Jonas Salk Papers
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A Guide to Preparing Multiple Choice Items
A Guide to Preparing Multiple Choice Items Introduction The most commonly used type of test item in admissions, certification, and licensure examinations is the multiple choice item. The purpose of this guide is to assist test developers and representatives of professional associations in becoming more skilled in writing multiple choice test items. Preparing multiple choice items may appear on the surface to be a relatively simple task, given familiarity with the subject matter. However, experienced test authors find that this task actually requires a great deal of skill, patience, and creativity. In the sections that follow, general knowledge is used as the content of the examples, in order to facilitate understanding of the principles by professionals from diverse content areas. The skills needed for writing quality items are similar regardless of content discipline. Like any other skill, multiple choice item writing requires a significant amount of painstaking practice with appropriate feedback. It is essential that you try out your multiple choice items on others. This process will help you to uncover ambiguities in wording and unintended violations of item writing principles. Feedback from others will greatly enhance your item writing quality and productivity. Parts of the Multiple Choice Item All multiple choice items consist of two basic parts: the stem and the responses. The stem is the introductory statement or question that elicits the correct answer. The responses are suggested answers which complete the statement or answer the question asked in the stem, only one of which is the correct answer. In the examples that follow, four responses (i.e., 1 correct response and 3 incorrect responses) are presented. -
Jonas Salk at the National Press Club, April 12, 1965
Jonas Salk at the National Press Club, April 12, 1965 Jonas Salk, May 1962. A.F.P. – D.P.A. Photos. National Press Club Archives On the tenth anniversary of the licensing of the polio vaccine he developed, Dr. Jonas E. Salk (1914-1995) visited Washington to accept a joint congressional resolution that hailed the vaccine as “one of the most significant medical achievements of our time.” At the White House, President Johnson offered Salk his congratulations. The day also marked the twentieth anniversary of the death of former President Franklin D. Roosevelt, who, having suffered from paralytic polio since 1921, had established the foundation that funded Salk’s efforts. Following his meetings with Congress and the President, Salk gave a talk and answered reporters’ questions at a National Press Club luncheon. In the title of its lead editorial ten years earlier celebrating the successful testing of the new vaccine, the New York Times proclaimed the “Dawn of a New Medical Day.” Testing of the vaccine, like the funding for its development, had engaged the participation of millions of ordinary American citizens. Through March of Dimes campaigns, hundreds of thousands of volunteers went door-to-door raising $41 million in 1952 alone from average donations of 27 cents. The tests involved 1.8 million school children, 200,000 volunteers, 64,000 teachers, and 60,000 physicians, nurses, and health officials, making it the largest clinical trial in history. Interpreting the jubilant 1 reaction to news that the vaccine had been proven safe and effective, the Times commented, “Gone are the old helplessness, the fear of an invisible enemy, the frustration of physicians.” Poliomyelitis, also known as infantile paralysis, is an extremely contagious viral infection caused by any of three types of poliovirus. -
Poliomyelitis in the Lone Star State
POLIOMYELITIS IN THE LONE STAR STATE: A BRIEF EXAMINATION IN RURAL AND URBAN COMMUNITIES THESIS Presented to the Graduate Council of Texas State University in Partial Fulfillment of the Requirements For the Degree Master of Arts By Jason C. Lee San Marcos, Texas December, 2005 Insert signature page here ii COPYRIGHT By Jason Chu Lee 2005 iii ACKNOWLEDGEMENTS It leaves me in a stupor to contemplate all those I have to thank for aiding me in this effort. If I leave anybody out, please accept my most humble apologies, as the list is long. I will be the first to admit that this work is flawed, despite the best efforts of my committee to save me from myself. Had I utilized them more, this piece would only be improved. I had never undertaken a project of this scope before and though I believe I have accomplished much, the experience has been humbling. Never again will I utter the phrase, “just a thesis.” My biggest thanks go out to Dr. Mary Brennan, my committee chair and mentor. Without her guidance I most certainly would have needed to take comprehensive finals to graduate. She helped me salvage weeks of research that I thought had no discernable use. But Dr. Brennan, despite her very, very busy schedule with the department and her family, still found the time to help me find my thesis in all the data. She is well loved in the department for obvious reasons, as she has a gift for being firm and professional while remaining compassionate. Dr. James Wilson and Dr. -
Vaccine Symposium Louis Pasteur As Pioneers Who Fundamentally Changed the Nature of Presented by the MSU Department of Microbiology & Immunology Human Health
Maurice Hilleman, 1919-2005, was a 1941 MSU graduate who saved the lives of millions by developing a wide array of vaccines. nd 2 Maurice Hilleman A Miles City native, Hilleman graduated atop his class at what was then Montana State College with dual degrees in chemistry and microbiology. His name often accompanies those of Jonas Salk and Vaccine Symposium Louis Pasteur as pioneers who fundamentally changed the nature of Presented by the MSU Department of Microbiology & Immunology human health. The abstract on a National Institutes of Health obituary for Hilleman describes him this way: "Microbe hunter, pioneering virologist, and the world's leading vaccinologist." Mi Among Hilleman's scientific achievements: • A hepatitis B vaccine that was the first vaccine to prevent a cancer in humans (liver cancer, or hepatoma). • A measles-mumps-and-rubella combination vaccine chat marked the first time vaccines for different viruses were successfully combined in a single shot. • Vaccines for meningitis and pneumonia. • A mumps vaccine that came after Hilleman isolated the virus by swabbing the back of his daughter Jeryl Lynn's throat when she was stricken with the disease (50 years later it is still the basis for most mumps vaccines). • A more complete understanding of the ways different strains of the flu change slightly from year to year, which led to the practice of developing an annual seasonal flu vaccine. • The first successful prediction of a coming influenza pandemic and development of a vaccine that thwarted it, 2018 possibly saving close to a million people in 1957. Indeed, Hilleman was responsible for developing 8 out of the 14 recommended vaccinations today. -
Dreams Hope Courage Reality Table of Contents
dreams hope courage reality Table of Contents 1. About Salk 14. Key Contacts 3. The Salk Difference 15. Financial Overview 4. Scientific Priorities 16. Salk Leadership 6. Discoveries 17. Board of Trustees 8. Salk Scientists 18. Salk Architecture 10. Salk by the Numbers 20. Get to Know Us 11. Why I Support Salk... 21. Our Mission 12. Supporting Discoveries About Salk Jonas Salk changed the world. Inspired to rid civilization of polio, he used basic science to solve its mysteries and in the process helped alter the course of the 20th century along with the future of science, medicine and human health. Untold millions have benefited from his work. The Salk Institute was created to attract the best scientific minds in the world. We’ve built on his vision and have become the leading center for independent research, delving into the most serious biological questions of our time. Experts come from around the globe to work in open collaboration—conducting innovative and daring research, mapping discoveries and developing the blueprints so that cures can happen, anywhere in the world. Twelve Nobel laureates have called the Salk Institute home. 1 It’s this “critical mass of intellect,” which embraces the most modern technologies and prizes discovery over credit, that distinguishes Salk. And it results in some of the world’s most breathtaking findings, which advance our understanding of cancer, aging and the brain. These are the first steps that will lead to tomorrow’s cures for cancer, Alzheimer’s, Parkinson’s, heart disease, metabolic diseases, ALS, schizophrenia, childhood development disorders and spinal cord injuries. -
Re-Thinking Pandemics: State, Society, and Disease in British History, 1830-1960
Providence College DigitalCommons@Providence History & Classics Undergraduate Theses History & Classics Spring 2021 Re-thinking Pandemics: State, Society, and Disease in British History, 1830-1960 Meghan Walsh Follow this and additional works at: https://digitalcommons.providence.edu/history_undergrad_theses Part of the European History Commons, and the History of Science, Technology, and Medicine Commons Re-thinking Pandemics: State, Society, and Disease in British History, 1830-1960 by Meghan Walsh HIS 490 History Honors Thesis Department of History and Classics Providence College Spring 2021 This thesis is dedicated to the 3 million people who lost their lives to COVID-19 and to all the frontline workers and essential employees, without whom nothing would be possible. “Epidemics all follow this similar arc where people deny or dismiss the threat until it becomes impossible to ignore any more,” - Mark Honigsbaum, medical historian at City, University of London CONTENTS ACKNOWLEDGEMENTS………………………………………………………………………vi INTRODUCTION …………………………………………...……………………………………1 CHAPTER 1: THE STORY OF CHOLERA ……………………………………………………..8 CHAPTER 2: IGNORING INFLUENZA………………………………………………………..23 CHAPTER 3: TREATING POLIO ……………………………………………………………...36 CONCLUSION: HOW THINGS HAVE CHANGED…………………………………………...54 BIBLIOGRAPHY.........………………………………………………………………………….59 v ACKNOWLEDGEMENTS A project this size truly takes a village, and I am eternally grateful to mine for seeing me through to the end of this. Researching and immersing myself in the lives and experiences of British citizens from three major pandemics, whilst living in one, was an interesting journey, but several people ensured I never went on it alone. To Dr. Smith and Dr. Murphy, thank you for making this possible and for granting me the opportunity to write a senior thesis. Your comments, guidance and encouragement were invaluable. -
Symposium on the Biology of Cells Modified by Viruses Or Antigens1
SYMPOSIUM ON THE BIOLOGY OF CELLS MODIFIED BY VIRUSES OR ANTIGENS1 II. ON THE ANALYSIS OF ANTIBODY SYNTHESIS AT THE CELLULAR LEvEl} GIUSEPPE ATTARDI,• MELVIN COHN,• KENGO HORIBATA1 AND EDWIN S. LENNOX• Department of Microbiolof/11, WaBI&ington Unil16f'aity School of Medicine, St. Lou.ia, Miuouri, and Department of Chemiltry, Univeraity of Illinoia, Urbana, lllinoi1 The title of this symposium implies a simi ability of a cell to perform new syntheses, that larity which is not obvious between the cell is, to differentiate under the external stimulus of ular responses to virus infection and to antigenic virus or antigen. It is in this way that the rela stimulation. In fact, no analogy between these tionship between production of virus and anti two types of cellular response is apparent either body, implicit in the title of the symposium, can from a consideration of the natures of the stimuli, be justified; both phenomena provide a model a specific nucleotide sequence on the one hand for the study of cellular differentiation. and almost any foreign chemical configuration When virus and antibody production are con on the other, or from an examination of the sidered as aspects of the same phenomenon, products of the response, identical units in the i.e., cellular variation, it is not surprising that case of the virus and complementary antibody the methodology developed by virologists over units in the case of the antigen. Furthermore, so many years should eventually become useful little is known about the mechanisms of the two for the study of antibody production. In par responses at the chemical level that one would ticular we are referring to that aspect of the hesitate to compare them. -
Lesson 3 – on the Shoulders of Heroes: Toward a World Without Polio
1 Lesson 3 – On the Shoulders of Heroes: Toward a World without Polio Many scientists work to understand a topic at the same time. They are often working to answer different questions about the same topic. But, sometimes they are working on the same question, such as how to make a vaccine. Even then, they often take different approaches. The story of overcoming polio is a good example. The individuals and teams below all contributed to the world’s progress toward defeating polio. JOHN HAVEN EMERSON John Haven Emerson was an inventor at heart. He never graduated from high school, but he got 35 patents for inventions. He liked to invent respiratory equipment. He is famous for some of his inventions. For example, he improved the iron lung used to treat polio patients who could not breathe on their own. His version was introduced in 1931. It was made at his company in Cambridge, Massachusetts, called the J. H. Emerson Company. It was lighter, quieter, simpler, and more reliable than other versions available at the time. HILARY KOPROWSKI Hilary Koprowski became a medical doctor in 1939 at Warsaw University in Poland. He studied polio virus in the late 1940s at a company called Lederle Laboratories. The labs were in Pearl River, New York. He believed that a polio vaccine made with live virus and given by mouth would be the best kind. He tested the vaccine on himself in 1948. It was tested in mentally disabled children living at a group home in New York in 1950. The caretakers were afraid the children would get polio because they lived together. -
Surviving Superbugs Ending the Arms Race with Infectious Disease Contents
SPRING | 2017 WHERE CURES BEGIN. SURVIVING SUPERBUGS ENDING THE ARMS RACE WITH INFECTIOUS DISEASE CONTENTS 12 FRONTIERS 02 DISCOVERIES Janelle Ayres poses a 30 NEXT GEN radical strategy for surviving infection: 32 SPOTLIGHT Superbugs. 38 EVENTS 20 OBSERVATIONS 42 WAYS OF GIVING Inside the mind of 43 PERSPECTIVE Salk’s new Board Chair, Ted Waitt 44 RESOLUTION 24 INTERSECTION Maintaining the Salk Institute’s iconic architectural vision ON THE COVER: The bacteria Salmonella Typhimurium interacts with its host in surprising ways that may change how we think about infectious disease. ON THE TABLE OF CONTENTS: An original sketch (circa 1963) of the Salk Institute, designed by famed architect Louis Kahn. It shows a conceptual meeting place (foreground), living place (back right) and laboratories (back left). Credit: Louis I. Kahn Collection, University of Pennsylvania and Pennsylvania Historical and Museum Commission. PRESIDENT’S LETTER Dear Friends, Thoughts of rejuvenation arrive with spring and in this issue of Inside Salk you’ll find that much of our current work at the Institute focuses on innovative ways to achieve vibrancy and health. You’ll meet Janelle Ayres, one of our rising star faculty members, who is challenging the traditional use—and sometimes overuse—of antibiotics to fight infectious diseases. As anyone who reads the headlines knows, diseases that have long been controlled by antibiotic medications are staging a worldwide resurgence. According to the Centers for Disease Control, at least 2 million people in the U.S. become infected with antibiotic-resistant diseases each year and around 23,000 die. Janelle proposes a new way of tackling this problem: rather than trying to kill the invading bacteria, she aims to harness the body’s own “good” bacteria—its microbiome—to counter the damaging effects of pathogens. -
David Bodian 1910-1992
DAVID BODIAN 1910-1992 A Biographical Memoir by MARK E. MOLLIVER © 2012 National Academy of Sciences Any opinions expressed in this memoir are those of the author and do not necessarily reflect the views of the National Academy of Sciences. DAVID BODIAN May 15, 1910–September 18, 1992 BY MARK E. MOLLIVER 1 DAVID BODIAN WILL BE REMEMBERED as one of the most innovative neurosci- entists of the 20th century. Committed to science, humanity, and education, he never sought recognition or power. His demeanor was marked by gentle modesty and dedication to colleagues and students. David’s kindness and modesty are inspiring in view of his numerous contributions to biomedical science, especially his role in one of the most significant biomedical advances of the past century. Over the course of his career he made discoveries that provided the groundwork for development of the polio vaccine that has nearly eradicated poliomyelitis, one of the most feared diseases in the world. Production of the vaccine was an urgent national priority that depended on the contributions and collaboration DAVID BODIAN DAVID of many researchers, and was marked by intense competition and drama. I will being inspired by a new high school science course that included laboratories for problem solving and inquiring summarize a few highlights of Bodian’s role in the polio adventure, and refer you into the workings of nature. to a fascinating account of the polio story in the book Polio: An American Story Based on his intelligence and excellent academic (Oshinsky, 2008). performance, Bodian finished high school in three years and entered Crane Junior College. -
The Emergence of Immunology in Pittsburgh
AAI LOOKS BACK The Emergence of Immunology in Pittsburgh by Bryan Peery and John Emrich With IMMUNOLOGY 2014™ taking place in Pittsburgh, Pennsylvania, May 2–6, AAI salutes the current prominence of this city in biomedical research and reflects on the individuals and events contributing to its emergence as an international center for immunology. Pittsburgh, a major center itsit doors to the ¿rst class in for immunological research, 1886.1 Initially, the college was began its steep ascent to completelyc autonomous, but in that acclaim just 60 years 1892,1 it entered into a formal ago when it attracted a relationshipr with Western few ambitious, young University,U of¿cially becoming immunologists to the theth Medical Department of University of Pittsburgh WesternW University, although (Pitt). Among the scientists iti was the stockholders, who arrived in the late 1940s notn the university, who had and 1950s were several ownershipo and authority over distinguished members of theth department. the American Association Western University of Immunologists (AAI), underwentu dramatic changes in including Jonas Salk (AAI 19081 to raise both the standards ’47), Frank Dixon (AAI ’50, PittsburghPittsburgh MunicipalMunicipal Hospital,Hospital 19391939 anda prominence of the school. A president 1971–72), F. Sargent Pittsburgh City Photographer Collection, University of Pittsburgh new name—the University of Cheever (AAI ’50, president Pittsburgh—was adopted, the 1963–64), and Niels Jerne campus was relocated from its (AAI ’65). We chronicle below the achievements of these and site in Pittsburgh’s North Side section to the Oakland area of the other leading immunologists and their roles in shaping the city; and the university formally acquired the medical college. -
Max Planck Institute for the History of Science Making Mutations
MAX-PLANCK-INSTITUT FÜR WISSENSCHAFTSGESCHICHTE Max Planck Institute for the History of Science 2010 PREPRINT 393 Luis Campos and Alexander von Schwerin (eds.) Making Mutations: Objects, Practices, Contexts Table of Contents The Making of “Making Mutations”.........................................................................................3 Alexander von Schwerin & Luis Campos Identifying Mutation Women in Mutation Studies: The Role of Gender in the Methods, Practices, and Results of Early Twentieth-Century Genetics ......................................................................................11 Marsha L. Richmond Mutant Sexuality: The Private Life of a Plant.........................................................................49 Luis Campos Generating Plants and Women: Intersecting Conceptions of Biological and Social Mutations in Susan Glaspell's “The Verge” (1921)................................................................71 Jörg Thomas Richter Non-Evolutionary Mutants? A Note on the Castorrex Rabbit ................................................85 Thierry Hoquet Organisms Tracing the Totsuzen in Tanaka's Silkworms: An Exploration of the Establishment of Bombyx Mori Mutant Stocks................................................................................................ 109 Lisa A. Onaga Supporting the Balance View: Dobzhansky’s Construction of Drosophila pseudoobscura ...................................................................................................................... 119 Matt Dunn The First