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The immunoproteasome in antigen processing and other
immunological functions
1,2 3 1,2
Michael Basler , Christopher J Kirk and Marcus Groettrup
Treatment of cells with interferon-g leads to the replacement of quantity of the generated peptides for presentation on
the constitutive catalytic proteasome subunits b1, b2, and b5 MHC class I molecules [3–6]. Because of a pivotal role
by the inducible subunits LMP2 (b1i), MECL-1 (b2i), and LMP7 in class-I ligand generation, the immunoproteasome shapes
(b5i), respectively, building the so-called immunoproteasome. the naı¨ve CD8-T-cell repertoire in the thymus and cyto-