Zoion’s lead product is an epithelial sodium channel blocker compound to treat canine keratoconjunctivitis sicca (KCS) or dry eye.

Zorbius Biopharma Inc. (Morrisville) provides analytical, formulation and nanotechnology-related services to pharmaceutical, biotech and medical device companies. zorbius.com

ZY Therapeutics Inc. (Cary) is developing a drug delivery platform for cancer therapeutics using nanotechnology.

Zylera Pharmaceuticals LLC (Research Triangle Park) develops, acquires and commercializes prescription products and dietary supplements, specifically for pediatric and women’s health. zylera.com

Zymeron Corporation (Research Triangle Park) researches and develops nanomaterials and polymer-based biomaterials with applications in in vitro diagnostics, sample collection and drug delivery and formulation. zymeron.com

NCBiotech Company Directory editorial content provided by NCBiotech Life Science Intelligence Unit. All rights reserved. The contents of this publication may not be reproduced by any means, in whole or in part, without prior written consent of the North Carolina Biotechnology Center.

The North Carolina Biotechnology Center is a private, nonprofit corporation that transforms North Carolina’s life science opportunities into economic prosperity through innovation, commercialization, education and business growth. It’s headquartered in the Research Triangle Park, with regional offices in Asheville, Charlotte, Greenville, Wilmington and Winston-Salem.

This listing of bioscience companies is current as of June 2018.

Photos: Advanced Chemotherapy Technologies, BASF, BioLabs North Carolina, bioMASON, Campbell University, Duke University, iStock, Jim Sink, Medicago, NCBiotech, N.C. Community College System/BioNetwork, NCState/BTEC, NCState/Roger Winstead, N.C. Sweet Potato Commission/Brian Warren Farm, Nypro, PPD, RTI, Shutterstock, Site Selection Magazine, TransEnterix, U.S. Department of Defense and Wake Forest Baptist Medical Center

44 | ncbiotech.org/directory Received NCBiotech investment Accolades for North Carolina

Raleigh ranked 2nd best-performing large city North Carolina named based on opportunities best state for business. for prosperity and innovation. Forbes, “Best States for Business,” 2017 Milken, “Best-Performing Cities,” 2018

North Carolina ranked Raleigh-Durham metro area ranked #6 for NIH funding 4th among 16 U.S. awarded in 2017. life sciences clusters. Research America, 2017 JLL, “Life Sciences Outlook,” 2017

North Carolina won the Prosperity Cup for the most competitive state for the fourth year. Site Selection Magazine, “Prosperity Cup,” 2017

Raleigh-Durham ranked North Carolina ranked #8 among the nation’s #5 in economic top biopharma clusters. growth potential. GEN, “Top 10 Business Facilities, U.S. Biopharma Clusters,” 2017 “13th Annual Rankings Report,” 2017

Raleigh, Charlotte, Durham and Wilmington placed in the top 20 best places for business and careers. Forbes, “The Best Places for Business and Careers,” 2017

Photos: BASF, istockphoto.com, NCState/Roger Winstead, shutterstock.com, Wake Forest Baptist Medical Center The Basics Where can you find more than 700 life science companies with 63,000 highly skilled workers?

A growing life science economy of $86B a year? The birthplace of contract research organizations?

The global epicenter of biomanufacturing and ag biotech?

Look no further: North Carolina.

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