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NEUTRONS The Institut Laue-Langevin FOR SCIENCE The Institut Laue-Langevin (ILL) is an international research centre where The ILL was founded to provide scientific communities in its member neutrons are used to probe the microscopic structure and dynamics of a countries with a unique flux of slow neutrons and a matching suite of broad range of materials from the molecular, atomic and nuclear point experimental facilities (some 40 instruments) for use in fields as varied of view. The ILL is owned and operated by three founding countries as solid-state physics, materials science, chemistry, the biosciences and - France, Germany and the United Kingdom. the earth sciences as well as nuclear physics and engineering. The three Associate countries contributed a total of 58 M€ to the Institute in 2007, a sum enhanced by significant contributions from the … an exceptional centre of excellence and a fine ILL’s Scientific Member countries, Austria, Belgium, the Czech Republic, Hungary, Italy, Poland, Spain, Sweden and Switzerland. ILL’s overall example of successful co-operation in Europe budget in 2007 amounted to approximately 75 M€. The Institute has ever since been an exceptional centre of excellence and a fine example of successful co-operation in Europe, a prototype of the European Research Area. It operates the most intense neutron source in the world. About 2000 visiting scientists, performing a total of 750 experiments each year and the output in high impact journals, bear witness to the scientific success of the facility. 002 Annual Report 2007 003 We thank everyone who contributed to the production of this report Editors: Giovanna Cicognani and Andrew Harrison Production team: Katja Jenkins, Marco Civelli, Pascale Deen, Emmanuel Farhi, Péter Falus, Monica Jimenez, Ulli Koester, Marie-Hélène Lemée-Cailleau, Stéphane Rols, Anne Stunault, Susana Teixeira Design and Typesetting: Synthèse ECA - Patrick Feuillye Tel: +33(0)4 76 90 02 73 - Fax: +33 (0)4 76 04 95 92 Photography: by ILL and Artechnique - [email protected] Printing: Imprimerie Pont de Claix Further copies can be obtained from: Institut Laue-Langevin Scientific Coordination Office (SCO) BP 156 - F-38042 Grenoble Cedex 9 (France) Tel: +33 (0)4 76 20 72 40 - Fax: +33 (0)4 76 48 39 06 email: [email protected] - web: www.ill.eu ILL Chronicle 2007 Founded on 19 January 1967 by the signing of a convention between the governments 17 January of the French Republic and the Federal Republic of Germany, the ILL celebrates its 40th anniversary. Meeting of an instrument subcommittee to discuss the proposed high flux diffractometer 1 February DRACULA. Meeting of an instrument subcommittee to discuss the status of the IN16B project. 2 February Outdoor meeting of ILL management and ILL’s Heads of Service. 9 February Science on Stage Festival. 2-6 April ILL and ESRF welcome Commissioner Janez Poto8nik. 5 April ILL PhD students Clip session. 13 April Arrival of Oliver Zimmer to succeed Hans Börner as the new Head of Nuclear 15 April and Particle Physics group. Meeting of the ILL Scientific Council and its Subcommittees. 17-20 April Meeting of the Subcommittee on Administrative Questions (SAQ). 26-27 April Meeting of the Steering Committee. 14-15 June ILL invites its staff members and their families to an Open Day. 16 June Signing of the new contract between the Swedish Research Council and the ILL. 1 July Kick-off of the second phase (‘M1’) of the ILL Millennium Programme. 10 July A symposium marks the retirement of Hans Börner, Nuclear and Particle Physics group leader. 27 August Visit of Mr Pascal Couchepin, Vice-president of the Swiss Confederation 10 September and Head of the Federal Department of Home Affairs. Visit of the Audit Commission. 10-14 September Following a leak on the helium circuit of the cold source’s compressor, 12 September the reactor was automatically shut down. It was restarted on 13 September. Christian Vettier leaves the ILL after 8 years as the Head of Science Division. 20 September Outdoor meeting of ILL management and ILL’s Heads of Service. 21 September Welcome to Dr. José Luis Martinez, new Deputy Director and Head of the Project and 1 October Techniques Division. Andrew Harrison becomes the new Head of Science Division. First meeting of the newly installed Project Management Committee 1 October for a discussion of the new instrument and infrastructure projects of the M1 phase. The reactor had to be shut down 12 days before schedule due to a minor defect 5 October in the fuel element. French Science Festival week: the ILL and the ESRF manned a common 5-7 October exhibition stand in the centre of Grenoble. Final Groupe Permanent visit. 11 October Meeting of experts on small-angle neutron scattering to discuss 19 October the design of ILL’s 3rd SANS instrument D33. Meeting of the Subcommittee on Administrative Questions (SAQ). 25-26 October Meeting of the ILL Scientific Council and its Subcommittees. 6-9 November A workshop is organised in Madrid to celebrate the 20th Anniversary 28 November of Spain becoming a scientific member of the ILL. Meeting of the Steering Committee. 29-30 November NOMAD review. 12-13 December Publications NEUTRONS FOR SCIENCE Biology Arnaudov L.N., De Vries R., Cohen Stuart M.A. Time-resolved small-angle neutron scattering during heat-induced fibril formation from bovine -lactoglobulin. Journal of Chemical Physics 124, 084701-1-084701-6 (2006) Balog E., Smith J.C., Perahia D. Conformational heterogeneity and low-frequency vibrational modes of proteins. Physical Chemistry - Chemical Physics 8, 5543-5548 (2006) Blakeley M,Gilboa A.J.K., Habash J., Helliwell J.R., Myles D., Raftery J. Neutron protein crystallography: Technical aspects and some case studies at current capabilities and beyond. In «Neutron Scattering in Biology - Techniques and Applications» Fitter J. et al. Eds. (Springer, 2006) pp. 63-72 Callow P., Sukhodub A., Taylor J.E., Kneale G.G. Shape and subunit organisation of the DNA methyltransferase M.AhdI by small-angle neutron scattering. Journal of Molecular Biology 369, 177-185 (2007) Cárdenas M., Arnebrant T., Rennie A., Fragneto G., Thomas R.K., Lindh L. Human saliva forms a complex film structure on alumina surfaces. Biomacromolecules 8, 65-69 (2007) Cavalcanti L.P., Haas A., Bordallo H.N., Konovalov O., Gutberlet T., Fragneto G. In situ X-ray and neutron diffraction study of lipid membrane swelling. European Physical Journal Special Topics 141, 217-221 (2007) Collins K.D., Neilson G.W., Enderby J.E. Ions in water: Characterizing the forces that control chemical processes and biological structure. Biophysical Chemistry 128, 95-104 (2007) Di Costanzo L., Moulin M., Haertlein M., Meilleur F., Christianson D.W. Expression, purification, assay, and crystal structure of perdeuterated human arginase I. Archives of Biochemistry and Biophysics 465, 82-89 (2007) Doster W. Brownian oscillator analysis of molecular motions in biomolecules. In «Neutron Scattering in Biology - Techniques and Applications» Fitter J. et al. Eds. (Springer, 2006) pp. 461-483 Fitter J. Conformational dynamics measured with proteins in solution. In «Neutron Scattering in Biology - Techniques and Applications» Fitter J. et al. Eds. (Springer, 2006) pp. 399-418 Forsyth V.T., Parrot I.M. High-angle neutron fiber diffraction in the study of biological systems. In «Neutron Scattering in Biology - Techniques and Applications» Fitter J. et al. Eds. (Springer, 2006) pp. 85-105 Gabel F., Bellissent-Funel M.C. C-phycocyanin hydration water dynamics in the presence of trehalose: An incoherent elastic neutron scattering study at different energy resolutions. Biophysical Journal 92, 4054-4063 (2007) Gerard F.C.A., de Almeida Ribeiro E., Albertini A.A.V., Gutsche I., Zaccaï G., Ruigrok R.W.H., Jamin M. Unphosphorylated Rhabdoviridae phosphoproteins form elongated dimers in solution. Biochemistry 46, 10328-10338 (2007) Annual Report 2007 Publications NEUTRONS FOR SCIENCE Biology (2) Hasegawa Y., Loidl R., Badurek G., Filipp S., Klepp J., Rauch H. Evidence for entanglement and full tomographic analysis of Bell states in a single-neutron system. Physical Review A 76, 052108-1-052108-6 (2007) Kneller G.R., Calandrini V. Estimating the influence of finite instrumental resolution on elastic neutron scattering intensities from proteins. Journal of Chemical Physics 126, 125107-1-125107-8 (2007) Krueger J.K., Wignall G.D. Small-angle neutron scattering from biological molecules. In «Neutron Scattering in Biology - Techniques and Applications» Fitter J. et al. Eds. (Springer, 2006) pp. 127-160 Lechner R.E., Longeville S. Quasielastic neutron scattering in biology, Part I: Methods. In «Neutron Scattering in Biology - Techniques and Applications» Fitter J. et al. Eds. (Springer, 2006) pp. 309-354 Lechner R.E., Longeville S. Quasielastic neutron scattering in biology, Part II: Applications. In «Neutron Scattering in Biology - Techniques and Applications» Fitter J. et al. Eds. (Springer, 2006) pp. 355-397 Lehnert U., Weik M. Relating protein dynamics to function and structure: The purple membrane. In «Neutron Scattering in Biology - Techniques and Applications» Fitter J. et al. Eds. (Springer, 2006) pp. 419-434 Middendorf H.D. Biomolecular spectroscopy using pulsed-source instruments. In «Neutron Scattering in Biology - Techniques and Applications» Fitter J. et al. Eds. (Springer, 2006) pp. 435-460 Niimura N. Neutron protein crystallography: Hydrogen and hydration in proteins. In «Neutron Scattering in Biology - Techniques and Applications» Fitter J. et al. Eds. (Springer, 2006) pp. 43-62 Niimura N., Arai S., Kurihara K., Chatake T., Tanaka I., Bau R. Recent results on hydrogen and hydration in biology studied by neutron macromolecular crystallography. Cellular and Molecular Life Sciences 63, 285-300 (2006) Paciaroni A., Casciola M., Cornicchi E., Marconi M., Onori G., Donnadio A., Sganappa M., De Francesco A. Low-frequency dynamics of water absorbed in Nafion membranes as a function of temperature. Philosophical Magazine 87, 477-483 (2007) Perrin J.C., Lyonnard S., Volino F.