NCBiotech Company Directory

Many thanks to our sponsors for making this directory possible July 2012

Alston & Bird • BASF • Bayer CropScience

Golden LEAF Biomanufacturing Training and Education Center

Cannon Research Center • Fujifilm Diosynth Biotechnologies • GlaxoSmithKline

NC Community Colleges BioNetwork • Piedmont Triad Research Park

Pozen • PPD • Smith Anderson

ncbiotech.org/directory ncbiotech.org/directory

2012CoDirectoryCOVER-final_km-5-14-12.indd 2-3 5/14/12 5:02 PM NCBiotech Company Directory 2012

Growing a healthier world, one harvest at a time.

Chairman,Our Board task of Directors is simple, yet monumental. To provide enough food for the world, while John L. Atkins,protecting III, FAIA it at the same time. We believe that with the right combination of innovative President andscience, Chief Executivetenacious Officer problem solving and unshakable passion, we can do it. We will meet E. Norris Tolson Science For A Better Life the needs of today while laying a foundation for a better tomorrow. And in doing so, we Senior Vice President, Science andwill Business not only Development grow a healthier world, we will make sure that abundance endures for us all. Kenneth R. Tindall, Ph.D. Learn more at www.BayerCropScience.us. Senior Vice President, Statewide Operations and Economic Development Michael Wilkins

Regional Offices Vice President, Statewide Operations Steven Casey, MBA Executive Director, Eastern Office Mark Phillips Executive Director, Greater Charlotte Office Cover photos (back and front cover, left to right): NC Research Campus, NCBiotech Center, BASF SE, Executive Director, Piedmont Triad Office NCBiotech Center, UNCW/Marbionc/Jamie Moncrief, RTI International, East Carolina University, NC Nancy Johnston State University Photo (above) NCBiotech Center Executive Director, Southeastern Office Randall Johnson, MBA NCBiotech Company Directory is produced by Red Hand Media LLC Executive Director, Western Office 5605 77 Center Drive, Suite 101, Charlotte, NC 28217. Telephone 704-523-6987. Fax 704-523-4211. Jonathon Lawrie, Ph.D. Editorial content provided by underwriters.

Growing a healthier world, one harvest at a time. Our task is simple, yet monumental. To provide enough food for the world, while protecting it at the same time. We believe that with the right combination of innovative science, tenacious problem solving and unshakable passion, we can do it. We will meet Science For A Better Life the needs of today while laying a foundation for a better tomorrow. And in doing so, we will not only grow a healthier world, we will make sure that abundance endures for us all. Learn more at www.BayerCropScience.us.

Bayer CropScience LP, 2 TW Alexander Drive, Research Triangle Park, NC 27709. Always read and follow label instructions. Bayer and the Bayer Cross are registered trademarks of Bayer. For additional product information, call toll-free 1-866-99-BAYER (1-866-992-2937) or visit our Web site at www.BayerCropScience.us.

BCS_COM_M2_1097_BizNC_R1.indd Saved at 4-4-2012 3:43 PM Printed At None Client Bayer Crop Science Media Type Magazine DEPARTMENT: Art Director Copywriter Acct. Manager Studio Artist Proofreader Traffic Production Live 7” x 10” Trim 8.125” x 10.875” Bleed 8.375” x 11.125” APPROVAL: Job Title Corp. Bus. NC Ad Pubs Business or North Carolina Addl. Notes: None Ad Code None

Bayer_redo.5H.indd 1 4/27/12 3:03:37 PM

Bayer CropScience LP, 2 TW Alexander Drive, Research Triangle Park, NC 27709. Always read and follow label instructions. Bayer and the Bayer Cross are registered trademarks of Bayer. For additional product information, call toll-free 1-866-99-BAYER (1-866-992-2937) or visit our Web site at www.BayerCropScience.us.

BCS_COM_M2_1097_BizNC_R1.indd Saved at 4-4-2012 3:43 PM Printed At None Client Bayer Crop Science Media Type Magazine DEPARTMENT: Art Director Copywriter Acct. Manager Studio Artist Proofreader Traffic Production Live 7” x 10” Trim 8.125” x 10.875” Bleed 8.375” x 11.125” APPROVAL: Job Title Corp. Bus. NC Ad Pubs Business or North Carolina Addl. Notes: None Ad Code None NCBiotech’s Regional Offices

77 Research Winston-Salem Triangle 95 85 Piedmont RTP 40 Eastern Triad 40 Greater 85 Raleigh Asheville Charlotte Greenville 26 77 Western 95 Charlotte

Southeastern Advantage North Carolina 40 North Carolina’s 500+ companies enjoy outstanding quality of Wilmington life in addition to:

• Workforce Training • Collaborative Community • Low Business Costs

Top Regional Biotechnology Assets

Eastern Piedmont Triad SouthEastern Regional Office: Greenville Regional Office: Winston-Salem Regional Office: Wilmington Phone: 252-328-9981 Phone: 252-725-6672 Phone: 910-763-5747

Sector Strengths: Sector Strengths: Sector Strengths: • Ag Biotech • Regenerative Medicine • Marine Biotech • Functional Biofuels • Nanobiotechnology • Contract Research • Marine Biotech • Medical Devices • Pharmaceuticals and Nutraceuticals ncbiotech.org/east ncbiotech.org/triad ncbiotech.org/southeast

Greater Charlotte Research Triangle Park Western Regional Office: Charlotte Headquarters: Research Triangle Park Regional Office: Asheville Phone: 704-687-8563 Phone: 919-541-9366 Phone: 828-290-1431

Sector Strengths: Sector Strengths: Sector Strengths: • Bioinformatics • Biomanufacturing • Medical Devices • Health and Nutrition • Contract Research • Natural Products • Ag Biotech • Fermentation • Biomedical Technologies ncbiotech.org/west ncbiotech.org/charlotte ncbiotech.org

North Carolina Companies 1 Companies 1 – Al

Advanced Animal Diagnostics Inc. (Morrisville) develops diagnostics to detect and manage disease states, reproductive, nutritional and overall health status of production animals. AAD’s first product is a diagnostic test for mastitis in dairy cows. www.advancedanimaldiagnostics.com

Advanced Liquid Logic Inc. (RTP) uses digital microfluidics to develop molecular diagnostics, bioassays and life-science research tools. www.liquid-logic.com

Aerial Biopharma LLC (Morrisville) develops biologic and small-molecule central nervous system therapeutics, including treatments for narcolepsy and chronic pain. www.aerialbio.com

Aerie Pharmaceuticals Inc. (RTP) researches and develops treatments for glaucoma. www.aeriepharma.com

Affinergy Inc. (RTP) uses biotechnology

Grifols methods to create application-specific coatings for orthopedic and cardiovascular 13C Molecular Inc. (Fayetteville) provides Actavis US (Lincolnton) manufactures OTC medical devices. stable-isotope labeled, custom synthesized and prescription hydrocortisone, anti-fungal www.affinergy.com organic compounds to the pharmaceutical and permethrin products as creams, and biomedical industries. ointments, liquids and suppositories. Agile Sciences Inc. (Raleigh) identifies small www.13cmolecular.com www.actavis.us molecules that inhibit and disperse bacterial biofilms. The company investigates AAIPharma Services Corp. (Wilmington and Adherex Technologies Inc. (RTP) applications in medicine, agriculture and Durham) provides drug product development develops cancer therapeutics. Its lead industry. services such as formulation development, product under development is Eniluracil, www.agilesci.com analytical chemistry and manufacturing. The an oral dihydropyrimidine dehydrogenase company’s solid-dose manufacturing facility inhibitor to improve the tolerability and Ajinomoto North America (Raleigh) provides clinical and commercial supplies on effectiveness of oncology drugs. manufactures pharmaceutical-grade amino contract. www.adherex.com acids and custom-blended amino acid www.aaipharma.com mixtures. Adroit Pharmaceutical Development LLC www.ajiaminoscience.com AccuGenomics Inc. (Wilmington) develops (Durham) identifies new and improved gene expression tests to diagnose and formulations and process technologies. Alaeras Inc. (Cary) designs and manufactures monitor cancer treatment. Its primary focus is on inhalation and drug-delivery products. The company www.accugenomics.com dermatological product development. develops a platform technology for dry- www.adroitpharmdev.com powder nasal vaccines that do not require Ace Bio-PharmTech LLC (High Point) uses refrigeration. asymmetric synthesis technologies to ADS Pharma Consulting LLC (Cary) www.alaeras.com develop R&D processes, formulations of provides drug development services, branded and generic pharmaceuticals and including Active Pharmaceutical Ingredient Aldagen Inc. (Durham) develops adult active pharmaceutical ingredients. route development and manufacture, stem cell products for tissue repair and www.acebiopharm.com analytical, pre- and formulation development, regeneration. clinical batch manufacture and chemistry, www.aldagen.com manufacturing and controls regulatory affairs. www.adspharma.net 2 North Carolina Companies Companies Al – Ar

Alderon BioSciences Inc. (Newport) AlphaVax Inc. (RTP) develops vaccine Applied Catheter Technologies Inc. develops point-of-care diagnostics. technology with applications in infectious (Winston-Salem) develops drug-coated disease, cancer and biodefense threats. catheters for male urethral stricture and Alera Labs LLC (RTP) provides contract www.alphavax.com abdominal adhesions. research, molecular microbiology and www.appliedcatheter.com analytical chemistry laboratory services Alte Biosciences Inc. (Cary) develops to small and mid-size pharmaceutical and therapeutics targeting irritable bowel disease, Applied Micro Products Inc. (Chapel Hill) medical device companies. rheumatoid arthritis and related disorders. manufactures wood preservation products www.aleralabs.com www.altebio.com such as AMP21, a natural carbon source encased in a time-release delivery system. Algaen Corp. (Winston-Salem) explores American Distillation Inc. (Leland) www.appliedmicroproducts.com microalgae to develop, produce and market manufactures industrial-grade ethyl alcohol products and technologies for the nutraceutical, and offers contract manufacturing services Applied Pharma Research USA LLC pharmaceutical and bio-energy industries. such as distillation, dehydration, reaction, (Charlotte) develops and licenses oral and www.algaen.com carbon treating and blending. topical healthcare products and drug-delivery www.americandistillation.net systems. APR also provides contract R&D Alganomics LLC (Southport) researches and services. The Charlotte site is the US headquarters developing algae-culturing systems to create Analytical Solutions Inc. (RTP) provides and business development office. bioproducts, including biofuels. analytical laboratory services, including www.apr.ch www.algaeresource.com product development services and drug diffusion/release studies. Aptiv Solutions (Morrisville and Raleigh) Algynomics Inc. (Chapel Hill) uses www.asi-rtp.com offers adaptive clinical trials, translational phenotyping and genomics to develop research services, regulatory services, diagnostics and therapeutics for chronic Andersen Scientific Inc. (Morrisville) provides pharmacovigilance, clinical staffing and pain and related conditions. ethylene oxide sterilization and validation other operational clinical research support. www.algynomics.com services. Andersen’s sterilization cycles include www.aptivsolutions.com microbiological and other testing. Alion Science and Technology Inc. www.ansci.us Arbovax Inc. (Raleigh) develops vaccines (Durham) is a Department of Defense against arthropod-borne diseases. Arbovax’s contractor that operates four bioscience Antech Diagnostics Inc. (Morrisville) provides technology modifies arthropod-borne viruses research laboratories in the Triangle. clinical and veterinary hematology analysis, (arboviruses) to prevent them from replicating www.alionscience.com clinical chemistry, urinalysis and coagulation in mammalian cells. testing. www.arbovax.com Almac Clinical Services (Durham) provides www.antechglp.com clinical trial material manufacturing, Archer Daniels Midland Co.’s (Southport) packaging and distribution services. APP Pharmaceuticals LLC (Raleigh) manufacturing plant in Southport makes citric www.almacgroup.com/clinical-trial-supply manufactures injectable pharmaceutical acid used in soft drinks and food products. products in four therapeutic areas: www.admworld.com Almac Diagnostics (Durham) develops anti-infective, anesthesia/analgesia, critical biomarkers and molecular diagnostics. care and oncology. Argos Therapeutics Inc. (Durham) develops www.almacgroup.com www.apppharma.com immunotherapy treatments for cancer and infectious diseases. ALP Life Sciences LLC (Black Mountain) Appealing Products Inc. (Raleigh) develops www.argostherapeutics.com develops diagnostics and therapeutics for liver products for forensics and personal protection diseases and related inflammatory diseases. from toxic materials such as inorganics, gases Array BioPharma Inc. (Morrisville) develops www.alplifesciences.com and poisons in foods, animal feeds and liquids. targeted, small-molecule drugs to treat cancer www.appealingproducts.com and inflammatory diseases. www.arraybiopharma.com

Higher Education Arysta LifeScience North America LLC North Carolina’s academic institutions include four, soon to be five, medical (Cary) develops and manufactures crop protection products. schools, three pharmacy schools, two land-grant universities and numerous www.arysta-na.com campuses providing specialized programs in such fields as biotechnology, ag biotech, nanobiotechnology, medical engineering and biomanufacturing.

North Carolina Companies 3 Companies As – Bi

Ascletis Inc. (Chapel Hill) develops treatments BD Medical (Wilson) manufactures medical North Carolina is a world leader in for cancer and infectious diseases. devices and injection- and infusion-based vaccine manufacturing, with more than www.ascletis.com drug-delivery products. 15 production facilities. www.bd.com Asinex (Winston-Salem) designs small-molecule libraries and provides lead optimization, Banner Pharmacaps Inc. (High Point) BD Technologies (RTP) develops technologies custom synthesis and other chemistry researches, develops and produces for parenteral drug delivery, diabetes care, services. The Winston-Salem location is the gelatin-based oral dosage products. diagnostics and biosensors and cell and tissue company’s US headquarters. www.banpharm.com engineering. The RTP site is BD’s Corporate www.asinex.com Technology R&D center. BASF Corp. (RTP) researches and develops www.bd.com/technologies Asklepios Inc. (Chapel plant-health products such as fungicides, Hill) develops protein- and cellular-based insecticides and herbicides. The RTP site Beckman Coulter Genomics (Morrisville) therapies using a proprietary technology represents the company’s Crop Protection provides genomics services including platform called Biological Nano Particles Chemicals business. sequencing, sample preparation, genotyping, (BNP). www.basf.com gene expression and biologics testing, with www.askbio.com support for regulatory compliance. BASF Plant Science LP (RTP) conducts www.beckmangenomics.com Asymchem Laboratories (Morrisville) plant biotechnology research and develops provides contract chemical- and drug- agricultural products through its gene- Bent Creek Institute Inc. (Asheville) manufacturing services. Asymchem’s discovery platform, focusing on yield and conserves and develops plant biodiversity administrative headquarters is in North quality traits in crops such as corn, soybeans assets and maintains the North Carolina Carolina and its manufacturing plants and rice. Arboretum’s Bent Creek Germplasm are in China. www.basf.com/plantscience Repository. It also administers the US www.asymchem.com Botanical Safety Laboratory, a consortium Baxter Healthcare Corp. (Marion) produces of university botanical research sites. Attagene Inc. (RTP) develops cell-based intravenous and peritoneal dialysis solutions, www.bentcreekinstitute.org assays that are used to evaluate the mode of as well as empty containers and component action and toxicity of chemical compounds parts for other Baxter facilities. BestSweet Inc. (Mooresville) manufactures and drug candidates. www.baxter.com confectionery-based dosage forms for www.attagene.com non-prescription drug products and dietary Bayer CropScience LP (RTP, Clayton supplements. Avioq Inc. (RTP) develops immunodiagnostic and Morrisville) uses the tools of plant www.bestsweet.com assays for retrovirus detection. biotechnology to develop seeds and www.avioq.com products for crop protection and non- Better Medicines LLC (Durham) provides agricultural and structural pest control. contract drug discovery research and Avjet Biotech Inc. (Pinehurst) has two The Clayton site performs pesticide development services through its divisions: Red Wolf Refining, whose thermal research, specifically in turfgrasses and consortium of independent contract catalytic refining system converts triglycerides ornamentals. The company’s R&D research organizations. into aviation biofuels; and Pinehurst Biologics, Innovation Center and BioAnalytics and www.bettermedicines.net which produces enzymes and other products Regulatory Affairs operations are in from algae. Morrisville. BHV Pharma Inc. (RTP) develops therapeutics www.redwolfrefining.com www.bayercropscience.us for metabolic disorders, including diabetes and obesity. Avoca Inc. (Merry Hill) develops and BD Biosciences (Durham) manufactures www.bhvpharma.com manufactures botanical extraction products. pipettes, conical and round-bottom tubes, Avoca also provides extraction services on cell inserts, tissue-culture plates and dishes BioAgilytix Labs Inc. (RTP) provides contract. for BD Biosciences’ Discovery Labware unit. bioanalytical testing services such as assay pharmachemlabs.com/divisions/avoca www.bdbiosciences.com development, assay validation and sample analysis. b3bio Inc. (RTP) develops RNA oligonucleotide- BD Diagnostics - TriPath (Burlington and www.bioagilytix.com based drugs to treat cancer, inflammation and Durham) manufactures cervical cancer . screening products. BioCI Systems Inc. (Raleigh) provides www.bd.com/tripath sterilization validation services and other contract laboratory testing services. home.earthlink.net/~bioci/main.html 4 North Carolina Companies Companies Bi – Bi

BioCryst Pharmaceuticals Inc. (Durham) BioGaia Biologics Inc. (Raleigh) develops Biolex Therapeutics (Pittsboro and RTP) designs and develops small-molecule and sells probiotic products. develops follow-on biologics, therapeutic pharmaceuticals that block key enzymes www.biogaia.com proteins and monoclonal using involved in infectious diseases, inflammatory its patented LEX System, which involves diseases and cancer. Biogen Idec (RTP) develops and genetically modified aquatic plants known www.biocryst.com manufactures biological therapeutics to as Lemna. treat neurological disorders. It operates a www.biolex.com BioCytics Inc. (Huntersville) researches and large-scale manufacturing facility and develops cellular therapies and personalized customer-service center in RTP. BioLink Life Sciences Inc. (Cary) provides medicine technology to diagnose and treat www.biogenidec.com contract product development support cancer. through custom synthesis and testing. www.biocytics.com BioKier Inc. (Chapel Hill) develops therapeutics www.biolinkonline.com for diabetes and related disorders. BioDelivery Sciences International Inc. www.biokier.com BioLume Inc. (Wendell) develops and (RTP) develops drug delivery technologies in commercializes bioluminescent (light the areas of pain management and oncology BioLeap LLC (Chapel Hill) provides drug- producing) proteins for the food, beverage, supportive care. discovery and -design services using cosmetic and diagnostic imaging markets. www.bdsi.com computational fragment-based drug-design www.biolume.net technology. BioDyne Water Reclamation Inc. (Raleigh) www.bioleap.com BioMarck Pharmaceuticals Ltd. (Durham) develops and provides biological wastewater develops drugs to treat pulmonary diseases treatment systems and services. and disorders, such as chronic obstructive www.biodynegroup.com North Carolina is home to 17 UNC pulmonary disease, asthma, chronic bronchitis System campuses, 25 private universities, and cystic fibrosis. 10 technology-transfer offices and www.biomarck.com 25257 Generic Ad. 04/05/2012 08:59 Page 1 58 community colleges.

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www.fujifilmdiosynth.com Companies Bi – Ca

BNOAT Oncology Inc. (Durham) develops compounds to treat cancer and related complications.

Botanics Integrated LLC (RTP) researches botanical extracts and develops biochemically standardized products for use in pharmaceuticals, natural products and cosmetics. www.botanicsintegrated.com

BotaniPharm LLC (Candler) develops botanical medicines using biologically standardized, forest-grown goldenseal. www.botanipharm.com

Burke Research Associates LLC (Morganton) conducts Phase III and IV clinical trials for gastrointestinal disorders such as ulcerative t ional colitis, Crohn’s disease and diverticulitis. T I n t erna R Burleson Research Technologies Inc. (Morrisville) provides laboratory services and BioMed Coatings (Franklin) manufactures Biotechnics LLC (Hillsborough), a subsidiary proof-of-concept, pre-clinical, clinical and specialty polymer coatings infused with an of WIL Research Co., provides contract toxicology studies. FDA-registered biocide, silver chloride. The toxicologic pathology and histology services. www.brt-labs.com coatings are used in healthcare and other www.wilresearch.com commercial settings as a surface antimicrobial. C Change Surgical LLC (Winston-Salem) www.biomedcoatings.com BioTrackers Inc. (Charlotte) develops develops medical technologies to enhance bacterial, or microbe, source tracking patient safety and improve surgical efficiency. BioMedomics Inc. (RTP) develops assays and technology. www.cchangesurgical.com technologies for personalized medicine molecular diagnostics. BioVendor LLC (Candler) sells biological Calvert Labs (Cary) provides preclinical www.biomedomics.com reagents and research products, including research and contract drug discovery and enzyme-linked immunosorbent assay kits development services such as lead identification bioMérieux Inc. (Durham) develops in-vitro and other assays, antibodies, proteins and and lead optimization services. products to diagnose infectious diseases, other molecules for life-sciences research. www.calvertlabs.com cancer and cardiovascular disease and to The Candler site is the US headquarters. detect microorganisms in agri-foods, www.biovendor.com Camargo Pharmaceutical Services LLC pharmaceuticals and cosmetics. (Durham) provides contract drug development www.biomerieux-usa.com Bioventus LLC (Durham) researches and services, including formulation and testing, develops biomaterials, cell-based therapies regulatory and all phases of clinical Bioptigen Inc. (Durham) develops in vivo and other products to treat osteoarthritis development. optical imaging systems for biomedical and orthopedic injuries, as well as related www.camargopharma.com applications. and pain. www.bioptigen.com www.smith-nephew.com Cancer Advances Inc. (Durham), a subsidiary of Cato Bioventures, develops therapeutics to BioResource International Inc. (Morrisville) BioZyme Inc. (Apex) develops cancer treat gastrointestinal cancers. discovers and develops animal feed enzymes. diagnostics and provides contract www.canceradvancesinc.com www.briworldwide.com enzymological services. CanDiag Inc. (Waxhaw) develops and BioShape Solutions Inc. (RTP) develops Blue Ridge Institute for Medical Research commercializes blood tests to diagnose medical devices that deliver antibiotics to (Horse Shoe) researches protein kinase breast cancer. prevent and treat orthopedic implant enzymes and targeted cancer therapies. infections. www.brimr.org www.bioshapesolutions.com

6 North Carolina Companies CompaniesCompanies Ca 1 –– CeAr

Cannon Research Center (Charlotte) Carolina Environmental Inc. (Cary) provides Catena Pharmaceuticals Inc. (Durham) conducts clinical studies, translational industrial hygiene laboratory services such as develops anti-angiogenic G-protein coupled research and other bench research asbestos testing, microbiology analysis and receptor (GPCR) antagonist compounds with activities for Carolinas Medical Center. fungi analysis. a focus on cancer and fibrosis. www.carolinasmedicalcenter.org/research www.ceilabs.com www.catenapharma.com

Capture Pharmaceuticals Inc. (Chapel Hill) Carolina Liquid Chemistries Corp. Cathtek Inc. (Winston-Salem) develops develops oral and topical formulations of (Winston-Salem) develops and manufactures and manufactures catheters and related diethylenetriaminepentaacetic acid prodrugs in-vitro diagnostic reagents for chemistry accessories. as radionuclide decorporation agents. analyzers used in hospital, reference and www.cathtek.com physician labs. The company’s office in CardioPharma Inc. (Wilmington) develops Winston-Salem researches and develops a Cato Research Ltd. (Durham) provides combinatorial products to treat cardiovascular new assay for syphilis. contract research services that range from disease. www.carolinachemistries.com design and management of preclinical and www.cardio-pharma.com clinical studies to submission of regulatory Carolina Medical Products (Farmville) documents. Cardioxyl Pharmaceuticals Inc. (Chapel Hill) manufactures prescription and OTC liquids www.cato.com develops therapies for cardiovascular disease and ointments for oral and topical use. using nitroxyl technology. www.carolinamedical.com Cell Microsystems Inc. (Chapel Hill) www.cardioxyl.com develops bioscience research tools for use Catalent Pharma Solutions (RTP) develops in analytical research laboratories. Its first Carolina BioPharm Inc. (Raleigh) develops inhalation products and provides analytical product line is used for cell sorting and cell small-molecule cancer treatments. testing and other scientific services. separation. www.carolinabiopharm.com www.catalent.com cellmicrosystems.wordpress.com

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CellSolutions LLC (Greensboro) develops and Chaperone Therapeutics Inc. (Durham) Chem-Tex Laboratories Inc. (Concord) manufactures reagents for use in diagnostics develops small-molecular compounds develops and manufactures specialty and clinical chemistry tests. for neurodegenerative diseases and chemicals for the textile paper and industrial noise-induced hearing loss. polymer industries. One product, called Celplor LLC (Raleigh) provides molecular www.chaperonetherapeutics.com Bac-Shield, contains a natural microbial biology contract research services such as extracted from snow crab shells. cDNA cloning, recombinant protein Charis Diagnostics LLC (Raleigh) offers www.chemtexlaboratories.com expression and purification, genotyping, custom assay development, monoclonal stable cell line development, virus production development and production and Chemtura USA (Gastonia) manufactures and enzyme-linked immunosorbent assay other contract research services. specialty chemicals and crop protection (ELISA) development. www.charisdiagnostics.com products. www.celplor.com www.chemtura.com Charles River Laboratories Inc. (Raleigh) CEM Corp. (Matthews) designs and develops provides drug discovery and development Chesson Laboratory Associates Inc. microwave laboratory instrumentation and process services. (Durham) develops polymer-based medical scientific methods for life sciences, analytical www.criver.com products. laboratories and processing plants. www.chessonlabs.com www.cem.com Charles River Laboratories Inc. - PAI (Durham) provides pathology and toxicology Chiltern International Inc. (Wilmington) Cempra Pharmaceuticals Inc. (Chapel Hill) contract services. conducts Phase I through IV global clinical develops antibiotics for treating drug-resistant www.criver.com trials across a broad therapeutic range and bacterial infections. including biometrics, regulatory affairs and www.cempra.com Charter Medical Ltd. (Winston-Salem) resourcing. develops and manufactures products for www.chiltern.com Cenduit LLC (Durham) provides clinical trial the collection, separation, manipulation, drug supply management services as well as transportation, storage and administration Chimerix Inc. (Durham) develops oral clinical trial data collection and management of blood, blood components and vital fluids antiviral therapeutics for viral diseases services. in the biotechnology and pharmaceutical including adenoviruses, CMV, BK virus, HPV, www.cenduit.com industries. HIV and HCV. www.chartermedical.com www.chimerix.com CeNeRx Biopharma Inc. (Cary) develops therapeutics for depression, anxiety, epilepsy, Chelsea Therapeutics International Ltd. Chirazyme Labs Inc. (Greenville) produces pain, glaucoma, spasticity and other disorders (Charlotte) acquires and develops products to enzymes for stereospecific epoxidation of the central nervous system. treat rheumatoid arthritis, psoriasis and other intermediates in pharmaceutical synthesis. www.cenerx.com inflammatory conditions. www.chirazyme.com www.chelsearx.com Centice Corp. (Morrisville) creates and Cirrus Pharmaceuticals Inc. (RTP) provides commercializes computational sensor Chematron Inc. (Charlotte) manufactures product development services, including technology for pharmaceutical development, textile chemicals and has the capability for physical and chemical characterization, biotechnology, healthcare, process contractual custom manufacture of specialty formulation development, stability testing, manufacturing and homeland security. chemicals. process development, as well as scale-up www.centice.com www.chematron.com and technical transfer to manufacturing. www.cirruspharm.com CertiRx Corp. (RTP) develops products that Chem-Bac Laboratories Inc. (Charlotte) is an reduce the risk of injury or death from FDA-registered analytical testing laboratory. CivaTech Corp. (Raleigh) develops materials counterfeit drugs. www.chembac.com for radiation therapy, including stent www.certirx.com applications. ChemoGenics Biopharma LLC (RTP) www.civatech.com Cetero Research (Cary) provides early-phase provides drug discovery research services clinical research services such as clinical such as medicinal chemistry, DMPK, CivaTech Oncology Inc. (RTP) develops pharmacology, bioanalytical services and bioinformatics and preclinical models in radioactive devices to treat localized tumors. scientific affairs support. cancer, inflammation and metabolic www.civatechoncology.com www.cetero.com diseases. www.chemogenicsbiopharma.com

8 North Carolina Companies Companies Ci – Co

CiVentiChem (RTP) provides contract Cognosci Inc. (RTP) develops neurorestorative Cook Medical (Winston-Salem) develops research and development services, including therapies for Alzheimer’s disease, multiple and manufactures devices used in medicinal chemistry, lead optimization, GMP/ sclerosis, traumatic brain injury, nerve gastrointestinal endoscopy to diagnose GLP analytical services and custom synthesis crush and other disease and trauma and treat esophageal, gastric, pancreatic, of pharmaceutical intermediates. indications. biliary and colonic disorders. www.cvchem.com www.cognosci.com www.cookgroup.com

Clearside Biomedical Inc. (Raleigh) develops CoLucid Pharmaceuticals Inc. (Durham) Corn Products International (Winston- and commercializes ophthalmic therapeutic develops therapies for central nervous Salem) manufactures sweeteners and starches products that use an ocular microinjection system (CNS) disorders such as migraine, from corn. platform to target individual compartments chronic pain and Alzheimer’s disease. www.cornproducts.com of the eye. www.colucid.com www.clearsidebio.com Cornerstone Therapeutics Inc. (Cary) Columbia Life Systems Inc. (Chapel Hill) acquires, develops and commercializes Clinical Sensors Inc. (Chapel Hill) develops develops a computer-controlled oxygen products for the respiratory, hospital and diagnostic tests and nitric oxide sensors for blender for therapeutic research. related specialty markets. the early detection of sepsis. www.smartblender.com www.crtx.com

Cmed Inc. (Durham) provides clinical ConvaTec Inc. (Greensboro) manufactures Cotton Incorporateds (Cary) The Agricultural research services and manages early-phase products for ostomy, skin and advanced & Environmental Research Division improves studies (Phase I - IIb) with a focus in oncology, wound care. cotton cultivation through genetic and infectious disease, respiratory and cardiology. www.convatec.com biotechnology tools, enhancing yield, www.cmedresearch.com quality and resistance of cotton varieties. www.cottoninc.com Companies Co – Eb

Countervail Corp. (Charlotte) develops and CropSolution Inc. (RTP) develops DARA BioSciences Inc. (Raleigh) acquires commercializes products to protect against agrochemicals that protect crops from promising early-stage drug candidates from and treat exposure to chemical weapons and diseases, insect pests and weeds. third parties and advances their clinical pesticide poisoning. www.cropsolution.com development for later sale or license to www.countervailcorp.com pharmaceutical companies. CTMG Inc. (Greenville and Raleigh) provides www.darabiosciences.com Covidien Inc. (Raleigh) manufactures site-specific clinical-trial research services, acetaminophen, the active ingredient in including patient recruitment, personnel, DaVINCI Biomedical Research Products Tylenol® and contrast media used in diagnostic expertise and systems. Inc. (Garner) is an AAALAC-accredited imaging tests and pharmaceuticals. www.ctmginc.com contract lab that performs GLP and non-GLP covidien.com preclinical animal studies. DaVINCI has Curaxis Pharmaceutical Corp. (Raleigh) experience in regenerative medicine, CP Diagnostics Inc. (Charlotte) develops develops treatments that could reduce or cardiovascular, orthopedic and medical non-invasive, breath-based methods to halt the effects of Alzheimer’s Disease. device applications. diagnose disease. www.curaxispharma.com www.davincibiomed.com

Craft Technologies Inc. (Wilson) provides Cygnus Technologies Inc. (Southport) Dharma Laboratories LLC (Morrisville) analytical and method development services develops immunochemical reagents and provides formulation development services to identify specific compounds in biological methods for analytical research and human for late stage compounds, matured products materials, food and animal feed. and animal diagnostic applications. and specialty pharmaceutical products. www.crafttechnologies.com www.cygnustechnologies.com DNA:SI Labs (Burlington) provides forensic Creative Bioreactor Designs Inc. Cytex Therapeutics Inc. (Durham) develops DNA and identity testing services to law- (Winston-Salem) develops, manufactures and bio-artificial devices to treat osteoarthritis and enforcement and other government agencies. sells custom bioreactors for tissue engineering other orthopedic diseases. www.dnasi.com and regenerative medicine applications. www.cytextherapeutics.com www.creative-bioreactors.com Drumetix Laboratories LLC (Greensboro) Cytonet LLC (Durham) develops, produces provides myotonic dystrophy protein kinase Cromoz Inc. (RTP) develops non-toxic, and markets cell therapeutic products, (DMPK) absorption, distribution, metabolism water-soluble carbon nano tubes that can be including human liver cells, to treat liver and excretion (ADME) services and bioanalytical used as a drug delivery tool to reduce the diseases. support for discovery and preclinical drug amount of drug used during chemotherapy www.cytonetllc.com metabolism and toxicokinetic studies. and reduce potential drug side effects. www.drumetix.com www.cromoz.com Daily Manufacturing Inc. (Rockwell) manufactures vitamins, minerals and herbals. DSM Pharmaceuticals Inc. (Greenville) Crop Microclimate Management Inc. The company also manufactures products for manufactures sterile injectables (liquid and (Apex) researches and develops technologies other supplement companies with their own freeze-dried), solid dose (tablets and capsules), to improve crop productivity by mitigating brand names. semi-solid (creams and ointments) and liquid the impact of environmental stresses. www.daily-mfg.com products. www.cropstress.com www.dsm.com

Duke Clinical Research Institute (Durham) is an academic clinical research organization that conducts clinical research projects from pilot study to global trials, device trials to outcomes analyses. www.dcri.duke.edu

Eboo Pharmaceuticals Inc. (Durham) develops small-molecule drugs targeted at the opioid receptor family to treat Parkinson’s disease, depression and other disorders. N C S U / R o g er Wins t ead 10 North Carolina Companies Companies Ec – En

Ecoblend LLC (Pittsboro) develops and Eisai Inc. (RTP) discovers, develops and ENCO Pharmaceutical Development Inc. manufactures organic weed and pest control markets pharmaceuticals in three main (Cary) is a cGMP-compliant contract testing products, using soy methyl esters as a main therapeutic areas - neurology, gastrointestinal laboratory, with analytical development ingredient. disorders and oncology/critical care. Eisai’s RTP services ranging from raw-materials testing www.ecoblend.us facility does pharmaceutical production and through Phase III stability studies and release formulation R&D. testing. Effipharma Inc. (Chapel Hill) discovers and www.eisai.com www.encopharma.com develops therapeutics to treat disorders of the central nervous system, with a particular focus EMSL Analytical Inc. (Morrisville, Charlotte Endacea Inc. (RTP) develops adenosine on Parkinson’s disease, Alzheimer’s and other and Kernersville) provides analytical services, receptor antagonists as drug candidates for cognitive impairments and schizophrenia. including microbiology, asbestos, indoor air inflammatory diseases, sepsis, asthma and www.effipharma.com quality and food testing. renal impairment. The company is also www.emsl.com developing a sepsis biomarker as a Ei, A Pharmaceutical SolutionWorks companion diagnostic. (Kannapolis) develops and manufactures EN-CAS Analytical Laboratories (Winston- www.endacea.com liquid, semi-solid and powder prescription Salem) provides GLP-compliant analytical and non-prescription skin-care and chemistry contract services for agrochemical, EnSolve Biosystems Inc. (Raleigh) animal-health products. veterinary and bioanalytical research. EN-CAS produces proprietary biologically based www.eisolutionworks.com has experience with preclinical and clinical treatment systems to address oily bilge trials support, pesticides, herbicides and water and process waste streams, as well veterinary drugs. as bioenzymatic degreasers and oil-spill Novozymes, a major ag biotech company www.en-cas.com cleanup products. and the world’s largest enzyme producer, www.ensolve.com is one of the many multinational Enci Therapeutics Inc. (Chapel Hill) companies with North American develops monoclonal antibody-based headquarters in North Carolina. therapeutics to treat breast cancer. Companies En – Fl

ENVIGEN Pharmaceuticals Inc. (RTP) Exela Pharma Sciences LLC (Lenoir) develops classes of new small drug-like develops and manufactures injectable, molecules to treat life-threatening diseases ophthalmic and inhalation pharmaceuticals. including cancer, HIV/AIDS and neurological The Lenoir site is a sterile manufacturing disorders. facility, compliant with cGMP and other FDA www.envigenpharma.com regulations. www.exela.us Envincio LLC (Cary) develops, manufactures and markets pest control solutions for use Exodos Life Science Inc. (Chapel Hill) is a in a variety of professional and household semi-virtual pharmaceutical development environments, including biopesticides and company advancing product concepts piscicides used in aquaculture. through the 505(b)(2) process to early www.envincio.com clinical proof-of-principle and sale. www.exodosls.com Environmental Testing Solutions Inc. (Asheville) offers microbiological and chemical Expression Analysis Inc. (Durham) provides testing for drinking water and wastewater and gene expression and genotyping assays, aquatic biomonitoring toxicity testing. DNA sequencing services, sequence www.etsnclab.com enrichment technologies, marker-assisted breeding and bioinformatics support. The EPL Inc. (RTP) provides histology, pathology laboratory is CLIA-registered and supports and toxicology services. The company GLP compliance. also offers biorepository storage, study www.expressionanalysis.com monitoring and data reporting services for

t hoKine i c Te hnolo g ies clinical trials. Fair Products Inc. (Cary) manufactures and O r www.epl-inc.com distributes tobacco crop care products including insecticides, sucker control, ripeners Entegrion Inc. (RTP) develops biologic Esoterix Clinical Trials Services (Durham) a and fertilizers. technologies for hemorrhage control, division of LabCorp, offers laboratory services www.fairproductsinc.com resuscitation and active wound care. The from safety to specialty testing, supporting company also provides blood supply-related phase I through IV clinical trials. Fervent Pharmaceuticals LLC (Greenville) contract R&D services to the US Department of www.esoterixtrials.com develops a non-hormonal product, FP-101, to Defense. treat vasomotor symptoms associated with www.entegrion.com Ethicon Inc. (Raleigh) designs, develops and menopause. manufactures biomaterial-based medical www.ferventpharma.com ENTEX Technologies Inc. (Chapel Hill) adhesives, including the family of DERMA- provides advanced biological and filtration BOND topical skin adhesives. FHI 360 (RTP) develops responses to wastewater treatment that can be customized www.ethicon.com HIV/AIDS and other health and nutrition for various industries. concerns in resource-poor settings. The www.entexinc.com Eton Bioscience Inc. (Durham) laboratory in Durham offers medical-device specializes in DNA sequencing and offers and pharmaceutical testing services. EntoGenetics Inc. (Charlotte) engineers the other services such as gene and peptide www.fhi360.org production of spider silk through the genetic synthesis, mutagenesis and mammalian cell transformation of silkworms. Spider silk is a expression. First Choice Laboratories Inc. (Raleigh) very strong fiber that has applications in the www.etonbio.com provides analytical testing services and biomedical, defense and textile industries. technical support for the nutritional www.entogenetics.com Eurofins Agroscience Services Inc. supplement, pharmaceutical, medical (Mebane and Creedmoor) provides contract device and biotechnology industries. EntoGenex Biotechnology LLC (Chapel Hill) research services, product development www.firstchoicelaboratories.com develops mosquito-control products using consulting and technical support to the biological technologies such as Trypsin crop protection, agricultural biotechnology Fleming Laboratories Inc. (Charlotte) Modulating Oostatic Factor (TMOF), a small and pest control industries. The company manufactures animal feed supplements. protein that interferes with digestion in provides worker-exposure testing and mosquito larvae and leads to their starvation. project-management services at its site in www.entogenex.com Creedmoor. www.eurofinsagro.com 12 North Carolina Companies Companies Fl – Ge

Flexcell International Corp. (Hillsborough) Furiex Pharmaceuticals Inc. (Morrisville) GE Healthcare (Durham) provides diagnostic designs and manufactures products for conducts and finances early-stage preclinical imaging agents which highlight organs, cytomechanics research, studying cellular and proof-of-concept drug development to tissues and cells inside the human body, responses to mechanical forces such as clinical milestones with partner companies. for the early detection, diagnosis and tension or compression. www.furiex.com management of disease. www.flexcellint.com www.ge.com G3 Medical Inc. (Asheville) provides packaging Foothills Bio-Energies (Lenoir) processes and sterilization services, including validation GEM Tox Consultants & Labs Inc. biodiesel from locally available feedstocks testing and regulatory consulting for medical- (Greenville) conducts research focused on such as oilseed crops and poultry fat. device manufacturers and healthcare providers. cancer biotechnology, food safety and www.foothillsbio-energies.com www.g3med.com toxicology, with a special focus on cancer biomarker discovery and validation. FSC Laboratories Inc. (Charlotte) develops Gaia Herbs Inc. (Brevard) grows and www.gemtoxlabs.com and markets pharmaceutical products and produces certified organic herbal products. medical devices, with a focus on children’s All growing, manufacturing, processing, Gene Facelift LLC (Kernersville) develops a unmet medical needs. researching, packaging and distribution genetic cosmetic, gene therapy in a topical www.fsclabs.com takes place in its North Carolina facilities. cream formulation to reduce wrinkles, www.gaiaherbs.com regenerate collagen and restore aging skin. Fujifilm Diosynth Biotechnologies USA www.genefacelift.com Inc. (Morrisville) provides biopharmaceutical Galaxy Diagnostics Inc. (RTP) provides contract process development and molecular diagnostic testing for Bartonella manufacturing. infection in humans and animals. The More than 80 agricultural biotechnology www.fujifilmdiosynth.com company commercializes proprietary companies have put down roots in North technologies developed at the NCSU Carolina, including international giants College of Veterinary Medicine. BASF Corp., Bayer CropScience Ltd., www.galaxydx.com Syngenta AG, Novozymes and Monsanto Co.

Plant Science

InnovatIon YIElds REsults

These are the words that drive us. That inspire us to be one of the world’s leaders in providing innovative solutions for plant biotechnology. To be the most collaborative partner for complex traits. To improve agricultural productivity and

provide healthier nutrition for people and animals. We are BASF Plant Science.

©2012 BASF Plant Science L.P. All rights reserved.

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BASF-5288BusNCadMECH APPROVALS 4-27-2012 3:03 PM Job No: BASF-5288 Digital Artist: Denise Ad Title: AdSponsorship Proofreader: None Prepared by: Denise Lingenfelser Copywriter: None Media Type: Print Ad Art Director: None Printed At: 100% Creative Director: Billy Bleed: None Production: Robin Trim: 7” x 4.875” Account: Sarah Live: 6.4644” x 4.2055” Project Manager: Stephanie Pubs: Business North Carolina

Document Path: Working:Users:dlingenfelser:Do...5288SponsorAd:BASF-5288BusNCadMECH Created: 4-27-2012 12:20 PM Current Date: 4-27-2012 3:03 PM Fonts: Helvetica Neue (45 Light, Condensed Bold), Minion Pro (Regular), Helvetica (Light Condensed, Medium) Images: BASFc_wh52-5trlg_4c.eps (48.57%), Image_5563 enlarged.jpg (CMYK; 1567 ppi; 19.14%) Inks: Cyan, Magenta, Yellow, Black Companies Ge – He

GeneCentric Diagnostics Inc. (Durham) Global Vaccines Inc. (RTP) is a nonprofit G-Zero Therapeutics Inc. (Chapel Hill) develops molecular diagnostic assays to company that develops vaccines against develops and commercializes small-molecule enable oncologists and their patients to developing-country diseases such as HIV/ therapeutic agents to protect the bone make informed, individualized treatment AIDS, polio, dengue fever, malaria and viral marrow from radiation or chemotherapy decisions. diarrhea (rotavirus). damage. www.globalvaccines.org www.gztherapeutics.com General Dynamics Corp. (Charlotte) is a defense contractor. The Charlotte location is GlycoMark Inc. (Winston-Salem) The Hamner Institutes for Health Sciences an electromechanical assembly and integration commercializes and distributes a diagnostic (RTP), a nonprofit research organization, facility that develops and makes products to diabetes enzymatic assay to laboratories in focuses on drug safety and development and detect chemicals and biologicals. the United States, Canada and Europe. supports translational research in partnership www.gdatp.com www.glycomark.com with academic institutions, industries and government agencies. Genewiz Inc. (RTP) provides custom DNA Goldsboro Laboratories LLC (Goldsboro) www.thehamner.org sequencing and synthesis, genomics, develops and manufactures vaccines for bioinformatics, molecular biology and GLP/ the swine, poultry and cattle divisions of Happy Jack Inc. (Snow Hill) manufactures cGMP regulatory-compliant services. Goldsboro Milling Company. insecticides and pharmaceutical preparations www.genewiz.com to treat dogs. Gorbec Pharmaceutical Services Inc. www.happyjackinc.com Genova Diagnostics Inc. (Asheville) (Durham) provides contract pharmaceutical performs diagnostics and molecular services including formulation, development HDH Pharma Inc. (Morrisville) provides genetics testing under federally designated and pilot-scale production, with a focus on contract chemistry research services to clinical lab standards to support physicians small-volume niche drugs. pharmaceutical and biotechnology in personalized chronic disease treatment www.gorbec.com companies, including medicinal and and prevention. process chemistry and custom synthesis. www.gdx.net GrassRoots Biotechnology Inc. (Durham) www.hdhpharma.com employs a systems biology approach to Gentris Corp. (Morrisville) performs clinical develop and commercialize biofuel and food Health Decisions Inc. (Durham) is a global pharmacogenomic testing and provides crops with increased yield, insect resistance clinical research organization that specializes biorepository services under federally and stress tolerance. in applying adaptive principles to both trial designated clinical lab standards. www.grassrootsbio.com design and operations. www.gentris.com www.healthdec.com Greer Laboratories Inc. (Lenoir) develops GFS US LLC (Winston-Salem) researches and and distributes animal and human allergy Heat Biologics Inc. (Chapel Hill) develops develops environmentally friendly enzyme, immunotherapy products and services. therapeutic vaccines to combat a range of antimicrobial and microbial products for the www.greerlabs.com cancers and infectious diseases. Americas. www.heatbio.com www.gfs-us.com Grifols Inc. (RTP, Raleigh and Clayton) develops and produces medical treatments Helical Sciences Inc. (Greensboro) develops GlaxoSmithKline (RTP and Zebulon) develops using blood or blood components for people a rapid, polymerase chain reaction-based and manufactures pharmaceutical products with life-threatening disorders in a variety of microbiological diagnostic product, with including anti-infectives and central nervous therapeutic areas including immunology, potential applications in water, food and system, respiratory, gastro-intestinal/ pulmonology and hemostasis. Grifols’ Clayton beverage. metabolic and oncology drugs and vaccines. plant is the company’s primary manufacturing www.helicalsciences.com The RTP site is the US headquarters. GSK facility, producing proteins to treat rare manufactures solid-dose products, including diseases including immune deficiencies and Hemo Bioscience Inc. (RTP) is an FDA- tablets and capsules at its Zebulon facility. genetic emphysema. Two R&D facilities are registered manufacturer of blood-typing The plant also does granulation, drying and located in Raleigh. reagents and diagnostics for the blood- packaging and contract manufacturing for www.grifols.com banking industry. other companies. www.hemobioscience.com www.gsk.com GTCAllison LLC (Mocksville) researches and develops diagnostic tests for animal Hemodynamic Therapeutics (Durham) pathogens. develops small-molecule combination www.gtcallison.com therapy for obesity-related hypertension. www.hemodynamictx.com

14 North Carolina Companies Companies He– Hy

HepatoSys Inc. (Cornelius) develops Hongene Biotechnology USA Inc. Humacyte Inc. (RTP) develops processes technologies for functional restoration of (Morrisville) develops and manufactures to engineer human tissue scaffolds that can donor livers for use in transplantation and bio-reagents such as nucleosides, nucleotides be shaped into tubes, sheets or particulates production of hepatocytes for research. and phosphoramidite products. for regenerative medicine uses. The current www.hepatosys.com hongeneusa.com product focus includes vascular disease, therapeutic filling and soft-tissue repair. Hibernaid Inc. (Chapel Hill) develops Hospira Inc. (Rocky Mount and Clayton) www.humacyte.com drug-induced hypothermia mechanisms manufactures injectable hospital products at to treat stroke, cardiorespiratory arrest and its facility in Rocky Mount and generic acute Hydro Service and Supplies Inc. (RTP) other ischemia-reperfusion injuries. injectable drugs for intravenous use at its provides design, manufacturing and facility in Clayton. Both facilities also provide installation of high-purity water systems High Point Clinical Trials Center (High Point) contract manufacturing services such as for laboratory and manufacturing processes. conducts Phase I and II clinical research aseptic filling, lyophilization, terminal It also provides microbiological and studies for pharmaceutical companies. sterilization and more. enzymatic water testing services. www.hpctrialscenter.com www.hospira.com www.hydroservice.com

High Point Pharmaceuticals LLC Howard Associates LLC (RTP) provides Hyperbranch Medical Technology Inc. (High Point) was spun out of TransTech Pharma preclinical contract research services to (Durham) is a biosurgical device company to manage the development of drugs for the . The company focused on the design, development and obesity and diabetes. uses rodent models to predict the efficacy manufacture of resorbable surgical sealants of experimental compounds, especially for for general and specialty surgery use. HOMS LLC (Pittsboro) develops, manufactures CNS diseases and to predict CNS side www.hyperbranch.com and markets natural products such as the Bite effects. Blocker line of insect repellents and Bio Block www.howardassociates.net organic insecticides. www.homs.com

Faculty with industry expertise facilitate hands-on learning in BTEC’s up-to-date labs. EnginEEring a brightEr futurE…

Through Training and educaTion The Golden LEAF Biomanufacturing Training and Education Center (BTEC) provides undergraduate, graduate and continuing education programs to develop skilled professionals for the biomanufacturing industry.

and by providing soluTions and services BTEC also offers an array of process development, analytical testing and development, and technology development services to industry. Located on NC State University’s to learn how your company can take advantage of btEC’s training and services, Centennial Campus in Raleigh. call bill Welsh at 919.513.0969. www.btec.ncsu.edu. Companies Ic – Ka

ICON Clinical Research (Durham) provides Inanovate Inc. (Durham) develops Integrated Laboratory Systems Inc. (RTP) drug development and clinical services, from nano-structured biochip substrates for provides GLP toxicology, histopathology, compound selection to Phase I-IV clinical high-throughput protein screening and molecular biology and research and studies, in areas including oncology, analysis. The company also provides a variety development services to government and cardiovascular and biosimilars. of microarray services such as protein commercial clients in agro-chemical, www.iconclinical.com printing/arraying and assay development. biopharmaceutical and environmental www.inanovate.com industries. Identizyme Defense Technologies Inc. www.ils-inc.com (Chapel Hill) develops a device to identify INC Research Inc. (Raleigh and Wilmington) terrorist nerve agents via a no-power provides Phase I-IV contract research services Intrexon Corp.’s (RTP) AgBio division colorimetric enzyme assay. across a variety of therapeutic areas, with the facilitates production of enhanced food, as capability to work with special populations, well as proteins and ingredients produced IDEXX Reference Laboratories Inc. such as women and pediatrics. in agricultural-based expression systems. (Greensboro) provides animal health diagnostic www.incresearch.com www.dna.com products and services for use in small animals, equine, poultry and dairy livestock. It also Indicus Pharma LLC (Raleigh) develops Invitrox Inc. (RTP) develops specialty disease provides microbiology-based water testing and manufactures generic formulations in diagnostics and therapeutic monitoring assays products. oral solid dosage forms, parenterals and using the characteristics of microparticles to www.idexx.com ophthalmics. detect early signs of cellular damage. www.indicuspharma.com www.invitrox.com ImmunogeniX LLC (Asheville) provides a cryonics biorepository for storage of patient Innovative Neurophysiology Inc. JABB of the Carolinas Inc. (Pine Level) tumor cell samples, with the goal of using (Durham) designs and develops advanced develops and manufactures fungal pesticides those cells in tumor vaccine immunology. tools, equipment and methodology for and biopesticide products. Products are www.immunogenixresearch.com neuroscience research. distributed through its partner company, www.inphysiology.com Terregena. ImmunoReagents Inc. (Raleigh) manufactures primary and secondary polyclonal antibodies InoLife Technologies Inc. (Raleigh) develops Jenken Biosciences Inc. (RTP) researches used in research and in vitro diagnostics for personalized medicine services and genetic and develops small-molecule TLR-4 the pharmaceutical and veterinary markets. testing for biomarkers including DNA testing antagonists for potential treatment of www.immunoreagents.com for paternity and ancestral origin, response to inflammation associated with chronic Plavix and predisposition to liver disease, inflammatory bowel disease, certain diseases. diabetes and organ damage. www.inolifetech.com www.jenkenbio.com

JLA International Inc. (Edenton) provides testing and analytical services for the food and beverage industry. It also provides technical consulting services. www.jlaglobal.com

Jubilant Clinsys Inc. (Raleigh) provides clinical research services in support of Phase I-IV drug development. www.clinsys.com

Kainos Medicine USA Inc. (Morrisville) discovers and develops drug candidates for the treatment of a variety of diseases, including dry mouth, diabetes and HIV. www.kainosmedicine.com

KaryoLogic Inc. (RTP) provides chromosome analysis services, such as karyotyping of human, rat and mouse cell lines, to research laboratories. www.karyologic.com 16 North Carolina Companies Ka – La

Katharos Inc. (Raleigh) develops a medical device technology for phosphate-selective adsorption to treat high blood phosphate levels in end-stage renal disease hemodialysis patients.

KBI BioPharma Inc. (Durham) provides contract development and manufacturing services, such as formulation, analytical method development, stability services, process development and API manufacturing. www.kbibiopharma.com

Kenactiv Innovations Inc. (Snow Hill) develops and manufactures bio-based fiber products from kenaf. www.kenactiv.com

KeraNetics LLC (Winston-Salem) develops and commercializes keratin-based biomaterials for use in regenerative medicine and trauma care. www.keranetics.com

King Bio Inc. (Asheville) develops and manufactures water-based homeopathic medicines and supplements for human and companion-animal health. King Bio also provides contract manufacturing services. www.kingbio.com

Kowa Research Institute Inc. (Morrisville), a division of Kowa Company Ltd., develops therapeutic drugs for the treatment of Smarter Growth diabetes, arteriosclerosis and atherosclerosis. # 1 Real Estate Market to Watch in 2012 www.kowaus.com # 1 Smartest City in NC

Krenitsky Pharmaceuticals Inc. (Durham) Smarter Business discovers and develops drug candidates, # 1 Best Place for Business and Careers with a focus on disorders of the nervous # 1 Fastest Growing City for Technology Jobs system. www.kpi-pharma.com Smarter Living # 1 Best City in America LAAMScience Inc. (Morrisville) develops # 1 Healthiest City for Women antimicrobial products such as medical masks # 1 Highest Quality of Life in NC and respirators, cleaning wipes and pet-care products. www.laamscience.com

Contact us to learn what Eastern North Carolina’s various academic makes Wake County the #1 research facilities are incorporating tools choice for business and talent. www.raleigh-wake.org used in marine and agricultural biotechnology and biomanufacturing to find new crops, medicines and opportunities for producing biofuels.

2012_04_wced_bnc.indd 1 4/27/12 2:04 PM Companies La – Me

Laboratory Corporation of America mAbRx Inc. (Wilmington) develops MEDTOX Diagnostics Inc. (Burlington) (Burlington, RTP and Kannapolis) provides therapeutic monoclonal antibodies for manufactures and distributes diagnostic drug clinical and anatomical laboratory services, cancer treatment. screening devices. including clinical trials testing services and www.mabrx.com www.medtox.com offers a broad range of genomic and esoteric tests. LabCorp’s Center for Occupational MARBIONC Development Group LLC Merck & Co. Inc. (Wilson and Durham) Testing provides urine, hair, oral fluid and (Wilmington) is a nonprofit organization that produces patented prescription products point-of-collection drugs of abuse testing develops and markets new products and and performs granulation and tableting services. LabCorp’s facility in Kannapolis is a technologies derived from marine and operations at its manufacturing facility in biorepository that has the capacity to house aquatic organisms. Wilson. Merck’s facility in Durham manufactures 15 million samples. www.marbionc.org elements of Varivax, a chicken pox vaccine www.labcorp.com and expects to be fully FDA-approved for the Marble Laboratories LLC (Winston-Salem) manufacture of this and other vaccine LeukoMed Inc. (Raleigh) researches, provides contract testing, process products by 2014. develops and commercializes medicines for development, laboratory services and www.merck.com inflammatory disorders using compounds auditing to biotechnology companies. licensed from area universities. Mercury Science Inc. (Durham) develops www.leukomed.com MastCell Pharmaceuticals Inc. (Raleigh) novel and customized methods of analytical develops therapeutic agents for the treatment analysis, with expertise in environmental Life Technologies Inc. (Durham) develops of allergic disorders. analysis of soil, water and food. human and animal hepatic cell products and www.mastcellpharma.com www.mercuryscience.com provides contract laboratory (in vitro) services, focused primarily on drug metabolism and Maverick Biofuels Inc. (Chapel Hill) converts Meridian Laboratory Corp. (Charlotte) toxicology. biomass, municipal waste, coal and natural provides CLIA-certified and COLA-accredited www.invitrogen.com gas into petroleum-free fuels and bioplastics. patient testing services, as well as testing of www.maverickbiofuels.com water quality for use in dialysis. LipoScience Inc. (Raleigh) develops and www.meridianlaboratory.com markets clinical diagnostic applications of MDx Health Inc. (Durham) develops gene Nuclear Magnetic Resonance Spectroscopy, methylation diagnostic tests for early cancer Merrion Pharmaceuticals LLC (Wilmington) including the NMR LipoProfile® test which it detection and personalized treatment develops new oral formulations of previously uses to diagnose cardiovascular disease. decisions. injectable-only medicines. www.liposcience.com www.mdxhealth.com www.merrionpharma.com

Liquidia Technologies Inc. (RTP) utilizes Medicago USA Inc. (Durham) develops Merz Pharmaceuticals LLC (Greensboro) its PRINT platform technology and GMP vaccines based on proprietary manufacturing develops and distributes neurology, manufacturing capabilities to develop technologies and Virus-Like-Particles. The dermatology and podiatry prescription and engineered particles for improved delivery vaccines are manufactured using a transient non-prescription therapeutics. This is the of biologics and small molecules for vaccine protein expression system in tobacco plants. company’s US headquarters. and therapeutic applications. www.medicago.com www.merzusa.com www.liquidia.com MedKoo Biosciences Inc. (Chapel Hill) Metabolon Inc. (RTP) offers biochemical Lumena Pharmaceuticals Inc. (RTP) manufactures small molecular anticancer profiling services for the discovery of develops treatments for metabolic diseases reference agents for oncology research and biomarkers and pathways associated with such as obesity and type 2 diabetes through provides drug discovery contract research disease and diagnostic products based on non-systemically absorbed compounds services. those discoveries. having targets in the lumen of the gut. www.medkoo.com www.metabolon.com www.lumenapharma.com Metrics Inc. (Greenville) provides contract development and manufacturing of Educational Assistance pharmaceutical products. Services include development of full-scale analytical methods, More than 1,700 educators throughout the state have taken the North validation and testing, clinical trial materials Carolina Biotechnology Center’s summer workshops, improving lab skills and packaging. www.metricsinc.com and equipment access for more than 600,000 students.

18 North Carolina Companies Companies Mi – Mo

Micell Technologies (Durham) develops Mimesis Inc. (Greensboro) produces Momentum Research Inc. (Durham) combination-product therapies for tissue-specific extracellular matrices, derived manages and directs Phase I-IV clinical interventional cardiology. Its products from decellularized tissues, for culturing stem research projects and specializes in include drug-eluting cardiovascular stents and progenitor cells. cardiovascular clinical trials management. and balloons. www.mimesisinc.com www.momentum-research.com www.micell.com Minu LLC (Pittsboro) researches and develops MonomerChem Inc. (RTP) provides Microbac Laboratories Inc. (Wilson and ophthalmology products. contract drug development services, Fayetteville) offers chemical and microbiological www.minullc.com including custom synthesis, medicinal testing services for the agrochemical, chemistry, lead optimization and synthesis pharmaceutical and consumer products Molecular Orthopaedics Inc. (Chapel Hill) of reference standards and metabolites. industries at its GMP-certified laboratory in develops gene therapies for osteoarthritis, www.customsynthesis.com Wilson. Microbac’s laboratory in Fayetteville with applications in human and animal health. offers microbiological testing and sampling Monsanto Co.’s (RTP, Kannapolis and Mount services for wastewater, environmental and Molecular Toxicology Inc. (Boone) Olive) facility in RTP analyzes the physiological food safety purposes. manufactures reagents, assay kits and other traits of plants in the company’s corn, soy and www.microbac.com products for genetic toxicology research and cotton research and development pipeline. testing, as well as products for industrial Its research facility in Kannapolis focuses on Microban International Ltd. (Huntersville) microbiology and quality control. the taste and nutritional composition of develops and manufactures antimicrobial www.moltox.com vegetables and enhanced nutrition in food- technologies used in consumer, industrial focused row crops such as soybeans. Its Mt. and medical products. Molecules in Action LLC (Chapel Hill) Olive facility is a crops research station. www.microban.com provides custom molecular modeling, virtual www.monsanto.com drug screening, molecular simulations and consulting services. www.moleculesinaction.com

NOW LEASING We take pride in instigating innovation.

e Piedmont Triad Research Park () mixes intellectual and investment connectivity with state of the art wet labs. Wake Forest Biotech Place, the latest development, is a world-class biotechnology research and innovation center with both pre-built and custom space available. Let us WHERE INNOVATION LIVES show you the bene ts of an urban lifestyle.

For more information about PTRP and Wake Forest Biotech Place, please visit our website at www.PTRP.com or call (336) 716-8672. Companies Mx – No

NanoVector Inc. (Raleigh) commercializes Novametics Inc. (Raleigh) develops blood a plant virus nanoparticle to develop a family coagulation diagnostic products. of targeted-delivery, small-molecule cancer www.novametics.com drugs. www.nanovectorinc.com Novan Therapeutics (Durham) develops nitric oxide releasing nanoparticle Natland International Corp. (RTP) provides technology, which has therapeutic potential contract research synthesis of pharmaceuticals in applications related to immune system and custom organic chemicals. response, wound healing and blood pressure www.natland.com regulation. www.novantherapeutics.com Natural Products & Glycotechnology Research Institute Inc. (Pittsboro) Novartis Animal Health US Inc. (Greensboro) develops new methods for the synthesis of researches, develops and commercializes oligosaccharides to be used in the development animal treatments for pet owners, farmers of vaccines or diagnostic tools. and veterinarians. The Greensboro location is the US headquarters and operations center Nature’s Pearl Corp. (Advance) manufactures for its veterinary health business. al nutraceutical and cosmeceutical products www.ah.novartis.us from muscadine grape seeds and skins. Its products are manufactured in a cGMP facility Novartis Vaccines and Diagnostics Inc.

Mission H ospi t and have been studied in clinical trials for (Holly Springs) develops and manufactures efficacy. seasonal trivalent flu vaccines. MxBiodevices LLC (Greenville) develops www.naturespearlproducts.com www.novartisvaccines.com dermal wound healing products. nContact Inc. (Morrisville) develops a cardiac NovaTarg Inc. (Durham) discovers, Mycorrhiza Biotech LLC (Burlington) coagulation device for the endoscopic develops and commercializes pharmaceutical researches the application of biotechnology treatment of cardiovascular arrhythmias, treatments for cancer and metabolic diseases. in mycorrhizal fungi and truffles, including the including atrial fibrillation. www.novatarg.org development of bioremediation methods and www.ncontactinc.com detection assays. Novella Clinical Inc. (Durham and www.mycorrhizabiotech.com NephroGenex Inc. (RTP) develops kidney Wilmington) provides CRO support services disease therapeutics, with a focus on diabetic to biopharmaceutical and medical device Mycosynthetix Inc. (Hillsborough) manages nephropathy. companies. Services range from protocol a large collection of fungal isolates and www.nephrogenex.com development through final clinical study metabolites used in drug discovery and report. agrochemical and biofuels research. Neuronex Inc. (Morrisville) develops drugs www.novellaclinical.com www.mycosynthetix.com that treat central nervous system diseases and disorders. Novo Nordisk Pharmaceutical Industries NanoCor Therapeutics Inc. (Chapel Hill) www.neuronexinc.com Inc. (Clayton) manufactures insulin products develops an intracellular genetic protein therapy and pre-filled insulin delivery devices. for the treatment of chronic heart failure. Neuroscience Research Institute of North www.novonordisk-clayton.com www.nanocorthx.com Carolina (Winston-Salem) is a non-profit corporation that conducts NIH-funded Novolipid Inc. (RTP) develops technologies NanoMedica Inc. (Winston-Salem) research on brain functions, alcoholism, to make current cancer drugs safer and more provides ultrasensitive detection reagents and Parkinson’s disease, schizophrenia and pain effective by covalently attaching cytotoxic nanotechnology-based drug discovery services regulations. chemotherapeutic drugs to small lipids. and tools to biopharmaceutical companies. www.neurosciencenc.org www.novolipid.com www.nanomedica.com North Carolina Clinical Research (Raleigh) Novozymes North America Inc. Nanosyn (Durham) specializes in biological conducts Phase I-IV trials in a variety of (Franklinton) manufactures enzymes, screening and profiling of compounds and therapeutic areas at its outpatient clinical microorganisms, biopharma ingredients chemical libraries, medicinal and process research facility. and other bio-industrial products which chemistry and other drug discovery services. www.nccr.com are used in aquaculture, brewing, detergents, www.nanosyn.com fuel ethanol, food products and textiles. www.novozymes.com 20 North Carolina Companies Companies Nu – Op

Nufarm Americas Inc. (Morrisville) Oak-Bark Corp. (Wilmington and Riegelwood) Onconix Inc. (Lewisville) identifies and manufactures and markets insecticides, develops and manufactures semi-bulk and markets cancer diagnostic products. It fungicides, plant growth regulators and bulk chemicals, specializing in organosulfur has a blood test for cervical cancer on the herbicides. This site serves as Nufarm’s products. The production facility is located market. primary research and development facility in Riegelwood and the corporate office is www.onconix.net in the United States. located in Wilmington. www.nufarm.com www.oak-bark.com Oncoscope Inc. (Durham) develops optical imaging systems for guided biopsy of Nutrasearch LLC (RTP) provides contract Ocean Therapeutics Inc. (Cary) in-licenses, epithelial tissues in the esophagus, colon, research on the effects of foods and food out-licenses and develops new medicines lung, cervix and bladder. ingredients on disease and pre-disease and drug candidates from marine organisms www.oncoscope.com conditions, such as obesity, diabetes and in a variety of therapeutic areas. high blood pressure. Nutrasearch also www.oceantherapeutics.com Oncotide Pharmaceuticals Inc. (RTP) distributes human primary cells and discovers and develops drugs that modulate cell-based products. Ockham (Cary and Wilmington) provides protein phosphatases to disrupt cancer cells’ www.nutrasearch.net clinical and non-clinical drug development, ability to proliferate and survive. trial management and consulting services. www.oncotide.com Nutrasorb NC LLC (Kannapolis) develops www.ockham.com functional foods, dietary supplements and OpAns LLC (Durham) provides preclinical, cosmetic ingredients using naturally Ocular Systems Inc. (Winston-Salem) analytical and purification contract services concentrated phytonutrients such as provides corneal endothelial cells for to pharmaceutical companies. anthocyanins from fruits and vegetables. transplantation, as well as related supplies www.opans.com www.nutrasorb.com and devices. It is an FDA-registered human tissue establishment. www.ocularsystemsinc.com Companies Or – Ph

Pearl Therapeutics Inc. (Raleigh) develops combination therapies and formulations of inhaled drugs for chronic respiratory diseases such as asthma and COPD. www.pearltherapeutics.com

Peptagen Inc. (Raleigh) develops nasally- administered cytotoxic T-lymphocyte nanoparticle vaccines for the prevention and treatment of pathogenic diseases and cancer. www.peptagen.com

Pfizer Animal Health Global Poultry (RTP and Maxton) develops and manufactures vaccines and for flock health. The company is a supplier of in-ovo technology. www.pfizerglobalpoultry.com

Pfizer Inc. (Sanford and Cary) manufactures clinical trial and commercial materials for

Basf vaccines such as Prevnar and Meningitec. The Cary location researches and develops Oriel Therapeutics Inc. (RTP), a subsidiary PAREXEL International Corp. (Durham) pain therapeutics. of Sandoz, develops respiratory products as provides drug-development and launch www.pfizer.com generic alternatives to patented drugs for services, including clinical development, asthma and COPD. It also develops and integrated advanced technologies, regulatory Pfizer Neusentis (RTP), formerly Icagen, commercializes pre-metered unit and affairs consulting and commercialization discovers, develops and commercializes multi-dose dry powder delivery systems. services. small-molecule drugs that target ion www.parexel.com channels, with a focus on epilepsy, pain Oryx Bio Inc. (Raleigh) develops biosensors and inflammatory disorders. and bioseparation products for use in Parion Sciences Inc. (Durham) develops bioanalysis research and biopharmaceutical therapies that use topical inhibitors of the PharmaCore Inc. (High Point) provides production. epithelial sodium channel to correct immune- custom organic synthesis, medicinal www.oryxbio.com system defects in respiratory diseases such as chemistry and GMP scale-up for drug cystic fibrosis and COPD. discovery and development. Osmotica Pharmaceutical Corp. www.parion.com www.pharmacore.com (Wilmington) specializes in drug-delivery technologies and neurology-based therapies, Patheon Inc. (RTP and Morrisville) provides PharmaDirections Inc. (Cary) provides including a treatment for Parkinson’s disease. contract development and manufacturing scientific and regulatory drug development www.osmotica.com services, from preclinical development to and project management with a focus on commercial manufacturing in parenteral, preclinical, CMC and regulatory services. Oxygen Biotherapeutics Inc. (Morrisville) solid, semi-solid and liquid forms. Patheon’s www.pharmadirections.com develops medical and cosmetic products laboratory in RTP offers analytical that deliver oxygen to tissues in the body that development services supporting PharmAgra Labs Inc. (Brevard) conducts are oxygen-deprived as a result of a wound, pre-clinical through registration batches. contract research and development in stroke or other condition. www.patheon.com organic and medicinal chemistry. The www.oxybiomed.com company is also developing applications Pathfinder Pharmaceuticals Inc. (Durham) for sulforaphane, a patented compound PACE Analytical Services Inc. (Asheville) studies viral replication mechanisms at a derived from broccoli. provides inorganic and aquatic toxicity testing cellular level to develop drugs for viral www.pharmagra.com services, as well as sampling services for infections and related cancers. groundwater, wastewater and soil. www.pathfinderpharma.com www.pacelabs.com

22 North Carolina Companies CompaniesCompanies Ph 1 –– ArPi

PharmaLogika Inc. (Willow Springs) Pharm-Olam International (RTP) provides Phytonix Corp. (Asheville) develops and develops, manufactures and markets Phase I-IV clinical research services. commercializes biofuels from algae and prescription medication and medical www.pharm-olam.com cyanobacteria. devices primarily for neurological diseases, www.phytonix.com as well as over-the-counter medications PharmStar Pharmaceuticals Inc. (Wilson) and supplements for humans and animals. makes Aquaprin, an FDA-approved water- PhytoPharmacon LLC (Garner) discovers, www.pharmalogika.com soluble aspirin. develops and commercializes a portfolio of www.pharmstarinc.com botanically derived pharmaceuticals and PharmaNet/i3 (Cary) provides contract medical foods. research services for Phase IIB through Phase Phenogen Sciences Inc. (Charlotte) provides www.phytopharmacon.com IV clinical drug development. predictive testing and risk assessment tools www.pharmanet-i3.com that help physicians proactively manage Piedmont Biofuels (Pittsboro) provides patient health. product testing, development and PharmAthene Inc. (Durham) develops and www.phenogensciences.com consulting services. Piedmont is also a manufactures biological and chemical defense biofuels cooperative and developer of products, including an anthrax vaccine. Physcient Inc. (Durham) develops new enzymatic biodiesel technology. www.pharmathene.com surgical tools designed to decrease tissue www.biofuels.coop damage during surgery. Pharmgle Inc. (Chapel Hill) provides contract www.physcient.com Piedmont Pharmaceuticals (Greensboro) research and drug-development services, develops and licenses human health and including synthesis, screening, formulation Physicians Laboratories (Kernersville) animal health therapeutics with a focus on development and testing. produces and distributes Revival Soy protein parasitology and drug delivery systems. www.pharmgle.com products and diet products. www.piedmontpharma.com www.revivalsoy.com Companies Pi – Qu

Piedmont Research Center (Morrisville), a Polyzen Inc. (Apex) designs and manufactures Proactive Genomics LLC (Winston-Salem) division of Charles River, provides a full customized disposable medical devices. develops a genetic test for men to assess their spectrum of in vivo and in vitro oncology www.polyzen.com genetic risk for prostate cancer. research services. www.proactivegenomics.com/about www.criver.com/en-us/prodserv/bytype/ POZEN Inc. (Chapel Hill) develops products discovery for the treatment of acute and chronic pain Procter & Gamble (Greensboro and Browns and pain-related conditions. Summit) manufactures Nyquil, Dayquil, Pioneer Hi-Bred International Center for www.pozen.com cough syrups and other OTC products at its Dryland Research - Coastal Plains (Kinston) Swing Road location. It manufactures conducts research on the conventional and PPD Inc. (Wilmington, Durham and Morrisville) antiperspirants, deodorants, toothpaste transgenic development of corn, soybeans provides drug discovery, development and denture-care products at its Brown and other crops, with an emphasis on and lifecycle management services to Summit location. drought-resistant crops. pharmaceutical, biotechnology, medical www.pg.com device, academic and government Pioneer Surgical Technology Inc. (Greenville organizations. PPD’s RTP locations include ProTrials Research Inc. (Chapel Hill) provides and Raleigh) develops injectable biopolymers clinical operations, medical communications, services for Phase I-IV clinical trials in a variety used as regenerative medicine in orthopedic a preclinical lab and other drug development of therapeutic areas. applications. functions. www.protrials.com www.pioneersurgical.com www.ppdi.com Purdue Pharmaceuticals LP (Wilson) Pique Therapeutics Inc. (Durham) develops PRA International Inc. (Raleigh) provides produces and packages oral solid dosage therapeutic vaccines for the treatment of CRO services for all phases of clinical tablets and is a distribution center for cancer. development. prescription products. www.piquetherapeutics.com www.praintl.com www.purduepharma.com

Pisgah Labs Inc. (Pisgah Forest) manufactures Precision BioSciences Inc. (RTP) develops QOL Medical LLC (Raleigh) acquires, grows active pharmaceutical ingredients on a technology to produce custom, genome- and commercializes existing or approved and contract basis. Pisgah Labs’ cGMP facility editing enzymes for mammalian or plant complementary new metabolic disease and includes an aseptic manufacturing suite. genes. The technology is called Directed pediatric gastroenterology products. www.pisgahlabs.com Nuclease Editor. www.qolmed.com www.precisionbiosciences.com Plant Health Care Inc. (Raleigh) develops Qualiber Inc. (Chapel Hill) develops technologies to promote plant health and Precision PlantSciences Inc. (Durham) nanotechnologies to solve drug delivery increase crop yields. develops Precision Biosciences’ technology, challenges for siRNA, small molecules and www.planthealthcare.com called Directed Nuclease Editor, for agricultural gene-based therapeutics, with a focus on applications. cancer, hepatitis and liver diseases. Plureon Corp. (Winston-Salem) develops a www.precisionbiosciences.com www.qualiberinc.com technology platform based on pluripotent stem cells extracted from amniotic fluid Prima Biomed USA Inc. (Cary) develops Qualicaps Inc. (Whitsett) manufactures and placenta. These cells may be used in Cvac(tm), an autologous, dendritic-cell empty two-piece capsules (gelatin and regenerative medicine and other therapies. immune stimulant to treat ovarian cancer. hypromellose) and encapsulation www.plureon.com www.primabiomed.com.au equipment under cGMP regulations for use by pharmaceutical, OTC and dietary- supplement manufacturers. www.qualicaps.com

Qualitest Pharmaceuticals Inc. (Charlotte) manufactures generic pharmaceuticals. The company’s solid-dose manufacturing facility in Charlotte also includes laboratory space for quality control and R&D. www.qualitestrx.com vo c a I n . A 24 North Carolina Companies CompaniesCompanies Qu 1 – ArRt

Quality Chemical Laboratories RF Wastewater (Raleigh) focuses on Rockwell Automation Life Sciences (Wilmington) offers contract analytical biological wastewater treatment, using (Cary) provides automation control, process and microbiological testing services to lignocellulosic materials as biofilm media optimization and execution systems for pharmaceutical companies, including for activated sludge system retrofits and manufacturers. Rockwell’s Cary location is raw-material and finished-product testing, upgrades. the headquarters for the Americas life stability testing, method development and www.rfwastewater.com sciences division. validation. www.rockwellautomation.com/lifesciences www.qualitychemlabs.com Rheomics Inc. (Chapel Hill) develops technologies to measure fluid viscosity and RTI Health Solutions (RTP) provides Qualyst Inc. (Durham) develops and cell membrane rigidity. These technologies consulting and contract research services commercializes cell-based drug toxicity- will be incorporated into biomedical to help pharmaceutical, biotechnology, testing products used in pharmaceutical instruments designed to diagnose clotting diagnostics and medical-device companies development, based on its proprietary disorders and cancer metastasis. develop and commercialize their products. hepatocyte technologies. www.rtihealthsolutions.org www.qualyst.com Rho (Chapel Hill) provides clinical development and contract research services RTI International (RTP) is a nonprofit QuarTek Corp. (Greensboro) develops to the biotechnology, pharmaceutical and organization that provides research and nanotechnology processes with applications medical-device industries. technical services to governments and in antimicrobials, advanced textiles, nano- www.rhoworld.com businesses, including drug discovery and sensors, diagnostics and biofuels. The development, analytical chemistry, company also provides accelerator services Ridge Diagnostics Inc. (RTP) markets a microbiology, medical device and for startup nanotechnology companies. blood test as an aid for diagnosing depression. diagnostics research. www.quartekcorp.com Other products are being developed for www.rti.org treatment monitoring and for diagnosis of Quintiles (Durham, Morrisville and Williamston) other neuropsychiatric diseases. is a contract research organization that www.ridgedx.com provides clinical- and product-development services for pharmaceuticals, biosimilars and medical devices. Quintiles’ facility in Williamston is a clinical-data-entry center to support the company’s clinical-development business. www.quintiles.com

Regado Biosciences Inc. (Durham) discovers and develops injectable antithrombotics, including anticoagulants and antiplatelet agents. www.regadobiosciences.com

Research Triangle Park Laboratories Inc. (Raleigh) provides contract analytical laboratory services for environmental, pharmaceutical, biotechnology, dietary supplements and manufacturing industries. www.rtp-labs.com

North Carolina has many world-class facilities for academic and industrial researchers, including 37 commercial wet lab/incubator sites, dozens of core labs offering a wide range of services and/or highly specialized equipment and seven research parks. Companies Sa – Sm

SePRO Research & Technology Campus (Whitakers) acquires, develops, manufactures and markets products for aquatics and horticulture. SePRO’s research and technology campus in Whitakers is the primary research and development site for the company. www.sepro.com

Serum Source International Inc. (Charlotte) supplies animal serum for cell-culture research. www.serumsourceintl.com

Shoaf Scientific Consultants Inc. (Lexington) provides consulting and research services for clients developing new methods for manufacturing biological and biochemical sensors and other biomedical products. www.shoafbiochem.com

Medi c a g o Shure Foods Inc. (Greenville) produces gelated crab by treating the uncooked crab Saha Pharmaceuticals Inc. (Durham) Scientific Analytical Institute Inc. meat with a protein binding agent. develops technology to reduce the toxicity (Greensboro) conducts environmental, of anticancer drugs. indoor-air-quality, forensic and materials testing. SipcamAdvan (Durham) develops and www.sailab.com manufactures herbicides, pesticides, Salix Pharmaceuticals Inc. (Raleigh) fungicides and biocides. develops and markets prescription SciKon Innovation Inc. (Chapel Hill) develops www.sipcamadvan.com pharmaceutical products for the treatment medical and pharmaceutical biotools using of gastrointestinal diseases. tissue-engineering principles to include cell SIRGA Advanced Biopharma Inc. (RTP) www.salix.com ecosystems, living thermodynamics, nutrient discovers and develops small-molecule drugs transport and delivery and “cell systems” to treat HIV and other drug-resistant infectious Salzburg Therapeutics Inc. (Yadkinville) approaches. diseases. develops systems that deliver activated www.scikoninnovation.com www.sirgaab.com forms of anti-cancer drugs and nanoparticles directly to cancer cells. Sciteck Inc. (Arden) provides forensic drug Smart Perfusion LLC (Denver) develops a www.sztipharm.com testing services and diagnostic products. device to expand the time an organ is viable Sciteck develops, manufactures and sells for transplantation. Sandoz Inc. (Wilson) manufactures oral- products for biotechnology, urinalysis, clinical www.smartperfusion.com dosage generic pharmaceuticals. chemistry, toxicology, pharmaceuticals, www.us.sandoz.com treatment and safety applications. SmartFlow Technologies Inc. (Apex) www.sciteck.org provides filtration, separation and purification Sapheon Inc. (Morrisville) develops medical for biotechnology, biofuels, biopharmaceutical devices and technology to treat vascular SCYNEXIS Inc. (RTP) offers fully integrated processing, animal healthcare, dairy processing, diseases. contract research services including medicinal enzyme manufacturing and wastewater. www.sapheoninc.com chemistry, biological screening, ADMET-PK, www.smartflow-tech.com process chemistry and cGMP manufacturing ScieIntl LLC (Greensboro) develops to discover and develop compounds for Smithers Viscient LLC (Snow Camp) computation technologies to screen clinical testing. provides environmental testing services for chemicals and target databases in order to www.scynexis.com the pharmaceutical, veterinary, agriculture, identify and optimize leads for preclinical chemical and personal-care industries. The candidates. ScieIntl’s technologies can also Seachaid Pharmaceuticals Inc. (Durham) company’s lab in Snow Camp conducts avian be used to discover small molecule enzyme discovers and develops human therapeutics. and wildlife toxicology testing. activators. www.seachaid.com www.smithersviscient.com www.ScieIntl.com

26 North Carolina Companies CompaniesCompanies So 1 –– SuAr

Solstas Lab Partners (Greensboro, High Point, SoyMeds Inc. (Davidson) develops a Stiefel Laboratories Inc. (RTP), a GSK Wilmington and Raleigh) provides laboratory recombinant protein expression system in company, develops skin-care therapies. testing services to hospitals, nursing homes, soybean seeds to enable production of stable The company’s primary research and home health, clinics, urgent-care facilities and and cost-effective therapeutics, including development facility is in RTP. other businesses. shelf-stable vaccines. www.stiefel-us.com www.solstas.com www.soymeds.com Structure Medical Inc. (Mooresville) is a Southeastern Laboratories Inc. (Goldsboro) Specialty Scientific LLC (High Point) contract manufacturer of orthopedic medical provides research and laboratory support provides contract laboratory services devices, including implantable orthopedic to water and wastewater-treatment including antimicrobial testing and other fracture fixation and spinal instrumentation companies. SEL’s analytical services include analytical and testing services. products. microbiological and chemical testing. www.specialtytesting.com www.structuremedical.com www.selaboratories.com Sprout Pharmaceuticals Inc. (Raleigh) Suncare Research Laboratories LLC Southern Research Institute - Advanced develops a Phase III compound to treat (Winston-Salem) provides services to Energy & Transportation Technologies hypoactive sexual desire disorder. sunscreen and dermatological product (Durham) provides research and analytical www.sproutpharma.com manufacturers. services and facilities to government and www.suncarelab.com commercial clients in energy, fuel and Sterigenics (Haw River and Charlotte) transportation technologies. provides gamma radiation sterilization and SureMilk LLC (RTP) develops products to www.southernresearch.org/life-sciences ethylene oxide sterilization for medical and diagnose and treat low caloric content in pharmaceutical products. breast milk. The average wage for NC’s nearly 58,000 www.sterigenics.com www.suremilk.com life-science workers in 2010 was $78,178. That’s nearly twice the $40,872 statewide average for the private sector overall. NC Community Colleges

ncbionetwork.org

Randy Durren Instructor, Piedmont Community College 2012 Biotechnology Instructor of the Year

NC Community Colleges create success at seven BioNetwork training centers across the state: Capstone Center and Validation Academy, Wake Technical Community College, Raleigh Bioprocessing Center, Pitt Community College, Greenville Pharmaceutical Center, Forsyth and Guilford Technical Community Colleges, Winston-Salem and Greensboro National Center for Biotechnology Workforce, Forsyth Technical Community College, Winston-Salem BioAgriculture Center, Robeson Community College, Lumberton BioEducation Center, Gaston College, Dallas BioBusiness Center, Asheville-Buncombe Technical Community College, Asheville Companies Sy – Tr

Symmetry Biosciences Inc. (RTP) provides Tandem Labs Inc. (Durham) provides TeraDiscoveries Inc. (RTP) uses high- contract research and specialized chemistry bioanalytical and immunoanalytical services, performance computing and the principles services to the biotech, pharmaceutical, specializing in GLP-compliant LC/MS/MS of personalized medicine to enable clients medical device, agrochemical and fine bioanalytical services for all phases of drug and partners to speed drug development, chemical industries. discovery and development. especially in oncology. www.symmetrybiosciences.com www.tandemlabs.com www.teradiscoveries.com

Synecor Labs (Durham) is an AAALAC- Targacept Inc. (Winston-Salem) develops TheraLogics Inc. (Chapel Hill) discovers and accredited large-animal, preclinical contract neuronal nicotinic receptors (NNRs) develops treatments for human diseases research organization. It provides preclinical therapeutics for diseases and disorders using human transcription factor NF-kB testing services, specializing models for safety, of the nervous system. technologies. toxicology and efficacy studies. www.targacept.com www.theralogics.org www.synecorlabs.com TcLand Inc. (Raleigh) discovers, develops Thermocline Ventures Inc. (Raleigh) creates Synereca Pharmaceuticals Inc. (Chapel Hill) and validates gene expression biomarkers for physiologically based health monitoring develops orally active drugs that restore or unmet medical needs in transplantation and systems. increase the effectiveness of existing antibiotics. auto-immune disease. www.thermoclineventures.com www.synereca.com www.tcland-expression.com TIRF Technologies Inc. (Morrisville) develops Syngenta Biotechnology Inc. (RTP) works in TearScience Inc. (Morrisville) develops and manufactures biosensor devices and plant biotechnology to develop insect control diagnostic and treatment procedures for reagentless assays for biodetection and and drought tolerance. Research Triangle Park evaporative dry eye. analysis of biomolecular interactions. is the company’s central location for biofuels www.TearScience.com www.tirftechnologies.com product development. www.syngentabiotech.com Technology Crops International (Winston- Touch Scientific Inc. (Raleigh) develops Salem) designs, evaluates and produces high-speed, small-sample diagnostic tests Syngenta Crop Protection Inc. (Greensboro) specialty crop-derived material for the and equipment for the ophthalmic market. develops and markets weed-, insect- and biotechnology industry and manages the www.touchscientific.com disease-control products. supply chain from the field through creation www.syngenta-us.com of nutritional and industrial oil products. Toxicology Services Inc. (Chapel Hill) works www.technologycrops.com with small and mid-sized pharmaceutical Synpac Inc. (Durham) develops a drug for the companies and CROs to plan, conduct and treatment of Pompe disease. Teleflex Medical (RTP and Asheboro) designs, summarize toxicology studies, including PK/ manufactures and distributes medical devices, ADME studies. Synteract Inc. (Morrisville) provides surgical instruments and disposable medical www.toxicologyservices.net clinical trial services and focuses on clinical products. Its facility in Asheboro manufactures monitoring and site management, safety disposable catheters and related products for Trana Discovery Inc. (Cary) identifies surveillance and project management. critical and cardiac care. anti-infective therapies to treat infectious www.synteract.com www.teleflexmedical.com diseases. www.tranadiscovery.com Synthon Pharmaceuticals Inc. (RTP) Tengion Inc. (Winston-Salem) develops and develops, markets and distributes generic manufactures human neo-organs and TranS1 Inc. (Wilmington) designs, develops pharmaceutical products. neo-tissues for regenerative medicine, using and markets medical devices to treat www.synthon.com the Autologous Organ Regeneration Platform™. degenerative conditions of the spine www.tengion.com affecting the lower back. Synthonix Inc. (Wake Forest) designs, www.trans1.com manufactures and markets molecules to Teotten Diagnostics Inc. (RTP) develops aid in drug discovery. diagnostics for infectious diseases associated TransEnterix Inc. (Morrisville) designs and www.synthonix.com with hospital procedures and the use of develops medical devices for minimally invasive medical devices such as central venous surgery, including a surgical system called TAB Clinical Trials (Cary) provides clinical trial catheters. SPIDER™, which enables surgeons to perform support from pre-IND stage of development www.teotten.com an operation through a single site access. to post-market approval for drugs and devices. www.transenterix.com www.tabclinical.com

28 North Carolina Companies Companies Tr – Tr

TransTech Pharma Inc. (High Point) Triad BioGreen Technologies Inc. Triangle BioSystems International develops and commercializes therapeutics (Greensboro) develops technology to produce (Durham) develops, produces, markets for human diseases of the central nervous and market algae-based biofuels. and supports biomedical analog signal and cardiovascular systems, as well as www.triadbiogreen.com processing products that advance the diabetes, obesity and cancer. research and performance capabilities of www.ttpharma.com Triangle Biofuels Industries Inc. (Wilson) its customers in the neurophysiology and produces biodiesel from virgin and waste ultrasound marketplace. TransViragen Inc. (RTP) provides in vivo vegetable oil, including locally-sourced www.trianglebiosystems.com discovery research services, including a full soybean, canola, camelina and corn oils. suite of genetically modified mouse and www.trianglebiofuels.com Triangle Research Labs LLC (RTP) rat model services, from custom-model provides research services focused on generation to phenotyping. Triangle Biology LLC (RTP) provides drug metabolism, drug-drug interactions, www.transviragen.com preclinical drug discovery contract research in vivo pharmacokinetics and toxicology, services, including biology assays/assay drug characterization, drug transporters, TransWorld Heart Corp. (Charlotte) develops development, compound profiling, high diabetes research, virology, hepatotoxicity medical devices for the management of throughput screening, DMPK and in vivo and neural toxicology. heart disease. pharmacology. www.triangleresearchlabs.com transworldmed.com/transworldheart www.triangle-biology.com TriboFilm Research Inc. (Raleigh) develops Tranzyme Pharma (RTP) develops small- low-friction, thin-film coatings for medical molecule drugs for gastrointestinal motility devices as well as optical coatings. disorders. The North Carolina Biotechnology Center www.tribofilmresearch.com www.tranzyme.com has made more than $17 million in small- company loans, which the companies have leveraged into more than $1.6 billion in additional funding.

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RBH 7552 Business NC Biotech Company Directory HP 2012 ad.indd 1 3/5/2012 10:49:49 AM Companies Tr – Xe

Viamet Pharmaceuticals Inc. (Morrisville) discovers and develops small-molecule compounds that target metalloenzymes in infectious disease, oncology and crop protection. www.viamet.com

ViiV Healthcare (RTP), in conjunction with parent companies GlaxoSmithKline and Pfizer, develops drugs to treat AIDS. www.viivhealthcare.com

H i g hland Bre w ery Vijaya Pharmaceuticals LLC (RTP) provides drug discovery research services, including TriE Medical Inc. (Morrisville) provides design, Urogenix Inc. (Durham), a wholly-owned medicinal chemistry and synthetic organic documentation and testing services for subsidiary of Astellas Pharma, conducts chemistry services. medical device development, with expertise preclinical research focused on urological www.vijayapharma.com in designing drug delivery systems and disorders. biomedical monitoring devices. Vindica Therapeutics Inc. (Raleigh) develops www.triemedical.com Valeant Pharmaceuticals North America an anti-thrombotic and anti-infective central (Durham) develops and manufactures venous catheter that provides controlled Tritest Inc. (Raleigh, Wilmington and pharmaceuticals for neurology and release of nitric oxide. Clemmons) provides water and soil testing dermatology markets. services using analytical tools such as www.valeant.com ViraSource LLC (RTP) propagates and purifies bioassays and microbiology techniques. BSL-2 viruses and provides animal models of www.tritestinc.com Vascular BioSciences Inc. (Durham) viral infections and anti-viral immune develops technologies to detect and treat responses. Tryton Medical Inc. (Durham) develops vascular-based disease. www.virasource.com stent systems for the treatment of coronary www.vascularbiosciences.com artery bifurcation lesions. West Pharmaceutical Services Inc. (Kinston) www.trytonmedical.com Vascular Pharmaceuticals Inc. (Cary) manufactures syringe plungers and IV system develops and commercializes therapeutic components, using compression molding. TUNTek LLC (Durham) develops technology products to treat secondary complications www.westpharma.com and products for early detection of cancer of diabetes. and other chronic diseases. www.vascularpharma.com Wilmington Pathology Associates www.tuntekllc.com (Wilmington) offers surgical pathology and V-Bio Inc.’s (Charlotte) CLIA-certified cytopathology diagnostic services. The TyraTech Inc. (Morrisville) develops natural laboratory provides antibody assays and company is part of Solstas Lab Partners. pesticides that are safe for humans and virus isolation and identification in support www.wilmingtonpathology.com animals by targeting invertebrate-specific of clinical trials and research studies. receptors. www.v-bio.com Wilmington Pharmaceuticals (Wilmington) www.tyratech.com develops fast-dissolving dosage forms for Venafair LLC (Asheville) develops vascular established medicines. UCB Biosciences Inc. (Raleigh) researches agents for the treatment of varicose veins. www.wilmingtonpharma.com and develops therapeutics to treat central nervous system disorders and immunology Venganza Inc. (Raleigh) uses RNA World Ocean Solutions LLC (Wilmington), diseases. interference technology to control plant working with the Center for Marine Science at www.ucb.com pests and reduce the application of UNC-Wilmington and MARBIONC, manufac- fungicides and other pesticides. tures brevatoxins and okadaic acid. United Therapeutics Corp. (RTP) develops www.venganzainc.com www.oceansolutions.net and commercializes products to treat cardiopulmonary diseases, infectious Vertellus Specialties Inc. (Greensboro) Xenobiotic Detection Systems Inc. diseases and cancer. manufactures specialty chemicals for the (Durham) offers patented bioassays to facilitate www.unither.com agriculture, nutrition, pharmaceutical, assessment of environmental and human medical and personal care markets. health risks. www.vertellus.com www.dioxins.com 30 North Carolina Companies X-i – Zy

X-in8 Biologicals Corp. (Chapel Hill) develops technologies to prevent and treat ischemia reperfusion injury in the context of organ transplant, myocardial infarction and stroke.

Yasoo Health Inc. (Morrisville) develops condition-specific nutraceutical products consisting of essential nutrients and natural compounds. www.yasoo.com

Yukon Medical LLC (Durham) develops pharmaceutical drug preparation and delivery devices with a focus on drug reconstitution. www.yukonmedical.com

Zenalux Biomedical Inc. (Durham) uses biophotonics to develop diagnostic tools, including an optical system for the clinical detection of cancer. www.zenalux.com

Zen-Bio Inc. (RTP) provides in vitro contract research services and human tissues and cells for drug discovery, especially in the area of human metabolic disease and dermatology. www.zen-bio.com

Zinfandel Pharmaceuticals Inc. (RTP) uses pharmacogenetics to improve prediction of risk for Alzheimer’s disease and facilitate the development of effective therapies. www.opalstudy.org

ZOA Biologicals LLC (Kannapolis) researches and develops medical products useful to humans and animals.

Zoion Pharma Inc. (RTP) develops drugs for veterinary disorders. Zoion’s lead product is an epithelial sodium channel blocker compound to treat canine keratoconjunctivitis sicca (KCS) or dry eye.

Zor Pharmaceuticals LLC (Wilmington) develops and commercializes therapies for the treatment of cancer, especially pancreatic cancer. www.zorpharma.com

Zylera Pharmaceuticals LLC (RTP) develops, acquires and commercializes prescription products and dietary supplements, specifically for pediatric and women’s health. www.zylera.com Committed to North Carolina

North Carolina Biotechnology Center

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BASF believes that plant biotechnology is key for the 21st century, and North Carolina is a hub for innovation. With our Plant The futures of the local growing biotechnology community Science headquarters now in Research Triangle Park, we continue and the state’s economy are intrinsically linked. The industry’s to grow as one of the world’s leading providers of biotech solutions expansion and development means more local jobs, significant for agriculture. BASF Plant Science has developed a unique gene- scientific advancements and an improved local quality of life. discovery platform for yield and quality traits in crops such as corn, Alston & Bird harbors the expertise and drive to support soybeans and rice. Projects include higher-yielding row crops and biotechnology and its continued success in North Carolina. nutritionally enhanced corn for animal feed.

Biotechnology is playing a pivotal role in transforming North Carolina is known for its rich agricultural history, and North Carolina’s economy for the future. The Golden LEAF Bayer CropScience is committed to cultivating the industry’s Biomanufacturing Training and Education Center at N.C. State future. Our role in the biotechnology sector focuses on University supports this role by preparing the current and future improving agricultural crops such as cotton, canola, rice, biomanufacturing workforce through innovative hands-on training soybean and wheat. Partnerships with local universities and and educational programs at its world-class facility. Come see why companies are what have made a North Carolina address so our local, national and international activities are making BTEC the rewarding for Bayer CropScience. premier biomanufacturing training organization in the world.

32 North Carolina Companies Committed to North Carolina

Uncompromising Excellence. Commitment to Care. A well-developed network of biotechnology, training and education in the life sciences are essential components for biomedical research. At Cannon Research Center we strive for world-class excellence in patient-centered clinical and transla- Fujifilm Diosynth Biotechnologies is a leading provider tional research, and we depend on a strong and well-developed of contract development and manufacturing services to biotechnology infrastructure to provide new ideas and pharmaceutical and biotechnology companies across the approaches. Well-trained research scientists and technicians are world. With more than 15 years in the community and the human resources we rely on for advances in medicine and nearly 400 employees, we are happy to be a part of the biomedical research. biotechnology community in Research Triangle Park.

As the biotechnology and life-science industry continues to grow and thrive in North Carolina, NC Community Colleges’ BioNetwork provides subject-matter experts and specialized The Piedmont Triad Research Park mixes intellectual training through all 58 institutions, resulting in more relevant, and investment connectivity with state-of-the-art labs. The PTRP job-ready workers for employers in our state. This relationship is a community not only cultivates new ideas in health sciences and wonderful example of how NC Community Colleges work with biotechnology, but also supports life outside the lab. The result employers to provide industry-specific, hands-on training to is a holistic urban lifestyle, understanding that where people companies looking to expand or locate their operations in North live is as important as what they do to live. We take pride in Carolina. instigating innovation.

POZEN Inc. is pleased to be a part of the biotechnology PPD is an industry-leading contract-research organization community in North Carolina. Since 1996, POZEN has successfully providing drug discovery, development and lifecycle created and secured regulatory approval for novel integrated management services. With nearly 3,000 employees in North therapies that deliver superior patient outcomes. North Carolina’s Carolina, and our global headquarters in Wilmington, since strong biotechnology presence serves as a fertile environment for 1986, the strength of the state’s biotechnology industry has POZEN with its products that are designed to deliver benefits to played a significant role in the continued growth and success customers while being both affordable and accessible. of our business.

Smith Anderson is pleased to support the biotech and life-sciences industries in North Carolina and around the world. North Carolina’s strong science, thriving industry and low To meet the challenges facing life-sciences companies, business costs offer biotechnology companies a unique businesses need experienced and highly responsive advisers. opportunity for growth. NCBiotech’s mission is to provide At Smith Anderson, comprehensive legal expertise is combined long-term economic and societal benefits to North Carolina with deep life-sciences industry knowledge to provide clients through support of biotechnology research, business, with solutions that achieve exceptional results. education and strategic policy statewide.

North Carolina Companies 33 NCBiotech Company Directory

Many thanks to our sponsors for making this directory possible July 2012

Alston & Bird • BASF • Bayer CropScience

Golden LEAF Biomanufacturing Training and Education Center

Cannon Research Center • Fujifilm Diosynth Biotechnologies • GlaxoSmithKline

NC Community Colleges BioNetwork • Piedmont Triad Research Park

Pozen • PPD • Smith Anderson

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