JNCASR IISc Mathematics Initiative and International Network in Theoretical Immunology present an International meeting Theoretical and Experimental Immunology August 16, 2011 Faculty Hall, Indian Institute of Science (IISc) WITH BEST COMPLIMENTS Hitachi Japan UV-Vis Spectrophotometer, HPLC, Fluorescence Spectrophotometer, Plate Readers & Amino Acid Analyzer PRODUCT Implen GmbH, Germany Nanophotometer: UV- VIS Spectrophotometer for all applications PROFILE Polyscience, USA Refrigerated Circulators Guava Technologies Bench Top Flow Cytometers Ingeny International, Netherlands Ingeny Denaturing Gradient Gel Electrophoresis System for DNA Mutation detection for 28x18 gels. Available in 20, 32, and 48 wells JPK Instruments AG, Germany Atomic Force Microscopes –Bio AFM for Life Science and Nano Materials Applications with accessories for various applications Formulatrix, USA Protein Crystal Imaging system, Well Solution Mixers and Drop Setters. Software for drop analysis Prince Technologies, Netherlands Capillary Electrophoresis Systems, peqLab Biotechnogies GmbH, Germany Programmable PCR Thermal cycles, Electrophoresis units and Power Packs., Thermal Blocks and Mixers Kubota Corporation, Japan High-speed Refrigerated Centrifuges, Table top Centrifuges Sonics & Materials Inc, USA Probe Sonicators Please contact: Omni International, USA Tissue Homogenizers INKARP INSRUMENTS PVT. LTD. Nirosoavi, Italy No. 29, ‘Adigiri’, First Cross, High Pressure Homogenizers Mico Layout, Mahalaxmipuram, Bangalore – 560 086 Kodak, USA X-ray films, Gel doc Systems, Image Stations, In-Vivo Imaging Systems for Smaller Animals Website: Hermle Labortechnik GmbH, Germany www.inkarp.co.in High-speed Refrigerated/Non-refrigerated Table Top Centrifuges Gilson Inc, USA Email: Prep HPLC Systems, Fraction Collectors and Liquid Handling Systems. [email protected] [email protected] Bay Biosicence, Japan Flow Cytometers Ph: +91-80-2349 0523/2349 2253 Jeiotech, Korea Shakers, Incubators Shakers, Refrigerated Shakers, Ovens, Incubators, Plant Growth Fax: +91-80-2349 0523 Chambers, Refrigerated Circulators, Water baths and Shaking Water baths. IISc Mathematics Initiative and International Network in Theoretical Immunology present an International Meeting Theoretical and Experimental Immunology August 16, 2011 Faculty Hall, Indian Institute of Science (IISc) GENERAL INSTRUCTIONS 1. Students who have registered “on line” are requested to arrive on August 16, 2011 at 8: 30 am in the Faculty Hall, IISc to collect their registration materials. 2. Do note that outstation students will need to make their own arrangements for stay. The website does list reasonable places to stay in Bangalore. 3. Traffic in Bangalore is chaotic, so please give yourself sufficient time to ensure that you are not late for the meeting. 4. Please display your badge all the time. Entry into the auditoriums, food areas etc. will NOT be permitted without the badge. 5. Kindly switch off your mobile inside the auditorium. 6. Speakers are requested to load their slides prior to the session. Student volunteers will help you in the process. Kindly preview your slides before the presentation. 7. The meeting schedule is rather tight and we kindly request all speakers and chairpersons to please keep to time. 8. For any information, clarifications and assistance, please contact local organization committee members and student volunteers at the registration desk. iii iv CONTENTS General Instructions iii MAP of IISc iv Contents v Meeting Organization vi Message vii Program ix Abstracts 1 List of Speakers 18 List of Participants 19 Honored Guests 29 List of Company Sponsors 34 v MEETING ORGANIZATION Govindan Rangarajan (Chairman) Sathees C. Raghavan Department of Mathematics Department of Biochemistry Indian Institute of Science Indian Institute of Science [email protected] [email protected] Dipankar Nandi (Convener) Deepak K. Saini Department of Biochemistry Department of Molecular Reproduction, Indian Institute of Science Development and Genetics [email protected] Indian Institute of Science [email protected] Anjali A. Karande Department of Biochemistry Parag P. Sadhale Indian Institute of Science Department of Microbiology and [email protected] Cell Biology Indian Institute of Science R. Manjunath [email protected] Department of Biochemistry Indian Institute of Science Dipshikha Chakravortty [email protected] Department of Microbiology and Cell Biology Narendra M. Dixit Indian Institute of Science Department of Chemical Engineering [email protected] Indian Institute of Science [email protected] S.G. Ramachandra Central Animal facility Soumyendu Raha Indian Institute of Science SERC [email protected] Indian Institute of Science [email protected] William R. Surin FACS Facility Udaykumar Ranga Indian Institute of Science MBGU, JNCASR [email protected] [email protected] vi MESSAGE We are delighted that a meeting on “Theoretical and Experimental Immunology” is being held in the Indian Institute of Science, Bangalore. This meeting is certainly a unique experiment of its kind – but one whose time has probably come! Immunology, in general, is the study of the host defense network against infections, tumors, allergies etc. Experimental immunology is well studied and has shed light on the inner workings of immune cells. Studies in this field have led to a better understanding of the host defense network. On the other hand, theoretical immunology, utilizing mathematical tools, is a relatively newer area of study. Theoretical immunology involves the development of mathematical and computational models of biological phenomena that unravel, in synergy with experiments, new insights into the workings of our immune system. We are happy that this meeting has brought in top notch researchers in the fields of theoretical and experimental immunology. It is heartening to know that the response to this specialized meeting has been good with over 150 student registrations from different parts of the country. Students are encouraged to take the maximum advantage and interact with faculty present in this meeting. To ensure that students get the maximum advantage, speakers have been requested to ensure that the talks are pedagogic in nature. The first half may give the audience an overview of the field and the second half may focus on the speaker’s research contributions. We are hopeful that this meeting will seek answers to questions, which are at the heart of our understanding of Immunology, and may pave the way for the design of potent adjuvants and vaccines. This meeting has been possible due to the active participation of several people and institutions. We thank IISc for permission to use the various facilities required to conduct this meeting. The support from the Department of Mathematics and the Department of Biochemistry, IISc is greatly appreciated. The generous financial assistance from JNCASR, Centre for Scientific & Industrial Consultancy, IISc and a large number of private companies is greatly appreciated. We thank Carmen Molina-Paris and Grant Lythe for suggesting Bangalore to be the venue for this year’s annual meeting of the vii International Network in Theoretical Immunology (INTI). We appreciate the support from other INTI members. The staff of the IISc Mathematics Initiative (IMI) has played a stellar role in setting up the web site, taking care of general administrative duties and finances. We thank Grant Lythe, Srabanti Rakshit and Mukta Deobagkar for allowing their images to adorn the posters and Abstract book for this meeting. We appreciate the help of Emmanuel Stephen and Rajkumar D. from D. Nandi’s laboratory. In addition, several faculty and students from the Division of Biological Sciences, IISc have contributed to the organization of this meeting for which we are extremely thankful. Finally, we welcome you to this event in Bangalore and look forward to your active participation in making this meeting a resounding success! With warm wishes, G. Rangarajan Dipankar Nandi Chairperson Convenor viii PROGRAM Theoretical and Experimental Immunology Meeting (TEIM) Faculty Hall Indian Institute of Science, Aug 16, 2011 Bangalore 8:30 am – 9:15 am: Registration 9:15 am Introductory remarks by G. Rangarajan, Chairperson, TEIM Welcome by D. N. Rao, Divisional Chairman, Division of Biological Sciences, IISc Vote of thanks by D. Nandi, Convenor, TEIM 9:30 am PLENARY TALK Chairperson: G. Rangarajan, Indian Institute of Science, Bangalore Development and maintenance of the T cell pool in health and disease Robin Callard Institute of Child Health, London, UK 10: 10 am – 10:30 am: TEA SESSION 1 Chairperson: Carmen Molina-Paris, Leeds University 10:30 am – 10:55 am: Studies on the dynamics of germinal centers J. Faro University of Vigo, Spain 10: 55 am – 11: 20 am: Agent based simulation of T cell based immune response: modeling an adoptive transfer experiment Gib Bogle University of Auckland, New Zealand 11: 20 am – 11: 45 am: T cells and ageing: effects of age on survival and function Vineeta Bal NII, New Delhi, India ix SESSION II Chairperson: Anjali Karande 11: 45 am – 12:10 pm: Brownian motion and the adaptive immune system Grant Lythe University of Leeds, UK 12: 10 pm – 12: 35 pm: Modelling Cytotoxic T Lymphocyte mediated killing of target cells Saikrishna Gadhamsetty Utrecht University, Netherlands 12: 35 – 1 pm: Potential of gamma delta T lymphocytes for immunotherapy of cancer S. V. Chiplunkar