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Natural Coral As a Biomaterial Revisited
American Journal of www.biomedgrid.com Biomedical Science & Research ISSN: 2642-1747 --------------------------------------------------------------------------------------------------------------------------------- Research Article Copy Right@ LH Yahia Natural Coral as a Biomaterial Revisited LH Yahia1*, G Bayade1 and Y Cirotteau2 1LIAB, Biomedical Engineering Institute, Polytechnique Montreal, Canada 2Neuilly Sur Seine, France *Corresponding author: LH Yahia, LIAB, Biomedical Engineering Institute, Polytechnique Montreal, Canada To Cite This Article: LH Yahia, G Bayade, Y Cirotteau. Natural Coral as a Biomaterial Revisited. Am J Biomed Sci & Res. 2021 - 13(6). AJBSR. MS.ID.001936. DOI: 10.34297/AJBSR.2021.13.001936. Received: July 07, 2021; Published: August 18, 2021 Abstract This paper first describes the state of the art of natural coral. The biocompatibility of different coral species has been reviewed and it has been consistently observed that apart from an initial transient inflammation, the coral shows no signs of intolerance in the short, medium, and long term. Immune rejection of coral implants was not found in any tissue examined. Other studies have shown that coral does not cause uncontrolled calcification of soft tissue and those implants placed under the periosteum are constantly resorbed and replaced by autogenous bone. The available porestudies size. show Thus, that it isthe hypothesized coral is not cytotoxic that a damaged and that bone it allows containing cell growth. both cancellous Thirdly, porosity and cortical and gradient bone can of be porosity better replacedin ceramics by isa graded/gradientexplained based on far from equilibrium thermodynamics. It is known that the bone cross-section from cancellous to cortical bone is non-uniform in porosity and in in vitro, animal, and clinical human studies. -
Avascular Necrosis As a Part of ‘Long COVID-19’ Sanjay R Agarwala,1 Mayank Vijayvargiya,2 Prashant Pandey2
Case report BMJ Case Rep: first published as 10.1136/bcr-2021-242101 on 2 July 2021. Downloaded from Avascular necrosis as a part of ‘long COVID-19’ Sanjay R Agarwala,1 Mayank Vijayvargiya,2 Prashant Pandey2 1Orthopaedics, PD Hinduja SUMMARY I or II, 92%–97% of the patients do not require National Hospital, Mumbai, ’Long COVID-19’ can affect different body systems. At surgery and can be managed with bisphosphonate Maharashtra, India present, avascular necrosis (AVN) as a sequalae of ’long therapy. Hence, it is crucial to diagnose AVN early 2Orthopaedics, PD Hinduja COVID-19’ has yet not been documented. By large- scale to decrease the morbidity and the requirement of National Hospital and Medical surgery. Research Centre, Mumbai, use of life- saving corticosteroids in COVID-19 cases, Here, we report three cases of symptomatic AVN Maharashtra, India we anticipate that there will be a resurgence of AVN cases. We report a series of three cases in which patients of the femoral head after being treated for COVID- Correspondence to developed AVN of the femoral head after being treated 19. This is the first case report of AVN as sequalae Dr Sanjay R Agarwala; for COVID-19 infection. The mean dose of prednisolone of ‘long COVID-19’. drsa2011@ gmail.com used in these cases was 758 mg (400–1250 mg), which is less than the mean cumulative dose of around 2000 CASE PRESENTATION Accepted 23 May 2021 mg steroid, documented in the literature as causative for Case 1 AVN. Patients were symptomatic and developed early A- 36- year old male patient was diagnosed with AVN presentation at a mean of 58 days after COVID-19 COVID-19 on 6 September 2020, for which the diagnosis as compared with the literature which shows patient was admitted in intensive care at another that it generally takes 6 months to 1 year to develop AVN hospital because of dropping saturation. -
Stage-Related Results in Treatment of Hip Osteonecrosis with Core-Decompression and Autologous Mesenchymal Stem Cells
Acta Orthop. Belg., 2015, 81, 406-412 ORIGINAL STUDY Stage-related results in treatment of hip osteonecrosis with core-decompression and autologous mesenchymal stem cells Pietro PERSIANI, Claudia DE CRISTO, Jole GRACI, Giovanni NOIA, Michele GURZÌ, Ciro VILLANI From Universitary Department of Anatomic, Histologic, Forensic and Locomotor Apparatus Sciences, Section of Locomotor Apparatus Sciences, Policlinico Umberto I, Sapienza University of Rome Our aim is to analyse the clinical outcome of a series thetic hip replacement. Therapy with glucocorti- of patients affected by avascular necrosis of the femo- coids and alcohol abuse are some of the main known ral head and treated with core-decompression tech- causative factors (21). Several pathophysiological nique and autologous stromal cells of the bone mechanisms were formulated about this pathology, marrow. including fat emboli, microvascular occlusion of We enrolled in our study 29 patients with 31 hips in epiphysis vessels and micro fracture of trabecular total affected by avascular necrosis of the femoral 13,18 head. bone ( ). An early diagnosis and a continuous The clinical and radiological outcome has been monitoring of patients with risk factors (corticoste- assessed through self-administered questionnaires roids therapy, alcoholism, or irradiated patients) are (HHS, VAS and SF12) X-ray and Magnetic Reso- very important in order to highlight the AVNFH nance. typical alteration as early as possible. Of all the examined hips, 25 showed a relief of the The treatment of osteonecrosis is one of the most symptoms and a resolution of the osteonecrosis, 11 of controversial subjects in the orthopaedic literature. these were at Stage I and 14 at Stage II. -
Case Report Tillaux Fracture in Adult
Case Report Syed et al: Tillaux fracture in adult Tillaux Fracture In Adult: A Case Report Syed T, Storey P, Rocha R, Kocheta A, Singhai S Study performed at Rotherham District General Hospital, Rotherham, South Yorkshire, United Kingdom Abstract Case report We report a rare case of Tillaux fracture of the ankle in a 36-year-old man. He sustained the injury in a football tackle and presented to us with pain and swelling of the left ankle. After preliminary X- rays, a CT scan was done which showed a Tillaux type fracture which is a rare injury after epiphyseal fusion. The ankle was treated with open reduction and internal fixation with screws and plaster for 6 weeks. At 3 months the patient had no pain in the ankle and able to mobilize full weight bearing on that side. Keywords : Ankle fracture, Tillaux fracture, Anterolateral tibial avulsion Address of correspondence: How to cite this article: Dr. Towheed Syed, Syed T, Storey P, Rocha R, Kocheta A, Singhai S. Tillaux Fracture 4-4-3-18/401, Senior heights, Street In Adult: A Case Report. Ortho J MPC. 2020;26(2): 95-98 no.3, Lalamma gardens, Puppalguda, Available from: Manikonda, Hyderabad - 500089 https://ojmpc.com/index.php/ojmpc/article/view/126 Email – [email protected] Introduction aim to educate the clinicians about this rare injury in adults, which is worthy of discussion. Tillaux fracture is an uncommon, rare ankle injury, described as an avulsion fracture of Case report anterolateral part of distal tibia due to the stronger pull of the anterior tibiofibular A 36-year-old gentleman presented to the ligament, by an external rotation force to the emergency department immediately after foot causing a Salter Harris type III injury [1- trauma sustained in a football tackle. -
Clinical Management of Severe Acute Respiratory Infections When Novel Coronavirus Is Suspected: What to Do and What Not to Do
INTERIM GUIDANCE DOCUMENT Clinical management of severe acute respiratory infections when novel coronavirus is suspected: What to do and what not to do Introduction 2 Section 1. Early recognition and management 3 Section 2. Management of severe respiratory distress, hypoxemia and ARDS 6 Section 3. Management of septic shock 8 Section 4. Prevention of complications 9 References 10 Acknowledgements 12 Introduction The emergence of novel coronavirus in 2012 (see http://www.who.int/csr/disease/coronavirus_infections/en/index. html for the latest updates) has presented challenges for clinical management. Pneumonia has been the most common clinical presentation; five patients developed Acute Respira- tory Distress Syndrome (ARDS). Renal failure, pericarditis and disseminated intravascular coagulation (DIC) have also occurred. Our knowledge of the clinical features of coronavirus infection is limited and no virus-specific preven- tion or treatment (e.g. vaccine or antiviral drugs) is available. Thus, this interim guidance document aims to help clinicians with supportive management of patients who have acute respiratory failure and septic shock as a consequence of severe infection. Because other complications have been seen (renal failure, pericarditis, DIC, as above) clinicians should monitor for the development of these and other complications of severe infection and treat them according to local management guidelines. As all confirmed cases reported to date have occurred in adults, this document focuses on the care of adolescents and adults. Paediatric considerations will be added later. This document will be updated as more information becomes available and after the revised Surviving Sepsis Campaign Guidelines are published later this year (1). This document is for clinicians taking care of critically ill patients with severe acute respiratory infec- tion (SARI). -
Acute Chest Syndrome, Avascular Necrosis of Femur, and Pulmonary Embolism All at Once: an Unexpected Encounter in the First-Ever Admission of a Sickle Cell Patient
Open Access Case Report DOI: 10.7759/cureus.17656 Acute Chest Syndrome, Avascular Necrosis of Femur, and Pulmonary Embolism All at Once: An Unexpected Encounter in the First-Ever Admission of a Sickle Cell Patient Akhilesh Annadatha 1 , Dhruv Talwar 1 , Sourya Acharya 1 , Sunil Kumar 1 , Vivek Lahane 1 1. Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed University), Wardha, IND Corresponding author: Dhruv Talwar, [email protected] Abstract Acute chest syndrome (ACS) is defined as the radiological appearance of pulmonary infiltrates with fever or respiratory symptoms like chest pain, breathlessness, and cough in a patient with sickle cell disease (SCD). It is also a very common cause of mortality in sickle cell patients, if not identified in early stages and treated aggressively. Radiological image is similar to bacterial pneumonia, so sickle cell disease with a radiological picture similar to pneumonia and associated respiratory symptoms is known as acute chest syndrome. Pneumonia and infarction have been implicated in pathogenesis. The reason for the appearance of acute chest syndrome in patients with SCD is not established but some triggers like sepsis, presence of vaso- occlusive crises have been noted. When there is a block in the blood supply to the bone, patients with sickle cell disease may also develop avascular necrosis of the neck of the femur causing narrowing of joint and collapse of the bone. Patients with sickle cell disease have a baseline hypercoagulable state thereby predisposing the patient to develop deep vein thrombosis and pulmonary embolism. Here, we present a case of a 25-year-old SCD patient with a fairly stable course of the disease. -
Symptomatic Middle Ear and Cranial Sinus Barotraumas As a Complication of Hyperbaric Oxygen Treatment
İst Tıp Fak Derg 2016; 79: 4 KLİNİK ARAŞTIRMA / CLINICAL RESEARCH J Ist Faculty Med 2016; 79: 4 http://dergipark.ulakbim.gov.tr/iuitfd http://www.journals.istanbul.edu.tr/iuitfd SYMPTOMATIC MIDDLE EAR AND CRANIAL SINUS BAROTRAUMAS AS A COMPLICATION OF HYPERBARIC OXYGEN TREATMENT HİPERBARİK OKSİJEN TEDAVİSİ KOMPLİKASYONU: SEMPTOMATİK ORTA KULAK VE KRANYAL SİNUS BAROTRAVMASI Bengüsu MİRASOĞLU*, Aslıcan ÇAKKALKURT*, Maide ÇİMŞİT* ABSTRACT Objective: Hyperbaric oxygen therapy (HBOT) is applied for various diseases. It is generally considered safe but has some benign complications and adverse effects. The most common complication is middle ear barotrauma. The aim of this study was to collect data about middle ear and cranial sinus barotraumas in our department and to evaluate factors affecting the occurrence of barotrauma. Material and methods: Files of patients who had undergone hyperbaric oxygen therapy between June 1st, 2004, and April 30th, 2012, and HBOT log books for the same period were searched for barotraumas. Patients who were intubated and unconscious were excluded. Data about demographics and medical history of conscious patients with barotrauma (BT) were collected and evaluated retrospectively. Results: It was found that over eight years and 23,645 sessions, 39 of a total 896 patients had BT; thus, the general BT incidence of our department was 4.4%. The barotrauma incidence was significantly less in the multiplace chamber (3.1% vs. 8.7%) where a health professional attended the therapies. Most barotraumas were seen during early sessions and were generally mild. A significant accumulation according to treatment indications was not determined. Conclusion: It was thought that the low barotrauma incidence was related to the slow compression rate as well as training patients thoroughly and monitoring them carefully. -
Bilateral Diaphragm Paralysis and Sleep Apnoea Without Diurnal Respiratory Failure
Thorax: first published as 10.1136/thx.43.1.75 on 1 January 1988. Downloaded from Thorax 1988;43:75-77 Bilateral diaphragm paralysis and sleep apnoea without diurnal respiratory failure J R STRADLING, A R H WARLEY From the Osler Chest Unit, Churchill Hospital, OxJord This is a case history of a patient with isolated bilateral increased at 3 6 kPa (27 mm Hg) and was presumed to be due diaphragm paralysis. It is presented because it offers insight to basal atelectasis. into possible mechanisms of the respiratory failure which Two months later overnight oximetry was performed usually develops in this condition. (Biox 2A). The awake semirecumbent arterial oxygen satura- tion (Sao2) was 93%. Most of the night was spent with a Case report stable Sao2 ofabout 92%. During three periods of 20 minutes there were regular recurrent dips in Sao, (rate 45/hour) to The patient, now 40 years old, presented in 1973 with about 80% (lowest 69%), presumed to be associated with mesangiocapillary glomerulonephritis (hypocompliment- rapid eye movement (REM) sleep. At this stage no further aemic with C3 nephritic factor) and subsequently developed action was taken except to advise sleeping propped up. progressive renal failure. In 1978 classical neuralgic amyotro- Two full sleep studies were performed 12 and 18 months phy (brachial neuritis) occurred in both arms and remitted later. They gave similar results. The patient's height and over the next three months, his sister having had similar weight at this time were 1-9 m and 94 kg respectively. Awake episodes some years before. Four months later he underwent values of Pao, and Paco, in the semirecumbent posture were a successful cadaver renal transplant. -
Pediatric Orthopedic Injuries… … from an ED State of Mind
Traumatic Orthopedics Peds RC Exam Review February 28, 2019 Dr. Naminder Sandhu, FRCPC Pediatric Emergency Medicine Objectives to cover today • Normal bone growth and function • Common radiographic abnormalities in MSK diseases • Part 1: Atraumatic – Congenital abnormalities – Joint and limb pain – Joint deformities – MSK infections – Bone tumors – Common gait disorders • Part 2: Traumatic – Common pediatric fractures and soft tissue injuries by site Overview of traumatic MSK pain Acute injuries • Fractures • Joint dislocations – Most common in ED: patella, digits, shoulder, elbow • Muscle strains – Eg. groin/adductors • Ligament sprains – Eg. Ankle, ACL/MCL, acromioclavicular joint separation Chronic/ overuse injuries • Stress fractures • Tendonitis • Bursitis • Fasciitis • Apophysitis Overuse injuries in the athlete WHY do they happen?? Extrinsic factors: • Errors in training • Inappropriate footwear Overuse injuries Intrinsic: • Poor conditioning – increased injuries early in season • Muscle imbalances – Weak muscle near strong (vastus medialus vs lateralus patellofemoral pain) – Excessive tightness: IT band, gastroc/soleus Sever disease • Anatomic misalignments – eg. pes planus, genu valgum or varum • Growth – strength and flexibility imbalances • Nutrition – eg. female athlete triad Misalignment – an intrinsic factor Apophysitis • *Apophysis = natural protruberance from a bone (2ndary ossification centres, often where tendons attach) • Examples – Sever disease (Calcaneal) – Osgood Schlatter disease (Tibial tubercle) – Sinding-Larsen-Johansson -
SALTER HARRIS FRACTURES in CHILDREN
SALTER HARRIS FRACTURES in CHILDREN Kyra Frost 11/12/19 Diagnostic Radiology RAD 4001 Dr. Kumaravel Clinical History salter harris type 2 left tibia • 10 year old previously healthy boy comes into the Ed with a one day history of pain, swelling, and inability to move his left ankle after falling while playing tag. • Current Sx: • Pain and swelling around the ankle • Pain did not improve after taking Ibuprofen and putting ice on the • Physical exam findings: • Vital signs with in normal limits with the exception of mild tachycardia most likely related to pain: T: 99 HR: 110 RR: 15 BP: 118/78 Spo2: 100 % RA • Swelling at the left ankle joint and pain with passive ROM • Pt was unable to preform active ROM due to pain, and was unable to bear weight on affected left side. • Pt had 5+ strength in right lower extremity, DTR were 2+ throughout, and distal dorsalis pedis was 2+ bilaterally on exam • Work- Up • Xray of left, ankle, and foot • Xray of right, ankle, and foot for comparison McGovern Medical School Radiograph of left ankle • The average cost for an Xray of the Salter Harris foot is: type II Growth Plate 50-130$ Our patient was most likely billed 300-600 dollars Patient: 10/ 24/2019: Plain Radiographic Film in AP Plain Xray radiograph film in AP and Lateral view and Lateral views showing a minimally displaced of an 11 year old boy Salter Harris II Fracture of the distal tibia (of note – not original image due to formatting https://www.newchoicehealth.com/places/texas/houston/x- issues) ray McGovern Medical School Breaking it Down: Is -
Avascular Necrosis of Bone Following Allogeneic Stem Cell Transplantation: MR Screening and Therapeutic Options
Bone Marrow Transplantation, (1998) 22, 565–569 1998 Stockton Press All rights reserved 0268–3369/98 $12.00 http://www.stockton-press.co.uk/bmt Avascular necrosis of bone following allogeneic stem cell transplantation: MR screening and therapeutic options A Wiesmann1, P Pereira2,PBo¨hm3, C Faul1, L Kanz1 and H Einsele1 1Department of Hematology and Oncology, 2Department of Diagnostic Radiology, 3Department of Orthopedics, University of Tu¨bingen, Germany Summary: chondral bone, whereas osteonecrosis of the metaphyseal or diaphyseal bone is commonly referred to as bone infarct.1 With improvement in long-term survival after allo- There are several causes of osteonecrosis such as trauma, geneic stem cell transplantation, late complications with benign and malignant hematologic diseases, radiation, significant morbidity are of increasing importance. We alcoholism, Gaucher’s disease, collagen disease and retrospectively analysed 272 recipients of an allogeneic decompression disease.2–9 Treatment with corticosteroids is stem cell transplant for the development of osteo- another risk factor in the pathogenesis of osteonecrosis as necrosis. The incidence among allograft recipients was first mentioned in 1950.10 Therefore, avascular necrosis is 6.3% (17/272) for the whole patient population, and a well-described complication after renal and cardiac trans- 11.8% (17/144) for long-term survivors. All patients plantation, especially in patients receiving high-dose ster- were treated with high-dose prednisolone, 16 for severe oids for graft rejection.10–17 In 1987, Atkinson et al18 first acute or extensive chronic graft-versus-host disease described a 10% incidence of osteonecrosis after allogeneic (GVHD) and one patient for graft rejection. -
Pediatric Ankle Fractures
CHAPTER 26 PEDIATRIC ANKLE FRACTURES Sofi e Pinney, DPM, MS INTRODUCTION stronger than both the physis and bone. As a result, there is a greater capacity for plastic deformation and less chance of The purpose of this review is to examine the current intra-articular fractures, joint dislocation, and ligamentous literature on pediatric ankle fractures. I will discuss the disruptions. However, ligamentous injury may be more anatomic considerations of a pediatric patient, how to common than originally believed (1). A case-control study evaluate and manage these fractures, and when to surgically by Zonfrillo et al found an association between an increased repair them. Surgical techniques and complications will be risk of athletic injury in obese children, and concluded a briefl y reviewed. higher body mass index risk factor for ankle sprains (4). Ankle fractures are the third most common fractures in Secondary ossifi cation centers are located in the children, after the fi nger and distal radial physeal fracture. epiphysis. The distal tibial ossifi cation center appears at 6-24 Approximately 20-30% of all pediatric fractures are ankle months of age and closes asymmetrically over an 18-month fractures. Most ankle fractures occur at 8-15 years old. The period fi rst central, then medial and posterior, with the peak injury age is 11-12 years, and is relatively uncommon anterolateral portion closing last at 15 and 17 years of age for under the age 5. This injury is more common in boys. females and males, respectively. The distal fi bula ossifi cation The most common cause of pediatric ankle fractures is a center appears at 9-24 months of age and closes 1-2 years rotational force, and is often seen in sports injuries associated after the distal tibial.