foods Article White Button Mushroom Extracts Modulate Hepatic Fibrosis Progression, Inflammation, and Oxidative Stress In Vitro and in LDLR-/- Mice Paloma Gallego 1,†, Amparo Luque-Sierra 2,† , Gonzalo Falcon 3, Pilar Carbonero 3, Lourdes Grande 1, Juan D. Bautista 3, Franz Martín 2,4,* and José A. Del Campo 1,5,* 1 Unit for Clinical Management of Digestive Diseases and CIBERehd, Valme University Hospital, 41014 Seville, Spain;
[email protected] (P.G.);
[email protected] (L.G.) 2 Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), University of Pablo de Olavide-University of Sevilla-CSIC, 41013 Seville, Spain;
[email protected] 3 Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Sevilla, 41012 Seville, Spain;
[email protected] (G.F.);
[email protected] (P.C.);
[email protected] (J.D.B.) 4 Biomedical Research Network on Diabetes and Related Metabolic Diseases-CIBERDEM, 28029 Madrid, Spain 5 ALGAENERGY S.A. Avda. de Europa 19, Alcobendas, 28018 Madrid, Spain * Correspondence:
[email protected] (F.M.);
[email protected] (J.A.D.C.); Tel.: +34-954-467-427 (F.M.); +34-955-015-485 (J.A.D.C.) † These authors contributed equally to this work. Citation: Gallego, P.; Luque-Sierra, Abstract: Liver fibrosis can be caused by non-alcoholic steatohepatitis (NASH), among other condi- A.; Falcon, G.; Carbonero, P.; Grande, tions. We performed a study to analyze the effects of a nontoxic, water-soluble extract of the edible L.; Bautista, J.D.; Martín, F.; Del mushroom Agaricus bisporus (AB) as a potential inhibitor of fibrosis progression in vitro using human Campo, J.A.