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Signal Changes to Suggest Infarction and There Was No Accompanying 130 LETTERS TO THE JOURNAL signal changes to suggest infarction and there was no are causal. The frequency of conjunctivitis as the accompanying focal neurological deficit.6 However, precipitant for pre-septal cellulitis is not known; magnetic resonance angiography revealed distortion however, Moraxella has been isolated from conjunc­ of the vasculature on the right side following surgery. tival swabs in a patient with pre-septal cellulitis.1 Whilst diagnostic features of an optic tract lesion Neisseria gonorrhoeae can cause acute purulent can include a contralateral relative afferent pupillary conjunctivitis in neonates (one cause of ophthalmia defect and 'bow-tie' optic atrophy,7.8 these were not neonatorum), children and adults. Though rare in seen in our patient, but involvement by tumour of adults, rapid progression to ulcerative keratitis and both optic nerves and chiasm are likely to have even perforation can occur, especially with penicil­ complicated these signs. It is perhaps more surprising linase-producing strains?-5 N. gonorrhoeae has not that visual acuity and colour vision have been so well been reported as a cause of pre-septal cellulitis. preserved. We are grateful to the Child Growth Foundation for Case Report financial support for C. J. DeV. A 31-year-old homosexual man presented with a 2 C.J. DeVile, MA, MRCP day history of acute purulent conjunctivitis in his T. Lavy, FRCS, FRCOphth right eye. He had been started on fusidic acid eye C. Timms, DBO(T) drops by a casualty department on the previous day. W. Harkness, FRCS There was no history of trauma, foreign body injury D. Taylor, FRCS, FRCOphth or lid lesions. On examination his visual acuity was 6/9 right eye, 6/5 left eye. There was moderate The Hospital for Children NHS Trust periorbital erythema and swelling, with associated Great Ormond Street marked conjunctival injection, chemosis and purulent London discharge. Right eye movements in all directions UK were limited by pain. Pupil responses were normal and there was no obvious proptosis. Ocular exam­ ination was otherwise normal. A presumptive diag­ References nosis of right orbital cellulitis was made. He was 1. Pierre-Kahn A, Sainte-Rose C, Renier D. Surgical therefore admitted and commenced on intravenous approach to children with craniopharyngiomas and Magnapen (Beecham; flucloxacillin 500 mg/ampicil­ severely impaired vision: special considerations. Pediatr lin 500 mg) q.d.s. and intravenous metronidazole 500 Neurosurg 1994;21 (Suppl 1 ) :50-6. 2. AI-Wahhabi B, Choudhury AR, AI-Moutaery KR, mg t.d.s. A CT scan was performed the day after Aabed M, Faqeeh A. Giant craniopharyngioma with admission because initial treatment response was blindness reversed by surgery. Childs Nerv Syst poor. This demonstrated the inflammatory changes 1993;9:292-4. to be exclusively pre-septal (Fig. 1). There was no 3. Frisen L, Sjostrand J, Norrsell K, Lindgren S. Cyclic compression of the intracranial optic nerve: patterns of visual failure and recovery. J Neurol Neurosurg Psychiatry 1976;39:1109-13. 4. Kennedy HB, Smith RJS. Eye signs in craniopharyn­ gioma. Br J OphthalmoI1975;59:689-95. 5. Hoffman HJ. Surgical management of craniopharyn­ gioma. Pediatr Neurosurg 1994;21 (Suppl 1 ) :44-9. 6. Ward TN, Bernat JL, Goldstein AS. Occlusion of the anterior choroidal artery. J Neurol Neurosurg Psychiatry 1984;47:1048-9. 7. Savino PJ, Paris M, Schatz NJ, Orr LS, Corbett JJ. Optic tract syndrome: a review of 21 patients. Arch Ophthal­ mol 1978;96:656-63. 8. Newman SA, Miller NR. Optic tract syndrome: neuro­ ophthalmologic considerations. Arch Ophthalmol 1983; 101:1241-50. Sir, Neisseria gonorrhoeae: A Previously Unreported Cause of Pre-septal Cellulitis Orbital cellulitis typically occurs following dental or Fig. 1. CT scan of head and orbits showing pre-septal soft tissue involvement in the right eye. There is apparent sinus infections. Limitation of infection to the pre­ proptosis due to lid oedema and rotation of the film. septal tissues, at least initially, occurs when factors (Provided by the Department of Medical Illustration, St such as infected lid lesions, trauma or conjunctivitis lames's University Hospital.) LETTERS TO THE JOURNAL 131 sub-periosteal abscess and his paranasal sinuses were Neisseria gonorrhoeae is an intracytoplasmic clear. Apart from a mild neutrophilia of 8.82 X 109/1 Gram-negative diplococcus found within polymor­ 9 (normal range 2.0-7.5 x 10 /1) his full blood count phonuclear leucocytes (PMNLs) and may be isolated and plasma viscosity were normal. Blood cultures from smears or cultures of conjunctival discharge, were negative. synovial fluid, skin lesion aspirate and blood. The Two conjunctival swabs were taken on admission: organism attaches to epithelial surfaces and invades one in the casualty department and one on the ward. intracellularly, which may account for its ability to No smear was taken for Gram staining. The cultures gain access to pre-septal tissues. Rapid progression from the conjunctival swabs showed a heavy growth from purulent conjunctivitis to corneal ulceration of Gram-negative cocci, identified as Neisseria and perforation can occur and has become more gonorrhoeae and later confirmed by a reference frequent with the greater prevalence of penicillinase­ laboratory. The findings were reported 5 days after producing strains of Neisseria gonorrhoeae samples were taken and the report from the (PPNG).2,6 Whilst a Gram stain on a smear of reference laboratory returned a week later. The conjunctival discharge might have suggested an causative isolate was found to be sensitive to atypical pathogen earlier in this case, the release of penicillin and other antimicrobials tested including a report would have awaited culture results with a ampicillin, erythromycin, cefuroxime and chloram­ follow-up report of antimicrobial sensitivities. phenicol. Although both penicillin-resistant and multi-drug­ The patient subsequently admitted to a treated resistant strains are reported, the organism is episode of gonorrhoea 'years ago'. He denied any typically sensitive to penicillin.7.s In cases of peni­ recent genito-urinary symptoms. Urethral, rectal, cillin resistance the use of spectinomycin, azithromy­ pharyngeal and conjunctival swabs were taken within cin or third-generation cephalosporins such as 1 2 weeks, when reviewed by the genito-urinary ceftriaxone is advocated.9. 0 Treatment should be physicians, and were negative for both Neisseria prolonged for at least 1 week, as compared with the gonorrhoeae and Chlamydia trachomatis. Contact one-off dosages used for urethral infection. I I tracing was also carried out by the department of This case suggests it is worth while taking genito-urinary medicine. The patient's own HIV conjunctival swabs from all patients with suspected status was negative when screened 6 months pre-septal or orbital cellulitis. Identification of the previously but that of his male partner was positive. unusual pathogen described in this case would not He declined a repeat HIV test. A syphilis screen was have been possible without the benefit of the negative. The pre-septal cellulitis slowly improved conjunctival swab. In sexually active patients with over a period of 5 days. He was discharged on topical periorbital infection Neisseria gonorrhoeae should be chloramphenicol and a 1 week course of oral considered as a possible causal organism, especially if Magnapen and metronidazole. Complete resolution there is a previous history of sexually transmitted of conjunctival injection took 5 weeks. Visual acuity diseases. In such cases genito-urinary assessment is in his right eye returned to 6/5. A repeat conjunctival mandatory. swab was negative. He has remained well over a follow-up period of over 4 months. There was no T. R. M. Henderson evidence of infection in the left eye at any stage. A. P. Booth A. J. Morrell Discussion Department of Ophthalmology St James's University Hospital Pre-septal cellulitis due to Neisseria gonorrhoeae Leeds LS9 7TF infection is, to our knowledge, previously unre­ ported. This case probably represents autoinocula­ tion from an asymptomatic episode of genital gonorrhoea. The resultant purulent conjunctivitis in References the absence of any demonstrable sinus infection is 1. Cox NH, Knowles MA, Porteus ID. Pre-septal cellulitis the presumed precursor for the patient's pre-septal and facial erysipelas due to Moraxella species. Clin Exp DermatoI 1994;19:321-3. infection. The possibility of opportunistic infection 2. Saad N, Francis IC, Kappagoda MB, Bradbury R. re mains. His sex, age and clinical features, namely of Adult penicillinase-producing gonococcal keratocon­ an acute purulent conjunctivitis, chemosis, periocular junctivitis. Med J Aust 1988;149:710-1. oedema and eye movement restriction with pain and 3. Wan WL, Farkas GC, May WN, Robin JB. The clinical tenderness, mirror reported characteristics? characteristics and course of adult gonococcal con­ junctivitis. Am J OphthalmoI 1986;102:575-83. Iridocyclitis can occur at the same time as 4. Kestelyn P, Bogaerts J, Meheus A. Gonorrheal keratoconjunctivitis and has also been reported in keratoconjunctivitis in African adults in Rwanda. Sex association with arthritis and prostatitis during Transm Dis 1987;14:191-4. genital infection.4,5 5. Ullman S, Roussel TJ, Forster RK. Gonococcal 132 LETTERS TO THE JOURNAL keratoconjunctivitis [review]. Surv Ophthalmol 1987; who have provided medical care for the children in 32:199-208. Mostar. Children found to have ophthalmic problems 6. Hoosen AA, Mody GM, Goga IE, Kharsany AB, Van den Ende 1. Prominence of penicillinase-producing were registered for subsequent re-evaluation. This strains of Neisseria gonorrhoeae in gonococcal arthritis: report contains the results of an ophthalmologist's experience in Durban, South Africa. Br 1 Rheumatol assessment of the children living on the East Bank of 1994;33:840-l. Mostar. 7. Ross 1D, Moyes A, McMillan A, Young H. Temporal changes in the sensitivity of Neisseria gonorrhoeae to penicillin in Edinburgh. lnt 1 STD AIDS 1995;6:1 10-3. 8.
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