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Official Journal of the Asian Pacific Society of Respirology Official Journal of the Asian Pacifi c Society of Respirology R e s p i r o l o g y Volume 24 û Supplement 1 û March 2019 Volume 24 Supplement 1 March 2019 TSANZSRS 2019 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientifi c Meeting 29 March–2 April 2019 Gold Coast Convention and Exhibition Centre, QLD, Australia Disclaimer This abstract book has been produced using author-supplied copy. Editing has been restricted to some corrections of spelling and style where appropriate. The publisher assumes no responsibility for any claims, instructions, methods or drug dosages contained in the abstracts. It is recommended that these are verified independently. The contents contained herein are correct at the time of printing and may be subject to change. Contents ANZSRS Oral Abstracts New Investigators Awards (AO 001–AO 009) ANZSRS Oral Abstracts (AO 010–AO 018) ANZSRS Poster Abstracts ANZSRS Poster Abstracts (AP 001–AP 017) TSANZ Oral Abstracts TSANZ Ann Woolcock New Investigator Award (TO 001–TO 006) TSANZ Respiratory Nurses SIG Symposium 1 (TO 007–TO 008) TSANZ Respiratory Nurses SIG Symposium 3 (TO 009–TO 011) Cystic Fibrosis 1 (TO 012–TO 017) Evidence-Based Medicine and Practice (TO 018–TO 021) OLIV 1 (TO 022–TO 027) Primary Care / Palliative Care / Tobacco (TO 028–TO 033) Respiratory Infectious Diseases 1 (TO 034–TO 039) Asthma and Allergy 1 (TO 040–TO 045) Cell, Immunology and Molecular Biology of the Lung 1 (TO 046–TO 051) Chronic Obstructive Pulmonary Disorder (COPD) 1 (TO 052–TO 057) Interventional Pulmonolgy / Bronchology 1 (TO 058–TO 063) Occupational and Environmental Lung Disease / Population Health (TO 064–TO 069) Asthma and Allergy 2 (TO 070–TO 075) Cell, Immunology and Molecular Biology of the Lung 2 (TO 076–TO 080) SIG Orals: Chronic Obstructive Pulmonary Disorder (COPD) 2 (TO 081–TO 086) Cystic Fibrosis 2 (TO 087–TO 093) TSANZ Late Breaking Abstracts (TOL 001–TOL 004) Physiology and Sleep 1 (TO 094–TO 099) Asthma and Allergy 3 (TO 100–TO 105) Chronic Obstructive Pulmonary Disorder (COPD) 3 (TO 106–TO 111) Lung Cancer (TO 112–TO 117) Physiology and Sleep 2 (TO 118–TO 123) Chronic Obstructive Pulmonary Disorder (COPD) 4 (TO 124–TO 129) Interventional Pulmonolgy / Bronchology 2 (TO 130–TO 135) OLIV 2 (TO 136–TO 141) Paediatric (TO 142–TO 147) Respiratory Infectious Diseases 2 (TO 148–TO 153) TSANZ Poster Abstracts Asthma and Allergy 1 (TP 002–TP 010) Asthma and Allergy 2 (TP 011–TPL 002) Cell, Immunology and Molecular Biology of the Lung (TP 021–TPL 005) Chronic Obstructive Pulmonary Disease (COPD) 1 (TP 035–TP 044) Chronic Obstructive Pulmonary Disease (COPD) 2 (TP 045–TP 057) Cystic Fibrosis (TP 058–TPL 010) Evidence-Based Medicine and Practice (TP 068–TP 077) Interventional Pulmonolgy / Bronchology (TP 078–TP 094) Lung Cancer (TP 095–TP 108) Occupational and Environmental Lung Diseases / Population Health (TP 109–TPL 011) OLIV 1 (TP 116–TPL 012) OLIV 2 (TP 133–TPL 014) Paediatric (TP 134–TP 143) Primary Care / Palliative Care / Tobacco (TP 144–TP 150) Respiratory Infectious Diseases 1 (TP 152–TP 159) Respiratory Infectious Diseases 2 (TP 161–TPL 020) Physiology and Sleep (TP 172–TPL 019) TSANZ Respiratory Nurses SIG Symposium Session 2 (TP 184–TP 189) ABSTRACTS AO 002 CONTROLLED VS UNCONTROLLED BREATHING PROTOCOL AO 001 IN ADULTS USING MULTIPLE BREATH NITROGEN WASHOUT COMPARISON OF ESTIMATING ELASTIC RECOIL FROM (MBNW) TO MEASURE VENTILATION HETEROGENEITY OESOPHAGEAL BALLOON AND THE FORCED OSCILLATION HANDLEY BM1,2, THAMRIN C2,3, MILNE S1,2,3, SCHOEFFEL RE1, 1,2 1,2,3 NILSEN K1,2,4, THOMPSON B1,2, CHAPMAN D4,6, THIEN F2,3, KING FARROW C , KING GG 1 G4,5, TONGA K4,5, THAMRIN C4,5 Department of Respiratory Medicine, Royal North Shore Hospital, St 2 1The Alfred Hospital, Melbourne, Australia, 2Monash University, Leonards, NSW 2065, Australia, Airway Physiology and Imaging Group, 3 Melbourne, Australia, 3Eastern Health, Melbourne, Australia, 4The Woolcock Institute of Medical Research, NSW, 2037, Australia, Sydney Woolcock Institute, Sydney, Australia, 5The University of Sydney, Medical School, University of Sydney, NSW 2006, Australia Sydney, Australia, 6University of Technology Sydney, Sydney, Australia Introduction/Aim. Multiple Breath Nitrogen Washout (MBNW) pro- Introduction/Aim. Loss of elastic recoil occurs with aging as well as vides indices of ventilation heterogeneity, which may help detect and in diseases such as emphysema and asthma. The gold standard method quantify early onset of small airway dysfunction. Two protocols are com- of measuring elastic recoil involves an oesophageal balloon to estimate monly used: uncontrolled tidal breathing vs 1-L controlled tidal volume transpulmonary pressure (Ptp); however, the test is invasive and thus of breathing. We aimed to determine if the two protocols provided equivalent limited clinical use. This study aims to examine a new method of asses- MBNW indices in healthy adults, and compared FRC obtained from both sing elastic recoil using the forced oscillation technique (FOT), an easy- protocols against plethysmographic FRC. We also examined factors con- to-perform, emerging lung function test in the clinical setting. tributing to any observed differences. Methods. Subjects with asthma (n = 16) and healthy controls (n = Method. Healthy individuals with a smoking history <5pk yrs, per- 17) completed spirometry and plethsmography before insertion of an formed both the 1-L controlled breathing and uncontrolled tidal breathing ® oesophageal balloon. Subjects then performed inspiratory capacity protocols, in randomised order, on the Eco Medics Exhalyzer D system, manoeuvres during which Ptp and FOT were simultaneously obtained. according to ATS/ERS criteria. Indices from each protocol were extracted The relationship between transrespiratory pressure, FOT reactance and from the pooled results 3 trials per session: FRC, LCI (lung clearance lung volume was used to calculate a surrogate measure of Ptp. The Cole- index), Scond and Sacin (ventilation heterogeneity primarily in the con- batch equation V = A−Be(-kP) was then used to model the relationship ductive and acinar airways, respectively). For the uncontrolled protocol, between volume (expressed as %predTLC) and Ptp derived from both Scond and Sacin were corrected for tidal volume. The two protocols were methods, and the agreement between the two models compared in terms compared using paired-t tests, correlations, and Bland-Altman plots. of k (compliance) and B/A ratio (measure of elastic recoil). We also exam- Results. Data from 13 (8 males) individuals (age range 19-51 yrs, Æ Æ Æ ined differences between controls and asthma. mean SD BMI 23 2.56, FEV1% pred 102.15 15.7 FEV1/FVC 84.4 Results. There was no difference in k (0.026 Æ 0.022 vs 0.029 Æ Æ 6.92) are presented. FRC measurements between the two methods 0.014, P = 0.23) between the two models, while bias was seen in B/A were highly correlated (r = 0.98, P < 0.0001). There were no significant (61.4 Æ 18.6 vs 78.3 Æ 18.3, P < 0.01). There were no differences in k or differences between the two methods for FRC, Scond and LCI, while B/A between controls and asthma, however change in FEV1 post- Sacin was higher using the 1-L controlled protocol (paired t-test, P = bronchodilator was negatively correlated with B/A (r2 = 0.57, P < 0.001) in 0.009). However, Bland-Altman plots revealed significant proportional asthma. bias, i.e. the differences in FRC and Sacin between the two protocols Conclusion. FOT provides a promising surrogate for elastic recoil depended on their magnitudes (P = 0.0158 and P < 0.0001, respectively). that is easy to implement into clinical practice. Using this technique, we Furthermore, the 1-L controlled protocol increasingly overestimated suggest that increase of elastic recoil may contribute to the loss of revers- FRCpleth in individuals with larger FRCpleth (P = 0.030). ibility in asthma. Conclusion. Lung volume and ventilation heterogeneity assessed using the two protocols may not be comparable in taller individuals. These preliminary results will aid in the ongoing standardisation efforts for MBNW, which are critical for its clinical application, and form a basis for future comparisons in patients with lung disease. Key Words: Multi-Breath Nitrogen Washout (MBNW), FRC, Protocols Nomination for New Investigator Award: Yes Grant Support: No Editorial material and organization © 2019 Asian Pacific Society of Respirology. Respirology (2019) 24 (Suppl. 1), 4–21 Copyright of individual abstracts remains with the authors. doi: 10.1111/resp.13490 Abstracts 5 AO 003 AO 004 VENTILATION MEASUREMENTS FROM HYPERPOLARIZED CONCORDANCE OF BRONCHODILATOR RESPONSE (BDR) 3HE MAGNETIC RESONANCE IMAGING ARE A MARKER OF IN ASTHMA AND COPD AIRWAY CLOSURE IN SUBJECTS WITH AIRFLOW WALLIS R1, SCHOEFFEL R1, FARROW C1,2, MASCARENHAS S1, 1 1,2,3 OBSTRUCTION HANDLEY B , KING GG 1 NILSEN K1,2, THOMPSON BR1,2, HARRIS B5, ROBINSON P4, Department of Respiratory Medicine, Royal North Shore Hospital, 2 COWIN G5, THIEN F2,3 NSLHD, St Leonards, 2065 Sydney, Australia, Woolcock Institute of 3 1The Alfred Hospital, Melbourne, Australia, 2Central Clinical School, Medical Research, Glebe, 2037 Sydney, Australia, Northern Clinical Monash University, Melbourne, Australia, 3Eastern Health, Melbourne, School, University of Sydney, St Leonards, 2065 Sydney, Australia Australia, 4The Royal Children’ Hospital, Melbourne, Australia, 5The University of Queensland, Brisbane, Australia Introduction/Aim. BDR is clinically important in obstructive airways diseases. The concordance between spirometry and Forced Oscillation Introduction/Aim. Images from Hyperpolarised 3He magnetic reso- Technique (FOT) BDR is unknown. We aim to determine the concordance nance imaging (3He MRI) provide exquisite detail of gas distribution in BDR between spirometry and FOT in asthma & COPD. across the lung.
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