1 Conference Proceedings Paper 2 Cyclodextrins in traditional and alternative drug 3 formulations 4 Rita Ambrus*, Csilla Bartos, Gábor Katona, Tamás Kiss, Zoltán Aigner, Piroska Szabó-Révész 5 Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, 6 Szeged Hungary,
[email protected] (R.A.);
[email protected] (Cs. B.);
[email protected] 7 (G. K.);
[email protected] (T. K.);
[email protected] (Z. A.),; 8
[email protected] (P. Sz.) 9 * Correspondence:
[email protected]; Tel.: +36-208-232-139 10 Abstract: Our research interest focused on the development of preparation protocols using 11 cyclodextrins (CDs) combined with other additives to produce suitable formulations (to reach 12 local or systemic effect) to get effective therapies in different diseases. Niflumic acid, levodopa, 13 and ciprofloxacin were used as a model active ingredients for preparation of samples which could 14 be used by oral, intranasal and pulmonary applications. α-, β-, HPβCD and different kind of 15 polymer as stabilizer (Polyvinyl alcohol, PVA; Polyvinylpyrrolidone, PVP) were also applied in 16 order to change the unfavorable features and increase bioavailability of drugs. Samples were 17 produced by kneading, solvent evaporation, co-grinding and spray drying technologies. The 18 micrometric properties, structural characterization, in vitro drug release, permeability, 19 aerodynamic tests and cytotoxicity studies were applied for characterization of products. The 20 introduced case studies justified the role and efficacy of cyclodextrins in drug formulation. 21 Keywords: niflumic acid, levodopa, ciprofloxacin, cyclodextrins, technological protocols, 22 alternative administration, physico-chemical characterization, in vitro tests, citotoxicity studies 23 24 1.