Luigicerulo Curriculum Vitæ Et Studiorum
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Molecular Mechanisms of Cancer Drug Resistance
PhD Program in Translational and Molecular Medicine DIMET UNIVERSITY OF MILANO-BICOCCA SCHOOL OF MEDICINE AND SCHOOL OF SCIENCE Molecular Mechanisms of Cancer Drug Resistance Coordinator: Prof. Andrea Biondi Tutor: Dr. Roberto Giovannoni Dr. Gabriele Romano Matr.No.709074 XXVIII Cycle Academic Year 2014-2015 ...un terzo di istinto, un terzo di memoria, un terzo di volontà... Table of Contents CHAPTER 1 6 INTRODUCTION 6 CHEMORESISTANCE: INTRINSIC MOLECULAR MECHANISMS 7 DRUG TRANSPORTERS 7 DRUG METABOLISM 8 DRUG TARGETS 9 DNA DAMAGE REPAIR SYSTEMS 10 TUMOR SUPPRESSOR GENES 11 INDUCTION OF APOPTOSIS 13 PRO-SURVIVAL SIGNALS 14 ACQUIRED DRUG RESISTANCE: THE ROLE OF MICROENVIRONMENT 16 ECM STRUCTURE AND CELL ADHESION SIGNALING 16 VASCULARIZATION, NEO-ANGIOGENESIS AND ANGIOGENETIC SIGNALS 18 CANCER ASSOCIATED FIBROBLASTS 20 IMMUNE SYSTEM 21 EPITHELIAL TO MESENCHYMAL TRANSITION AND TUMOR STEM CELLS 22 SHOOTING TO THE TARGET: THE PERSONALIZED MEDICINE 26 DRUG RESISTANCE EXPERIMENTAL MODELS 29 CANCER CELL LINES 30 CELL LINE XENOGRAFTS 32 PATIENT DERIVED XENOGRAFTS 33 IMMUNOCOMPETENT ALLOGRAFTS 35 GEMMS 36 THE RIGHT MODEL 36 SCOPE OF THE THESIS 38 CHAPTER 2: RESVERATROL INHIBITS PROLIFERATION AND STRONGLY DECREASES MOTILITY IN GLIOMA STEM CELLS, MODULATING THE WNT SIGNALING PATHWAY 38 CHAPTER 3: A FUNCTIONAL BIOLOGICAL NETWORK CENTERED ON XRCC3: A NEW POSSIBLE MARKER OF CHEMORADIOTHERAPY RESISTANCE IN RECTAL CANCER PATIENTS 38 CHAPTER 4: INHIBITION OF GSK3Β BYPASS DRUG RESISTANCE OF P53-NULL 39 COLON CARCINOMAS BY ENABLING NECROPTOSIS IN RESPONSE -
Business Process Management & Enterprise Architecture Track
BIO - Bioinformatics Track Track Co-Chairs: Juan Manuel Corchado, University of Salamanca, Spain Paola Lecca, University of Trento, Italy Dan Tulpan, University of Guelph, Canada An Insight into Biological Data Mining based on Rarity and Correlation as Constraints .............................1 Souad Bouasker, University of Tunis ElManar, Tunisia Drug Target Discovery Using Knowledge Graph Embeddings .........................................................................9 Sameh K. Mohamed, Insight Centre for Data Analytics, Ireland Aayah Nounu, University of Bristol, UK Vit Novacek, INSIGHT @ NUI Galway, Ireland Ensemble Feature Selectin for Biomarker Discovery in Mass Spectrometry-based Metabolomics ............17 Aliasghar Shahrjooihaghighi, University of Louisville, USA Hichem Frigui, University of Louisville, USA Xiang Zhang, University of Louisville, USA Xiaoli Wei, University of Louisville, USA Biyun Shi, University of Louisville, USA Craig J. McClain, University of Louisville, USA Molecule Specific Normalization for Protein and Metabolite Biomarker Discovery ....................................23 Ameni Trabelsi, University of Louisville, USA Biyun Shi, University of Louisville, USA Xiaoli Wei, University of Louisville, USA HICHEM FRIGUI, University of Louisville, USA Xiang Zhang, University of Louisville, USA Aliasghar Shahrajooihaghighi, University of Louisville, USA Craig McClain, University of Louisville, USA BPMEA - Business Process Management & Enterprise Architecture Track Track Co-Chairs: Marco Brambilla, Politecnico di -
Applied Computing 2004
AI and Computational Logic and Image Analysis (AI) Track Chair: C.C. Hung, Southern Polytechnic State University, USA Track Co-Chair: Agostinho Rosa, LaSEEB –ISR – IST, Portugal Track Editorial...........................................................................................................................................3 Experimenting with a Real-Size Man-Hill to Optimize Pedagogical Paths..........................................3 Gregory Valigiani, University of Calais Yannick Jamont, Paraschool Company Claire Bourgeois Republique, University of Bourgogne Raphael Biojout, Paraschool Company Evelyne Lutton, INRIA Rocquencourt Pierre Collet, University of Calais An Hybridization of an Ant-based Clustering Algorithm with Growing Neural Gas Networks for Classification Tasks ...................................................................................................................................8 Marco A. Montes de Oca, Monterrey Institute of Technology, Mexico Leonardo Garrido, Monterrey Institute of Technology, Mexico José L. Aguirre, Monterrey Institute of Technology, Mexico Reinforcement Learning Agents with Primary Knowledge Designed by Analytic Hierarchy Process.......................................................................................................................................................18 Kengo Katayama, Okayama University of Science, Japan Takahiro Koshiishi, Okayama University of Science, Japan Hiroyuki Narihisa, Okayama University of Science, Japan Estimating Manifold Dimension by Inverion -
S41467-019-10037-Y.Pdf
ARTICLE https://doi.org/10.1038/s41467-019-10037-y OPEN Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system Laura Rinaldi1, Rossella Delle Donne1, Bruno Catalanotti 2, Omar Torres-Quesada3, Florian Enzler3, Federica Moraca 4, Robert Nisticò5, Francesco Chiuso1, Sonia Piccinin5, Verena Bachmann3, Herbert H Lindner6, Corrado Garbi1, Antonella Scorziello7, Nicola Antonino Russo8, Matthis Synofzik9, Ulrich Stelzl 10, Lucio Annunziato11, Eduard Stefan 3 & Antonio Feliciello1 1234567890():,; Activation of G-protein coupled receptors elevates cAMP levels promoting dissociation of protein kinase A (PKA) holoenzymes and release of catalytic subunits (PKAc). This results in PKAc-mediated phosphorylation of compartmentalized substrates that control central aspects of cell physiology. The mechanism of PKAc activation and signaling have been largely characterized. However, the modes of PKAc inactivation by regulated proteolysis were unknown. Here, we identify a regulatory mechanism that precisely tunes PKAc stability and downstream signaling. Following agonist stimulation, the recruitment of the chaperone- bound E3 ligase CHIP promotes ubiquitylation and proteolysis of PKAc, thus attenuating cAMP signaling. Genetic inactivation of CHIP or pharmacological inhibition of HSP70 enhances PKAc signaling and sustains hippocampal long-term potentiation. Interestingly, primary fibroblasts from autosomal recessive spinocerebellar ataxia 16 (SCAR16) patients carrying germline inactivating mutations of CHIP show a dramatic dysregulation of PKA signaling. This suggests the existence of a negative feedback mechanism for restricting hormonally controlled PKA activities. 1 Department of Molecular Medicine and Medical Biotechnologies, University Federico II, 80131 Naples, Italy. 2 Department of Pharmacy, University Federico II, 80131 Naples, Italy. 3 Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, A-6020 Innsbruck, Austria. -
V Seminar INVALSIDATA:A TOOL for TEACHING
V Seminar INVALSI DATA: A TOOL FOR TEACHING AND SCIENTIFIC RESEARCH February 25th-28th, 2021 ROME 1 2 INTRODUCTION The Seminar "INVALSI data: a tool for teaching and scientific research", now at its fifth edition, has become in recent years an opportunity for meeting and discussion on the use of National Surveys INVALSI results and, in general, on the world of evaluation and school. Evaluation does not only mean standardized monitoring of learning levels, but also evaluation and comparison of its functions and potential in relation to the practices and tools through which the school system is able to carry out its educational and formative mission. This year, keynotes of national and international experts were organized on issues related to the evaluation of the education system and the use of data to support school policies. One of the objectives of the seminar was to bring the world of scientific research and schools closer together in order to build a privileged and concrete space in which enriching the debate by sharing ideas and experiences between education and research stakeholders. The variety of topics improve a multidisciplinary approach to evaluation in the educational and school field, trying to give an account of the contribution that schools can provide to society by making possible the development of knowledge and skills. The Seminar is organised by the research group of Area 2 - Statistical Service: Patrizia Falzetti (Manager), Cecilia Bagnarol, Andrea Bendinelli, Leonardo Boulay, Emiliano Campodifiori, Michele Cardone, Silvia Donno, Paola Giangiacomo, Patrizia Giannantoni, Jana Kopecna, Giuseppina Le Rose, Francesca Leggi, Michele Marsili, Monica Papini, Veronica Pastori, Veronica Riccardi, Maria Carmela Russo, Chiara Sacco, Antonio Severoni, Valeria F. -
Dusan Agrez University of Ljubljana, Slovenia Teodoro Aguilera
Dusan Agrez University of Ljubljana, Slovenia Teodoro Aguilera University of Extremadura, Spain Mohammad Alsharman University of Waterloo, Canada Davorin Ambrus University of Zagreb, Croatia Daniel Belega University Politehnica of Timisoara, Romania Krzysztof Brzostowski Wroclaw University of Science and Technology, Poland Sebastian Budzan Silesian University of Technology, Poland Thiago Cabral State University of Campinas, Brazil Riccardo Carotenuto University of Reggio Calabria, Italy Andrea Cataldo University of Salento, Italy Chao Chen Southeast University, China Panteleimon Chriskos Aristotle University of Thessaloniki, Greece Lorenzo Ciani DINFO - University of Florence, Italy Devarshi Das Indian Institute of Technology Ropar, India Mehdi Davoudi Department of Electrical Engineering, Politecnico di Milano, Italy Alessio De Angelis University of Perugia, Italy Guido De Angelis Regione Umbria, Italy 2019 Outstanding Reviewers Transactions on Instrumentation and Measurement Bruno De Castro São Paulo State University, Brazil Luca De Vito University of Sannio, Italy Giuseppe Di Leo University of Salerno, Italy Kang Donghoon Korea Institute of Science and Technology, Republic of Korea Yavuz Ege BAU Necatibey Education Faculty, Turkey Güvenir Esen Turkish Standards Institution, Turkey Daniele Fontanelli Universita' di Trento, Italy Mohamad Forouzanfar Stanford Research Institute (SRI) , United States of America David Forsyth Henan Polytechnic University, China Guglielmo Frigo Swiss Federal Institute of Technology (EPFL), Switzerland Yuan Gao Apple Inc, United States of America Wenpeng Gao Harbin Institute of Technology, China Fei Gao College of Computer, Zhejiang University of Technology, China Boby George Indian Institute of Technology Madras, India Carlo Guarnieri Calò Carducci RWTH Aachen University, Germany Hamed Hamzehbahmani Durham University, United Kingdom Yonghui Hu North China Electric Power University, China 2019 Outstanding Reviewers Transactions on Instrumentation and Measurement Jiabin Jia University of Edinburgh, United Kingdom Sakol Julrat U.S. -
AI and Computational Logic and Image Analysis (AI) Track Co-Chairs: C.C
AI and Computational Logic and Image Analysis (AI) Track Co-Chairs: C.C. Hung, School of Computing and Soft. Eng., USA Agostinho Rosa, LaSEEB –ISR – IST, Portugal An Evidential Approach in Ensembles Yaxin Bi, University of Ulster, UK Werner Dubitzky, University of Ulster, UK Solving First-Order Constraints in the Theory of Finite or Infinite Trees Khalil Djelloul, Laboratoire d’Informatique Fondamentale de Marseille, France Thi-Bich-Hanh Dao, Laboratoire d’Informatique Fondamentale d’Orleans, France A Small-World Model of the Human Mind Jose Luis Malaquias, University Coimbra, Portugal Agostinho Claudio da Rosa, ISR-LaSEEB, Portugal Carlos Maunel BA Correia, University Coimbra, Portugal Facial Emotion Recognition by Adaptive Processing of Tree Structures Jia-Jun Wong, Nanyang Technological University, Singapore Siu-Yeung Cho, Nanyang Technological University, Singapore Adaptive Dynamic Run-length Coding for Image Segmentation Sara Arasteh, Southern Polytechnic State University, USA Chih-Cheng Hung, Southern Polytechnic State University, USA Enmin Song, Huazhong University of Science and Technology, China On Handling Conflicts between Rules with Numerical Features Tony Lindgren, Stockholm University and Royal Institute of Technology, Sweden Poster Papers A Quantitative Analysis of Implicational Paradoxes in Classical Mathematical Logic Yuichi Goto, Saitama University Jingde Cheng, Saitama University Cooperative Active Contour Model and Its Application to Remote Sensing Noriko Masumoto, Saitama University Norihiko Yoshido, Saitama University -
Business Mastergbaaaa
PROFILE OF PROF. DR. GIOVANNI BATTISTA DAGNINO Giovanni Battista DAGNINO is Professor in the Department of Economics and Business of the University of Catania, Italy, where he is Coordinator of the PhD Program in Economics and Management and Academic Director of GRIM-Group of Research on Insurance and Banking Economics and Management. In addition, he is faculty member of the European Institute for Advanced Studies in Management in Brussels, Fellow of the Strategic Planning Society in London, and Friend of the European Investment Bank Institute in Luxembourg. He has held visiting positions at the Tuck School of Business at Dartmouth, Wharton School, London Business School, IESE Business School, Grenoble Ecole de Management, the University of Mannheim and IAE Business School, Universidad Austral, Buenos Aires. In 2008-2010 he has served as Deputy Chair and Interim Chair of his Department. At the Tuck School of Business at Dartmouth he taught “Strategy Implementation” and “Coopetition Strategy” in the MBA program. At the University of Catania he teaches or has taught “Advanced Topics in Strategic Management” and “Research Methods” in the PhD program, as well “Finance and Strategic Management” and “Management of Global Financial Services” in the MSc in Corporate Finance. He graduated at Bocconi University of Milan and studied Political Science and International Affairs at the University of Palermo, before receiving his PhD from the University of Catania and MURST. He was co-chair of the 30th Anniversary Strategic Management Society Annual Conference “Strategic Management at the Crossroads” (Rome 2010), as well as of the Strategic Management Society Special Conference “New Frontiers in Entrepreneurship: Strategy Governance and Evolution” (Catania 2007). -
Alberto ALOISIO - Short CV
Alberto ALOISIO - Short CV Education (1988) degree in Physics, Laurea cum laude, University of Naples ‘Federico II', Italy Research Experiences, pre and post-lauream (1985) Summer Student at CERN (Geneva, Switzerland) (1989-1991) Two-year fellowship granted by Istituto Nazionale di Fisica Nucleare, Naples Faculty Positions (1991-1998) Assistant Professor (Physics) at University of Naples 'Federico II', Italy (1999-2003) Associate Professor of Physics at University of Sannio, Italy (2004-2011) Associate Professor of Physics at University of Naples ‘Federico II', Italy (2012-present) Full Professor of Physics at University of Naples ‘Federico II', Italy Teaching Experience (1991-1995) Physics II, degree in Physics, Univ. of Naples; (1995-1998) Laboratory of Physics I, degree in Physics, Univ. of Naples; (1999-2003) Experimental Physics, degree in Geology, Univ. of Sannio; (1999-2003) Laboratory of Computer Architecture, degree in Computer Science, Univ. of Naples; (2004-2011) Laboratory of Digital Systems, degree in Physics (LM), Univ. of Naples; (2012-present) Digital Electronics, degree in Physics (LM) Univ. of Naples; (2004-present) Computer Architecture, degree in Computer Science, Univ. of Naples; (2005-present) Member of the Council of the PhD School of Physics, Univ. of Naples Peer-review Activity (1999-2003) Reviewer of the Research Programs of National Interest (PRIN) of the Italian Ministry of University and Research (2004-present) Member of the Reviewer Board for the evaluation of Programs of National Interest (PRIN) (2004) Member -
Strategic Planning Dimensions in Italian
BUSINESS EDUCATION & ACCREDITATION ♦ Volume 4 ♦ Number 1♦ 2012 STRATEGIC PLANNING DIMENSIONS IN ITALIAN UNIVERSITIES Giovanni Bronzetti, University of Calabria Romilda Mazzotta, University of Calabria Maria Teresa Nardo, University of Calabria ABSTRACT The paper examines the strategic planning process in Italian Universities. We identify two macro strategic planning dimensions: one for the process and one for the plan substance. We create a synthetic indicator of plan and process quality. Based on quality of plan and process we create a cluster matrix of universities. We also conduct empirical research to determine if university size is correlated with quality of strategic planning. We find a positive correlation between university size and the process and plan quality. JEL: L52, O21 KEYWORDS: Strategic Planning, Italy, University INTRODUCTION trategic planning is an approach to plan the future for the university. Through strategic planning, resources are assigned to increase benefits to various stakeholders including students, employers Sand society. The tool of strategic planning is the plan that guides reallocation of resources. Formalized strategic planning develop in America during the 1950s, in the mid-1960s and throughout the 70s expanding to most large corporations (Mintzberg, 1994). In public organizations strategic planning developed during the 1980s in Anglo-Saxons contest and during the 1990s in Italy. In higher education the idea was spreading knowledge was a target to be pursued independent from the costs incurred (Kelly and Shaw, 1987). Recently however, universities face funding reductions requiring them to optimize choices. Strategic planning assumes the key role for design the future path of the university (Shirley, 1983). In other words, it has become necessary for universities to define their mission, analyze their frontiers and identify eventual growth and improvement opportunities in a competitive setting. -
M29042904 - DAGNINODAGNINO PRINT.Inddprint.Indd Viiiviii 228/05/20128/05/2012 15:4215:42 Contributors Ix
Contributors Asli Arikan Visiting Assistant Professor of Management and Human Resources, Max M. Fisher College of Business Ohio State University arikan_1@fi sher.osu.edu Africa Ariño Professor of General Management and Academic Director of Anselmo Rubiralta Research Center on Globalization and Strategy IESE Business School [email protected] Jay B. Barney Professor of Management and Chase Chair for Excellence in Corporate Strategy, Max M. Fisher College of Business Ohio State University [email protected] Joel A.C. Baum Professor of Strategy and Organization and Canadian National Chair in Strategic Management, Rotman School of Business University of Toronto [email protected] Arturo Capasso Professor of Corporate Governance Director of the Economics and Management Program University of Sannio at Benevento [email protected] Ramon Casadesus- Masanell Professor of Business Administration Harvard Business School [email protected] Bruno Cassiman Professor of Economics and Strategy, IESE Business School Senior Researcher at the Center for R&D and Innovation Policy viii Giovanni Battista Dagnino - 9780857938688 Downloaded from Elgar Online at 10/01/2021 12:53:05PM via free access MM29042904 - DDAGNINOAGNINO PPRINT.inddRINT.indd vviiiiii 228/05/20128/05/2012 115:425:42 Contributors ix University of Leuven [email protected] Sandro Castaldo Professor of Marketing Management Bocconi University sandro.castaldo@sda- bocconi.it Asda Chintakananda Assistant Professor Nanyang Technological University, Singapore [email protected] Maria Cristina -
Global Communications Newsletter
GLOBAL COMMUNICATIONS NEWSLETTER October 2020 ISSN 2374-1082 CHAPTER REPORT This initiative encouraged both young and experienced researchers of the IEEE VTS/ComSoc Italy Chapter to take an Activities of the ComSoc/VTS Italy Chapter during active part in the competition, by proposing ideas and methods during the lockdown period. Despite the competitive nature of the COVID-19 Pandemic the initiative, the Call for Ideas was meant as an opportunity for By Francesco Benedetto, Roma Tre University, Roma; Silvia Ullo, our scientific community to come together and define creative University of Sannio in Benevento, Benevento; Barbara Masini, and unexpected solutions to face a situation that was unimag- inable until a few months ago. This call further demonstrated CNR - IEIIT, Bologna; Gianni Pasolini, University of Bologna, Bolo- how crucial and strategic the VTS/ComSoc activities are for gna; and Fabrizio Granelli, Chair of the IEEE ComSoc/VTS Italy the Country, as the proposed solutions addressed very relevant Chapter, University of Trento, Italy topics. Examples of application areas for the Healthcare theme (but During the pandemic of COVID-19, the IEEE VTS/ComSoc not limited to) were: Italy Chapter activated several initiatives for its members to (i) Remote diagnosis, initial treatment and follow-up of keep them engaged in community activities, even if remotely. patients. A competitive Call for Ideas was opened to spring up solu- (ii) Real time support or training for medical personnel using tions to the challenges posed by Coronavirus, leveraging the videoconferencing or telepresence systems. use of Information and Communications Technologies (ICTs). (iii) Planning of medical resources. The main objectives of the initiative were: (iv) Follow-up of patients with other diseases.