Antipsychotics

BMF 84 - Antipsychotics

Antipsychotic medications (neuroleptics) are used for the Antipsychotics are may be classified as typical or atypical, or treatment of psychosis, mainly schizophrenia and manic first and second generation respectively. Typical antipsychotics depression (bipolar disorder). They reduce symptoms such include; Chlorpromazine, Haloperidol, Pimozide, Trifluoperazine, as hallucinations, delusions, and paranoia, and can also be and Sulpiride. Atypical include; Amisulpride, Aripiprazole, used to help severe anxiety or depression. Antipsychotic Clozapine, Olanzapine, Quetiapine and Risperidone. Atypical medications have been available for the treatment of antipsychotics, are useful in patients that do not respond psychosis for over half a century. The first being chlorpromazine to treatment with typical antipsychotics. They cause less (Thorazine), introduced in the early 1950’s. The list now extrapyramidal side effects and have a greater efficacy to extends to over 20 different compounds. treat negative symptoms. Atypical antipsychotics also block dopamine, but to a lesser degree than the older drugs. They Antipsychotics act by blocking dopamine receptors in the brain also work on serotonin. and interfering with dopaminergic transmission. Side effects include movement disorders similar to Parkinson’s disease, Some antipsychotics are available in depot form, i.e. Haloperidol such as shaking/tremor, involuntary body movements and decanoate, Flupenthixol decanoate, Fluphenazine decanoate, inner restlessness. These are referred to as extrapyramidal Pipothiazine palmitate and Zuclopenthixol decanoate. These symptoms, and can be controlled with anticholinergic drugs are injected into muscle every 2 to 4 weeks and release such as orphenadrine and procyclidine. Other side effects slowly over time. This prevents patients forgetting to take include lethargy, weight gain and sexual dysfunction. Longer their medication. term there is increased risk of developing type 2 diabetes, high blood pressure, heart problems and osteoporosis.

www.chiron.no | E-mail: [email protected] | Tel.: +47 73 87 44 90 | Fax.: +47 73 73 87 44 99 | BMF 84 p.1/6, 11_16 BMF 84 - Antipsychotics

Chiron offer a range of antipsychotic reference materials and associated internal standards;

Catalogue No. Description Cas No. Concentration Solvent Volume Aripiprazole (Abilify) 2305.23-100-AN Aripiprazole 129722-12-9 100 µg/mL acetonitrile 1 mL 2305.23-K-AN Aripiprazole 129722-12-9 1000 µg/mL acetonitrile 1 mL 2305.23-10MG Aripiprazole 129722-12-9 neat neat 10 mg 2305.23-25MG Aripiprazole 129722-12-9 neat neat 25 mg 9653.23-100-AN Aripiprazole-d8 (butyl-d8) 1089115-04-7 100 µg/mL acetonitrile 1 mL Dehydroaripiprazole hydrochloride 11004.23-K-ME 1008531-60-9 1000 µg base/mL methanol 1 mL (Aripiprazole Impurity E) Amisulpride (Solian) 10349.17-10MG (+/-)-Amisulpride 71675-85-9 neat neat 10 mg 10349.17-50MG (+/-)-Amisulpride 71675-85-9 neat neat 50 mg 10349.17-100MG (+/-)-Amisulpride 71675-85-9 neat neat 100 mg Chlorpromazine (Largactil) 10350.17-K-ME Chlorpromazine hydrochloride 69-09-0 1000 µg base/mL methanol 1 mL 10350.17-50MG Chlorpromazine hydrochloride 69-09-0 neat neat 50 mg 10350.17-100MG Chlorpromazine hydrochloride 69-09-0 neat neat 100 mg Chlorpromazine-d6 oxalate 10841.17-100-ME 1276197-23-9 100 µg/mL methanol 1 mL (N,N-dimethyl-d6) Clozapine (Clozaril) 9275.18-100-ME Clozapine 5786-21-0 100 µg/mL methanol 1 mL 9275.18-K-ME Clozapine 5786-21-0 1000 µg/mL methanol 1 mL 9275.18-10MG Clozapine 5786-21-0 neat neat 10 mg 9275.18-25MG Clozapine 5786-21-0 neat neat 25 mg 9275.18-100MG Clozapine 5786-21-0 neat neat 100 mg Clozapine-d4 9406.18-100-ME 204395-52-8 100 µg/mL methanol 1 mL (4-methylpiperazinyl-2,2,6,6-d4) Clozapine-d4 9406.18-K-ME 204395-52-8 1000 µg/mL methanol 1 mL (4-methylpiperazinyl-2,2,6,6-d4) Clozapine-d4 9406.18-10MG 204395-52-8 neat neat 10 mg (4-methylpiperazinyl-2,2,6,6-d4) Norclozapine 10807.17-K-ME 6104-71-8 1000 µg/mL methanol 1 mL (N-Desmethylclozapine) 10808.18-100-ME Clozapine N-oxide 34233-69-7 100 µg/mL methanol 1 mL 10808.18-K-ME Clozapine N-oxide 34233-69-7 1000 µg/mL methanol 1 mL Droperidol 11983.22-10MG Droperidol 548-73-2 neat neat 10 mg Flupentixol Flupentixol dihydrochloride 10358.23-K-ME 2413-38-9 1000 µg base/mL methanol 1 mL (cis+trans) Flupentixol dihydrochloride 10358.23-10MG 2413-38-9 neat neat 10 mg (cis+trans)

www.chiron.no | E-mail: [email protected] | Tel.: +47 73 87 44 90 | Fax.: +47 73 73 87 44 99 | BMF 84 p.2/6, 11_16 www.chiron.no | E-mail: [email protected] | Tel.: +47 73 87 44 90 | Fax.: +47 73 73 87 44 99 | BMF 84 p.3/6, 11_16 BMF 84 - Antipsychotics BMF 84 - Antipsychotics

Catalogue No. Description Cas No. Concentration Solvent Volume cis-(Z)-Flupentixol 10712.23-K-ME 51529-01-2 1000 µg base/mL methanol 1 mL dihydrochloride cis-(Z)-Flupentixol 10712.23-10MG 51529-01-2 neat neat 10 mg dihydrochloride Fluphenazine 11163.22-K-ME Fluphenazine dihydrochloride 146-56-5 1000 µg base/mL methanol 1 mL 11163.22-10MG Fluphenazine dihydrochloride 146-56-5 neat neat 10 mg Fluspirilene 9748.29-10MG Fluspirilene 1841-19-6 neat neat 10 mg Haloperidol (Haldol) 10345.21-K-ME Haloperidol 52-86-8 1000 µg/mL methanol 1 mL 10345.21-50MG Haloperidol 52-86-8 neat neat 50 mg 10359.21-100-ME Haloperidol-d4 (4-chlorophenyl-d4) 1189986-59-1 100 µg/mL methanol 1 mL Olanzapine (Zyprexa) 11807.23-K-ME Levomepromazine maleate 7104-38-3 1000 µg base/mL methanol 1 mL 11807.23-10MG Levomepromazine maleate 7104-38-3 neat neat 10 mg 11807.23-50MG Levomepromazine maleate 7104-38-3 neat neat 50 mg Olanzapine (Zyprexa) 3761.17-100-AN Olanzapine 132539-06-1 100 µg/mL acetonitrile 1 mL 3761.17-K-AN Olanzapine 132539-06-1 1000 µg/mL acetonitrile 1 mL 3761.17-10MG Olanzapine 132539-06-1 neat neat 10 mg 3761.17-25MG Olanzapine 132539-06-1 neat neat 25 mg 3761.17-100MG Olanzapine 132539-06-1 neat neat 100 mg 3761.17-250MG Olanzapine 132539-06-1 neat neat 250 mg 3761.17-1G Olanzapine 132539-06-1 neat neat 1 g 9766.17-10-AN Olanzapine-d3 (N-methyl-d3) 786686-79-1 10 µg/mL acetonitrile 1 mL 3924.23-10-ME Olanzapine 10-N-β-D-glucuronide 186792-80-3 10 µg/mL methanol 1 mL N-Demethylolanzapine 11913.16-K-AN (4’-Desmethylolanzapine, 161696-76-0 1000 µg/mL acetonitrile 1 mL Olanzapine Impurity A) Perphenazine 9749.21-10MG Perphenazine 58-39-9 neat neat 10 mg Perphenazine-d4 9914.21-10MG 155593-75-2 neat neat 10 mg (phenothiazine-1,3,7,9-d4) Prochloroperazine 10856.20-10MG Prochloroperazine maleate 84-02-6 neat neat 10 mg Promazine 11164.17-K-ME Promazine hydrochloride 53-60-1 1000 µg base/mL methanol 1 mL 11164.17-10MG Promazine hydrochloride 53-60-1 neat neat 10 mg

Catalogue No. Description Cas No. Concentration Solvent Volume 2-(1-Hydroxypropyl)promazine 11989.20-K-ME 110080-35-8 1000 µg/mL methanol 1 mL (10H-Phenothiazine-2-methanol) 2-(1-Hydroxypropyl)promazine 11989.20-10MG 110080-35-8 neat neat 10 mg (10H-Phenothiazine-2-methanol) Quetiapine 10835.21-K-ME Quetiapine hemifumarate 111974-72-2 1000 µg base/mL methanol 1 mL 10835.21-10MG Quetiapine hemifumarate 111974-72-2 neat neat 10 mg Risperidone 10337.23-K-ME Risperidone 106266-06-2 1000 µg/mL methanol 1 mL 10337.23-10MG Risperidone 106266-06-2 neat neat 10 mg 10337.23-25MG Risperidone 106266-06-2 neat neat 25 mg (+/-)-9-Hydroxyrisperidone 10338.23-K-ME (Paliperidone, Risperidone 144598-75-4 1000 µg/mL methanol 1 mL Impurity C) 9-Hydroxyrisperidone 10338.23-10MG (Paliperidone, Risperidone 144598-75-4 neat neat 10 mg Impurity C) 9-Hydroxyrisperidone 10338.23-25MG (Paliperidone, Risperidone 144598-75-4 neat neat 25 mg Impurity C) Thioridazine 11419.21-K-ME Thioridazine hydrochloride 130-61-0 1000 µg base/mL methanol 1 mL Trifluoperazine 11192.21-K-ME Trifluoperazine dihydrochloride 440-17-5 1000 µg base/mL methanol 1 mL 11192.21-10MG Trifluoperazine dihydrochloride 440-17-5 neat neat 10 mg Triflupromazine Triflupromazine hydrochloride 11195.18-K-ME 1098-60-8 1000 µg base/mL methanol 1 mL (Trifluopromazine HCl) Triflupromazine hydrochloride 11195.18-10MG 1098-60-8 neat neat 10 mg (Trifluopromazine HCl) Trimipramine 9415.24-K-ME Trimipramine maleate 521-78-8 1000 µg/mL methanol 1 mL 9415.24-10MG Trimipramine maleate 521-78-8 neat neat 10 mg Trimipramine-d3 maleate 9416.24-100-ME 1185245-93-5 100 µg/mL methanol 1 mL (N-methyl-d3) Trimipramine-d3 maleate 9416.24-10MG 1185245-93-5 neat neat 10 mg (N-methyl-d3) Zuclopenthixol 10284.22-10MG Zuclopenthixol (cis+trans) 982-24-1 neat neat 10 mg 10285.24-10MG Zuclopenthixol acetate (cis+trans) 85721-05-7 neat neat 10 mg 10713.26-1MG cis-(Z)-Zuclopenthixol succinate 53772-83-1 (free base) neat neat 1 mg cis-(Z)-Zuclopenthixol-d4 succinate 1246833-97-5 10383.22-1MG neat neat 1 mg (N-hydroxyethyl-d4) (as trans-isomer)

www.chiron.no | E-mail: [email protected] | Tel.: +47 73 87 44 90 | Fax.: +47 73 73 87 44 99 | BMF 84 p.4/6, 11_16 BMF 84 - Antipsychotics BMF 84 - Antipsychotics

Catalogue No. Description Cas No. Concentration Antipsychotic & Antidepressant Mix Component part 7 Compounds at 25 μmol/L (0.025 μmol/mL) (freebase) 10345.21 Haloperidol [52-86-8] 25 µmol/L 3761.17 Olanzapine [132539-06-1] 25µmol/L 11913.16 N-Desmethylolanzapine [161696-76-0] 25 µmol/L 10337.23 Risperidone [106266-06-2] 25 µmol/L 10338.23 9-Hydroxyrisperidone [144598-75-4] 25 µmol/L 9288.17 Mirtazapine [85650-52-8] 25 µmol/L 11189.16 Desmethylmirtazapine hydrochloride [61337-68-6] 25 µmol/L S-4932-0.025uM-ME 1 x 1 mL ampoule S-4932-0.025uM-MEx5 5 x 1 mL ampoules

Chiron AS is an authorised distributor of ACQ Science. ! Please contact us for information on ACQ Science antipsychotic (Neuroleptic) accuracy controls in serum.

www.chiron.no | E-mail: [email protected] | Tel.: +47 73 87 44 90 | Fax.: +47 73 73 87 44 99 | BMF 84 p.4/6, 11_16 www.chiron.no | E-mail: [email protected] | Tel.: +47 73 87 44 90 | Fax.: +47 73 73 87 44 99 | BMF 84 p.5/6, 11_16 BMF 84 - Antipsychotics

For ordering and information about prices and delivery in your country, please contact your local distributor:

www.chiron.no | E-mail: [email protected] | Tel.: +47 73 87 44 90 | Fax.: +47 73 73 87 44 99 | BMF 84 p.6/6, 11_16