XANTHINE OXIDASE INHIBITORY ACTIVITY of Pandanus Amaryllifolius Roxb
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A Journal on Taxonomic Botany, Plant Sociology and Ecology
A JOURNAL ON TAXONOMIC BOTANY, PLANT SOCIOLOGY AND ECOLOGY ISSN 0034 – 365 X REINWARDTIA 13 (5) REINWARDTIA A JOURNAL ON TAXONOMIC BOTANY, PLANT SOCIOLOGY AND ECOLOGY Vol. 13(5): 391–455, December 20, 2013 Chief Editor Kartini Kramadibrata (Herbarium Bogoriense, Indonesia) Editors Dedy Darnaedi (Herbarium Bogoriense, Indonesia) Tukirin Partomihardjo (Herbarium Bogoriense, Indonesia) Joeni Setijo Rahajoe (Herbarium Bogoriense, Indonesia) Marlina Ardiyani (Herbarium Bogoriense, Indonesia) Topik Hidayat (Indonesia University of Education, Indonesia) Eizi Suzuki (Kagoshima University, Japan) Jun Wen (Smithsonian Natural History Museum, USA) Managing Editor Himmah Rustiami (Herbarium Bogoriense, Indonesia) Secretary Endang Tri Utami Layout Editor Deden Sumirat Hidayat Illustrators Subari Wahyudi Santoso Anne Kusumawaty Reviewers David Middleton (Royal Botanic Gardens Edinburgh, UK), Eko Baroto Walujo (LIPI, Indonesia), Ferry Slik (Xishuangbanna Tropical Botanical Garden, China), Henk Beentje (Royal Botanic Gardens Kew, UK), Hidetoshi Nagamasu (Kyoto Universi- ty, Japan), Kuswata Kartawinata (LIPI, Indonesia), Mark Hughes (Royal Botanic Gardens Edinburgh, UK), Martin Callmander (Missouri Botanic Gardens, USA), Michele Rodda (Singapore Botanic Gardens, Singapore), Mien A Rifai (AIPI, Indonesia), Rugayah (LIPI, Indonesia), Ruth Kiew (Forest Research Institute of Malaysia, Malaysia). Correspondence on editorial matters and subscriptions for Reinwardtia should be addressed to: HERBARIUM BOGORIENSE, BOTANY DIVISION, RESEARCH CENTER FOR BIOLOGY– LIPI, CIBINONG 16911, INDONESIA E-mail: [email protected] Cover images: Begonia hooveriana Wiriad. spec. nov. REINWARDTIA Vol 13, No 5, pp: 433−439 PANDAN (PANDANACEAE) IN FLORES ISLAND, EAST NUSA TENGGA- RA, INDONESIA: AN ECONOMIC-BOTANICAL STUDY Received August 02, 2012; accepted October 11, 2013 SITI SUSIARTI Herbarium Bogoriense, Botany Division, Research Center for Biology-LIPI, Cibinong Science Center, Jl. Raya Jakarta-Bogor Km. -
Pegloticase: a New Biologic for Treating Advanced Gout
Drug Evaluation Pegloticase: a new biologic for treating advanced gout Although pharmacologic therapies for hyperuricemia in patients with gout have been well established and are reasonably effective, a small proportion of patients are refractory to treatment and/or present with articular disease so severe as to render standard treatments inadequate. Pegloticase, a PEGylated mammalian urate oxidase with a novel mechanism of action, was recently approved in the USA for the treatment of chronic gout in adult patients refractory to conventional therapy. This paper outlines the development of this unique agent and provides details of the Phase III clinical trial program. A discussion of patient selection, treatment considerations, and risk management for infused pegloticase follows. As a new class of biologic agent offering documented and dramatic effects on lowering serum uric acid and remarkably rapid outcomes in resolving tophi, pegloticase can provide safe and effective management of hyperuricemia and gout for many patients, particularly those who have a high disease burden or who have previously failed to respond to other therapies. KEYWORDS: biologic therapy n chronic gout n hyperuricemia n pegloticase Herbert SB Baraf* & Alan K Matsumoto Among the rheumatic diseases, few are as well have disease that is refractory to current thera- George Washington University, understood as gout. The cause of gout, prolonged pies. These patients often have a chronic, symp- Center for Rheumatology & Bone Research, a Division of Arthritis & hyperuricemia resulting from excess production tomatic, destructive arthropathy, frequent acute Rheumatism Associates, 2730 or decreased excretion of uric acid (UA), was first flares of joint pain and disfiguring tophaceous University Blvd West, Wheaton, MD 20902, USA described by Garrod in the mid-19th century [1]. -
PM179 Pegloticase (Krystexxa)
Original Department: Pharmacy Management 03/23/2021 Approval: Policy #: PM179 Last Approval: 03/23/2021 Title: Pegloticase (Krystexxa) Approved By: UM Committee Line(s) of Business WAH-IMC (HCA) BHSO Medicare Advantage (CMS) Medicare SNP (CMS) Cascade Select Documentation required to determine medical necessity for Pegloticase (Krystexxa): History and/or physical examination notes and relevant specialty consultation notes that address the problem and need for the service: Diagnosis-Age-Medication list (current and past)- Labs/Diagnostics. BACKGROUND Krystexxa is a PEGylated uric acid specific enzyme indicated for treatment of chronic gout in adult patients refractory to conventional therapy.1-2 It is made up of a recombinant modified mammalian uricase produced by a genetically modified strain of Escherichia coli which is covalently bonded to monomethoxypoly (ethylene glycol) [mPEG].1 The recommended dose of Krystexxa is 8 mg administered every 2 weeks over no less than 120 minutes as an intravenous (IV) infusion. Before beginning therapy with Krystexxa, it is recommended that all oral urate-lowering therapies (ULTs) are discontinued and not restarted while on Krystexxa because concomitant use may blunt any increase in serum uric acid (SUA) levels. It is recommended to monitor SUA prior to infusions and consider discontinuing treatment if levels increase to above 6 mg/dL.1 Disease Overview Gout results from a metabolic disorder called hyperuricemia caused by an overproduction or underexcretion of uric acid. Hyperuricemia is typically defined as a serum uric acid level greater than 6.8 mg/dL; however, asymptomatic patients with elevated uric acid levels do not have gout and do not require treatment.3-4 Excessive amounts of uric acid in the blood lead to deposits of crystals in the joints and connective tissues and may cause excruciating pain. -
Periodic Table of Herbs 'N Spices
Periodic Table of Herbs 'N Spices 11HH 1 H 2 HeHe Element Proton Element Symbol Number Chaste Tree Chile (Vitex agnus-castus) (Capsicum frutescens et al.) Hemptree, Agnus Cayenne pepper, Chili castus, Abraham's balm 118Uuo Red pepper 33LiLi 44 Be 5 B B 66 C 7 N 7N 88O O 99 F 1010 Ne Ne Picture Bear’s Garlic Boldo leaves Ceylon Cinnamon Oregano Lime (Allium ursinum) (Peumus boldus) (Cinnamomum zeylanicum) Nutmeg Origanum vulgare Fenugreek Lemon (Citrus aurantifolia) Ramson, Wild garlic Boldina, Baldina Sri Lanka cinnamon (Myristica fragrans) Oregan, Wild marjoram (Trigonella foenum-graecum) (Citrus limon) 11 Na Na 1212 Mg Mg 1313 Al Al 1414 Si Si 1515 P P 16 S S 1717 Cl Cl 1818 Ar Ar Common Name Scientific Name Nasturtium Alternate name(s) Allspice Sichuan Pepper et al. Grains of Paradise (Tropaeolum majus) (Pimenta dioica) (Zanthoxylum spp.) Perilla (Aframomum melegueta) Common nasturtium, Jamaica pepper, Myrtle Anise pepper, Chinese (Perilla frutescens) Guinea grains, Garden nasturtium, Mugwort pepper, Pimento, pepper, Japanese Beefsteak plant, Chinese Savory Cloves Melegueta pepper, Indian cress, Nasturtium (Artemisia vulgaris) Newspice pepper, et al. Basil, Wild sesame (Satureja hortensis) (Syzygium aromaticum) Alligator pepper 1919 K K 20 Ca Ca 2121 Sc Sc 2222 Ti Ti 23 V V 24 Cr Cr 2525 Mn Mn 2626 Fe Fe 2727 Co Co 2828 Ni Ni 29 Cu Cu 3030 Zn Zn 31 Ga Ga 3232 Ge Ge 3333As As 34 Se Se 3535 Br Br 36 Kr Kr Cassia Paprika Caraway (Cinnamomum cassia) Asafetida Coriander Nigella Cumin Gale Borage Kaffir Lime (Capsicum annuum) (Carum carvi) -
Pegloticase - Drugbank
8/14/2018 Pegloticase - DrugBank Pegloticase Targets (1) Biointeractions (1) IDENTIFICATION Name Pegloticase Accession Number DB09208 Type Biotech Groups Approved, Investigational Biologic Classification Protein Based Therapies Recombinant Enzymes Description Pegloticase is a recombinant procine-like uricase drug indicated for the treatment of severe, treatment-refractory, chronic gout. Similarly to rasburicase, pegloticase metabolises the conversion of uric acid to allantoin. This reduces the risk of precipitate formation and development of gout, since allantoin is five to ten times more soluble than uric acid. In contrast to rasburicase, pegloticase is pegylated to increase its elimination half-life from about eight hours to ten or twelve days, and to decrease the immunogenicity of the foreign uricase protein. This modification allows for an application just once every two to four weeks, making this drug suitable for long-term treatment. Protein chemical formula C1549H2430N408O448S8 Protein average weight 34192.8533 Da Sequences > Pegloticase TYKKNDEVEFVRTGYGKDMIKVLHIQRDGKYHSIKEVATTVQLTLSSKKDYLHGDNSDVI PTDTIKNTVNVLAKFKGIKSIETFAVTICEHFLSSFKHVIRAQVYVEEVPWKRFEKNGVK HVHAFIYTPTGTHFCEVEQIRNGPPVIHSGIKDLKVLKTTQSGFEGFIKDQFTTLPEVKD RCFATQVYCKWRYHQGRDVDFEATWDTVRSIVLQKFAGPYDKGEYSPSVQKTLYDIQVLT LGQVPEIEDMEISLPNIHYLNIDMSKMGLINKEEVLLPLDNPYGKITGTVKRKLSSRL https://www.drugbank.ca/drugs/DB09208 1/9 8/14/2018 Pegloticase - DrugBank Download FASTA Format Synonyms Puricase Prescription Products Search MARKETING MARKETING NAME ↑↓ DOSAGE ↑↓ STRENGTH ↑↓ ROUTE -
Krystexxa® (Pegloticase)
Krystexxa® (pegloticase) (Intravenous) Document Number: IC-0158 Last Review Date: 10/01/2020 Date of Origin: 02/07/20103 Dates Reviewed: 11/2013, 08/2014, 07/2015, 07/2016, 09/2016, 12/2016, 03/2017, 06/2017, 09/2017, 12/2017, 03/2018, 06/2018, 10/2018, 10/2019, 10/2020 I. Length of Authorization Coverage is provided for six months and will be eligible for renewal. II. Dosing Limits A. Quantity Limit (max daily dose) [NDC Unit]: • Krystexxa 8 mg/mL single-use vial: 2 vials every 28 days B. Max Units (per dose and over time) [HCPCS Unit]: • 16 billable units every 28 days 1 III. Initial Approval Criteria Coverage is provided in the following conditions: • Patient is at least 18 years of age; AND • Patients at higher risk for glucose-6-phosphate dehydrogenase (G6PD) deficiency should be screened and found negative for G6PD before starting Krystexxa; AND • Documentation of baseline serum uric acid level > 8 mg/dL (current lab reports are required for renewal); AND Universal Criteria 1,2 • Therapy will not be given in combination with other urate lowering therapies such as allopurinol, febuxostat, probenecid, lesinurad, etc.; AND Chronic Gout † Ф 1 • Documented contraindication, intolerance, or clinical failure (i.e., inability to reduce serum uric acid to < 6 mg/dL) during a minimum (3) month trial on previous therapy with maximum tolerated dose of xanthine oxidase inhibitors (e.g., allopurinol or febuxostat) or uricosuric agents (e.g., probenecid, lenisurad, etc.); AND • Patient has one of the following: Proprietary & Confidential © 2020 Magellan Health, Inc. o 2 or more gout flares per year that were inadequately controlled by colchicine, nonsteroidal anti-inflammatory drugs (NSAIDS), or oral or injectable corticosteroids; OR o Nonresolving subcutaneous tophi † FDA-labeled indication(s); Ф Orphan Drug 1 IV. -
Ehealth DSI [Ehdsi V2.2.2-OR] Ehealth DSI – Master Value Set
MTC eHealth DSI [eHDSI v2.2.2-OR] eHealth DSI – Master Value Set Catalogue Responsible : eHDSI Solution Provider PublishDate : Wed Nov 08 16:16:10 CET 2017 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 1 of 490 MTC Table of Contents epSOSActiveIngredient 4 epSOSAdministrativeGender 148 epSOSAdverseEventType 149 epSOSAllergenNoDrugs 150 epSOSBloodGroup 155 epSOSBloodPressure 156 epSOSCodeNoMedication 157 epSOSCodeProb 158 epSOSConfidentiality 159 epSOSCountry 160 epSOSDisplayLabel 167 epSOSDocumentCode 170 epSOSDoseForm 171 epSOSHealthcareProfessionalRoles 184 epSOSIllnessesandDisorders 186 epSOSLanguage 448 epSOSMedicalDevices 458 epSOSNullFavor 461 epSOSPackage 462 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 2 of 490 MTC epSOSPersonalRelationship 464 epSOSPregnancyInformation 466 epSOSProcedures 467 epSOSReactionAllergy 470 epSOSResolutionOutcome 472 epSOSRoleClass 473 epSOSRouteofAdministration 474 epSOSSections 477 epSOSSeverity 478 epSOSSocialHistory 479 epSOSStatusCode 480 epSOSSubstitutionCode 481 epSOSTelecomAddress 482 epSOSTimingEvent 483 epSOSUnits 484 epSOSUnknownInformation 487 epSOSVaccine 488 © eHealth DSI eHDSI Solution Provider v2.2.2-OR Wed Nov 08 16:16:10 CET 2017 Page 3 of 490 MTC epSOSActiveIngredient epSOSActiveIngredient Value Set ID 1.3.6.1.4.1.12559.11.10.1.3.1.42.24 TRANSLATIONS Code System ID Code System Version Concept Code Description (FSN) 2.16.840.1.113883.6.73 2017-01 A ALIMENTARY TRACT AND METABOLISM 2.16.840.1.113883.6.73 2017-01 -
An Assessment of Plant Diversity in Home Gardens of Reang Community of Tripura
Pleione 12(2): 208 - 222. 2018. ISSN: 0973-9467 © East Himalayan Society for Spermatophyte Taxonomy doi: 10.26679/Pleione.12.2.2018.208-222 An assessment of plant diversity in Home gardens of Reang Community of Tripura Dipti Das1 and B. K. Datta Plant Taxonomy and Biodiversity Lab., Department of Botany, Tripura University, Suryamaninagar, Tripura West-799022, Tripura, India 1Corresponding author, e-mail: [email protected] [Received 30.10.2018; Revised 05.12.2018; Accepted 18.12.2018; Published 31.12.2018] Abstract Home gardens are small plots of land surrounding the house and are found in all traditional communities throughout the world. The present study tries to examine the role of Reang Home gardens in North Tripura district of Tripura. A total of 38 Home gardens in 4 hamlet or pada were randomly selected for the study. Total plant inventory and interview method were used to collect data. In Reang Home gardens at North Tripura District overall 148 species under 130 genera belonging to 55 families have been inventoried. Leguminosae and Poaceae were the most dominant families. Forty percent of the Reang Home garden plants were found to harbour edible plant species. (food, Fruits, vegetable, pulses, spices), 22% medicinal, 18% ornamental, 4% timber, 3% fine wood and other categories remain little over 3%. Reang Home garden shows a good diversity with multiple uses. Most Reang peoples rely on folk health care traditions. Domestication of wild plants for food, medicine and other purposes are an important activity. Key words: Home garden, Reang tribe, North Tripura INTRODUCTION Home gardens are small plots of land surrounding the house and are found in all traditional communities throughout the world. -
Dictionary of Cultivated Plants and Their Regions of Diversity Second Edition Revised Of: A.C
Dictionary of cultivated plants and their regions of diversity Second edition revised of: A.C. Zeven and P.M. Zhukovsky, 1975, Dictionary of cultivated plants and their centres of diversity 'N -'\:K 1~ Li Dictionary of cultivated plants and their regions of diversity Excluding most ornamentals, forest trees and lower plants A.C. Zeven andJ.M.J, de Wet K pudoc Centre for Agricultural Publishing and Documentation Wageningen - 1982 ~T—^/-/- /+<>?- •/ CIP-GEGEVENS Zeven, A.C. Dictionary ofcultivate d plants andthei rregion so f diversity: excluding mostornamentals ,fores t treesan d lowerplant s/ A.C .Zeve n andJ.M.J ,d eWet .- Wageninge n : Pudoc. -11 1 Herz,uitg . van:Dictionar y of cultivatedplant s andthei r centreso fdiversit y /A.C .Zeve n andP.M . Zhukovsky, 1975.- Me t index,lit .opg . ISBN 90-220-0785-5 SISO63 2UD C63 3 Trefw.:plantenteelt . ISBN 90-220-0785-5 ©Centre forAgricultura l Publishing and Documentation, Wageningen,1982 . Nopar t of thisboo k mayb e reproduced andpublishe d in any form,b y print, photoprint,microfil m or any othermean swithou t written permission from thepublisher . Contents Preface 7 History of thewor k 8 Origins of agriculture anddomesticatio n ofplant s Cradles of agriculture and regions of diversity 21 1 Chinese-Japanese Region 32 2 Indochinese-IndonesianRegio n 48 3 Australian Region 65 4 Hindustani Region 70 5 Central AsianRegio n 81 6 NearEaster n Region 87 7 Mediterranean Region 103 8 African Region 121 9 European-Siberian Region 148 10 South American Region 164 11 CentralAmerica n andMexica n Region 185 12 NorthAmerica n Region 199 Specieswithou t an identified region 207 References 209 Indexo fbotanica l names 228 Preface The aimo f thiswor k ist ogiv e thereade r quick reference toth e regionso f diversity ofcultivate d plants.Fo r important crops,region so fdiversit y of related wild species areals opresented .Wil d species areofte nusefu l sources of genes to improve thevalu eo fcrops . -
Krystexxa (Pegloticase)
Krystexxa (pegloticase) Line(s) of Business: Original Effective Date: HMO; PPO; QUEST Integration 10/01/2015 Medicare Advantage Current Effective Date: 01/01/2020 POLICY A. INDICATIONS The indications below including FDA-approved indications and compendial uses are considered a covered benefit provided that all the approval criteria are met and the member has no contraindications or exclusions to the prescribed therapy. FDA-Approved Indication Krystexxa is indicated for the treatment of chronic gout in adult patients refractory to conventional therapy. B. REQUIRED DOCUMENTATION The following information is necessary to initiate the prior authorization review: Initial therapy o Documentation supporting an inadequate response to allopurinol, febuxostat (Uloric), and probenecid (or clinical reason that a trial could not be completed) o Dose and length of therapy with allopurinol and febuxostat (Uloric) and probencid Continuation of therapy o Documentation supporting a positive clinical response to therapy with Krystexxa (e.g., chart notes, medical records) o Current uric acid levels C. CRITERIA FOR APPROVAL Chronic Gout Authorization of 12 months may be granted for members with a diagnosis of chronic gout when ALL of the following criteria are met: 1. Krystexxa will NOT be used concomitantly with oral urate-lowering therapies 2. Member has had an inadequate response to or a clinical reason for not completing at least a three-month trial (see Appendix) with ALL of the following medications at the medically appropriate maximum doses: a. Allopurinol or febuxostat b. Probenecid (alone or in combination with allopurinol or febuxostat) D. CONTINUATION OF THERAPY 2 Authorization of 12 months may be granted for all members (including new members) with a diagnosis of chronic gout that meet ALL initial authorization criteria and have NOT had two consecutive uric acid levels above 6 mg/dL since starting treatment with Krystexxa. -
The Chiba University International Collaborative Research
The Chiba University Internatinal Collaborative Research 2015 Contents Faculty of Letters ......................................................................................................................... 1 Faculty of Law, Politics and Economics ...................................................................................... 2 Graduate School of Humanities and Social Sciences ................................................................ 5 Faculty of Education .................................................................................................................... 8 Graduate School of Science ....................................................................................................... 14 Graduate School of Medicine ..................................................................................................... 63 Center for Forensic Mental Health ........................................................................................... 83 Graduate School of Pharmaceutical Sciences .......................................................................... 88 School of Nursing ....................................................................................................................... 98 Graduate School of Engineering ............................................................................................. 104 Graduate School of Advanced Integration Science ................................................................ 108 Center for Frontier Science .................................................................................................... -
9789814771382
30 What is the difference between holy basil,For ReviewUseful only sweet basil and hoary basil — and which one is “Thai basil”? Herbs Which type of chilli packs the most punch? What culinary secrets do “Chinese keys” unlock? & Which Thai herbs can relieve indigestion, Spices cough, rheumatism, fatigue and migraine? 30 Thai cuisine is famed for the complexity and delicacy of its flavours, of Useful largely the result of the herbs and spices used. Surprisingly, only 30 or so are needed. It is the ingenious combination of these ingredients Thailand that makes Thai food so distinctive. And at the same time that these herbs and spices add flavour and fragrance, they bring natural curative Herbs & Spices properties that have been recognised for their efficacy in traditional practice through the ages. Each herb or spice in this book is described in terms of its botanical characteristics, its culinary and medicinal uses (and other notable applications), and how it should be handled and stored to best pre- serve its qualities. In addition, a selection of classic recipes shows how of the various ingredients are brought together harmoniously in authentic H Thai fare. U G H Packed with information and photos, this book is an ideal guide to the T T.W. Thailand science of these useful plants, the practicalities of putting them to use, and the magic of Thailand’s cuisine and culture. A N Hugh T.W. Tan, Associate Professor at the Department of Biological Sciences, National University of Singapore, has been with the university teaching and researching botany and ecology for over 30 years.