Dnb Ophthalmology Question Bank Full Book
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Hereditary Reversion Pigmentation of the Eyelids with Heterochromia of the Iris
874 LEE MASTEN FRANCIS enucleated. The following report on the Other cells were round with hyper- specimen was submitted from the New chromatic nuclei; while scattered thruout York State Institute for the Study of the tumor were large deeply staining Malignant Diseases: cells with one or two nuclei but free from The gross appearance of a cross sec- pigment. There were apparently two tion of the eye shows a tumor lying in types of pigmented cells, the one a large the lower temporal quadrant of the eye, irregular cell with long protoplasmic evidently springing from the choroid processes densely filled with fine yellow- near the margin of the optic disc. This ish granules, evidently chromatophores. tumor measured 15x10 mm. and was The other type of pigmented cell was a slightly nodular irregular ovoid tumor. evidently a tumor cell of the type men- The surface appeared smooth, was dark tioned above but containing fewer gran- gray in color and was of a soft consist- ules than the chromatophores. Thruout ency. The retina was markedly detached the tumor were small areas of hemor- and contained a clear serous fluid. Cross rhage and between the cells could be section of the tumor mass showed a demonstrated here and there, free pig- deeply pigmented homogeneous surface. ment granules. Microscopically, the tumor varied as From this picture, we would make a to the cellular constituents. There were diagnosis of malignant melanoma, fre- areas showing many pigment cells and quently called melanosarcoma, but by other areas almost free from the same. some authorities considered as melanotic The tumor was very vascular showing many fine capillaries around which in carcinoma. -
Genes in Eyecare Geneseyedoc 3 W.M
Genes in Eyecare geneseyedoc 3 W.M. Lyle and T.D. Williams 15 Mar 04 This information has been gathered from several sources; however, the principal source is V. A. McKusick’s Mendelian Inheritance in Man on CD-ROM. Baltimore, Johns Hopkins University Press, 1998. Other sources include McKusick’s, Mendelian Inheritance in Man. Catalogs of Human Genes and Genetic Disorders. Baltimore. Johns Hopkins University Press 1998 (12th edition). http://www.ncbi.nlm.nih.gov/Omim See also S.P.Daiger, L.S. Sullivan, and B.J.F. Rossiter Ret Net http://www.sph.uth.tmc.edu/Retnet disease.htm/. Also E.I. Traboulsi’s, Genetic Diseases of the Eye, New York, Oxford University Press, 1998. And Genetics in Primary Eyecare and Clinical Medicine by M.R. Seashore and R.S.Wappner, Appleton and Lange 1996. M. Ridley’s book Genome published in 2000 by Perennial provides additional information. Ridley estimates that we have 60,000 to 80,000 genes. See also R.M. Henig’s book The Monk in the Garden: The Lost and Found Genius of Gregor Mendel, published by Houghton Mifflin in 2001 which tells about the Father of Genetics. The 3rd edition of F. H. Roy’s book Ocular Syndromes and Systemic Diseases published by Lippincott Williams & Wilkins in 2002 facilitates differential diagnosis. Additional information is provided in D. Pavan-Langston’s Manual of Ocular Diagnosis and Therapy (5th edition) published by Lippincott Williams & Wilkins in 2002. M.A. Foote wrote Basic Human Genetics for Medical Writers in the AMWA Journal 2002;17:7-17. A compilation such as this might suggest that one gene = one disease. -
Upregulations of Clcn3 and P-Gp Provoked by Lens Osmotic Expansion in Rat Galactosemic Cataract
Hindawi Journal of Diabetes Research Volume 2017, Article ID 3472735, 8 pages https://doi.org/10.1155/2017/3472735 Research Article Upregulations of Clcn3 and P-Gp Provoked by Lens Osmotic Expansion in Rat Galactosemic Cataract 1 2 1 Lixia Ji, Lixia Cheng, and Zhihong Yang 1Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao, China 2Department of Endocrinology, People’s Hospital of Weifang, Weifang, China Correspondence should be addressed to Lixia Ji; [email protected] Received 21 September 2017; Accepted 1 November 2017; Published 21 November 2017 Academic Editor: Hiroshi Okamoto Copyright © 2017 Lixia Ji et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. Lens osmotic expansion, provoked by overactivated aldose reductase (AR), is the most essential event of sugar cataract. Chloride channel 3 (Clcn3) is a volume-sensitive channel, mainly participating in the regulation of cell fundamental volume, and P-glycoprotein (P-gp) acts as its modulator. We aim to study whether P-gp and Clcn3 are involved in lens osmotic expansion of galactosemic cataract. Methods and Results. In vitro, lens epithelial cells (LECs) were primarily cultured in gradient galactose medium (10–60 mM), more and more vacuoles appeared in LEC cytoplasm, and mRNA and protein levels of AR, P-gp, and Clcn3 were synchronously upregulated along with the increase of galactose concentration. In vivo, we focused on the early stage of rat galactosemic cataract, amount of vacuoles arose from equatorial area and scattered to the whole anterior capsule of lenses from the 3rd day to the 9th day, and mRNA and protein levels of P-gp and Clcn3 reached the peak around the 9th or 12th day. -
Blue Light and Your Eyes
Blue Light and Your Eyes What is blue light? 211 West Wacker Drive, Suite 1700 Sunlight is made up of red, orange, yellow, green, blue, indigo and Chicago, Illinois 60606 violet light. When combined, it becomes the white light we see. 800.331.2020 Each of these has a different energy and wavelength. Rays on the PreventBlindness.org red end have longer wavelengths and less energy. On the other end, blue rays have shorter wavelengths and more energy. Light that looks white can have a large blue component, which can expose the eye to a higher amount of wavelength from the blue end of the spectrum. Where are you exposed to blue light? The largest source of blue light is sunlight. In addition, there are many other sources: • Fluorescent light • CFL (compact fluorescent light) bulbs • LED light • Flat screen LED televisions • Computer monitors, smart phones, and tablet screens Blue light exposure you receive from screens is small compared to the amount of exposure from the sun. And yet, there is concern over the long-term effects of screen exposure because of the close proximity of the screens and the length of time spent looking at them. According to a recent NEI-funded study, children’s eyes absorb more blue light than adults from digital device screens. This publication is copyrighted. This sheet may be reproduced—unaltered in hard print (photocopied) for educational purposes only. The Prevent Blindness name, logo, telephone number and copyright information may not be omitted. Electronic reproduction, other reprint, excerption or use is not permitted without written consent. -
Sudheendran-Dissertation
© Copyright by Narendran Sudheendran 2013 All Rights Reserved STUDYING MOUSE EMBRYONIC DEVELOPMENT WITH OCT A Dissertation Presented to the Faculty of the Department of Biomedical Engineering University of Houston In Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy in Biomedical Engineering by Narendran Sudheendran December 2013 STUDYING MOUSE EMBRYONIC DEVELOPMENT WITH OCT ___________________________ Narendran Sudheendran Approved: ________________________________ Chair of the Committee Kirill V. Larin, Associate Professor, Department of Biomedical Engineering Committee Members: ________________________________ Irina V. Larina, Assistant Professor, Department of Molecular Physiology and Biophysics, Baylor College of Medicine ________________________________ Rajesh C. Miranda, Associate Professor, Department of Neuroscience and Experimental Therapeutics, TAMHSC College of Medicine _______________________________ Howard Gifford, Associate Professor, Department of Biomedical Engineering _______________________________ Yingchun Zhang, Assistant Professor, Department of Biomedical Engineering ____________________________ _______________________________ Suresh K. Khator, Associate Dean, Metin Akay, Professor and Chairman, Cullen College of Engineering Department of Biomedical Engineering ACKNOWLEDGEMENTS I am extremely thankful to my advisor, Dr. Kirill Larin, for his guidance, support and encouragement throughout this work. I am extremely grateful to Dr. Irina Larina for her time and effort to help me during the entire course of my project. I would especially like to thank Saba, Maleeha, Dr. Shameena Bake and Chen for helping me with the experiments. I thank Esteban, Shang and Manmohan for reviewing my dissertation. I am thankful to Mohamad, Kiran, Venu, Stepan, Jiasong, Peter and the rest of the BOL team for their support and encouragement. I would like to thank Dr. Rajesh C. Miranda and Dr. Howard Gifford and Dr. Yingchun Zhang for their time to serve on my defense committee. -
Cataract Surgery and Diplopia
…AFTER CATARACT SURGERY Lionel Kowal RVEEH Melbourne חננו מאתך דעה בינה והשכל DISTORTION Everything in my talk is distorted by selection bias I don‟t do cataract surgery. I don‟t see the numerous happy pts that you produce I see a small Array of pts with imperfect outcomes that may /not be due to the cataract surgery DIPLOPIA AFTER CATARACT SURGERY ‘Old’ reasons ‘New’ reasons : Normal or near- normal muscle function: usually ≥1 ‘minor’ stresses on sensory & motor fusion Inf Rectus contracture after -- Anisometropia: Monovision & -caine damage Aniseikonia Other muscles damaged by -caine Metamorphopsia 2ary to macular disease Incidental 4ths and occult Minor acquired motility changes Graves‟ Ophthalmopathy of the elderly: Sagging eye uncovered by cataract surgery muscles Old, Rare & largely forgotten Other sensory issues: Big Amblyopia: fixation switch difference in contrast between Hiemann Bielschowsky images, large field defects. „OLD‟ REASONS : -CAINE TOXICITY IS IT A PERI- OR RETRO- BULBAR? If you add an EMG monitor to your injecting needle, whether you think you are doing a Retro- or Peri- Bulbar, you are IN the inf rectus ~ ½ of the time* *Elsas, Scott „OLD‟ REASONS : -CAINE TOXICITY CAN BE ANY MUSCLE, USU IR, ESP. LIR Day 1: LIR paresis : left hyper, restricted L depression, diplopia : everyone anxious ≤1% Day 7-10: diplopia goes : everyone happy Week 2+: LIR fibrosis begins - diplopia returns : left hypo, vertical & torsional diplopia, restricted L elevation: everyone upset 0.1-0.2% Hardly ever gets better Spontaneous recovery from inferior rectus contracture (consecutive hypotropia) following local anesthetic injury. Sutherland S, Kowal L. Binocul Vis Strabismus Q. -
Dismetabolic Cataracts
ndrom Sy es tic & e G n e e n G e f T o Journal of Genetic Syndromes Cavallini et al., J Genet Syndr Gene Ther 2013, 4:7 h l e a r n a r p u DOI: 10.4172/2157-7412.1000165 y o J & Gene Therapy ISSN: 2157-7412 Case Report Open Access Dismetabolic Cataracts: Clinicopathologic Overview and Surgical Management with B-MICS Technique Cavallini GM1, Forlini M1, Masini C1, Campi L1, Chiesi C1, Rejdak R2 and Forlini C3* 1Institute of Ophthalmology, University of Modena, Modena, Italy 2Department of Ophthalmology, Medical University of Lublin, Lublin, Poland 3Department of Ophthalmology, “Santa Maria Delle Croci” Hospital, Ravenna, Italy Abstract Background: Dismetabolic cataract is a loss of lens transparency due to an insult to the nuclear or lenticular fibers, caused by a metabolic disorder. The lens opacification may occur early or later in life, and may be isolated or associated to particular syndromes. We describe some of these metabolic conditions associated with cataract formation, and in particular we report our experience with a patient affected by lathosterolosis that presented bilateral cataracts. Methods: Our patient was a 7-years-old little girl diagnosed with lathosterolosis at age 2 years, through gas cromatography/mass spectrometry method for plasma sterol profile that revealed a peak corresponding to cholest- 7-en-3β-ol (lathosterol). Results: The lens samples obtained during surgical removal with B-MICS technique were sent to the Department of Pathology and routinely processed and stained with haematoxylin-eosin and PAS; then, they were examined under a light microscope. Histological examination revealed lens fragments with the presence of fibers disposed in a honeycomb way, samples characterized by the presence of homogeneous eosinophilic lens fibers, and other fragments characterized by bulgy elements referable to cortical fibers with degenerative characteristics. -
Eyemed Blue Light
BLUE LIGHT: FREQUENTLY ASKED QUESTIONS From ZZZs to disease, the blue light battle is on It’s indisputable: our eyes are overexposed to digital devices like never before. And in the background hides potentially harmful blue light that may affect our sleep, or even cause long-term vision issues. But, here’s some good news — you can act now to potentially minimize vision issues later with advanced lens filtering technology formulated to guard your eyes. Q: WHAT IS BLUE LIGHT? A: Blue light is a natural part of the light spectrum visible to the human eye; it can come from fluorescent lighting, electronic screens, and of course, the sun. By day, blue light can be associated with boosted mood and attention, but by night, it can be a culprit of interrupted sleep. 1 Q: HOW DOES BLUE LIGHT INTERRUPT SLEEP? A: Researchers know that exposure to light at night suppresses the secretion of melatonin, a hormone that tells us when it is time to sleep. And an extended lack of deep sleep has been linked to depression and a decline in the body’s ability to fight off certain diseases. 1 Q: CAN BLUE LIGHT EXPOSURE CAUSE LONG-TERM DAMAGE TO MY EYESIGHT? A: In addition to disrupting sleep, blue light has been found to contribute to retinal stress, which could lead to an early onset of age-related macular degeneration (AMD).2 Macular degeneration deteriorates healthy cells within the macula, creating a loss of central vision that may impact reading, writing, driving, color perception and other cognitive functions. In serious cases, blindness can occur. -
Taking Care of Our Eyes in the 21St Century Presented By: Carla Haynal Proprietary and Confidential | 1 HOW HAS the 21ST CENTURY AFFECTED OUR EYES?
Taking Care of Our Eyes in the 21st Century Presented by: Carla Haynal Proprietary and Confidential | 1 HOW HAS THE 21ST CENTURY AFFECTED OUR EYES? • Lots of apps, social media, smartphones, and tablets • Time is spent looking at screens and not outside • More close-up work Proprietary and Confidential | 2 HOW HAS THE 21ST CENTURY AFFECTED OUR EYES? • Digital eye strain • Increased cases of myopia (nearsightedness) • Unprotected UV ray exposure Proprietary and Confidential | 3 DIGITAL EYE STRAIN DIGITAL EYE STRAIN • Digital eye strain is the physical discomfort felt after prolonged exposure to digital screens. • The light intensity increases the closer our eyes are to the source, so it’s important to maintain your digital distance. Proprietary and Confidential | 5 SYMPTOMS OF DIGITAL EYE STRAIN • Sore, tired, burning or itching eyes • Watery or dry eyes • Blurred or double vision • Headache • Sore neck, shoulders, or back • Increased light sensitivity • Difficulty concentrating • Feeling that you cannot keep your eyes open Proprietary and Confidential | 6 DIGITAL EYE STRAIN ProprietaryProprietary andand ConfidentialConfidential || 77 DIGITAL EYE STRAIN Millennials GenXers Boomers 40% 60% 25% use devices use devices use devices 9 hours a day 9 hours a day 9 hours a day Proprietary and Confidential | 8 DIGITAL EYE STRAIN KEEP AN Reduce exposure with INCREASE BLUE LIGHT- ARM’S FONT SIZE REDUCING on digital devices LENGTH eyewear from computer 20 | 20 | 20 Every 20 minutes, look 20 feet away for 20 seconds. Proprietary and Confidential | 9 WHAT IS BLUE LIGHT? BLUE LIGHT • Blue light is the highest energy portion of visible light. • The sun, smart phones, tablets, computer monitors, TVs, and LED and CFL all emit blue light. -
Textbook of Ophthalmology, 5Th Edition
Textbook of Ophthalmology Textbook of Ophthalmology 5th Edition HV Nema Former Professor and Head Department of Ophthalmology Institute of Medical Sciences Banaras Hindu University Varanasi India Nitin Nema MS Dip NB Assistant Professor Department of Ophthalmology Sri Aurobindo Institute of Medical Sciences Indore India ® JAYPEE BROTHERS MEDICAL PUBLISHERS (P) LTD. New Delhi • Ahmedabad • Bengaluru • Chennai Hyderabad • Kochi • Kolkata • Lucknow • Mumbai • Nagpur Published by Jitendar P Vij Jaypee Brothers Medical Publishers (P) Ltd B-3 EMCA House, 23/23B Ansari Road, Daryaganj, New Delhi 110 002 I ndia Phones: +91-11-23272143, +91-11-23272703, +91-11-23282021, +91-11-23245672 Rel: +91-11-32558559 Fax: +91-11-23276490 +91-11-23245683 e-mail: [email protected], Visit our website: www.jaypeebrothers.com Branches 2/B, Akruti Society, Jodhpur Gam Road Satellite Ahmedabad 380 015, Phones: +91-79-26926233, Rel: +91-79-32988717 Fax: +91-79-26927094, e-mail: [email protected] 202 Batavia Chambers, 8 Kumara Krupa Road, Kumara Park East Bengaluru 560 001, Phones: +91-80-22285971, +91-80-22382956, 91-80-22372664 Rel: +91-80-32714073, Fax: +91-80-22281761 e-mail: [email protected] 282 IIIrd Floor, Khaleel Shirazi Estate, Fountain Plaza, Pantheon Road Chennai 600 008, Phones: +91-44-28193265, +91-44-28194897 Rel: +91-44-32972089, Fax: +91-44-28193231, e-mail: [email protected] 4-2-1067/1-3, 1st Floor, Balaji Building, Ramkote Cross Road Hyderabad 500 095, Phones: +91-40-66610020, +91-40-24758498 Rel:+91-40-32940929 Fax:+91-40-24758499, e-mail: [email protected] No. 41/3098, B & B1, Kuruvi Building, St. -
Refractive Errors
Refractive Errors - Epidemiology & Risk Factors (("refractive errors/epidemiology"[MAJR:noexp]) OR ("refractive errors/ethnology"[MAJR:noexp]) OR (hyperopia/epidemiology[MAJR:noexp]) OR (hyperopia/ethnology[MAJR:noexp]) OR (myopia/epidemiology[MAJR:noexp]) OR (myopia/ethnology[MAJR:noexp]) OR (astigmatism/epidemiology[MAJR:noexp]) OR (astigmatism/ethnology[MAJR:noexp]) OR (presbyopia/epidemiology[MAJR:noexp]) OR (presbyopia/ethnology[MAJR:noexp])) ((Refractive Errors[MAJR:noexp]) OR (Hyperopia[MAJR:noexp]) OR (Myopia[MAJR:noexp]) OR (Astigmatism[MAJR:noexp]) OR (Presbyopia[MAJR:noexp])) AND (Prevalence[MeSH Terms) ((Refractive Errors[MAJR:noexp]) OR (Hyperopia[MAJR:noexp]) OR (Myopia[MAJR:noexp]) OR (Astigmatism[MAJR:noexp]) OR (Presbyopia[MAJR:noexp])) AND (Risk Factors[MeSH Terms]) (("myopia/epidemiology"[MeSH Terms]) OR (("myopia"[MeSH Terms]) AND ("risk factors"[MeSH Terms]))) AND ((reading[tiab]) OR (near work[tiab]) OR (nearwork[tiab]) OR (cylinder power[tiab]) OR (optical power[tiab]) OR (accommodation[tiab])) (refractive error*[tiab] OR hyperopia[tiab] OR myopia[tiab] OR astigmatism[tiab] OR presbyopia[tiab]) AND (epidemiolog*[tiab] OR ethnolog*[tiab] OR prevalen*[tiab] OR risk factor*[tiab]) (myopia[tiab]) AND (reading[tiab] OR nearwork[tiab] OR near work[tiab]) Diagnosis – Reproducibility of Results ("refractive errors/diagnosis"[MAJR]) AND ("reproducibility of results"[MeSH Terms]) (refractive error*[tiab] OR hyperopia[tiab] OR myopia[tiab] OR astigmatism[tiab] OR presbyopia[tiab]) AND (diagnos*[tiab] OR reproducib*[tiab]) -
Association of British Dispensing Opticians Heads You Win, Tails
Agenda Heads You Win, Tails You Lose • The correction of ametropia • Magnification, retinal image size, visual Association of British The Optical Advantages and acuity Disadvantages of Spectacle Dispensing Opticians • Field of view Lenses and Contact lenses • Accommodation and convergence 2014 Conference Andrew Keirl • Binocular vision and anisometropia Kenilworth Optometrist and Dispensing Optician • Presbyopia. 1 2 3 Spectacle lenses Contact lenses Introduction • Refractive errors that can be corrected • Refractive errors that can be corrected using • Patients often change from a spectacle to a using spectacle lenses: contact lenses: contact lens correction and vice versa – myopia – myopia • Both modes of correction are usually effective – hypermetropia in producing in-focus retinal images – hypermetropia • apparent size of the eyes and surround in both cases • There are of course some differences – astigmatism – astigmatism between modes, most of which are • not so good with irregular corneas • better for irregular corneas associated with the position of the correction. – presbyopia – presbyopia • Some binocular vision problems are • Binocular vision problems are difficult to manage using contact lenses. easily managed using spectacle lenses. 4 5 6 The correction of ametropia using Effectivity contact lenses • A distance correction will form an image • Hydrogel contact lenses at the far point of the eye – when a hydrogel contact lens is fitted to an eye, The Correction of Ametropia the lens “drapes” to fit the cornea • Due to the vertex distance this far point – this implies that the tear lens formed between the will lie at slightly different distances from contact lens and the cornea should have zero the two types of correcting lens power and the ametropia is corrected by the BVP of the contact lens – the powers of the spectacle lens and the – not always the case but usually assumed in contact lens required to correct a particular practice eye will therefore be different.