DOCSLIB.ORG

1-Chloro-2-Propanol Hazard Summary Identification

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
1-Chloro-2-Propanol Hazard Summary Identification Common Name: 1-CHLORO-2-PROPANOL CAS Number: 127-00-4 RTK Substance number: 1610 DOT Number: UN 2611 Date: March 1998 Revision: November 2004 ------------------------------------------------------------------------- ------------------------------------------------------------------------- HAZARD SUMMARY WORKPLACE EXPOSURE LIMITS * 1-Chloro-2-Propanol can affect you when breathed in ACGIH: The recommended airborne exposure limit is and by passing through your skin. 1 ppm averaged over an 8-hour workshift. * Because this is a MUTAGEN, handle it as a possible carcinogen--WITH EXTREME CAUTION. * 1-Chloro-2-Propanol is a MUTAGEN. Mutagens may * Contact can irritate the skin. have a cancer risk. All contact with this chemical should * 1-Chloro-2-Propanol can severely irritate and burn the be reduced to the lowest possible level. eyes. * The above exposure limit is for air levels only. When skin * Breathing 1-Chloro-2-Propanol can irritate the nose and contact also occurs, you may be overexposed, even though throat. air levels are less than the limit listed above. IDENTIFICATION WAYS OF REDUCING EXPOSURE 1-Chloro-2-Propanol is a colorless liquid with a mild Ether- * Where possible, enclose operations and use local exhaust like odor. It is used to make other chemicals. ventilation at the site of chemical release. If local exhaust ventilation or enclosure is not used, respirators should be REASON FOR CITATION worn. * 1-Chloro-2-Propanol is on the Hazardous Substance List * Wear protective work clothing. because it is cited by ACGIH, DOT and NFPA. * Wash thoroughly immediately after exposure to 1-Chloro- * This chemical is on the Special Health Hazard Substance 2-Propanol and at the end of the workshift. List because it is a MUTAGEN. * Post hazard and warning information in the work area. In * Definitions are provided on page 5. addition, as part of an ongoing education and training effort, communicate all information on the health and HOW TO DETERMINE IF YOU ARE BEING safety hazards of 1-Chloro-2-Propanol to potentially exposed workers. EXPOSED The New Jersey Right to Know Act requires most employers to label chemicals in the workplace and requires public employers to provide their employees with information and training concerning chemical hazards and controls. The federal OSHA Hazard Communication Standard, 1910.1200, requires private employers to provide similar training and information to their employees. * Exposure to hazardous substances should be routinely evaluated. This may include collecting personal and area air samples. You can obtain copies of sampling results from your employer. You have a legal right to this information under OSHA 1910.1020. * If you think you are experiencing any work-related health problems, see a doctor trained to recognize occupational diseases. Take this Fact Sheet with you. 1-CHLORO-2-PROPANOL page 2 of 6 This Fact Sheet is a summary source of information of all enclose operations and/or provide local exhaust ventilation at potential and most severe health hazards that may result from the site of chemical release. Isolating operations can also exposure. Duration of exposure, concentration of the substance reduce exposure. Using respirators or protective equipment is and other factors will affect your susceptibility to any of the less effective than the controls mentioned above, but is potential effects described below. sometimes necessary. --------------------------------------------------------------------------- In evaluating the controls present in your workplace, consider: HEALTH HAZARD INFORMATION (1) how hazardous the substance is, (2) how much of the substance is released into the workplace and (3) whether Acute Health Effects harmful skin or eye contact could occur. Special controls The following acute (short-term) health effects may occur should be in place for highly toxic chemicals or when immediately or shortly after exposure to 1-Chloro-2- significant skin, eye, or breathing exposures are possible. Propanol: In addition, the following control is recommended: * Contact can irritate the skin. * 1-Chloro-2-Propanol can severely irritate and burn the * Where possible, automatically pump liquid 1-Chloro-2- eyes. Propanol from drums or other storage containers to process * Breathing 1-Chloro-2-Propanol can irritate the nose and containers. throat. Good WORK PRACTICES can help to reduce hazardous Chronic Health Effects exposures. The following work practices are recommended: The following chronic (long-term) health effects can occur at some time after exposure to 1-Chloro-2-Propanol and can last * Workers whose clothing has been contaminated by for months or years: 1-Chloro-2-Propanol should change into clean clothing promptly. Cancer Hazard * Contaminated work clothes should be laundered by * 1-Chloro-2-Propanol causes MUTATIONS (genetic individuals who have been informed of the hazards of changes). Such chemicals may have a cancer risk. exposure to 1-Chloro-2-Propanol. * Eye wash fountains should be provided in the immediate * Many scientists believe there is no safe level of exposure to work area for emergency use. a carcinogen. * If there is the possibility of skin exposure, emergency Reproductive Hazard shower facilities should be provided. * On skin contact with 1-Chloro-2-Propanol, immediately * While 1-Chloro-2-Propanol has been tested, it is not wash or shower to remove the chemical. At the end of the classifiable as to its potential to cause reproductive harm. workshift, wash any areas of the body that may have Other Long-Term Effects contacted 1-Chloro-2-Propanol, whether or not known skin contact has occurred. * 1-Chloro-2-Propanol has not been adequately tested for * Do not eat, smoke, or drink where 1-Chloro-2-Propanol is other (long-term) health effects. handled, processed, or stored, since the chemical can be swallowed. Wash hands carefully before eating, drinking, MEDICAL smoking, or using the toilet. Medical Testing PERSONAL PROTECTIVE EQUIPMENT There is no special test for this chemical. However, if illness occurs or overexposure is suspected, medical attention is WORKPLACE CONTROLS ARE BETTER THAN recommended. PERSONAL PROTECTIVE EQUIPMENT. However, for some jobs (such as outside work, confined space entry, jobs Any evaluation should include a careful history of past and done only once in a while, or jobs done while workplace present symptoms with an exam. Medical tests that look for controls are being installed), personal protective equipment damage already done are not a substitute for controlling may be appropriate. exposure. OSHA 1910.132 requires employers to determine the Request copies of your medical testing. You have a legal right appropriate personal protective equipment for each hazard and to this information under OSHA 1910.1020. to train employees on how and when to use protective equipment. WORKPLACE CONTROLS AND PRACTICES The following recommendations are only guidelines and may Unless a less toxic chemical can be substituted for a hazardous not apply to every situation. substance, ENGINEERING CONTROLS are the most effective way of reducing exposure. The best protection is to 1-CHLORO-2-PROPANOL page 3 of 6 Clothing Q: Is the risk of getting sick higher for workers than for * Avoid skin contact with 1-Chloro-2-Propanol. Wear community residents? protective gloves and clothing. Safety equipment A: Yes. Exposures in the community, except possibly in suppliers/manufacturers can provide recommendations on cases of fires or spills, are usually much lower than those the most protective glove/clothing material for your found in the workplace. However, people in the operation. community may be exposed to contaminated water as * All protective clothing (suits, gloves, footwear, headgear) well as to chemicals in the air over long periods. This should be clean, available each day, and put on before may be a problem for children or people who are already work. ill. * Safety equipment manufacturers recommend Butyl Rubber or Viton as protective materials. Q: What are the likely health problems from chemicals which cause mutations? Eye Protection A: There are two primary health concerns associated with * Wear indirect-vent, impact and splash resistant goggles mutagens: (1) cancers can result from changes induced in when working with liquids. cells and, (2) adverse reproductive and developmental * Wear a face shield along with goggles when working with outcomes can result from damage to the egg and sperm corrosive, highly irritating or toxic substances. cells. Respiratory Protection Q: Don't all chemicals cause cancer? IMPROPER USE OF RESPIRATORS IS DANGEROUS. A: No. Most chemicals tested by scientists are not cancer- Such equipment should only be used if the employer has a causing. written program that takes into account workplace conditions, requirements for worker training, respirator fit testing and medical exams, as described in OSHA 1910.134. * Where the potential exists for exposure over 1 ppm, use a NIOSH approved supplied-air respirator with a full facepiece operated in a pressure-demand or other positive- pressure mode. For increased protection use in combination with an auxiliary self-contained breathing apparatus operated in a pressure-demand or other positive-pressure mode. QUESTIONS AND ANSWERS Q: If I have acute health effects, will I later get chronic health effects? A: Not always. Most chronic (long-term) effects result from repeated exposures to a chemical. Q: Can I get long-term effects without ever having short- term effects? A: Yes, because long-term
Load more

Recommended publications
  • Toxicological Profile for Radon
    RADON 205 10. GLOSSARY Some terms in this glossary are generic and may not be used in this profile. Absorbed Dose, Chemical—The amount of a substance that is either absorbed into the body or placed in contact with the skin. For oral or inhalation routes, this is normally the product of the intake quantity and the uptake fraction divided by the body weight and, if appropriate, the time, expressed as mg/kg for a single intake or mg/kg/day for multiple intakes. For dermal exposure, this is the amount of material applied to the skin, and is normally divided by the body mass and expressed as mg/kg. Absorbed Dose, Radiation—The mean energy imparted to the irradiated medium, per unit mass, by ionizing radiation. Units: rad (rad), gray (Gy). Absorbed Fraction—A term used in internal dosimetry. It is that fraction of the photon energy (emitted within a specified volume of material) which is absorbed by the volume. The absorbed fraction depends on the source distribution, the photon energy, and the size, shape and composition of the volume. Absorption—The process by which a chemical penetrates the exchange boundaries of an organism after contact, or the process by which radiation imparts some or all of its energy to any material through which it passes. Self-Absorption—Absorption of radiation (emitted by radioactive atoms) by the material in which the atoms are located; in particular, the absorption of radiation within a sample being assayed. Absorption Coefficient—Fractional absorption of the energy of an unscattered beam of x- or gamma- radiation per unit thickness (linear absorption coefficient), per unit mass (mass absorption coefficient), or per atom (atomic absorption coefficient) of absorber, due to transfer of energy to the absorber.
    [Show full text]
  • Toxicological Profile for Hydrazines. US Department Of
    TOXICOLOGICAL PROFILE FOR HYDRAZINES U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Agency for Toxic Substances and Disease Registry September 1997 HYDRAZINES ii DISCLAIMER The use of company or product name(s) is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry. HYDRAZINES iii UPDATE STATEMENT Toxicological profiles are revised and republished as necessary, but no less than once every three years. For information regarding the update status of previously released profiles, contact ATSDR at: Agency for Toxic Substances and Disease Registry Division of Toxicology/Toxicology Information Branch 1600 Clifton Road NE, E-29 Atlanta, Georgia 30333 HYDRAZINES vii CONTRIBUTORS CHEMICAL MANAGER(S)/AUTHOR(S): Gangadhar Choudhary, Ph.D. ATSDR, Division of Toxicology, Atlanta, GA Hugh IIansen, Ph.D. ATSDR, Division of Toxicology, Atlanta, GA Steve Donkin, Ph.D. Sciences International, Inc., Alexandria, VA Mr. Christopher Kirman Life Systems, Inc., Cleveland, OH THE PROFILE HAS UNDERGONE THE FOLLOWING ATSDR INTERNAL REVIEWS: 1 . Green Border Review. Green Border review assures the consistency with ATSDR policy. 2 . Health Effects Review. The Health Effects Review Committee examines the health effects chapter of each profile for consistency and accuracy in interpreting health effects and classifying end points. 3. Minimal Risk Level Review. The Minimal Risk Level Workgroup considers issues relevant to substance-specific minimal risk levels (MRLs), reviews the health effects database of each profile, and makes recommendations for derivation of MRLs. HYDRAZINES ix PEER REVIEW A peer review panel was assembled for hydrazines. The panel consisted of the following members: 1. Dr.
    [Show full text]
  • Detection of Carcinogens As Mutagens in the Salmonella/Microsome Test
    Proc. Nat. Acad. Sci. USA Vol. 73, No. 3, pp. 950-954, March 1976 Medical Sciences Detection of carcinogens as mutagens in the Salmonella/microsome test: Assay of 300 chemicals: Discussion* (prevention of cancer and genetic defects/somatic mutation/environmental insult to DNA) JOYCE MCCANN AND BRUCE N. AMES Department of Biochemistry, University of California, Berkeley, Calif. 94720 Contributed by Bruce N. Ames, January 7, 1976 ABSTRACT About 300 carcinogens and non-carcinogens Non-Carcinogens. Classification as to non-carcinogenicity of a wide variety of chemical types have been tested for mu- is usually difficult because of the varying completeness and tagenicity in the simple Salmonella/microsome test. The test uses bacteria as sensitive indicators of DNA damage, and modes of treatment in many studies and the statistical limi- mammalian liver extracts for metabolic conversion of carcin- tations inherent in animal tests (4, 8-10). Recent criteria for ogens to their active mutagenic forms. There is a high corre- adequate carcinogenicity tests are much more stringent (4, lation between carcinogenicity and mutagenicity: 90% 8-10). The test should be of adequate duration (lifetime pre- (157/175) of the carcinogens were mutagenic in the test, in- ferred in rodents) in at least two animal species, at several cluding almost all of the known human carcinogens that dose levels, and positive controls should be of the same gen- were tested. Despite the severe limitations inherent in defin- ing non-carcinogenicity, few "non-carcinogens" showed any eral chemical type as the chemical under test. The applica- degree of mutagenicity [McCann et a]. (1975) Proc.
    [Show full text]
  • Lead, Mercury and Cadmium in Fish and Shellfish from the Indian Ocean and Red
    Journal of Marine Science and Engineering Review Lead, Mercury and Cadmium in Fish and Shellfish from the Indian Ocean and Red Sea (African Countries): Public Health Challenges Isidro José Tamele 1,2,3,* and Patricia Vázquez Loureiro 4 1 Department of Chemistry, Faculty of Sciences, Eduardo Mondlane University, Av. Julius Nyerere, n 3453, Campus Principal, Maputo 257, Mozambique 2 Institute of Biomedical Science Abel Salazar, University of Porto, R. Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal 3 CIIMAR/CIMAR—Interdisciplinary Center of Marine and Environmental Research, University of Porto, Terminal de Cruzeiros do Porto, Avenida General Norton de Matos, 4450-238 Matosinhos, Portugal 4 Department of Analytical Chemistry, Nutrition and Food Science, Faculty of Pharmacy, University of Santiago de Compostela, Santiago de Compostela, 15782 A Coruña, Spain; [email protected] * Correspondence: [email protected] Received: 20 March 2020; Accepted: 8 May 2020; Published: 12 May 2020 Abstract: The main aim of this review was to assess the incidence of Pb, Hg and Cd in seafood from African countries on the Indian and the Red Sea coasts and the level of their monitoring and control, where the direct consumption of seafood without quality control are frequently due to the poverty in many African countries. Some seafood from African Indian and the Red Sea coasts such as mollusks and fishes have presented Cd, Pb and Hg concentrations higher than permitted limit by FAOUN/EU regulations, indicating a possible threat to public health. Thus, the operationalization of the heavy metals (HM) monitoring and control is strongly recommended since these countries have laboratories with minimal conditions for HM analysis.
    [Show full text]
  • Food-Derived Mutagens and Carcinogens1
    [CANCER RESEARCH (SL'PPL.) 52. 2092s-2098s. April I, 1992] Food-derived Mutagens and Carcinogens1 Keiji Wakabayashi,2 Minako Nagao, Hiroyasu Esumi, and Takashi Sugimura National Cancer Center Research Institute, l-l, Tsukiji 5-chome, Chuo-ku, Tokyo 104, Japan Abstract pounds have planar structures that can be inserted between the base pairs of double-stranded DNA. Charred parts of broiled Cooked food contains a variety of mutagenic heterocyclic amines. All the mutagenic heterocyclic amines tested were carcinogenic in rodents fish and meat were also found to be mutagenic to TA98 after when given in the diet at 0.01-0.08%. Most of them induced cancer in metabolic activation (9, 10). These findings led to the isolations the liver and in other organs. It is noteworthy that the most abundant of the mutagenic compounds, IQ,' MelQ, MelQx from broiled heterocyclic amine in cooked food, 2-amino-l-methyl-6-phenylimi- fish and meat (5-7). Later PhIP was also isolated as member dazo(4,5-A|pyridine, produced colon and mammary carcinomas of this class of mutagens (11). These heterocyclic amines were in rats and lymphomas in mice but no hepatomas in either. 2-Amino-3- methylimidazo(4,5-/]quinoline induced liver cancer in monkeys. Forma formed by heating mixtures of creatinine, sugars, and amino acids, which are present in raw meat and fish (12-16). More tion of adducts with guanine by heterocyclic amines is presumably involved in their carcinogenesis. Quantification of heterocyclic amines in recently identified mutagens have been found to contain oxygen cooked foods and in human urine indicated that humans are continuously atoms (17-19).
    [Show full text]
  • Appendix G Restricted Chemicals
    APPENDIX G RESTRICTED CHEMICALS CHEMICAL NAME REASON FOR RESTRICTION Acetaldehyde Suspected carcinogen, highly flammable Acetamide Suspected animal carcinogen Acrylamide Suspected carcinogen, absorbs through skin AITCH-TU-ESS Cartridges Generates explosive and toxic gas (HIGH SCHOOL ONLY) Aldrin Suspected carcinogen, absorbs through skin Allyl Chloride Suspected carcinogen Aluminum Chloride, Anhydrous Water reactive; corrosive (Hydrate Salts Are Allowed) Ammonium Bichromate Oxidizer, corrosive, known human carcinogen Ammonium Nitrate AP/IB CHEMISTRY ONLY: Explosive if heated under confinement Ammonium Oxalate May be fatal if inhaled or ingested Ammonium Vanadate May be fatal if inhaled or ingested Anisidine (o-, p-isomers) Suspected carcinogen Barium Chloride Severely toxic; 0.8 gram fatal dose Barium Hydroxide Highly toxic, neurotoxin Barium Nitrate Poison, strong oxidant, highly toxic to eyes Benzone (Phenylbutazone) Irritant Benzo(a)pyrene Suspected carcinogen Bromine Poison, powerful oxidizer Bromoform Toxic by inhalation, unsuspected carcinogen iso-Butanol Suspected carcinogen, highly flammable sec-Butanol May form explosive hydroperoxides tert-Butanol Suspected carcinogen and mutagen, highly flammable 1,3-Butadiene Suspected carcinogen Caffeine Very toxic, 1 grain may be life threatening Calcium Carbide Flammable, reacts with water Calcium Chromate Suspected carcinogen Calcium Fluoride Mutagenic effects in animals, poison, toxic to humans Calcium Oxide Corrosive, irritating Carbol Fuchsin Suspect animal carcinogen and mutagen Carmine
    [Show full text]
  • Carcinogens and Reproductive Toxicants
    Facilities Management Environmental Health and Safety Principal Investigator: Date Approved: This document covers basic chemical safety information for carcinogens and reproductive toxicants. The use of any carcinogen or reproductive toxicant is subject to pre-approval by the Toxic Substances Committee. DO NOT USE CARCINOGENS OR REPRODUCTIVE TOXICANTS UNTIL YOU HAVE OBTAINED THE NECESSARY APPROVAL. Carcinogens and Reproductive Toxicants Refer to the University of Arkansas Chemical Hygiene Plan for a description of chemicals that will be considered as a Particularly Hazardous Substance (PHS) carcinogen or reproductive toxicant. Chemicals that meet the definition of a PHS carcinogen or reproductive toxicant must be used only in a designated area where limited access, special procedures, knowledge, and work skills are required. A designated area can be the entire laboratory, a specific laboratory workbench, or a laboratory hood. Designated areas must be clearly marked with signs that identify the chemical hazard and include an appropriate warning; for example: WARNING! CARCINOGEN/ REPRODUCTIVE TOXICANT WORK AREA Carcinogens are materials that have the potential to cause cancer. Reproductive toxicants are materials that have the potential to interfere with fertility, fetal development, and/or lactation. Mutagens are materials that can cause genetic mutations. Such mutations can often lead to cancer or reproductive toxicity. Please note that the use of Listed Carcinogens, halogenated liquids, ethidium bromide, and formaldehyde is not covered by this general SOP. Exposure, Signs and Symptoms and Chemical Properties Review the appropriate sections of the chemical specific Safety Data Sheet (SDS) for information on ways to detect exposure, appropriate exposure limits, signs and symptoms of exposures and chemical properties.
    [Show full text]
  • Mutagen Treatment As a Means for Selecting Immunogenic Variants from Otherwise Poorly Immunogenic Malignant Murine Tumors1
    [CANCER RESEARCH 43, 125-132, January 1983] 0008-5472/83/0043-OOOOS02.00 Mutagen Treatment as a Means for Selecting Immunogenic Variants from Otherwise Poorly Immunogenic Malignant Murine Tumors1 Philip Frost,2 Robert S. Kerbel,3 Elaine Bauer,2 Rose Tartamella-Biondo,4 and William Cefalu Department of Medicine, Long Beach Veterans Administration Hospital, Long Beach. California 90822 [P. F., E. B.. W. C.J: Departments of Medicine and Microbiology, University of California. Irvine. California ¡P.F.. R. T-B.j; and the Cancer Research Laboratories. Department of Pathology, Queens University, Kingston, Ontario, Canada [R. S. K.] ABSTRACT found to be nontumorigenic (turn ) and grew progressively only in highly immunosuppressed recipients such as 600-R X-irra- The selection of nontumorigenic (turn'), highly immunogenic diated hosts (4-6, 27-29). Three different tumors were used, variants from four different tumorigenic but poorly immuno namely, the PCC4 teratocarcinoma (4, 5), the P815 mastocy- genic murine tumors by mutagen treatment and cloning is toma (6, 27), and the Lewis lung carcinoma (29). In all cases, described. Several factors were found to determine the suc cloning of these tumors after treatment with MNNG resulted in cessful nature of this selection procedure including: the nature the selection of highly immunogenic tum~ variants at an ex of the tumor used; the nature of the mutagen; the number of traordinarily high frequency. These variants were shown to mutagen treatments; and the time at which cloning is performed share antigens with the parent tumor as well as each other; in after treatment. addition, they expressed a newly induced unique or private In some cases, e.g., the TA3 adenocarcinoma or the BALB/ antigen.
    [Show full text]
  • OECD Environmental Health and Safety Publications
    Unclassified ENV/JM/MONO(99)2 Organisation de Coopération et de Développement Economiques OLIS : 16-Feb-1999 Organisation for Economic Co-operation and Development Dist. : 17-Feb-1999 __________________________________________________________________________________________ English text only ENVIRONMENT DIRECTORATE Unclassified ENV/JM/MONO(99)2 JOINT MEETING OF THE CHEMICALS COMMITTEE AND THE WORKING PARTY ON CHEMICALS OECD SERIES ON TESTING AND ASSESSMENT Number 12 Detailed Review Document on Classification Systems for Germ Cell Mutagenicity in OECD Member Countries English textEnglish only 74491 Document complet disponible sur OLIS dans son format d'origine Complete document available on OLIS in its original format ENV/JM/MONO(99)2 2 ENV/JM/MONO(99)2 OECD Environmental Health and Safety Publications Series on Testing and Assessment No. 12 Detailed Review Document on Classification Systems for Germ Cell Mutagenicity in OECD Member Countries Environment Directorate ORGANISATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT Paris 1999 3 ENV/JM/MONO(99)2 Also published in the Series on Testing and Assessment: No. 1, Guidance Document for the Development of OECD Guidelines for Testing of Chemicals (1993; reformatted 1995) No. 2, Detailed Review Paper on Biodegradability Testing (1995) No. 3, Guidance Document for Aquatic Effects Assessment (1995) No. 4, Report of the OECD Workshop on Environmental Hazard/Risk Assessment (1995) No. 5, Report of the SETAC/OECD Workshop on Avian Toxicity Testing (1996) No. 6, Report of the Final Ring-test of the Daphnia magna Reproduction Test (1997) No. 7, Guidance Document on Direct Phototransformation of Chemicals in Water (1997) No. 8, Report of the OECD Workshop on Sharing Information about New Industrial Chemicals Assessment (1997) No.
    [Show full text]
  • Carcinogens and Mutagens Fact Sheet
    Carcinogens and Mutagens Fact Sheet This fact sheet is for general safety awareness. Individual Standard Operating Procedures for all experiments and processes involving carcinogens or mutagens must be developed by the laboratory. PROPERTIES & HAZARDS Carcinogens are chemicals that are known or suspected to cause cancer in humans. Cancer is a chronic effect and is typically the result of repeated or long-term exposure. Symptoms may develop many years after exposure. A known human carcinogen means there is sufficient evidence of a cause and effect relationship between exposure to the material and cancer in humans. A substance that has induced cancer in experimental animal studies is referred to as a suspected human carcinogen. Mutations are defined as causing a permanent change in the amount or structure of the genetic material in a cell. The term mutation applies both to heritable genetic changes that may be manifested at the phenotypic level and to the underlying DNA modifications when known. This hazard class is primarily concerned with chemicals that may cause mutations in the germ cells of humans that can be transmitted to the progeny. However, mutagenicity/genotoxicity tests in vitro and in mammalian somatic cells in vivo are also considered in classifying substances and mixtures within this hazard class. There are three categories for carcinogens and mutagens, Category 1A, 1B and 2, that you may see on the safety data sheet (SDS) or chemical bottle. In Section 2 – Hazard Identification of the SDS, a combination of the following hazard classifications, pictograms and hazard statements will be listed indicating a carcinogen or mutagen hazard.
    [Show full text]
  • PROVISIONAL PEER-REVIEWED TOXICITY VALUES for O-PHENYLENEDIAMINE (CASRN 95-54-5)
    EPA/690/R-16/007F l Final 09-27-2016 Provisional Peer-Reviewed Toxicity Values for o-Phenylenediamine (CASRN 95-54-5) Superfund Health Risk Technical Support Center National Center for Environmental Assessment Office of Research and Development U.S. Environmental Protection Agency Cincinnati, OH 45268 AUTHORS, CONTRIBUTORS, AND REVIEWERS CHEMICAL MANAGERS Elizabeth Owens, PhD National Center for Environmental Assessment, Cincinnati, OH Letitia Wong, PhD Oak Ridge Institute for Science and Education Research Participation Program National Center for Environmental Assessment, Cincinnati, OH DRAFT DOCUMENT PREPARED BY SRC, Inc. 7502 Round Pond Road North Syracuse, NY 13212 PRIMARY INTERNAL REVIEWER Suryanarayana Vulimiri, PhD National Center for Environmental Assessment, Research Triangle Park, NC This document was externally peer reviewed under contract to: Eastern Research Group, Inc. 110 Hartwell Avenue Lexington, MA 02421-3136 Questions regarding the contents of this PPRTV assessment should be directed to the EPA Office of Research and Development’s National Center for Environmental Assessment, Superfund Health Risk Technical Support Center (513-569-7300). ii o-Phenylenediamiamine TABLE OF CONTENTS COMMONLY USED ABBREVIATIONS AND ACRONYMS .................................................. iv BACKGROUND .............................................................................................................................1 DISCLAIMERS ...............................................................................................................................1
    [Show full text]
  • The Calculation of Median Lethal Dose (LD50) and Maximum Permissible Dose (MPD) Values of Sodium Arsenite in Female Swiss Albino Mice
    IOSR Journal of Environmental Science, Toxicology and Food Technology (IOSR-JESTFT) e-ISSN: 2319-2402,p- ISSN: 2319-2399.Volume 12, Issue 9 Ver. I (September. 2018), PP 89-91 www.iosrjournals.org The Calculation of Median Lethal Dose (LD50) And Maximum Permissible Dose (MPD) Values of Sodium Arsenite In Female Swiss Albino Mice *Shailendra Kumar And Preety Sinha Departement of Zoology, A. N. College, Patna, Bihar, India. Corresponding Author: Shailendra Kumar Abstract: Sodium arsenite is an environmental pollutant and is responsible for both knowing poisonings and accidental exposures that can cause harmful health issues and possibly death. Median lethal dose (LD50) is a statistically obtained dose of a compound that can be predicted to cause death in 50% of the mice when administered by a specific route as a single dose and mice noticed for a specific time period. In the present research, different doses i.e., 6, 9, 12, 15, 18, 21 and 24 mg/kg body weight of Sodium arsenite was given orally by gavage method to the seven different groups of Swiss albino mice. Signs and symptoms of toxicity and probable death of mice were observed for 3 hours and then at 6, 12, 24, 48 and 72 hours to calculate the Median lethal dose (LD50) and maximum permissible dose (MPD) of Sodium arsenite. The LD50 was found to 18 mg/kg body weight after oral administration in Swiss albino mice. Finally, MPD of Sodium arsenite by oral route in mice was found to be 1.8 mg/kg body weight. Keywords: Sodium arsenite, Swiss albino mice, LD50, MPD ----------------------------------------------------------------------------------------------------------------------------- ---------- Date of Submission: 27-08-2018 Date of acceptance: 11-09-2018 ----------------------------------------------------------------------------------------------------------------------------- ---------- I.
    [Show full text]