Immunogenicity and Safety of Fractional Doses of Yellow Fever Vaccines: a Randomized
medRxiv preprint doi: https://doi.org/10.1101/2020.08.18.20177527; this version posted October 29, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . 1 Immunogenicity and safety of fractional doses of yellow fever vaccines: a randomized, 2 double-blind, non-inferiority trial 3 4 Aitana Juan-Giner, MSc1,*, Derick Kimathi, MBChB2,3*, Kyra H. Grantz, BA4,5,6, Mainga M. 5 Hamaluba, MD2, Patrick Kazooba, MBChB7, Patricia Njuguna, MMed2, Gamou Fall, PhD8, 6 Moussa Dia, MSc8, Ndeye S. Bob, PhD8, Thomas P. Monath, MD9, Alan D. Barrett, PhD10, 7 Joachim Hombach, PhD11, Edgar M. Mulogo, PhD12, Immaculate Ampeire, MBChB13, Henry 2 7 7 8 K. Karanja, MSc , Dan Nyehangane, MSc , Juliet Mwanga-Amumpaire, MMed , Derek A.T. 9 Cummings, PhD4,5, Philip Bejon, Prof2,3, George M. Warimwe, PhD2,3,#, Rebecca F. Grais, 10 PhD1,#. 11 12 1 Epicentre, Paris, France 13 2 Kenya Medical Research Institute – Wellcome Trust Research Programme, Kilifi, Kenya 14 3 Centre for Tropical Medicine & Global Health, University of Oxford, UK 15 4 Department of Biology, University of Florida 16 5 Emerging Pathogens Institute, University of Florida 17 6 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health 18 7 Epicentre Mbarara Research Centre, Uganda 19 8 Institut Pasteur Dakar, Senegal 20 9 Crozet BioPharma LLC, Devens MA, USA 21 10 Sealy Institute for Vaccines Sciences and Department of Pathology, University of Texas 22 Medical Branch, USA 23 11 Immunization, Vaccines & Biologicals, World Health Organization, Geneva, Switzerland 24 12 Department of Community Health, Mbarara University of Science & Technology, Uganda 25 13 Expanded Program on Immunization, Ministry of Health, Uganda 26 27 *Co-first author; #Co-senior author 28 1 NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.
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