Screening for Developmental Dysplasia of the Hip

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Screening for Developmental Dysplasia of the Hip Evidence Synthesis Number 42 Screening for Developmental Dysplasia of the Hip U.S. Department of Health and Human Services Agency for Healthcare Research and Quality www.ahrq.gov This report may be used, in whole or in part, as the basis for development of clinical practice guidelines and other quality enhancement tools, or a basis for reimbursement and coverage policies. AHRQ or U.S. Department of Health and Human Services endorsement of such derivative products may not be stated or implied. AHRQ is the lead Federal agency charged with supporting research designed to improve the quality of health care, reduce its cost, address patient safety and medical errors, and broaden access to essential services. AHRQ sponsors and conducts research that provides evidence-based information on health care outcomes; quality; and cost, use, and access. The information helps health care decisionmakers—patients and clinicians, health system leaders, and policymakers—make more informed decisions and improve the quality of health care services. Evidence Synthesis Number 42 Screening for Developmental Dysplasia of the Hip Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 540 Gaither Road Rockville, MD 20850 http://www.ahrq.gov Contract No. 290-02-0024 Task No. 2 Technical Support of the U.S. Preventive Services Task Force Prepared by: Oregon Evidence-based Practice Center Oregon Health and Science University 3181 SW Sam Jackson Park Road Portland, Oregon 97239 Scott Shipman, MD, MPH, Principal Investigator Mark Helfand, MD, MPH, Co-Investigator Peggy Nygren, MA, Research Associate Christina Bougatsos, Research Assistant March 2006 Preface The agency for Healthcare Research and Quality (AHRQ) sponsors the development of Evidence Syntheses through its Evidence-based Practice Program. With guidance from the U.S. Preventive Services Task Force (USPSTF)* and input from Federal partners and primary care specialty societies, the Evidence-based Practice Center at the Oregon Health & Science University systematically reviews the evidence of the effectiveness of a wide range of clinical preventive services, including screening, counseling, and chemoprevention, in the primary care setting. The Evidence Syntheses— comprehensive reviews of the scientific evidence on the effectiveness of particular clinical preventive services—serve as the foundation for the recommendations of the USPSTF, which provide age- and risk-factor-specific recommendations for the delivery of these services in the primary care setting. Details of the process of identifying and evaluating relevant scientific evidence are described in the “Methods” section of each Evidence Synthesis. The evidence Syntheses document the evidence regarding the benefits, limitations, and cost-effectiveness of a broad range of clinical preventive services and will help further awareness, delivery, and coverage of preventive care as an integral part of quality primary health care. AHRQ disseminates the Evidence Syntheses on the AHRQ Web site (http://www.ahrq.gov/clinic/uspstfix.htm) along with recommendations of the USPSTF. The Recommendation Statements are also available through the National Guideline Clearinghouse (http://www.ngc.gov). We welcome written comments on this Evidence Synthesis. Comments may be sent to: Director, Center fro Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850. Carolyn Clancy, M.D. Helen Burstin, M.D., M.P.H. Director Director Agency for Healthcare Research and Center fro Primary Care, Prevention, and Quality Clinical Partnerships *The USPSTF is an independent panel of experts in primary care and prevention first convened by the U.S. Public Health Service in 1984. The USPSTF systematically reviews the evidence on the effectiveness of providing clinical preventive services—including screening, counseling, and chemoprevention—in the primary care setting. AHRQ convened the USPSTF in November 1998 to update existing Task Force recommendations and to address new topics. Acknowledgements This evidence synthesis was funded by the Agency for Healthcare Research & Quality (AHRQ) for the U.S. Preventive Services Task Force (USPSTF). The investigators thank, Ronald Turker, MD, for serving as a consultant, the USPSTF liaisons, Carol Loveland-Cherry, PhD, RN, Leon Gordis, MD, MPH, DrPH, Virginia Moyer, MD, MPH, and Barbara Yawn, MD, MSc, the AHRQ Medical Officer, Iris Mabry, MD, expert reviewers listed in the Appendix of this report for commenting on draft versions, Andrew Hamilton, MLS, MS for conducting the literature searches, and Miranda Walker for assisting with the manuscript. Requests for Reprints Reprints are available from the AHRQ Web site at www.ahrq.gov (click on Preventive Services). Disclaimer The authors of this article are responsible for its contents, including any clinical or treatment recommendations. No statement in this article should be construed as an official position of the Agency for Healthcare Research and Quality or the U.S. Department of Health and Human Services. Contents Screening for Developmental Dysplasia of the Hip Chapter 1. Introduction Burden of Condition ...............................................................................................................................1 Healthcare Interventions.........................................................................................................................3 Prior Recommendations .........................................................................................................................4 Scope of Evidence Synthesis..................................................................................................................5 Chapter 2. Methods Literature Search Strategy ......................................................................................................................6 Inclusion/Exclusion Criteria...................................................................................................................6 Data Extraction and Synthesis................................................................................................................8 Size of Literature Reviewed ...................................................................................................................8 Chapter 3. Results Previous Systematic Reviews.................................................................................................................9 Key Question 1: Does screening for DDH lead to improved outcomes (including reduced need for surgery and improved functional outcomes such as: gait, physical functioning, activity level, peer relations, family relations, school and occupational performance)?......................11 Key Question 2: Can infants at high risk for DDH be identified, and does this group warrant a different approach to screening than children at average risk?..........................................................13 Key Question 3: Does screening for DDH lead to early identification of children with DDH? .........16 3a: What is the accuracy of clinical examination and ultrasound? ...............................................16 3b: How does the age of the child affect screening parameters? ..................................................23 3c: How does the educational level and training of the screener impact screening?....................24 Key Question 4: What are the adverse effects of screening?...............................................................25 Key Question 5: Does early diagnosis of DDH lead to early intervention, and does early intervention reduce the need for surgery or improve functional outcomes? .......................................26 5a: Is the likelihood of surgical intervention reduced in children diagnosed at an earlier age?.................................................................................................................................................30 Key Question 6: What are the adverse effects of early diagnosis and/or intervention? ......................34 Key Question 7: What cost-effectiveness issues apply to screening for DDH? ..................................35 Chapter 4. Discussion Conclusions and Limitations of the Literature .....................................................................................36 Future Research ....................................................................................................................................39 References ...................................................................................................................................................40 Figures Figure 1. Analytic Framework Figure 2. Key Questions Figure 3. Variation in Late Detection Rate by Screening Method 1978-1996 Figure 4. Variation in Late Detection Rate by Year of Study Publication 1978-1996 Figure 5. Range of Published Rates of Avascular Necrosis & Avascular Necrosis Data Sources Tables Table 1. Previous Recommendations by the American Academy of Pediatrics and the Canadian Task Force for DDH for Newborns and Infants Table 2. Risk Factors Table 3. Population-based Comparative Studies: Clinical Exam Versus Ultrasound Table 4. Randomized Trials of Screening Table 5. Comparison of Screening Approaches Represented in Randomized Controlled Trials Table 6. Intervention Studies with Functional Outcomes Table 7. Summary of Findings of Systematic Evidence Review Appendices Appendix 1. Devices and
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