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Avascular Necrosis As a Part of ‘Long COVID-19’ Sanjay R Agarwala,1 Mayank Vijayvargiya,2 Prashant Pandey2

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Avascular Necrosis As a Part of ‘Long COVID-19’ Sanjay R Agarwala,1 Mayank Vijayvargiya,2 Prashant Pandey2 Case report BMJ Case Rep: first published as 10.1136/bcr-2021-242101 on 2 July 2021. Downloaded from Avascular necrosis as a part of ‘long COVID-19’ Sanjay R Agarwala,1 Mayank Vijayvargiya,2 Prashant Pandey2 1Orthopaedics, PD Hinduja SUMMARY I or II, 92%–97% of the patients do not require National Hospital, Mumbai, ’Long COVID-19’ can affect different body systems. At surgery and can be managed with bisphosphonate Maharashtra, India present, avascular necrosis (AVN) as a sequalae of ’long therapy. Hence, it is crucial to diagnose AVN early 2Orthopaedics, PD Hinduja COVID-19’ has yet not been documented. By large- scale to decrease the morbidity and the requirement of National Hospital and Medical surgery. Research Centre, Mumbai, use of life- saving corticosteroids in COVID-19 cases, Here, we report three cases of symptomatic AVN Maharashtra, India we anticipate that there will be a resurgence of AVN cases. We report a series of three cases in which patients of the femoral head after being treated for COVID- Correspondence to developed AVN of the femoral head after being treated 19. This is the first case report of AVN as sequalae Dr Sanjay R Agarwala; for COVID-19 infection. The mean dose of prednisolone of ‘long COVID-19’. drsa2011@ gmail.com used in these cases was 758 mg (400–1250 mg), which is less than the mean cumulative dose of around 2000 CASE PRESENTATION Accepted 23 May 2021 mg steroid, documented in the literature as causative for Case 1 AVN. Patients were symptomatic and developed early A- 36- year old male patient was diagnosed with AVN presentation at a mean of 58 days after COVID-19 COVID-19 on 6 September 2020, for which the diagnosis as compared with the literature which shows patient was admitted in intensive care at another that it generally takes 6 months to 1 year to develop AVN hospital because of dropping saturation. During post steroid exposure. his hospitalisation, the patient was administered intravenous methylprednisolone 80 mg per day for 9 days (totalling—720 mg of methylprednisolone BACKGROUND equivalent to 900 mg prednisolone) and intrave- A novel coronavirus named ‘COVID-19’ by the nous remdesivir and intravenous tocilizumab. The patient was discharged on oral prednisolone in WHO is the cause of the current pandemic that tapering dose over 28 days (total—350 mg). Total began in December 2019 in Wuhan city, Hubei steroid received by the patient was 1250 mg of province, China. By 28 January 2021, more than prednisolone equivalent. 100 200 107 individuals had been infected with Forty-five days after the COVID-19 diagnosis, COVID-19, of which 2 158 761 were fatal.1 the patient developed pain in the right groin. The http://casereports.bmj.com/ Emerging evidence suggests that COVID-19 patient had no history of hip pain prior to this. adversely affects different human body systems as Radiograph and MRI of hip done (67 days since a part of ‘long COVID-19’, such as Guillain-Barré COVID-19 diagnosis) showed bilateral hip AVN syndrome, lung fibrosis, pulmonary thromboem- (Ficat-Arlet stage II on both hips) (figure 1). bolism, cardiomyopathy, sensory dysfunction and stroke.2 Long COVID-19 is a term used to describe the long- term effects of COVID-19 infection that Case 2 continue for weeks or months after the patient has A 39- year- old male patient was diagnosed with recovered from COVID-19.3 National Institute for COVID-19 on 8 September 2020, the patient was given oral dexamethasone in tapering dose over 10 Health and Care Excellence defines ‘long COVID- on September 30, 2021 by guest. Protected copyright. 19’ as lasting for more than 12 weeks. Symptoms days (total—60 mg equivalent to 400 mg of prednis- of long COVID-19 can include fatigue, breath- olone) along with oral favipiravir 200mg. Fifty- seven lessness, anxiety and depression, palpitations, days later, the patient developed pain in the left groin chest pains, joint or muscle pain and not being region. Radiograph and MRI of the hip done showed able to think straight or focus (‘brain fog’).3 Since left hip AVN (Ficat-A rlet stage II) (figure 2). the outbreak, many agents that could have effi- cacy against COVID-19 have been used including Case 3 various antivirals; angiotensin receptor blockers; A- 37- year old male patient was diagnosed with chloroquine phosphate and corticosteroids. The COVID-19 on 15 November 2020, for which intra- efficacy of angiotensin receptor blockers and chlo- venous methylprednisolone (500 mg) was given equiv- roquine phosphate has not been well established.4 5 alent to 625 mg prednisolone. Forty- five days post Corticosteroids are life- saving in the management COVID-19 detection, the patient developed pain in © BMJ Publishing Group of COVID-19, however it is a predisposing factor the bilateral groin. The patient had no history of hip Limited 2021. No commercial 6 pain in the past. Radiographs and MRI were done 55 re-use . See rights and for the development of avascular necrosis (AVN). permissions. Published by BMJ. Based on this premise, in view of the large- scale days post COVID-19 detection that showed bilateral use of life-saving corticosteroids, there could be a hip AVN (Ficat-Arlet stage II) (figure 3). To cite: Agarwala SR, Vijayvargiya M, Pandey P. BMJ resurgence in the number of AVN cases. An early Case Rep 2021;14:e242101. diagnosis of AVN is important to arrest the disease’s OUTCOME AND FOLLOW-UP doi:10.1136/bcr-2021- progress and prevent subsequent femoral head The mean dose of prednisolone equivalent steroid 242101 collapse.7 If diagnosed early in Ficat-Arlet stage taken by the patient in our series was 758 mg (400 Agarwala SR, et al. BMJ Case Rep 2021;14:e242101. doi:10.1136/bcr-2021-242101 1 Case report BMJ Case Rep: first published as 10.1136/bcr-2021-242101 on 2 July 2021. Downloaded from Figure 1 MRI and anteroposterior radiograph of the 36- year- old male Figure 3 MRI and anteroposterior radiograph of the 37- year- old patient confirming bilateral avascular necrosis of the femoral head male patient confirming avascular necrosis of the femoral head of the (Ficat- Arlet stage II). bilateral hip (Ficat- Arlet stage II). mg–1250 mg). The time duration for the development of AVN duration for the development of AVN post COVID-19 diagnosis post COVID-19 diagnosis in our series was 62 days in the first in our series was 58 days (range 45–67 days). case, 67 days in the second case and 45 days in the third case, Treatment objective in AVN is to obtain pain relief, retard with a mean duration of 58 days (range 45–67 days). All the disease progression, prevent collapse and restore joint func- three patients were started on oral alendronate 70 mg weekly tion. Multitude treatment options are available for managing dosages along with intravenous zoledronic acid 5 mg annually.8 AVN ranging from conservative, medical to surgical modali- At the last mean follow-up of 70.7 days (30–84 days), none of ties, however no standardised protocol exists. Various medical the patients required surgery and were comfortable painwise. therapies tried in the past including iloprost, nifedipine and Mean Visual Analogue Score for pain reduced from 8 (6–9) to hyperbaric oxygen therapy have not shown significant bene- 2.7 (1–4) at the mean follow-up of 70.7 days. fits.7 Therefore, arthroplasty remains the mainstay of treatment. Although it provides good outcome but when performed at a DISCUSSION young age will necessitate at least one revision in the future. Corticosteroid use is considered to be one of the most common cause Successful use of bisphosphonates for the treatment of AVN in 8 for the development of AVN. The pathogenesis of steroid- induced adults was first reported by Agarwala et al. The authors have AVN is not well established, but postulated mechanisms include fat shown that bisphosphonates not only give good clinical outcome emboli, fat hypertrophy, hypercoagulable condition, vascular endo- but also retard progression of the disease and the need for a thelial dysfunction and abnormality of the bone marrow stem cell.9 surgery. Subsequently, various authors have published the role of There is a lack of consensus about the dosage and duration of bisphosphonates in management of AVN and it is now consid- steroids required to develop AVN. Some authors have reported ered to be as one of the standard options of treatment of AVN. that a cumulative dose of 2000 mg prednisone (or its equivalent) In our case series, AVN occurred with a low mean steroid was required for AVN development.10 Some studies have shown dosage of 758 mg with a minimum dose of 400 mg compared that 700 mg is the minimum dose required to develop AVN.11 with the literature which shows that a mean cumulative dose http://casereports.bmj.com/ However, McKee et al have shown that in their series of 15 of 2000 mg steroid is required for the development of AVN. patients who developed AVN, mean steroid dose in prednisone Further, the patient developed AVN very early with a mean equivalents was 850 mg with a range of 290 mg–3300 mg.12 The range of 58 days after COVID-19 diagnosis compared with the mean dose of prednisolone equivalent steroid taken in our series literature which shows that it generally takes 6 months to 1 year was 758 mg (range 400–1250 mg). to develop AVN post steroid exposure. Controversy exists about the time after the steroid administra- Post COVID-19, there is a greater propensity to develop AVN, tion to the development of AVN symptoms.
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