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1 www.chromadex.com table of contents Table of Contents 01 New Products 01 Handbook of Analytical Methods for Dietary Supplements 02 Introduction Letter-Mission Statement 03 How to Use this Catalog 04 Example of CofA 05 Examples of Product Labels 06 Contract Services Section 07 Bioassay Services (New) 15 Bioluminex (New) 18 Paclitaxel(Taxane) Related Standards 24 AHP™ Section – Monographs 26 AHP™ Verified Standards 27 Reference Materials(BRMs and XRMs) 30 Kits Section 33 Glossary defi nitions 51 General Catalog 52 General Information 303 Standard Terms and Conditions of Sale 304 International Distributors Back Cover new products for 2006/2007 new phytochemical standards available for: Stevia – a complete range of reference standards is now available in a kit format Mangosteen xanthones – 6 xanthones now available in a kit Paclitaxel(Taxanes) – New taxanes now available Horsechestnut – TWO purified saponins are now available in a kit Yellow star thistle – NEW compounds available Vitamins – A complete list of Primary(P) standards is now available Oleander – Oleandrin and other related compounds now available Annatto – Bixin and Norbixin are now available as Primary(P) reference standards Gentian – a complete list of bitter compounds now available Botanical Reference Materials(BRMs) – the list of new materials keeps growing Bulk Phytochemicals – we can now offer many compounds in gram quantities Tocotrienols are back Creatine Ethyl Ester and other related creatine compounds Sesamin and Sesamol for sesame extracts Bioassay Services are now available Black cohosh adulteration kit – is your black cohosh really black cohosh? Rooibos – new standards kit now available Chondroitin Enzymatic Digest HPLC kit – New and improved method Metafolin(Methylfolate) Primary(P) standard now available 2 www.chromadex.com HANDBOOK OF ANALYTICAL METHODS FOR DIETARY SUPPLEMENTS WASHINGTON, DC – The American Pharmacists Association (APhA), the national professional society of pharmacists, released has released a new reference book titled, Handbook of Analytical Methods for Dietary Supplements. The reference is a unique compilation that provides current methods plus appropriate validation data, when known, for 38 common supplements in the marketplace. Analytical method development will be a critical component of dietary supplement man- ufacturing in the coming years, the result of the FDA’s 2003 proposal to implement good manufacturing practices. The Handbook of Analytical Methods for Dietary Supplements provides a convenient starting point for laboratories to develop and validate analytical testing methods for dietary supplements. The reference contains monographs on the following 38 dietary ingredients: Artichoke, Ascorbic Acid, Bilberry, Black Cohosh, Boswellia, Chamomile, Chaste Tree, Chondroi- tin Sulfate, Coenzyme Q10, Devil’s Claw, Echinacea, Ephedra, Epimedium, Feverfew, Ginger, Ginkgo, Ginseng, Glucosamine, Goldenseal, Gotu Kola, Griffonia, Guggul, Hops, Kava, Melatonin, Milk Thistle, Olive Leaf, Passionflower, Red Clover, Rhodiola, Schisan- dra, Senna, Siberian Ginseng (Eleuthero), Skullcap, Soy, Turmeric, Valerian, Willow Bark. Each monograph follows a standard format for quick reference: chemical names, formu- las, and structures, along with information on solubility and other physical and chemical data; a description of common uses for each dietary supplement and its mode of action; discussion of reference standards and/or marker compounds used; information and directions for using various component-specific methods; and chromatography specifi- cations and representative chromatograms, when available. The work is written by Frank Jaksch, President and CEO, ChromaDex, Inc., Santa Ana, Calif., a supplier of phytochemical reference standards and a leader in the creation of botanical reference materials; Mingfu Wang, PhD, Assistant Research Professor, New Use Agriculture and Natural Plant Products Program, Rutgers University, Piscataway, NJ; and Mark Roman, PhD. The hardbound reference (ISBN 1-58212-055-2; 215 pages) may be purchased through ChromaDex at (949)419-0288 or fax: (949)419-0294. PRODUCT ID PRODUCT NAME QTY/ UNIT ASB-00008037-00B HANDBOOK OF ANALYTICAL 1 Book METHOD FOR DIETARY SUPPLEMENT 3 www.chromadex.com introduction letter Welcome to the new 2006/2007 ChromaDex Catalogue. This year ChromaDex has continued to “set THE standard” by adding many new products and services to our catalog. We have added several hundred new phytochemical refer- ence standards to our list, and we are now starting to offer many of these phytochemicals in larger sizes(grams to kilograms) for research purposes. We have also increased our line of Botanical Reference Materials(BRMs) to cover the continuously increasing demand for analytical tools for identity testing. Much of this demand is coming from the ever looming FDA final rule on Good Manufacturing Practices(GMPs), which are now scheduled for re- lease in December, as well as the increasing regulatory environments in Australia, Canada, Europe and Brazil. 2006 is scheduled to end with a bang, assuming the FDA releases the GMPs, which will make for a very interesting 2007. The ChromaDex Contract Services Group has continued to flourish during 2005 and 2006, and we have dramatically expanded our range of contract services and research capabilities. ChromaDex has a world class team of natural product and analytical chem- ists with state-of-the-art laboratory equipment and facilities, and we will continue to ex- pand our services. ChromaDex is also proud to announce the launch of our Bioluminex analytical bioassay kit. After licensing the intellectual property from Bayer Ag and finalizing the Bioluminex kit concept with a grant from the FDA, we finally have the kit ready for the market. We have also launched a new website dedicated to Bioluminex, at www.bioluminex.com. The dietary supplement industry has undergone a great deal of change over the past decade and should see even more dramatic changes over the next couple of years with increasing enforcement of regulatory policies worldwide. ChromaDex, since its inception in 1999, has taken an active role in this process and will continue to develop and provide the tools required to meet these changes. We look forward to working with you now and into the future. Sincerely, Frank Jaksch President and CEO ChromaDex, Inc. ChromaDex Mission Our customers are #1 priority. The existence of ChromaDex depends directly on its goal to improve product quality within the nutraceutical and botanical markets. ChromaDex will utilize its unique products and services to provide our customers with the means for assessing the quality of the products they pur- chase or manufacture. 4 www.chromadex.com how to use this catalog The Table of Contents is organized in two main sections: The Complete Alphabetical List of Compounds Section is the first place you should look for all your product needs. We have the most up-to-date and complete list for most botanical and phytochemical compounds sold by ChromaDex. We added many known alternative /pseudonyms for most compounds available to our customers. This section includes Primary, Secondary, and Reagent grade standards, along with links to XRM’s, BRM’s, and other associated reference materials within the ChromaDex catalog. If you are ever in doubt as to the availability or name of any compound, please check www.chromadex.com, as the list found in the members section of our website is drawn directly from our main catalog database. Please call Customer Services on 949 194 0288 for any other questions you may have. Key to product listings Product No. Description Qty Price ASB-00008910-005 HYPERICIN 2 5mg $295.00 1 ASB-00008910-010 10mg $495.00 Grade: P 3 Mycopophyrin;Cyclosan;Hypericin C30H16O8 15 16 4 6 5 FW: 504.45 Mp: 320C 7 Chemical Family: Anthraquinones 8 Appearance: Blue-Black crystals 17 9 From: Hypericum perforatum 10 For: St. Johns Wort 11 Long-Term Storage: -20C 12 CAS#: [548-04-9] 13 Merck Index#: 11,4799 14 1. Product Number/Part number 2. Product Name 3. Product Classification P = Primary SH = Secondary HPLC RG = Reagent Grade SG = Secondary GC BRM = Botanical Reference Materials XRM =Extract Reference Materials .4 Other Names 5. Chemical Formula 6. Formula Weight/Molecular Weight 7. Melting Point - Degrees Celsius 8. Chemical Family: Chemical group 9. Appearance: Chemical appearance 10. From: All ChromaDex products are extracted from natural plant material unless specified otherwise 11. For: Created for the analysis of a specific botanical. Some standards may be used for multiple botanical products. 12. Storage: Recommended storage conditions 13. CAS#: Chemical Abstracts registry number 14. Merck Index# 15. Package or Unit Size(s) - Grams, Milligrams, Kilograms, Milliliters, Liters, etc... 16. Price(s) - All prices are in US Dollars unless specified otherwise 17. Chemical Structure 5 www.chromadex.com example of ChromaDex Cof A 6 www.chromadex.com example of ChromaDex Labels Vial label P Part #: 01355-5 Actein Qty: 5mg Store at: Lot: 01355-810 Room Temp. Expiration: 10/2008 Kit box label SH Part #: 03589-HK Chondroitin HPLC Analysis Kit Kit Contains: 1) Chondroitin Disaccharide Mix Solution A (03611-A2) 1 X 2ml 2) Chondroitin Disaccharide Mix Solution B (03611-B2) 1 X 2ml 3) Chondroitin Disac charide Mix Solution C (03611-C2) 1 X 2ml 4) Chondroitinase ABC (03602-10) 4 X 5unit 5) Chondroitin Reference Material (03607-2) 1 X 2g 6) Chondroitin Buffer Solutioin (03608-5) 1 X 5ml 7) Chondroitin HPLC column 5u NH2 (03609-HC)
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  • Antioxidant Evaluation-Guided Chemical Profiling and Structure

    Antioxidant Evaluation-Guided Chemical Profiling and Structure

    www.nature.com/scientificreports OPEN Antioxidant evaluation-guided chemical profling and structure- activity analysis of leaf extracts from fve trees in Broussonetia and Morus (Moraceae) Xinxin Cao1, Lingguang Yang1, Qiang Xue1, Fan Yao1, Jing Sun1, Fuyu Yang2 & Yujun Liu 1* Morus and Broussonetia trees are widely used as food and/or feed. Among 23 phenolics identifed from leaves of fve Moraceae species using UPLC–QTOF–MS/MS, 15 were screened using DPPH/ABTS- guided HPLCs, including seven weak (favonoids with one hydroxyl on B-ring) and eight strong (four cafeoylquinic acids and four favonoids, each with a double hydroxyl on B-ring) antioxidants. We then determined the activity and synergistic efects of individual antioxidants and a mixture of the eight strongest antioxidants using DPPH-guided HPLC. Our fndings revealed that (1) favonoid glucuronide may have a more negative efect on antioxidant activity than glucoside, and (2) other compounds in the mixture may exert a negative synergistic efect on antioxidant activity of the four favonoids with B-ring double hydroxyls but not the four cafeoylquinic acids. In conclusion, the eight phenolics with the strongest antioxidant ability reliably represented the bioactivity of the fve extracts examined in this study. Moreover, the Morus alba hybrid had more phenolic biosynthesis machinery than its cross-parent M. alba, whereas the Broussonetia papyrifera hybrid had signifcantly less phenolic machinery than B. papyrifera. This diference is probably the main reason for livestock preference for the hybrid of B. papyrifera over B. papyrifera in feed. Morus and Broussonetia tree species (family: Moraceae) have high economic value; among other uses, their leaves are widely used as feed to improve meat quality.
  • Phytochem Referenzsubstanzen

    Phytochem Referenzsubstanzen

    High pure reference substances Phytochem Hochreine Standardsubstanzen for research and quality für Forschung und management Referenzsubstanzen Qualitätssicherung Nummer Name Synonym CAS FW Formel Literatur 01.286. ABIETIC ACID Sylvic acid [514-10-3] 302.46 C20H30O2 01.030. L-ABRINE N-a-Methyl-L-tryptophan [526-31-8] 218.26 C12H14N2O2 Merck Index 11,5 01.031. (+)-ABSCISIC ACID [21293-29-8] 264.33 C15H20O4 Merck Index 11,6 01.032. (+/-)-ABSCISIC ACID ABA; Dormin [14375-45-2] 264.33 C15H20O4 Merck Index 11,6 01.002. ABSINTHIN Absinthiin, Absynthin [1362-42-1] 496,64 C30H40O6 Merck Index 12,8 01.033. ACACETIN 5,7-Dihydroxy-4'-methoxyflavone; Linarigenin [480-44-4] 284.28 C16H12O5 Merck Index 11,9 01.287. ACACETIN Apigenin-4´methylester [480-44-4] 284.28 C16H12O5 01.034. ACACETIN-7-NEOHESPERIDOSIDE Fortunellin [20633-93-6] 610.60 C28H32O14 01.035. ACACETIN-7-RUTINOSIDE Linarin [480-36-4] 592.57 C28H32O14 Merck Index 11,5376 01.036. 2-ACETAMIDO-2-DEOXY-1,3,4,6-TETRA-O- a-D-Glucosamine pentaacetate 389.37 C16H23NO10 ACETYL-a-D-GLUCOPYRANOSE 01.037. 2-ACETAMIDO-2-DEOXY-1,3,4,6-TETRA-O- b-D-Glucosamine pentaacetate [7772-79-4] 389.37 C16H23NO10 ACETYL-b-D-GLUCOPYRANOSE> 01.038. 2-ACETAMIDO-2-DEOXY-3,4,6-TRI-O-ACETYL- Acetochloro-a-D-glucosamine [3068-34-6] 365.77 C14H20ClNO8 a-D-GLUCOPYRANOSYLCHLORIDE - 1 - High pure reference substances Phytochem Hochreine Standardsubstanzen for research and quality für Forschung und management Referenzsubstanzen Qualitätssicherung Nummer Name Synonym CAS FW Formel Literatur 01.039.